Metal ions including cobalt (Co) ions reportedly exhibit neurotoxic and antimicrobial properties. We hypothesized that oral exposure to Co may have implications for gut-dysbiosis with possible alterations of microbiota-gut-brain signaling in the host. In this preliminary study, we sought to examine whether exposure of male Wistar rats to cobalt chloride (CoCl2) at 0, 25, 50 and 100 mg/kg for two weeks affects select neurobehavioural indices, vagus nerve and brain morphology along with evaluation of associated changes in faecal bacterial flora, faecal fatty acids and the morphology of the intestines. CoCl2-exposed rats showed a dose-dependent reduction in hanging latency in the hanging wire (HW) test, reduced tendency to recognize novel objects in a Novel Object recognition (NOR) test, but increased interaction with open arms in the elevated plus maze (EPM) test, compared to controls. There were dose-dependent reductions in total heterotrophic count, coliforms, E. coli, Enterococcal and Lactobacilli counts in the faeces. Administration of CoCl2 at 100 mg/kg evoked the appearance of unsaturated fatty acids including palmitoleic, oleic and linoleic acids in the faeces as detected by gas chromatography-flame ion detection (GD-FID) analysis using fatty acid methyl esters (FAME) standards. Histopathological examination revealed chromatolysis of Purkinje cells in the cerebellum, although no significant lesions were present in the vagus nerve isolated from all the groups. In the intestines, there was moderate to severe infiltration of inflammatory cells into the duodenum, ileum, jejunum and colon while villi erosions were seen prominently in the ileum. These initial findings suggest that short-term exposure to Co can lead to gut-associated changes that may underlie neurotoxicity and alterations in behavior induced by Co.
{"title":"Cobalt-induced neuro-behavioural alterations are accompanied by profound Purkinje cell and gut-associated responses in rats","authors":"A. Akinrinde, K. Adigun, O. Mustapha","doi":"10.5620/eaht.2023010","DOIUrl":"https://doi.org/10.5620/eaht.2023010","url":null,"abstract":"Metal ions including cobalt (Co) ions reportedly exhibit neurotoxic and antimicrobial properties. We hypothesized that oral exposure to Co may have implications for gut-dysbiosis with possible alterations of microbiota-gut-brain signaling in the host. In this preliminary study, we sought to examine whether exposure of male Wistar rats to cobalt chloride (CoCl2) at 0, 25, 50 and 100 mg/kg for two weeks affects select neurobehavioural indices, vagus nerve and brain morphology along with evaluation of associated changes in faecal bacterial flora, faecal fatty acids and the morphology of the intestines. CoCl2-exposed rats showed a dose-dependent reduction in hanging latency in the hanging wire (HW) test, reduced tendency to recognize novel objects in a Novel Object recognition (NOR) test, but increased interaction with open arms in the elevated plus maze (EPM) test, compared to controls. There were dose-dependent reductions in total heterotrophic count, coliforms, E. coli, Enterococcal and Lactobacilli counts in the faeces. Administration of CoCl2 at 100 mg/kg evoked the appearance of unsaturated fatty acids including palmitoleic, oleic and linoleic acids in the faeces as detected by gas chromatography-flame ion detection (GD-FID) analysis using fatty acid methyl esters (FAME) standards. Histopathological examination revealed chromatolysis of Purkinje cells in the cerebellum, although no significant lesions were present in the vagus nerve isolated from all the groups. In the intestines, there was moderate to severe infiltration of inflammatory cells into the duodenum, ileum, jejunum and colon while villi erosions were seen prominently in the ileum. These initial findings suggest that short-term exposure to Co can lead to gut-associated changes that may underlie neurotoxicity and alterations in behavior induced by Co.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84607030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youssef Bouchriti, A. Korrida, Mohamed Ait Haddou, A. Achbani, H. Sine, J. Rida, Hayat Sine, Rachid Amiha, B. Kabbachi
It is well established that respiratory mortality and morbidity are associated with high concentrations of fine particles such as PM2.5. The aim of this study was to evaluate the long- and short-term impacts of PM2.5 on the population of Agadir, Morocco, using AirQ 2.1.1 software. The mean PM2.5 values were obtained from data collected at three sites. Baseline incidence data were obtained from the literature, and relative risk (RR) values were referenced from the World Health Organization. This study quantified long-term total mortality (LT-TM), lung cancer mortality (LT-LC), morbidity from acute lower respiratory tract infections (LT-ALRI), and morbidity from chronic obstructive pulmonary disease (LT-COPD), as well as short-term total mortality (ST-TM). The attributable proportions (AP) of LT-TM and LT-LC were estimated to 14.19% and 18.42%, respectively. Their excess deaths were estimated to 279 and 11 persons, respectively, and their RRs to 1.16 (95% CI: 1.10-1.22) and 1.23 (95% CI: 1.12-1.37), respectively. Furthermore, the AP of LT-ALRI and LT-COPD were estimated to 14.36% and 15.68%, respectively, their excess deaths to 33 and 4, and their RRs to 1.17 (95% CI: 1.11-1.31) and 1.19 (95% CI: 1.00-1.02), respectively. In comparison, the AP of ST-TM was estimated to 1.27%, with a 25-person excess death rate. This study was conducted to inform decision-making and to promote local policies on ambient air quality.
