Pub Date : 2017-11-06DOI: 10.4172/2329-9126-C1-005
H. Schutze, M. Chin, D. Weller, Sue Suchy, M. Harris
Globally, acute gastroenteritis is an ailment that is very common among children during their first 3 years of life at which they will most likely experience about 1 to 3 acute diarrheal illnesses that can generate complication such as dehydration and disseminated intravascular coagulation. The diagnosis itself and its accompanying complications can be easily identified though proper clinical and laboratory evaluation. The purpose of this study was to identify evidences of disseminated intravascular coagulation (DIC) and correlate with other clinical or laboratory tests related to other complications of acute gastroenteritis (AGE) such as dehydration and some metabolic imbalances. Almost all of pediatrics patient who are severely dehydrated, suffering from hypernatremia and with hyperammonemia are with evidences of DIC. Moreover, some of the variables found to be significantly associated with positive and strong relationship while some are not.
{"title":"Associating Disseminated Intravascular Coagulation with Clinical and Laboratory Evaluations of Pediatric Patients with Acute Gastroenteritis admitted at Gharyan Central and Teaching Hospital, Libya","authors":"H. Schutze, M. Chin, D. Weller, Sue Suchy, M. Harris","doi":"10.4172/2329-9126-C1-005","DOIUrl":"https://doi.org/10.4172/2329-9126-C1-005","url":null,"abstract":"Globally, acute gastroenteritis is an ailment that is very common among children during their first 3 years of life at which they will most likely experience about 1 to 3 acute diarrheal illnesses that can generate complication such as dehydration and disseminated intravascular coagulation. The diagnosis itself and its accompanying complications can be easily identified though proper clinical and laboratory evaluation. The purpose of this study was to identify evidences of disseminated intravascular coagulation (DIC) and correlate with other clinical or laboratory tests related to other complications of acute gastroenteritis (AGE) such as dehydration and some metabolic imbalances. Almost all of pediatrics patient who are severely dehydrated, suffering from hypernatremia and with hyperammonemia are with evidences of DIC. Moreover, some of the variables found to be significantly associated with positive and strong relationship while some are not.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114824703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-02-01DOI: 10.5923/J.CMD.20140401.02
D. Chickooree, V. Ram
Eagle's syndrome, the famous discovery of W. Eagle, is associated with repeated episodes of pain on rotating the neck, dysphagia and referred otalgia due to elongation of styloid process or ossified stylohyoid. Familiarity with Eagle's syndrome shows that its symptoms can be easily confused with other craniomandibular diseases. Since it is a rare clinical entity, its diagnosis is often hard to make, especially in the absence of sound clinical knowledge and good radiographs. Depending on the position of styloid process in relation to underlying anatomical structures, symptoms vary considerably, and in severe cases continuous compression of the carotid artery can lead to stroke and even death. The treatment of choice is mainly styloidectomy; however some conservative treatment is still being practiced. Very few studies have been reported in the literature classifying the elongation and calcification patterns of styloid process. In this review we aim to spread light on the epidemiology, clinical manifestation, diagnosis, and therapy for Eagle's syndrome and also target to help the general practitioner in differential diagnosis with other conditions that can provide similar signs and symptoms.
{"title":"Eagle’s Syndrome - View from the General Practitioners Perspective","authors":"D. Chickooree, V. Ram","doi":"10.5923/J.CMD.20140401.02","DOIUrl":"https://doi.org/10.5923/J.CMD.20140401.02","url":null,"abstract":"Eagle's syndrome, the famous discovery of W. Eagle, is associated with repeated episodes of pain on rotating the neck, dysphagia and referred otalgia due to elongation of styloid process or ossified stylohyoid. Familiarity with Eagle's syndrome shows that its symptoms can be easily confused with other craniomandibular diseases. Since it is a rare clinical entity, its diagnosis is often hard to make, especially in the absence of sound clinical knowledge and good radiographs. Depending on the position of styloid process in relation to underlying anatomical structures, symptoms vary considerably, and in severe cases continuous compression of the carotid artery can lead to stroke and even death. The treatment of choice is mainly styloidectomy; however some conservative treatment is still being practiced. Very few studies have been reported in the literature classifying the elongation and calcification patterns of styloid process. In this review we aim to spread light on the epidemiology, clinical manifestation, diagnosis, and therapy for Eagle's syndrome and also target to help the general practitioner in differential diagnosis with other conditions that can provide similar signs and symptoms.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128574536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.5923/J.CMD.20120205.02
M. Sudano, F. Turchi, P. Sossai
An unusual cause of spontaneous hypoglycemia is Insulin Autoimmune Syndrome (or Hirata Disease), characterized by high levels of insulinemia and circulating autoantibodies to insulin in subjects without prior insulin administration. In Western Countries less than 70 cases have been published so far. Here we report a case where IAS was the prodromical stage of new onset type 1 diabetes. HLA typing in IAS was rarely reported in Western cases, here we also discuss the peculiar HLA pattern of our patient.
