Pub Date : 2024-05-01Epub Date: 2024-03-26DOI: 10.3348/jksr.2023.0072
Yeon Jang, Ji Young Yoo, Joon Seog Kong
Parosteal lipoma is a rare tumor that occurs very close to the bone, and accounts for approximately 0.3% of all lipomas. Chondrolipoma, a lipoma with cartilaginous metaplasia, is also a rare tumor consisting of mature adipose and cartilage tissues. Therefore, a tumor with characteristics of both parosteal lipoma and chondrolipoma simultaneously is extremely rare. Herein, we report the imaging findings of a parosteal chondrolipoma arising in the right periscapular area, confirmed based on surgical resection and histopathologic examination.
{"title":"[Parosteal Chondrolipoma of the Scapula: A Case Report].","authors":"Yeon Jang, Ji Young Yoo, Joon Seog Kong","doi":"10.3348/jksr.2023.0072","DOIUrl":"10.3348/jksr.2023.0072","url":null,"abstract":"<p><p>Parosteal lipoma is a rare tumor that occurs very close to the bone, and accounts for approximately 0.3% of all lipomas. Chondrolipoma, a lipoma with cartilaginous metaplasia, is also a rare tumor consisting of mature adipose and cartilage tissues. Therefore, a tumor with characteristics of both parosteal lipoma and chondrolipoma simultaneously is extremely rare. Herein, we report the imaging findings of a parosteal chondrolipoma arising in the right periscapular area, confirmed based on surgical resection and histopathologic examination.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 3","pages":"676-681"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01Epub Date: 2024-01-22DOI: 10.3348/jksr.2023.0056
Min Gang Jo, Min Kyoung Lee, Jae Ho Shin, Min Guk Seo, So Lyung Jung
Purpose: To compare the efficacy and safety of radiofrequency ablation (RFA) and ethanol ablation (EA) followed by RFA in treating mixed cystic and solid thyroid nodules.
Materials and methods: We included 243 nodules from 243 patients who underwent RFA for mixed cystic and solid benign nodules. The nodules were divided into two groups (RFA alone and EA + RFA). We evaluated volume reduction rate (VRR), therapeutic success rate, improvement in symptomatic and cosmetic issues, complications, and adverse effects.
Results: The RFA group included 204 patients, and the EA + RFA group included 39 patients. The long-term success rates in the RFA only and EA + RFA groups were 90.2% and 97.4%, respectively. The mean VRR at the last follow-up in the RFA and EA + RFA groups were 81.6% and 87.2%, respectively. Therapeutic results were similar in both groups at the last follow-up. Cosmetic and symptomatic problems markedly improved in both groups. No major complications were observed.
Conclusion: Both RFA alone and EA + RA are safe and effective methods for treating mixed cystic and solid thyroid nodules, although EA + RFA is slightly more effective.
{"title":"The Comparison of Efficacy and Safety between Radiofrequency Ablation Alone and Ethanol Ablation Followed by Radiofrequency Ablation in the Treatment of Mixed Cystic and Solid Thyroid Nodule.","authors":"Min Gang Jo, Min Kyoung Lee, Jae Ho Shin, Min Guk Seo, So Lyung Jung","doi":"10.3348/jksr.2023.0056","DOIUrl":"10.3348/jksr.2023.0056","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety of radiofrequency ablation (RFA) and ethanol ablation (EA) followed by RFA in treating mixed cystic and solid thyroid nodules.</p><p><strong>Materials and methods: </strong>We included 243 nodules from 243 patients who underwent RFA for mixed cystic and solid benign nodules. The nodules were divided into two groups (RFA alone and EA + RFA). We evaluated volume reduction rate (VRR), therapeutic success rate, improvement in symptomatic and cosmetic issues, complications, and adverse effects.</p><p><strong>Results: </strong>The RFA group included 204 patients, and the EA + RFA group included 39 patients. The long-term success rates in the RFA only and EA + RFA groups were 90.2% and 97.4%, respectively. The mean VRR at the last follow-up in the RFA and EA + RFA groups were 81.6% and 87.2%, respectively. Therapeutic results were similar in both groups at the last follow-up. Cosmetic and symptomatic problems markedly improved in both groups. No major complications were observed.</p><p><strong>Conclusion: </strong>Both RFA alone and EA + RA are safe and effective methods for treating mixed cystic and solid thyroid nodules, although EA + RFA is slightly more effective.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 3","pages":"618-630"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-26DOI: 10.3348/jksr.2023.0011
Seong Hee Yeo, Hyun Jung Yoon, Injoong Kim, Yeo Jin Kim, Young Lee, Yoon Ki Cha, So Hyeon Bak
Purpose: To develop models to predict programmed death ligand 1 (PD-L1) expression in pulmonary squamous cell carcinoma (SCC) using CT.