{"title":"Mortality and morbidity assessment attributed to short- and long-term exposure to fine particles in ambient air of Agadir city, Morocco: The AirQ model approach","authors":"Youssef Bouchriti, A. Korrida, Mohamed Ait Haddou, A. Achbani, H. Sine, J. Rida, Hayat Sine, Rachid Amiha, B. Kabbachi","doi":"10.5620/eaht.2023009","DOIUrl":"https://doi.org/10.5620/eaht.2023009","url":null,"abstract":"It is well established that respiratory mortality and morbidity are associated with high concentrations of fine particles such as PM2.5. The aim of this study was to evaluate the long- and short-term impacts of PM2.5 on the population of Agadir, Morocco, using AirQ 2.1.1 software. The mean PM2.5 values were obtained from data collected at three sites. Baseline incidence data were obtained from the literature, and relative risk (RR) values were referenced from the World Health Organization. This study quantified long-term total mortality (LT-TM), lung cancer mortality (LT-LC), morbidity from acute lower respiratory tract infections (LT-ALRI), and morbidity from chronic obstructive pulmonary disease (LT-COPD), as well as short-term total mortality (ST-TM). The attributable proportions (AP) of LT-TM and LT-LC were estimated to 14.19% and 18.42%, respectively. Their excess deaths were estimated to 279 and 11 persons, respectively, and their RRs to 1.16 (95% CI: 1.10-1.22) and 1.23 (95% CI: 1.12-1.37), respectively. Furthermore, the AP of LT-ALRI and LT-COPD were estimated to 14.36% and 15.68%, respectively, their excess deaths to 33 and 4, and their RRs to 1.17 (95% CI: 1.11-1.31) and 1.19 (95% CI: 1.00-1.02), respectively. In comparison, the AP of ST-TM was estimated to 1.27%, with a 25-person excess death rate. This study was conducted to inform decision-making and to promote local policies on ambient air quality.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"457 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76063264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji-Soo Kim, Myung-Hwan Jeong, Heung-Sik Seo, Myeong-Kyu Park, Hee Ju Park, Seong-Soon Nah
Titanium dioxide (TiO2) was used in various applications in a wide range of products including food, cosmetics and photocatalyst. General toxicity studies of titanium dioxide, GST (Green Sludge Titanium) have been investigated in several reports, whereas studies concerning mutagenicity and genotoxicity have not been elucidated. Herein, we investigated the potential mutagenicity and genotoxicity of GST by genetic toxicology testing. The bacterial reverse mutation test was conducted by the pre-incubation method in the presence and absence of metabolic activation system (S9 mixture). The chromosome aberration test was performed using cultured Chinese hamster lung cell line in the absence and presence of S9 mixture. The micronucleus test was performed by using specific pathogen-free male ICR mice. Genotoxicity tests were conducted following the test guidelines of the Organisation for Economic Cooperation and Development with application of Good Laboratory Practice. No statistically significant increases were found in the bacterial reverse mutation test, in vitro chromosome aberration test, and in vivo micronucleus test when tested for induction of genotoxicity in GST. These results suggest that GST did not induce mutagenicity and genotoxicity in both in vitro and in vivo system.