{"title":"Insulin Autoimmune Syndrome (Hirata Disease): Case Report in a Caucasian Patient with New-Onset Diabetes","authors":"M. Sudano, F. Turchi, P. Sossai","doi":"10.5923/J.CMD.20120205.02","DOIUrl":"https://doi.org/10.5923/J.CMD.20120205.02","url":null,"abstract":"An unusual cause of spontaneous hypoglycemia is Insulin Autoimmune Syndrome (or Hirata Disease), characterized by high levels of insulinemia and circulating autoantibodies to insulin in subjects without prior insulin administration. In Western Countries less than 70 cases have been published so far. Here we report a case where IAS was the prodromical stage of new onset type 1 diabetes. HLA typing in IAS was rarely reported in Western cases, here we also discuss the peculiar HLA pattern of our patient.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115878484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.5923/J.CMD.20120204.01
E. Bisschop, R. Nundlall
Objective : to develop a reproducible method for electrophysiological study of pudendal nerves which can explore the different risk areas: sacral spinal, infrap iriformis area and ischiorectal fossa. This method is called "differential staged sacral reflexes (DSSR) ". 51 patients not suffering fro m pudendal neuralgia and 134 patients with pudendal neuralgia have been selected. The sacral reflexes (SR) are made at the ventral and dorsal quadrants of the anal sphincter and at the pubococcygeus muscle. Considering the values of the DSSR obtained on healthy subjects and on patients with pudendal neuralgia, maximu m threshold values have been established: a significant difference between ventral and dorsal quadrant of the anal sphincter: damage orientation at the level of the ischiorectal fossa; significant difference between dorsal quadrant of the anal sphincter and pubococcygeus muscle: damage orientation at the level of the infrapiriformis area. SR delayed uniformly at the three afore-mentioned muscles: damage orientation at the level of the sacral spinal. The DSSR allow in a reproducible way to investigate the pudendal nerve in all areas suitable to entrap this nerve, which is impossible with the method of pudendal nerve terminal motor latency (PNTM L).
{"title":"Differential Staged Sacral Reflexes: Methodology and Normal Values from 51 Healthy Subjects and 134 Patients with Pudendal Neuralgia","authors":"E. Bisschop, R. Nundlall","doi":"10.5923/J.CMD.20120204.01","DOIUrl":"https://doi.org/10.5923/J.CMD.20120204.01","url":null,"abstract":"Objective : to develop a reproducible method for electrophysiological study of pudendal nerves which can explore the different risk areas: sacral spinal, infrap iriformis area and ischiorectal fossa. This method is called \"differential staged sacral reflexes (DSSR) \". 51 patients not suffering fro m pudendal neuralgia and 134 patients with pudendal neuralgia have been selected. The sacral reflexes (SR) are made at the ventral and dorsal quadrants of the anal sphincter and at the pubococcygeus muscle. Considering the values of the DSSR obtained on healthy subjects and on patients with pudendal neuralgia, maximu m threshold values have been established: a significant difference between ventral and dorsal quadrant of the anal sphincter: damage orientation at the level of the ischiorectal fossa; significant difference between dorsal quadrant of the anal sphincter and pubococcygeus muscle: damage orientation at the level of the infrapiriformis area. SR delayed uniformly at the three afore-mentioned muscles: damage orientation at the level of the sacral spinal. The DSSR allow in a reproducible way to investigate the pudendal nerve in all areas suitable to entrap this nerve, which is impossible with the method of pudendal nerve terminal motor latency (PNTM L).","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"545 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123121619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.5923/J.CMD.20120204.03
A. Kiško, Ľ. Derňárová, J. Kmec, M. Vereb, A. Hudáková, M. Jakubikova, N. Kishko