Materials and methods: A total of 97 patients diagnosed with SCC who underwent PD-L1 expression assay were included in this study. We performed a CT analysis of the tumors using pretreatment CT images. Multiple logistic regression models were constructed to predict PD-L1 positivity in the total patient group and in the 40 advanced-stage (≥ stage IIIB) patients. The area under the receiver operating characteristic curve (AUC) was calculated for each model.
Results: For the total patient group, the AUC of the 'total significant features model' (tumor stage, tumor size, pleural nodularity, and lung metastasis) was 0.652, and that of the 'selected feature model' (pleural nodularity) was 0.556. For advanced-stage patients, the AUC of the 'selected feature model' (tumor size, pleural nodularity, pulmonary oligometastases, and absence of interstitial lung disease) was 0.897. Among these factors, pleural nodularity and pulmonary oligometastases had the highest odds ratios (8.78 and 16.35, respectively).
Conclusion: Our model could predict PD-L1 expression in patients with lung SCC, and pleural nodularity and pulmonary oligometastases were notable predictive CT features of PD-L1.
{"title":"Predictions of PD-L1 Expression Based on CT Imaging Features in Lung Squamous Cell Carcinoma.","authors":"Seong Hee Yeo, Hyun Jung Yoon, Injoong Kim, Yeo Jin Kim, Young Lee, Yoon Ki Cha, So Hyeon Bak","doi":"10.3348/jksr.2023.0011","DOIUrl":"https://doi.org/10.3348/jksr.2023.0011","url":null,"abstract":"<p><strong>Purpose: </strong>To develop models to predict programmed death ligand 1 (PD-L1) expression in pulmonary squamous cell carcinoma (SCC) using CT.</p><p><strong>Materials and methods: </strong>A total of 97 patients diagnosed with SCC who underwent PD-L1 expression assay were included in this study. We performed a CT analysis of the tumors using pretreatment CT images. Multiple logistic regression models were constructed to predict PD-L1 positivity in the total patient group and in the 40 advanced-stage (≥ stage IIIB) patients. The area under the receiver operating characteristic curve (AUC) was calculated for each model.</p><p><strong>Results: </strong>For the total patient group, the AUC of the 'total significant features model' (tumor stage, tumor size, pleural nodularity, and lung metastasis) was 0.652, and that of the 'selected feature model' (pleural nodularity) was 0.556. For advanced-stage patients, the AUC of the 'selected feature model' (tumor size, pleural nodularity, pulmonary oligometastases, and absence of interstitial lung disease) was 0.897. Among these factors, pleural nodularity and pulmonary oligometastases had the highest odds ratios (8.78 and 16.35, respectively).</p><p><strong>Conclusion: </strong>Our model could predict PD-L1 expression in patients with lung SCC, and pleural nodularity and pulmonary oligometastases were notable predictive CT features of PD-L1.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"394-408"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-27DOI: 10.3348/jksr.2024.0026
Yoon Seong Lee, Eun-Ah Park, Whal Lee
Treatment of patients with coronary artery disease commonly involves the use of balloon-expandable stent placements, currently recognized as the most prevalent approach for coronary artery revascularization. Nevertheless, the occurrence of restenosis remains a significant complication following percutaneous coronary interventions. The diagnostic role of coronary CT angiography (CCTA) in detecting stent restenosis has limitations primarily attributable to challenges in accurately discerning the lumen, due to issues such as blooming and motion artifacts. As a result, many cases often necessitate a transition to conventional coronary angiography. However, recent advancements in CT technology have led to notable improvements in both sensitivity and specificity, underscoring the growing significance of CCTA as a diagnostic tool. The consistent reporting of high negative predictive value is particularly noteworthy. This review aims to explore the historical context, current status, and recent trends in diagnosing coronary artery stent restenosis using CCTA.