{"title":"In vitro and in vivo evaluation of the genotoxicity of titanium dioxide, GST","authors":"Ji-Soo Kim, Myung-Hwan Jeong, Heung-Sik Seo, Myeong-Kyu Park, Hee Ju Park, Seong-Soon Nah","doi":"10.5620/eaht.2023008","DOIUrl":"https://doi.org/10.5620/eaht.2023008","url":null,"abstract":"Titanium dioxide (TiO2) was used in various applications in a wide range of products including food, cosmetics and photocatalyst. General toxicity studies of titanium dioxide, GST (Green Sludge Titanium) have been investigated in several reports, whereas studies concerning mutagenicity and genotoxicity have not been elucidated. Herein, we investigated the potential mutagenicity and genotoxicity of GST by genetic toxicology testing. The bacterial reverse mutation test was conducted by the pre-incubation method in the presence and absence of metabolic activation system (S9 mixture). The chromosome aberration test was performed using cultured Chinese hamster lung cell line in the absence and presence of S9 mixture. The micronucleus test was performed by using specific pathogen-free male ICR mice. Genotoxicity tests were conducted following the test guidelines of the Organisation for Economic Cooperation and Development with application of Good Laboratory Practice. No statistically significant increases were found in the bacterial reverse mutation test, in vitro chromosome aberration test, and in vivo micronucleus test when tested for induction of genotoxicity in GST. These results suggest that GST did not induce mutagenicity and genotoxicity in both in vitro and in vivo system.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88338754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To study the knowledge, attitudes and perceptions, to study the health effects, and to investigate the concentration of Pb and Cd in indoor dust samples, drinking water samples, and personal air samples and to assess the health risk among workers who worked at e-waste recycling shops in the southern region, Thailand. This cross-sectional descriptive study was conducted among workers from 136 electronic waste recycling stores in Southern Thailand, between January and July 2021. The study questionnaire was given to the 272 e-waste workers participating. Indoor dust, drinking water, and personal air samples were collected 27 e-waste shops and the concentrations of Pb and Cd in all samples were determined by graphite furnace atomic absorption spectrometry. Descriptive statistics and the simple linear regression were used to analyze. Overall, 176 employees (64.7%) suffered nasal irritation, 181 employees (66.5%) reported coughing/sneezing, and 163 employees (59.9%) had inconvenient breathing/jamming symptoms. Also, 158 employees (58.1%) had skin peeling symptoms, and 188 employees (69.1%) had muscle aches. The results indicate the positive influence of increasing knowledge and attitudes on the average practice score. The hazardous index (HI)-values of indoor dust samples, drinking water samples, and personal air samples were less than 1, was considered health-protective. The results will provide the direct evidence needed by e-waste managers to warn learners. Thus, there is a need for education programme to increase knowledge among the workers. In addition, information dissemination, involvement with organizations and associations is a necessity for workers in this study.
{"title":"Assessment of knowledge, attitude, perceptions and risk assessment among workers in e-waste recycling shops, Thailand","authors":"Somsiri Decharat, Peeranart Kiddee","doi":"10.5620/eaht.2022003","DOIUrl":"https://doi.org/10.5620/eaht.2022003","url":null,"abstract":"To study the knowledge, attitudes and perceptions, to study the health effects, and to investigate the concentration of Pb and Cd in indoor dust samples, drinking water samples, and personal air samples and to assess the health risk among workers who worked at e-waste recycling shops in the southern region, Thailand. This cross-sectional descriptive study was conducted among workers from 136 electronic waste recycling stores in Southern Thailand, between January and July 2021. The study questionnaire was given to the 272 e-waste workers participating. Indoor dust, drinking water, and personal air samples were collected 27 e-waste shops and the concentrations of Pb and Cd in all samples were determined by graphite furnace atomic absorption spectrometry. Descriptive statistics and the simple linear regression were used to analyze. Overall, 176 employees (64.7%) suffered nasal irritation, 181 employees (66.5%) reported coughing/sneezing, and 163 employees (59.9%) had inconvenient breathing/jamming symptoms. Also, 158 employees (58.1%) had skin peeling symptoms, and 188 employees (69.1%) had muscle aches. The results indicate the positive influence of increasing knowledge and attitudes on the average practice score. The hazardous index (HI)-values of indoor dust samples, drinking water samples, and personal air samples were less than 1, was considered health-protective. The results will provide the direct evidence needed by e-waste managers to warn learners. Thus, there is a need for education programme to increase knowledge among the workers. In addition, information dissemination, involvement with organizations and associations is a necessity for workers in this study.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78695186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Insung Chung, Hyeseung Ryu, Seong-yong Yoon, J. Ha
Sodium hypochlorite is widely used as the main component of cleaners and has an excellent bleaching and sterilizing effect in living and medical environments. In addition to bleaching, it is used for wastewater treatment and for sterilization in food factories, and also for disinfectants during the COVID-19 pandemic. This study analyzed reports of the health effects of sodium hypochlorite and classified them by toxicity along the exposure pathway. Most case reports described the health effects of acute high-concentration exposure, with a common case being dental exposure, mainly during treatment.