A 32-year-old active cyclist was referred fo r the evaluation because of syncope he had performed in preseason. He was found to be normostenic, acyanotic, normotensive with clear lungs and a regular pulse of 60 bp m, with normal dual heart sounds and a grade Levine 2/6 continuous diastolic murmu r in the second intercostal space of the left parasternal area. He had no family history of premature card iac death and his lipids were normal. Rest ECG showed a regular sinus rhythm of 62 bp m with inco mplete right bundle branch block and no significant ST-T changes. A transthoracic ECHO in parasternal short-axis view revealed an anomalous colour flow jet in diastole arising fro m the lateral wall into the main pulmonary artery and coronary artery fistula with non-significant left -to-right shunt (Qp/Qs ratio 1.2).came under suspicion. In contrast, it has not been confirmed clearly by the transoesophageal ECHO. Coronary angiography was without coronary stenosis and confirmed a 'serpentine' anomalous drainage supposedly from left anterior descending artery to the main pulmonary artery. A complex anato my of sacculary dilated fistula that originates fro m the pro ximal left anterio r descending artery and drainages the main pulmonary artery was showed in detail by a 64 slice MDCT scanning. Myocardial Tc-99m Myoview perfusion SPECT imag ing showed no perfusion defects in maximal physical stress and follo w-up without intervention was suggested. In addition, due to the results of holter ECG monitoring, head-up tilt testing, carotid sinus massage and programmed atrial stimulat ion syncope was concluded as vasovagal, but its nature still remains discussible. After a three year follow-up patient remains asympto matic and recently performed control myocardial perfusion SPECT showed no signs of stress related myo cardial ischemia. In conclusion, several imaging techniques are needed for an accurate diagnosis of coronary fistula and for the suggestion of proper further management. In some cases syncope may be the first man ifestation of CAF, but it is still unclear if it is directly related to the coronary anomaly.
一名32岁的活跃自行车运动员在季前赛中因晕厥而接受评估。患者血压正常，无脏水，肺清晰，脉搏正常，60 bp m，双心音正常，左胸骨旁第二肋间隙连续舒张性杂音2/6级。无早死家族史，血脂正常。静息心电图显示正常窦性心律62 bp m，右束支阻滞不完全，ST-T无明显改变。经胸胸骨旁短轴位回声显示舒张期异常彩色血流射流，由侧壁进入肺动脉主动脉和冠状动脉瘘，无明显左向右分流(Qp/Qs比1.2)。受到怀疑。相比之下，经食管回声并没有明确证实。冠状动脉造影未见冠状动脉狭窄，并证实从左前降支到肺动脉主动脉有“蛇形”异常引流。64层多层螺旋ct扫描显示了一个复杂的囊状扩张瘘，起源于左前降支前段，并以肺动脉为主引流。心肌Tc-99m Myoview灌注SPECT显像显示最大生理应激无灌注缺损，建议不干预随访。此外，根据动态心电图监测、平头倾斜试验、颈动脉窦按摩和程序性心房刺激的结果，晕厥被推断为血管迷走神经性，但其性质仍有争议。经过三年的随访，患者无症状，最近进行的对照心肌灌注SPECT显示没有应激相关心肌缺血的迹象。总之，需要多种影像学技术来准确诊断冠状动脉瘘并建议适当的进一步治疗。在某些情况下，晕厥可能是CAF的第一个男性表现，但尚不清楚它是否与冠状动脉异常直接相关。
{"title":"An Unusual Presentation of Coronary Artery Fistula in Athlete - Case Report","authors":"A. Kiško, Ľ. Derňárová, J. Kmec, M. Vereb, A. Hudáková, M. Jakubikova, N. Kishko","doi":"10.5923/J.CMD.20120204.03","DOIUrl":"https://doi.org/10.5923/J.CMD.20120204.03","url":null,"abstract":"A 32-year-old active cyclist was referred fo r the evaluation because of syncope he had performed in preseason. He was found to be normostenic, acyanotic, normotensive with clear lungs and a regular pulse of 60 bp m, with normal dual heart sounds and a grade Levine 2/6 continuous diastolic murmu r in the second intercostal space of the left parasternal area. He had no family history of premature card iac death and his lipids were normal. Rest ECG showed a regular sinus rhythm of 62 bp m with inco mplete right bundle branch block and no significant ST-T changes. A transthoracic ECHO in parasternal short-axis view revealed an anomalous colour flow jet in diastole arising fro m the lateral wall into the main pulmonary artery and coronary artery fistula with non-significant left -to-right shunt (Qp/Qs ratio 1.2).came under suspicion. In contrast, it has not been confirmed clearly by the transoesophageal ECHO. Coronary angiography was without coronary stenosis and confirmed a 'serpentine' anomalous drainage supposedly from left anterior descending artery to the main pulmonary artery. A complex anato my of sacculary dilated fistula that originates fro m the pro ximal left anterio r descending artery and drainages the main pulmonary artery was showed in detail by a 64 slice MDCT scanning. Myocardial Tc-99m Myoview perfusion SPECT imag ing showed no perfusion defects in maximal physical stress and follo w-up without intervention was suggested. In addition, due to the results of holter ECG monitoring, head-up tilt testing, carotid sinus massage and programmed atrial stimulat ion syncope was concluded as vasovagal, but its nature still remains discussible. After a three year follow-up patient remains asympto matic and recently performed control myocardial perfusion SPECT showed no signs of stress related myo cardial ischemia. In conclusion, several imaging techniques are needed for an accurate diagnosis of coronary fistula and for the suggestion of proper further management. In some cases syncope may be the first man ifestation of CAF, but it is still unclear if it is directly related to the coronary anomaly.