首页 > 最新文献

TARGETS最新文献

英文 中文
Patent prosecution in proteomics 蛋白质组学的专利申请
TARGETS
Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02319-5
Keala Chan, Dennis Fernandez
{"title":"Patent prosecution in proteomics","authors":"Keala Chan, Dennis Fernandez","doi":"10.1016/S1477-3627(03)02319-5","DOIUrl":"10.1016/S1477-3627(03)02319-5","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 81-84"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02319-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76267520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
It's a knockout! 太棒了!
TARGETS
Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02323-7
JulieP. Howard
{"title":"It's a knockout!","authors":"JulieP. Howard","doi":"10.1016/S1477-3627(03)02323-7","DOIUrl":"10.1016/S1477-3627(03)02323-7","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 76-77"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02323-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79897028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic approaches for generating comprehensive protein interaction maps 生成综合蛋白质相互作用图的蛋白质组学方法
TARGETS
Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02316-X
Daniel Auerbach , Michael Fetchko , Igor Stagljar

The availability of complete genome sequences of numerous model organisms has initiated the development of new approaches in biological research to complement conventional biochemistry and genetics. In this context, high-throughput methods for detecting protein interactions, such as mass spectrometry and yeast two-hybrid assays, have produced vast amounts of data that can be exploited to infer protein function and regulation. In this review, we explore different genome-wide protein interaction studies and comment on their extrapolation towards understanding protein functions. It is likely that improvements of these approaches, together with more sophisticated databases and the invention of novel technologies, will help to decipher the complex interactions among proteins and to integrate interacting proteins into existing and novel cellular pathways.

许多模式生物全基因组序列的可用性已经启动了生物研究新方法的发展，以补充传统的生物化学和遗传学。在这种情况下，检测蛋白质相互作用的高通量方法，如质谱法和酵母双杂交测定，已经产生了大量的数据，可以用来推断蛋白质的功能和调节。在这篇综述中，我们探讨了不同的全基因组蛋白质相互作用的研究，并评论了它们对理解蛋白质功能的推断。这些方法的改进，加上更复杂的数据库和新技术的发明，很可能有助于破译蛋白质之间复杂的相互作用，并将相互作用的蛋白质整合到现有的和新的细胞途径中。
{"title":"Proteomic approaches for generating comprehensive protein interaction maps","authors":"Daniel Auerbach ,&nbsp;Michael Fetchko ,&nbsp;Igor Stagljar","doi":"10.1016/S1477-3627(03)02316-X","DOIUrl":"10.1016/S1477-3627(03)02316-X","url":null,"abstract":"<div><p>The availability of complete genome sequences of numerous model organisms has initiated the development of new approaches in biological research to complement conventional biochemistry and genetics. In this context, high-throughput methods for detecting protein interactions, such as mass spectrometry and yeast two-hybrid assays, have produced vast amounts of data that can be exploited to infer protein function and regulation. In this review, we explore different genome-wide protein interaction studies and comment on their extrapolation towards understanding protein functions. It is likely that improvements of these approaches, together with more sophisticated databases and the invention of novel technologies, will help to decipher the complex interactions among proteins and to integrate interacting proteins into existing and novel cellular pathways.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 85-92"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02316-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86752315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Haemozoin (malaria pigment): a unique crystalline drug target 血色素(疟疾色素):一种独特的结晶药物靶点
TARGETS
Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02310-9
Timothy J. Egan

Historically, chloroquine has been the most important antimalarial. Current evidence suggests that resistance to this drug is not the result of a change in its target, which remains important in the design of novel antimalarials, an area of active research. Many studies support the hypothesis that this target is haematin, whereas a recent report suggests that the haemozoin (malaria pigment) crystal itself might in fact be the target. A detailed understanding of the mechanism and structure of this interaction could revolutionise the search for new antimalarials in the near future.