{"title":"Health effects of sodium hypochlorite: review of published case reports","authors":"Insung Chung, Hyeseung Ryu, Seong-yong Yoon, J. Ha","doi":"10.5620/eaht.2022006","DOIUrl":"https://doi.org/10.5620/eaht.2022006","url":null,"abstract":"Sodium hypochlorite is widely used as the main component of cleaners and has an excellent bleaching and sterilizing effect in living and medical environments. In addition to bleaching, it is used for wastewater treatment and for sterilization in food factories, and also for disinfectants during the COVID-19 pandemic. This study analyzed reports of the health effects of sodium hypochlorite and classified them by toxicity along the exposure pathway. Most case reports described the health effects of acute high-concentration exposure, with a common case being dental exposure, mainly during treatment.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"78 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91447693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, 16 children’s products with the highest detection potential of phthalates were selected, and a phthalate assay and transdermal delivery analysis (NIER, US EPA Wipe [stress condition], US EPA Wipe [physiological condition], and US EPA Hand Wipe) were conducted with these products. The content of 6 controlled phthalates (DBP, BBP, DEHP, DNOP, DINP, and DIDP) was measured and most products contained more phthalates than the regulated guidelines (a total content of 6 phthalates to be ≤0.1%). For transdermal delivery, all items were found to be lower in the NIER transdermal delivery test method compared to the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method. For the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method, a similar result was observed, except for DINP. The average daily dose (ADD) estimated by determining the exposure algorithm for each transdermal delivery test method was highest in mats with a large contacting surface area and a long exposure time in the respective test methods. Conclusively, there was a difference between the NIER transdermal delivery test method and the US EPA Wipe transdermal delivery test method.
本研究选取了16种邻苯二甲酸盐检测潜力最高的儿童产品，对这些产品进行邻苯二甲酸盐测定和透皮给药分析(NIER、US EPA Wipe[应激状态]、US EPA Wipe[生理状态]和US EPA Hand Wipe)。测定了6种受控邻苯二甲酸酯(DBP、BBP、DEHP、DNOP、DINP和DIDP)的含量，大多数产品的邻苯二甲酸酯含量超过了规定的标准(6种邻苯二甲酸酯的总含量≤0.1%)。对于透皮给药，与美国EPA Hand Wipe(应激状态和生理状态)透皮给药测试方法相比，NIER透皮给药测试方法中所有项目都较低。对于美国EPA Hand Wipe(应激状态和生理状态)透皮给药试验方法，除了DINP外，观察到类似的结果。通过确定每种透皮给药试验方法的暴露算法估计的平均日剂量(ADD)在各自试验方法中接触表面积大、暴露时间长的垫子中最高。最后，NIER透皮给药试验方法与美国EPA Wipe透皮给药试验方法存在差异。
{"title":"Evaluation of transdermal exposure of phthalates in children’s products","authors":"Jihye Hwang, Young-Wook Lim, Ji-Yeon Yang, Dong-chun Shin","doi":"10.5620/eaht.2022005","DOIUrl":"https://doi.org/10.5620/eaht.2022005","url":null,"abstract":"In this study, 16 children’s products with the highest detection potential of phthalates were selected, and a phthalate assay and transdermal delivery analysis (NIER, US EPA Wipe [stress condition], US EPA Wipe [physiological condition], and US EPA Hand Wipe) were conducted with these products. The content of 6 controlled phthalates (DBP, BBP, DEHP, DNOP, DINP, and DIDP) was measured and most products contained more phthalates than the regulated guidelines (a total content of 6 phthalates to be ≤0.1%). For transdermal delivery, all items were found to be lower in the NIER transdermal delivery test method compared to the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method. For the US EPA Hand Wipe (stress condition and physiological condition) transdermal delivery test method, a similar result was observed, except for DINP. The average daily dose (ADD) estimated by determining the exposure algorithm for each transdermal delivery test method was highest in mats with a large contacting surface area and a long exposure time in the respective test methods. Conclusively, there was a difference between the NIER transdermal delivery test method and the US EPA Wipe transdermal delivery test method.