{"title":"[Coronary CT Angiography-Based Assessment of Coronary in-Stent Restenosis: A Journey through Past and Present Trends].","authors":"Yoon Seong Lee, Eun-Ah Park, Whal Lee","doi":"10.3348/jksr.2024.0026","DOIUrl":"https://doi.org/10.3348/jksr.2024.0026","url":null,"abstract":"<p><p>Treatment of patients with coronary artery disease commonly involves the use of balloon-expandable stent placements, currently recognized as the most prevalent approach for coronary artery revascularization. Nevertheless, the occurrence of restenosis remains a significant complication following percutaneous coronary interventions. The diagnostic role of coronary CT angiography (CCTA) in detecting stent restenosis has limitations primarily attributable to challenges in accurately discerning the lumen, due to issues such as blooming and motion artifacts. As a result, many cases often necessitate a transition to conventional coronary angiography. However, recent advancements in CT technology have led to notable improvements in both sensitivity and specificity, underscoring the growing significance of CCTA as a diagnostic tool. The consistent reporting of high negative predictive value is particularly noteworthy. This review aims to explore the historical context, current status, and recent trends in diagnosing coronary artery stent restenosis using CCTA.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"258-269"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-26DOI: 10.3348/jksr.2024.0015
Eunhee Kim
{"title":"Response to \"Primary Angiitis of the Central Nervous System: Exclusion of Differentials and Long-Term Follow-Up\".","authors":"Eunhee Kim","doi":"10.3348/jksr.2024.0015","DOIUrl":"https://doi.org/10.3348/jksr.2024.0015","url":null,"abstract":"","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"482-483"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-27DOI: 10.3348/jksr.2024.0036
Jongmin Lee
{"title":"Congenital Coronary Artery Anomalies.","authors":"Jongmin Lee","doi":"10.3348/jksr.2024.0036","DOIUrl":"https://doi.org/10.3348/jksr.2024.0036","url":null,"abstract":"","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"434-436"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-05DOI: 10.3348/jksr.2023.0057
Juyoung Pak, Hyoung Nam Lee, Myung Sub Kim, Hyerim Park
Primary aldosteronism is a group of disorders in which the autonomous secretion of aldosterone is associated with hypertension and hypokalemia. It is crucial to determine the laterality of aldosterone hypersecretion because treatment options differ accordingly. Adrenal venous sampling (AVS) is considered the most reliable method for assessing the laterality of primary aldosteronism. This procedure is often technically challenging because of the small size and varied locations of the adrenal veins. A better understanding of anatomical variations and careful review of imaging studies would improve sampling success. This report presents three cases of anatomical variations encountered during AVS.
{"title":"Anatomical Variations Encountered during Adrenal Venous Sampling: A Report of Three Case Series and Review of Literature.","authors":"Juyoung Pak, Hyoung Nam Lee, Myung Sub Kim, Hyerim Park","doi":"10.3348/jksr.2023.0057","DOIUrl":"https://doi.org/10.3348/jksr.2023.0057","url":null,"abstract":"<p><p>Primary aldosteronism is a group of disorders in which the autonomous secretion of aldosterone is associated with hypertension and hypokalemia. It is crucial to determine the laterality of aldosterone hypersecretion because treatment options differ accordingly. Adrenal venous sampling (AVS) is considered the most reliable method for assessing the laterality of primary aldosteronism. This procedure is often technically challenging because of the small size and varied locations of the adrenal veins. A better understanding of anatomical variations and careful review of imaging studies would improve sampling success. This report presents three cases of anatomical variations encountered during AVS.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"456-462"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-26DOI: 10.3348/jksr.2023.0102
Min Hye Kim, Kyeong Ah Kim, Jeong Woo Kim, Seok Young Lee, Jae Woong Choi
Concomitant renal cell carcinomas (RCC) of both native and allograft kidneys are extremely rare, and only a few cases have been reported in the available English literature. A particularly rare variant within the adult population is the Xp11.2 translocation/transcription factor E3 (TFE3)-rearranged RCC. Although few case reports of TFE3-rearranged RCC have been reported in children who underwent kidney transplantation (KT), no case of adults with TFE3-rearranged RCC following KT has been reported. Herein, we presented the radiological and pathological findings of a rare metachronous papillary RCC in the allograft kidney and TFE3-rearranged RCC in the native kidney. The TFE3-rearranged RCC in the native kidney exhibited slow expansion in size over five years. Radiologically, it appeared as a slightly enhanced, lobulated mass on contrast-enhanced CT. MRI revealed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images.