历史上，氯喹一直是最重要的抗疟药。目前的证据表明，对这种药物的耐药性不是其靶点改变的结果，这在设计新的抗疟药物中仍然很重要，这是一个活跃的研究领域。许多研究支持这一目标是血红素的假设，而最近的一份报告表明，血红素(疟疾色素)晶体本身实际上可能是目标。对这种相互作用的机制和结构的详细了解可能会在不久的将来彻底改变新的抗疟药物的研究。
{"title":"Haemozoin (malaria pigment): a unique crystalline drug target","authors":"Timothy J. Egan","doi":"10.1016/S1477-3627(03)02310-9","DOIUrl":"10.1016/S1477-3627(03)02310-9","url":null,"abstract":"<div><p>Historically, chloroquine has been the most important antimalarial. Current evidence suggests that resistance to this drug is not the result of a change in its target, which remains important in the design of novel antimalarials, an area of active research. Many studies support the hypothesis that this target is haematin, whereas a recent report suggests that the haemozoin (malaria pigment) crystal itself might in fact be the target. A detailed understanding of the mechanism and structure of this interaction could revolutionise the search for new antimalarials in the near future.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 115-124"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02310-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73034692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 72
Jürgen Bajorath discusses integrating disciplines in the drug discovery industry j<s:1> rgen Bajorath讨论了药物发现行业的整合学科
TARGETS
Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02299-2
Jürgen Bajorath
{"title":"Jürgen Bajorath discusses integrating disciplines in the drug discovery industry","authors":"Jürgen Bajorath","doi":"10.1016/S1477-3627(03)02299-2","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02299-2","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 45-47"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02299-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89988680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New high-throughput NMR 新型高通量核磁共振
TARGETS
Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02296-7
Thomas S. May (freelance writer)
{"title":"New high-throughput NMR","authors":"Thomas S. May (freelance writer)","doi":"10.1016/S1477-3627(03)02296-7","DOIUrl":"10.1016/S1477-3627(03)02296-7","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 39-40"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02296-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76243807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of RNA interference RNA干扰的应用
TARGETS
Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02303-1
Hans Winkler, Steve Powell
{"title":"Applications of RNA interference","authors":"Hans Winkler,&nbsp;Steve Powell","doi":"10.1016/S1477-3627(03)02303-1","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02303-1","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 42-44"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02303-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91590625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Nematode model for obesity 线虫肥胖模型
TARGETS
Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02297-9
Vida Foubister (freelance writer)
{"title":"Nematode model for obesity","authors":"Vida Foubister (freelance writer)","doi":"10.1016/S1477-3627(03)02297-9","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02297-9","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 40-41"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02297-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91634014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Drugs targets and bioterrorism defense 毒品目标和生物恐怖主义防御
TARGETS
Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02294-3
David J Ecker
{"title":"Drugs targets and bioterrorism defense","authors":"David J Ecker","doi":"10.1016/S1477-3627(03)02294-3","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02294-3","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 35-37"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02294-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89988678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target validation using human tissue: from gene expression to function 使用人体组织的靶标验证:从基因表达到功能
TARGETS
Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02298-0
Robert A. Coleman, Kenneth L. Clark

Arguably, one of the main reasons for the pharmaceutical industry's current poor performance in bringing successful new drugs to market is its over-reliance on animal data in the discovery and development processes. We propose that more use should be made of donated human tissues in order to identify and validate drug targets and to discover and develop novel drugs to act upon them. We review the ways that human tissues may be used for this purpose, from the measurement of gene expression, through determination of specific protein abundance, to functional evaluation, both at the level of tissue and specific cell type. The proposal is not simply theoretical, as we provide a specific case history to illustrate these points.

可以说，制药业目前在将成功的新药推向市场方面表现不佳的主要原因之一是在发现和开发过程中过度依赖动物数据。我们建议更多地利用捐赠的人体组织来识别和验证药物靶点，并发现和开发新的药物来作用于它们。我们回顾了人类组织可能用于这一目的的方法，从基因表达的测量，通过确定特定蛋白质丰度，到组织水平和特定细胞类型的功能评估。这个建议不仅仅是理论上的，因为我们提供了一个具体的案例历史来说明这些观点。
{"title":"Target validation using human tissue: from gene expression to function","authors":"Robert A. Coleman,&nbsp;Kenneth L. Clark","doi":"10.1016/S1477-3627(03)02298-0","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02298-0","url":null,"abstract":"<div><p>Arguably, one of the main reasons for the pharmaceutical industry's current poor performance in bringing successful new drugs to market is its over-reliance on animal data in the discovery and development processes. We propose that more use should be made of donated human tissues in order to identify and validate drug targets and to discover and develop novel drugs to act upon them. We review the ways that human tissues may be used for this purpose, from the measurement of gene expression, through determination of specific protein abundance, to functional evaluation, both at the level of tissue and specific cell type. The proposal is not simply theoretical, as we provide a specific case history to illustrate these points.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 58-64"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02298-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90001919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
TARGETS
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1