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77445399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genotoxicity and oxidative stress potential of Ajakanga Landfill Leachate (ALL) were investigated in this study. Forty-two male albino rats of the Wistar strain (100 g and 150 g) were divided equally into six groups. Group A (control) animals were given distilled water as drinking water for forty-five days; while groups B-F animals were exposed to 12.5%, 25%, 50%, 75% and 100% leachate respectively via drinking water for forty-five days. The effect of the leachate was assessed on markers of oxidative stress in the liver, kidney and testes of rats; markers of liver function (Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined in the serum and the genotoxic effect of the leachate was investigated using micronucleus assay. Physicochemical and heavy metal analysis were also carried out on the leachate sample. Exposure to ALL resulted in increase in the activities of ALT and AST. A significant increase in malondialdehyde level as well as alterations in antioxidant status was observed in the liver, kidney and testes of the rats compared with control. There was also significant increase in micronuclei formation in the bone marrow of rats exposed to the leachate. Physicochemical and heavy metal analysis of the leachate revealed the presence of some heavy metals at high concentrations as well as other toxic constituents and the total number of active bacteria in the leachate sample were also high. In conclusion, ALL induced oxidative stress and genotoxicity in rats. This suggests that the leachate may be toxic to humans if exposure occurs.
{"title":"Evaluation of genotoxic and oxidative stress potential of Ajakanga Landfill Leachate in rats","authors":"O. Arojojoye, O. Nwaechefu, Samuel C. Nkwadinamor","doi":"10.5620/eaht.2022004","DOIUrl":"https://doi.org/10.5620/eaht.2022004","url":null,"abstract":"Genotoxicity and oxidative stress potential of Ajakanga Landfill Leachate (ALL) were investigated in this study. Forty-two male albino rats of the Wistar strain (100 g and 150 g) were divided equally into six groups. Group A (control) animals were given distilled water as drinking water for forty-five days; while groups B-F animals were exposed to 12.5%, 25%, 50%, 75% and 100% leachate respectively via drinking water for forty-five days. The effect of the leachate was assessed on markers of oxidative stress in the liver, kidney and testes of rats; markers of liver function (Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined in the serum and the genotoxic effect of the leachate was investigated using micronucleus assay. Physicochemical and heavy metal analysis were also carried out on the leachate sample. Exposure to ALL resulted in increase in the activities of ALT and AST. A significant increase in malondialdehyde level as well as alterations in antioxidant status was observed in the liver, kidney and testes of the rats compared with control. There was also significant increase in micronuclei formation in the bone marrow of rats exposed to the leachate. Physicochemical and heavy metal analysis of the leachate revealed the presence of some heavy metals at high concentrations as well as other toxic constituents and the total number of active bacteria in the leachate sample were also high. In conclusion, ALL induced oxidative stress and genotoxicity in rats. This suggests that the leachate may be toxic to humans if exposure occurs.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87032838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kazemifar, A. Shafikhani, H. Mozhdehipanah, S. Khamesi, M. Arami
Evidence suggests that the relationship between arsenic metabolism and diseases, including metabolic syndrome, is complex. The aim of this study was to evaluate the different types of arsenic methylation and its association with metabolic syndrome in an arsenic endemic area. A cross-sectional study was conducted on 132 subjects from Shahid-Abad Village, Qazvin province, Iran (arsenic endemic area). Demographic characteristics, metabolic syndrome, and urinary arsenic species, including iAs (inorganic arsenic), MMA (monomethylarsonic acid), and DMA (dimethylarsinic acid) were measured for all patients and their relationship was analyzed by appropriate statistical methods. In this study, 34.5% of the participants had metabolic syndrome. The decrease in %MMA, increase in %DMA and increase in secondary methylation index (DMA/MMA) were associated with increased risk of metabolic syndrome (p<0.05). We did not find any association between the incidence of metabolic syndrome with primary methylation index (MMA/iAs) and %iAs (p>0.05). This study showed that the prevalence of metabolic syndrome was significantly higher in people with metabolic syndrome than in the general population. A closer examination revealed that the secondary methylation index is related to the metabolic syndrome and its components. Given the higher prevalence of cardiovascular disease and diabetes in patients with metabolic syndrome, it is necessary to change the pathogenesis of the disease using comprehensive management methods for decreasing patient complications.