{"title":"Papillary Renal Cell Carcinoma in Transplanted Kidney and Xp11.2 Translocation/Transcription Factor E3-Rearranged Renal Cell Carcinoma in the Native Kidney: A Case Report.","authors":"Min Hye Kim, Kyeong Ah Kim, Jeong Woo Kim, Seok Young Lee, Jae Woong Choi","doi":"10.3348/jksr.2023.0102","DOIUrl":"https://doi.org/10.3348/jksr.2023.0102","url":null,"abstract":"<p><p>Concomitant renal cell carcinomas (RCC) of both native and allograft kidneys are extremely rare, and only a few cases have been reported in the available English literature. A particularly rare variant within the adult population is the Xp11.2 translocation/transcription factor E3 (TFE3)-rearranged RCC. Although few case reports of TFE3-rearranged RCC have been reported in children who underwent kidney transplantation (KT), no case of adults with TFE3-rearranged RCC following KT has been reported. Herein, we presented the radiological and pathological findings of a rare metachronous papillary RCC in the allograft kidney and TFE3-rearranged RCC in the native kidney. The TFE3-rearranged RCC in the native kidney exhibited slow expansion in size over five years. Radiologically, it appeared as a slightly enhanced, lobulated mass on contrast-enhanced CT. MRI revealed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"437-444"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-02-15DOI: 10.3348/jksr.2022.0171
Suho Kim, Jung Hee Shin, Soo Yeon Hahn, Haejung Kim, Myoung Kyoung Kim
Parathyroid glands are small endocrine glands that regulate calcium metabolism by producing parathyroid hormone (PTH). These are located at the back of the thyroid gland. Typically, four glands comprise the parathyroid glands, although their numbers may vary among individuals. Parathyroid diseases are related to parathyroid gland dysfunction and can be caused by problems with the parathyroid gland itself or abnormal serum calcium levels arising from renal disease. In recent years, as comprehensive health checkups have become more common, abnormal serum calcium levels are often found incidentally in blood tests, after which several additional tests, including a PTH test, ultrasonography (US), technetium-99m sestamibi parathyroid scan, single-photon-emission CT (SPECT)/CT, four-dimensional CT (4D-CT), and PET/CT, are performed for further evaluation. However, the parathyroid gland remains an organ less familiar to radiologists. Therefore, the normal anatomy, pathophysiology, imaging, and clinical findings of the parathyroid gland and its associated diseases are discussed here.
{"title":"The Parathyroid Gland: An Overall Review of the Hidden Organ for Radiologists.","authors":"Suho Kim, Jung Hee Shin, Soo Yeon Hahn, Haejung Kim, Myoung Kyoung Kim","doi":"10.3348/jksr.2022.0171","DOIUrl":"https://doi.org/10.3348/jksr.2022.0171","url":null,"abstract":"<p><p>Parathyroid glands are small endocrine glands that regulate calcium metabolism by producing parathyroid hormone (PTH). These are located at the back of the thyroid gland. Typically, four glands comprise the parathyroid glands, although their numbers may vary among individuals. Parathyroid diseases are related to parathyroid gland dysfunction and can be caused by problems with the parathyroid gland itself or abnormal serum calcium levels arising from renal disease. In recent years, as comprehensive health checkups have become more common, abnormal serum calcium levels are often found incidentally in blood tests, after which several additional tests, including a PTH test, ultrasonography (US), technetium-99m sestamibi parathyroid scan, single-photon-emission CT (SPECT)/CT, four-dimensional CT (4D-CT), and PET/CT, are performed for further evaluation. However, the parathyroid gland remains an organ less familiar to radiologists. Therefore, the normal anatomy, pathophysiology, imaging, and clinical findings of the parathyroid gland and its associated diseases are discussed here.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"327-344"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2024-03-26DOI: 10.3348/jksr.2023.0012
Chun Geun Lim, Hui Joong Lee
Purpose: Metabolic abnormalities in hepatic encephalopathy (HE) cause brain edema or demyelinating disease, resulting in symmetric regional cerebral edema (SRCE) on MRI. This study aimed to investigate the usefulness of the clustering analysis of SRCE in predicting the development of brain failure.