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123029039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.5923/j.cmd.20120204.02
F. Alsolami, X. Hou, I. Correa-Velez
Hypertension is a global health issue among the adult population. Adherence to antihypertensive medications is an effective step for better control of blood pressure and preventing the risk of complications. Several factors support or hinder hypertensive patients’ adherence. Objectives: This article reviews the factors affecting adherence to antihypertensive treatments, and reflects on these factors from a Saudi Arabian perspective. Methods: Papers and studies about antihypertensive medication adherence were reviewed from different databases including MEDLINE, PubMed, ScienceDirect and Google scholar. Results: Factors affecting antihypertensive treatments adherence are classified into three domains: Patient (e.g. sociodemographic, individual knowledge and skills), Health System, and Provider related factors.
{"title":"Factors Affecting Antihypertensive Treatment Adherence: A Saudi Arabian Perspective","authors":"F. Alsolami, X. Hou, I. Correa-Velez","doi":"10.5923/j.cmd.20120204.02","DOIUrl":"https://doi.org/10.5923/j.cmd.20120204.02","url":null,"abstract":"Hypertension is a global health issue among the adult population. Adherence to antihypertensive medications is an effective step for better control of blood pressure and preventing the risk of complications. Several factors support or hinder hypertensive patients’ adherence. Objectives: This article reviews the factors affecting adherence to antihypertensive treatments, and reflects on these factors from a Saudi Arabian perspective. Methods: Papers and studies about antihypertensive medication adherence were reviewed from different databases including MEDLINE, PubMed, ScienceDirect and Google scholar. Results: Factors affecting antihypertensive treatments adherence are classified into three domains: Patient (e.g. sociodemographic, individual knowledge and skills), Health System, and Provider related factors.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130103395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.5923/J.CMD.20120205.03
Akyala Ishaku. A, A. E. U., A. zua A. T, Agieni Ashem Godwin
Trans-placental transmission of parvovirus B19 during pregnancy has been reported as one of the leading causes of non-immune fetal hydrops, spontaneous abortion or intra-uterine fetal death. We therefore set out to determine the presence of parvovirus B19 (Ig G and IgM) antibodies and their risk factors among pregnant wo men attending ante-natal clin ic, at Federal Medical Center, Keffi, Nasarawa State, Nigeria.A total of 273 pregnant women (Age range 15-40 years) participated after informed consent and clearance fro m the research ethics committee. Each filled a self-ad ministered questionnaire and donated blood samples between January and August 2012. A reco mbinant parvovirus B19 IgM and Ig G ELISA kit fro m DeMediTec (USA) was used for the assays.Of the 273 participants, 36 (13.2 %) had IgM antibodies, while 75 (27.5%) had Ig G antibodies with those aged 15-20 and 36-40 years having the highest incidence and prevalence rates. Being a house wife, having more ch ild ren and histories of blood transfusion, miscarriage and still b irth were associated with infection (P < 0.05).The study reveals high incidence and prevalence of parvovirus B19 infect ion among the pregnant women. The presence of parvovirus B19 IgM antibody particularly in the first and second trimesters of pregnancy poses the danger of likely trans placental transmission leading to spontaneous abortion and intra-uterine fetal death.