{"title":"Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic.","authors":"A. Kazemifar, A. Shafikhani, H. Mozhdehipanah, S. Khamesi, M. Arami","doi":"10.5620/eaht.2020006","DOIUrl":"https://doi.org/10.5620/eaht.2020006","url":null,"abstract":"Evidence suggests that the relationship between arsenic metabolism and diseases, including metabolic syndrome, is complex. The aim of this study was to evaluate the different types of arsenic methylation and its association with metabolic syndrome in an arsenic endemic area. A cross-sectional study was conducted on 132 subjects from Shahid-Abad Village, Qazvin province, Iran (arsenic endemic area). Demographic characteristics, metabolic syndrome, and urinary arsenic species, including iAs (inorganic arsenic), MMA (monomethylarsonic acid), and DMA (dimethylarsinic acid) were measured for all patients and their relationship was analyzed by appropriate statistical methods. In this study, 34.5% of the participants had metabolic syndrome. The decrease in %MMA, increase in %DMA and increase in secondary methylation index (DMA/MMA) were associated with increased risk of metabolic syndrome (p<0.05). We did not find any association between the incidence of metabolic syndrome with primary methylation index (MMA/iAs) and %iAs (p>0.05). This study showed that the prevalence of metabolic syndrome was significantly higher in people with metabolic syndrome than in the general population. A closer examination revealed that the secondary methylation index is related to the metabolic syndrome and its components. Given the higher prevalence of cardiovascular disease and diabetes in patients with metabolic syndrome, it is necessary to change the pathogenesis of the disease using comprehensive management methods for decreasing patient complications.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"17 1","pages":"2020006-0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90316794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. E. Muze, Alexander Iheanyichukwu Opara, F. Ibe, O. C. Njoku
Geo-environmental assessment of activities of auto-mechanics at Alaoji Aba and Elekahia Port Harcourt, both in the Niger Delta region, Southern Nigeria were carried out with the main objective of determining the extent of soil contamination arising from anthropogenic activities within mechanic villages (MVs). Geochemical analysis of soil samples from the study area revealed that the concentrations of the trace metals ranged from <1 mg/kg for chromium (Cr) to 1,925 mg/kg for the lead (Pb). Soil analysis for polycyclic aromatic hydrocarbon (PAH) and total petroleum hydrocarbon (TPH) across the area revealed concentrations ranging from <0.02 to 1.80 mg/Kg and from <1.00 to 38,327 mg/kg respectively. Elevated levels of the heavy metals and TPH were observed at MV in Alaoji Aba when compared to MV in Elekahia Port Harcourt, and the control sites. These could be attributed to contamination due to the presence of these auto-mechanics in the area for over thirty years. The concentration of Pb and Cd recorded in some sample points were above USEPA (United State Environmental Protection Agency) and the National Environmental Standards and Regulations Enforcement Agency (NESREA) permissible limits. Results of PAH analysis showed the presence of naphthalene, phenanthrene, pyrene, fluorene, benzo(a)anthracene, acenaphthene, methylnaphthalene. Risk assessment analysis showed significant geo-accumulation values for Cd and Pb indicating heavy contamination. The monomial risk factor of the heavy metals in the MVs are in the order Cd>Pb>Cr, while potential ecological risk index analysis showed values indicating very high risk, considerable risk and a moderate risk to the area under study as well as the surrounding environment. These results suggest that the soils from the MVs which represent the mechanic workshops at Alaoji Aba and Elekahia Port Harcourt are considered to be of pollution concern due to elevated Pb and Cd levels. Hence, there is a serious need to regularly monitor the activities of auto-mechanics in the study area.