Materials and methods: MR findings and clinical data of 98 consecutive patients with HE were retrospectively analyzed. The correlation between the 12 regions of SRCE was calculated using the phi (Φ) coefficient, and the pattern was classified using hierarchical clustering using the φ2 distance measure and Ward's method. The classified patterns of SRCE were correlated with clinical parameters such as the model for end-stage liver disease (MELD) score and HE grade.
Results: Significant associations were found between 22 pairs of regions of interest, including the red nucleus and corpus callosum (Φ = 0.81, p < 0.001), crus cerebri and red nucleus (Φ = 0.72, p < 0.001), and red nucleus and dentate nucleus (Φ = 0.66, p < 0.001). After hierarchical clustering, 24 cases were classified into Group I, 35 into Group II, and 39 into Group III. Group III had a higher MELD score (p = 0.04) and HE grade (p = 0.002) than Group I.
Conclusion: Our study demonstrates that the SRCE patterns can be useful in predicting hepatic preservation and the occurrence of cerebral failure in HE.
目的:肝性脑病(HE)中的代谢异常会引起脑水肿或脱髓鞘疾病,导致核磁共振成像上的对称性区域脑水肿(SRCE)。本研究旨在探讨 SRCE 的聚类分析在预测脑衰竭发展方面的实用性:回顾性分析了连续 98 例 HE 患者的 MR 结果和临床数据。用phi(Φ)系数计算12个SRCE区域之间的相关性,并用φ2距离测量法和Ward法对模式进行分层聚类。SRCE的分类模式与终末期肝病模型(MELD)评分和HE分级等临床参数相关:结果:22对相关区域之间存在显著关联,包括红核和胼胝体(Φ = 0.81,p < 0.001)、小脑皱襞和红核(Φ = 0.72,p < 0.001)以及红核和齿状核(Φ = 0.66,p < 0.001)。经过分层聚类,24 例病例被分为 I 组,35 例被分为 II 组,39 例被分为 III 组。III组的MELD评分(p = 0.04)和HE分级(p = 0.002)均高于I组:我们的研究表明,SRCE模式可用于预测肝保存和 HE 脑衰竭的发生。
{"title":"Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy.","authors":"Chun Geun Lim, Hui Joong Lee","doi":"10.3348/jksr.2023.0012","DOIUrl":"10.3348/jksr.2023.0012","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic abnormalities in hepatic encephalopathy (HE) cause brain edema or demyelinating disease, resulting in symmetric regional cerebral edema (SRCE) on MRI. This study aimed to investigate the usefulness of the clustering analysis of SRCE in predicting the development of brain failure.</p><p><strong>Materials and methods: </strong>MR findings and clinical data of 98 consecutive patients with HE were retrospectively analyzed. The correlation between the 12 regions of SRCE was calculated using the phi (Φ) coefficient, and the pattern was classified using hierarchical clustering using the φ<sup>2</sup> distance measure and Ward's method. The classified patterns of SRCE were correlated with clinical parameters such as the model for end-stage liver disease (MELD) score and HE grade.</p><p><strong>Results: </strong>Significant associations were found between 22 pairs of regions of interest, including the red nucleus and corpus callosum (Φ = 0.81, <i>p</i> < 0.001), crus cerebri and red nucleus (Φ = 0.72, <i>p</i> < 0.001), and red nucleus and dentate nucleus (Φ = 0.66, <i>p</i> < 0.001). After hierarchical clustering, 24 cases were classified into Group I, 35 into Group II, and 39 into Group III. Group III had a higher MELD score (<i>p</i> = 0.04) and HE grade (<i>p</i> = 0.002) than Group I.</p><p><strong>Conclusion: </strong>Our study demonstrates that the SRCE patterns can be useful in predicting hepatic preservation and the occurrence of cerebral failure in HE.</p>","PeriodicalId":101329,"journal":{"name":"Journal of the Korean Society of Radiology","volume":"85 2","pages":"381-393"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}