{"title":"Parvovirus B19: Evaluation of Incidence, Prevalence and Risk Factors among Pregnant Women Attending Ante-Natal Clinic in Nasarawa State, North Central of Nigeria","authors":"Akyala Ishaku. A, A. E. U., A. zua A. T, Agieni Ashem Godwin","doi":"10.5923/J.CMD.20120205.03","DOIUrl":"https://doi.org/10.5923/J.CMD.20120205.03","url":null,"abstract":"Trans-placental transmission of parvovirus B19 during pregnancy has been reported as one of the leading causes of non-immune fetal hydrops, spontaneous abortion or intra-uterine fetal death. We therefore set out to determine the presence of parvovirus B19 (Ig G and IgM) antibodies and their risk factors among pregnant wo men attending ante-natal clin ic, at Federal Medical Center, Keffi, Nasarawa State, Nigeria.A total of 273 pregnant women (Age range 15-40 years) participated after informed consent and clearance fro m the research ethics committee. Each filled a self-ad ministered questionnaire and donated blood samples between January and August 2012. A reco mbinant parvovirus B19 IgM and Ig G ELISA kit fro m DeMediTec (USA) was used for the assays.Of the 273 participants, 36 (13.2 %) had IgM antibodies, while 75 (27.5%) had Ig G antibodies with those aged 15-20 and 36-40 years having the highest incidence and prevalence rates. Being a house wife, having more ch ild ren and histories of blood transfusion, miscarriage and still b irth were associated with infection (P < 0.05).The study reveals high incidence and prevalence of parvovirus B19 infect ion among the pregnant women. The presence of parvovirus B19 IgM antibody particularly in the first and second trimesters of pregnancy poses the danger of likely trans placental transmission leading to spontaneous abortion and intra-uterine fetal death.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134447968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-01DOI: 10.5923/J.CMD.20120205.01
A. Malekasgar, M. Pedram, Sayyed kamal Eshagh housaini
The majority of cases of ALL demonstrate an abnormal karyotype, either in chro mosome nu mber or structural changes. Abnormal chro mosome number in childhood acute lymphoblastic leukemia defines distinct biological subgroups with a different response to treatment. The tubes are cultured with three different protocols to save time if one protocol failed. Cultures are then harvested, and cells are fixed and chromosome spreads are prepared. Of 25 patient studied, one patient had psudodiploid karyotype, three patients had tetra-ploid karyotype, four patients had low hypo-diploid karyotype, four patients had high hyper-diploid karyotype, five patients had low hyper-d iploid karyotype and eight patients had normal karyotype. Some other factors like, Age, Sex, Consanguinity, Hemoglob in, W BC count, and Type of the leukemia cell also have been evaluated. We found excess number of patients having hypodiploid karyotype but still response to treatment protocols were satisfactory. By co mparison between 4 different cultures methods, we find d irect method to be more efficient for ploidy analysis.
{"title":"Numerical Chromosomal Abnormalities in Patients with Acute Lymphoblastic and Myeloid Leukemia in Iran","authors":"A. Malekasgar, M. Pedram, Sayyed kamal Eshagh housaini","doi":"10.5923/J.CMD.20120205.01","DOIUrl":"https://doi.org/10.5923/J.CMD.20120205.01","url":null,"abstract":"The majority of cases of ALL demonstrate an abnormal karyotype, either in chro mosome nu mber or structural changes. Abnormal chro mosome number in childhood acute lymphoblastic leukemia defines distinct biological subgroups with a different response to treatment. The tubes are cultured with three different protocols to save time if one protocol failed. Cultures are then harvested, and cells are fixed and chromosome spreads are prepared. Of 25 patient studied, one patient had psudodiploid karyotype, three patients had tetra-ploid karyotype, four patients had low hypo-diploid karyotype, four patients had high hyper-diploid karyotype, five patients had low hyper-d iploid karyotype and eight patients had normal karyotype. Some other factors like, Age, Sex, Consanguinity, Hemoglob in, W BC count, and Type of the leukemia cell also have been evaluated. We found excess number of patients having hypodiploid karyotype but still response to treatment protocols were satisfactory. By co mparison between 4 different cultures methods, we find d irect method to be more efficient for ploidy analysis.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"596 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116315665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-31DOI: 10.5923/J.CMD.20120203.01
Thatiana Lacerda Nobre
Introduction: The patellofemoral syndrome (PDS) is a disease characterized by pain in the patellofemoral l and physical changes resulting from this joint biomechanics. The rate of incidence is high and its etiology remains unknown. Objective: This literature review aims to compare the effectiveness of open kinetic chain exercises with closed kinetic chain into the functional recovery of patients with the patella-femoral syndrome. Methods: We conducted a systematic review in the database LILACS, MEDLINE and PUB MED SCIELO as search term words patellofemoral syndrome, Open Kinetic Chain and Closed Kinetic Chain. Discussion: The imbalance of forces of patella dynamic stabilizers, Vastus medialis oblique (VMO) and vastus lateralis (VL), is still considered the primary factor for the onset of symptoms. Since this change causes an increase in reaction force and patellofemoral compression. In order to recover the balance of forces of the muscles acting as stabilizers of the knee and as a means of restoring stability to the joint, exercises in open kinetic chain (OKC) and closed kinetic chain (CKC) has been used in rehabilitation programs patellofemoral disorders. Conclusion: The benefits for implementing these protocols are not well documented; scientific evidences are insufficient to prove the real effectiveness of these exercises in improving the performance of quadriceps muscle or assist in muscle balance of patellofemoral stabilizers.