对尼日利亚南部尼日尔三角洲地区的Alaoji Aba和Elekahia Port Harcourt的汽车修理工活动进行了地质环境评估，主要目的是确定机械村(MVs)内人为活动引起的土壤污染程度。研究区土壤样品的地球化学分析表明，研究区土壤中微量金属的浓度范围为Pb>Cr，潜在生态风险指数分析显示，研究区及周边环境存在极高、相当和中等风险。这些结果表明，代表阿劳吉阿坝和埃莱卡希亚港哈考特机械车间的农场土壤由于铅和Cd水平升高而被认为是污染问题。因此，有一个严重的需要定期监测在研究领域的自动机械师的活动。
{"title":"Assessment of the geo-environmental effects of activities of auto-mechanic workships at Alaoji Aba and Elekahia Port Harcourt, Niger Delta, Nigeria.","authors":"N. E. Muze, Alexander Iheanyichukwu Opara, F. Ibe, O. C. Njoku","doi":"10.5620/eaht.2020005","DOIUrl":"https://doi.org/10.5620/eaht.2020005","url":null,"abstract":"Geo-environmental assessment of activities of auto-mechanics at Alaoji Aba and Elekahia Port Harcourt, both in the Niger Delta region, Southern Nigeria were carried out with the main objective of determining the extent of soil contamination arising from anthropogenic activities within mechanic villages (MVs). Geochemical analysis of soil samples from the study area revealed that the concentrations of the trace metals ranged from <1 mg/kg for chromium (Cr) to 1,925 mg/kg for the lead (Pb). Soil analysis for polycyclic aromatic hydrocarbon (PAH) and total petroleum hydrocarbon (TPH) across the area revealed concentrations ranging from <0.02 to 1.80 mg/Kg and from <1.00 to 38,327 mg/kg respectively. Elevated levels of the heavy metals and TPH were observed at MV in Alaoji Aba when compared to MV in Elekahia Port Harcourt, and the control sites. These could be attributed to contamination due to the presence of these auto-mechanics in the area for over thirty years. The concentration of Pb and Cd recorded in some sample points were above USEPA (United State Environmental Protection Agency) and the National Environmental Standards and Regulations Enforcement Agency (NESREA) permissible limits. Results of PAH analysis showed the presence of naphthalene, phenanthrene, pyrene, fluorene, benzo(a)anthracene, acenaphthene, methylnaphthalene. Risk assessment analysis showed significant geo-accumulation values for Cd and Pb indicating heavy contamination. The monomial risk factor of the heavy metals in the MVs are in the order Cd>Pb>Cr, while potential ecological risk index analysis showed values indicating very high risk, considerable risk and a moderate risk to the area under study as well as the surrounding environment. These results suggest that the soils from the MVs which represent the mechanic workshops at Alaoji Aba and Elekahia Port Harcourt are considered to be of pollution concern due to elevated Pb and Cd levels. Hence, there is a serious need to regularly monitor the activities of auto-mechanics in the study area.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"23 1","pages":"2020005-0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72989475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Concurrent occurrence of chromium (Cr), copper (Cu) and arsenic (As) from chromated copper arsenate (CCA) wood preservative in aquatic ecosystems demands that their joint-actions in eliciting toxic effects be assessed for adequate understanding of the health risk they may pose to biota. Clarias gariepinus was exposed to As2O3 , CrO3 and CuO and their composite mixtures (1:1 and 1:1:1) at various concentrations (0 – 600 mg/L) for 96-h to determine the acute toxicity using OECD (1992) protocol. C. gariepinus was then exposed to sub-lethal concentrations corresponding to 6.25, 12.5, 25.0, 50.0 and 100% of the 96-h LC50 for 7 days to assess the cytogenotoxic effects using piscine micronucleus (MN) test. The 96-h LC50 showed that the metals/metalloid demonstrated differential interactions in a concentration dependent pattern. The 96-h LC50 showed that Cr was the most toxic while Cu and As:Cu were indeterminate (Cr > Cr:Cu > As:Cr > As > As:Cr:Cu > Cu = As:Cu indeterminate). Isobologram and synergistic ratio (SR) models predicted antagonistic interaction between Cu:Cr and As:Cr and synergism between As:Cu in the causation of morbidity and mortality of C. gariepinus. Interaction factor model predicted antagonism as common interactive mechanism among the metal/metalloid mixtures in the induction of MN and abnormal nuclear erythrocytes in C. gariepinus. Predicted interactions among the three metals/ metalloid were largely antagonism and synergism towards the induction of acute toxicity and cytogenotoxicity. The models employed herein may be useful in establishing environmental safe limits for mixtures of metals/metalloids against the induction of acute toxicity and DNA damage in lower aquatic vertebrates.
铬化砷酸铜(CCA)木材防腐剂在水生生态系统中同时存在铬(Cr)、铜(Cu)和砷(As)，需要评估它们在引发毒性效应方面的联合作用，以充分了解它们可能对生物群构成的健康风险。采用OECD(1992)方案，将不同浓度(0 - 600 mg/L)的As2O3、CrO3和CuO及其复合混合物(1:1和1:1:1)暴露于Clarias gariepinus中96小时，以确定其急性毒性。分别以96 h LC50的6.25、12.5、25.0、50.0和100%亚致死浓度对加里滨棘鱼进行7 d的细胞基因毒性试验。96 h LC50表明，金属/类金属表现出浓度依赖模式的差异相互作用。96 h LC50显示Cr毒性最大，Cu和As:Cu不确定(Cr > Cr:Cu > As:Cr > As > As:Cr:Cu > Cu = As:Cu不确定)。等线图和协同比(SR)模型预测了Cu:Cr和As:Cr之间的拮抗相互作用以及As:Cu之间的协同作用在引起加里平螺旋体发病和死亡中的作用。相互作用因子模型预测了金属/类金属混合物在诱导鸡淋巴细胞MN和核红细胞异常中的共同相互作用机制为拮抗。预测三种金属/类金属之间的相互作用主要是拮抗和协同作用，以诱导急性毒性和细胞遗传毒性。本文采用的模型可能有助于建立金属/类金属混合物的环境安全限值，以防止在低等水生脊椎动物中诱发急性毒性和DNA损伤。
{"title":"Experimental modeling of the acute toxicity and cytogenotoxic fate of composite mixtures of chromate, copper and arsenate oxides associated with CCA preservative using Clarias gariepinus (Burchell 1822)","authors":"Olukunle S. Fagbenro, C. Alimba, A. A. Bakare","doi":"10.5620/eaht.e2019010","DOIUrl":"https://doi.org/10.5620/eaht.e2019010","url":null,"abstract":"Concurrent occurrence of chromium (Cr), copper (Cu) and arsenic (As) from chromated copper arsenate (CCA) wood preservative in aquatic ecosystems demands that their joint-actions in eliciting toxic effects be assessed for adequate understanding of the health risk they may pose to biota. Clarias gariepinus was exposed to As2O3 , CrO3 and CuO and their composite mixtures (1:1 and 1:1:1) at various concentrations (0 – 600 mg/L) for 96-h to determine the acute toxicity using OECD (1992) protocol. C. gariepinus was then exposed to sub-lethal concentrations corresponding to 6.25, 12.5, 25.0, 50.0 and 100% of the 96-h LC50 for 7 days to assess the cytogenotoxic effects using piscine micronucleus (MN) test. The 96-h LC50 showed that the metals/metalloid demonstrated differential interactions in a concentration dependent pattern. The 96-h LC50 showed that Cr was the most toxic while Cu and As:Cu were indeterminate (Cr > Cr:Cu > As:Cr > As > As:Cr:Cu > Cu = As:Cu indeterminate). Isobologram and synergistic ratio (SR) models predicted antagonistic interaction between Cu:Cr and As:Cr and synergism between As:Cu in the causation of morbidity and mortality of C. gariepinus. Interaction factor model predicted antagonism as common interactive mechanism among the metal/metalloid mixtures in the induction of MN and abnormal nuclear erythrocytes in C. gariepinus. Predicted interactions among the three metals/ metalloid were largely antagonism and synergism towards the induction of acute toxicity and cytogenotoxicity. The models employed herein may be useful in establishing environmental safe limits for mixtures of metals/metalloids against the induction of acute toxicity and DNA damage in lower aquatic vertebrates.","PeriodicalId":101307,"journal":{"name":"Environmental analysis, health and toxicology","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76887846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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