髌骨股骨综合征(PDS)是一种以髌骨股骨疼痛和这种关节生物力学引起的物理变化为特征的疾病。发病率高，其病因尚不清楚。目的:本文献综述旨在比较开放式动力链运动与封闭式动力链运动对髌骨-股综合征患者功能恢复的效果。方法:在数据库LILACS、MEDLINE和PUB MED SCIELO中进行系统检索，检索词为髌骨综合征、开放动力链和封闭动力链。讨论:髌骨动力稳定器股内侧斜肌(VMO)和股外侧肌(VL)的力量不平衡仍然被认为是症状发生的主要因素。因为这种变化会增加反作用力和髌股压迫。为了恢复作为膝关节稳定剂的肌肉力量平衡，并作为恢复关节稳定性的一种手段，开放式动力链(OKC)和封闭式动力链(CKC)运动已被用于髌股疾病的康复计划。结论:实施这些协议的好处并没有得到很好的证明;科学证据不足以证明这些运动在改善股四头肌的表现或协助髌股稳定器的肌肉平衡方面的真正有效性。
{"title":"Comparison of Exercise Open Kinetic Chain and Closed Kinetic Chain in The Rehabilitation of Patellofemoral Dysfunction: an Updated Revision","authors":"Thatiana Lacerda Nobre","doi":"10.5923/J.CMD.20120203.01","DOIUrl":"https://doi.org/10.5923/J.CMD.20120203.01","url":null,"abstract":"Introduction: The patellofemoral syndrome (PDS) is a disease characterized by pain in the patellofemoral l and physical changes resulting from this joint biomechanics. The rate of incidence is high and its etiology remains unknown. Objective: This literature review aims to compare the effectiveness of open kinetic chain exercises with closed kinetic chain into the functional recovery of patients with the patella-femoral syndrome. Methods: We conducted a systematic review in the database LILACS, MEDLINE and PUB MED SCIELO as search term words patellofemoral syndrome, Open Kinetic Chain and Closed Kinetic Chain. Discussion: The imbalance of forces of patella dynamic stabilizers, Vastus medialis oblique (VMO) and vastus lateralis (VL), is still considered the primary factor for the onset of symptoms. Since this change causes an increase in reaction force and patellofemoral compression. In order to recover the balance of forces of the muscles acting as stabilizers of the knee and as a means of restoring stability to the joint, exercises in open kinetic chain (OKC) and closed kinetic chain (CKC) has been used in rehabilitation programs patellofemoral disorders. Conclusion: The benefits for implementing these protocols are not well documented; scientific evidences are insufficient to prove the real effectiveness of these exercises in improving the performance of quadriceps muscle or assist in muscle balance of patellofemoral stabilizers.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127349008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-31DOI: 10.5923/J.CMD.20120203.02
M. Aydın, S. Bulur, Y. Türker, K. Süner, A. Şahin, H. Özhan
Lyme disease is a tick-borne spirochete infection that may affect the heart. Cardiac manifestations include conduction disturbances and other pathologies of the heart. Disturbance of atrioventricular (AV) node conduction is the most common cardiac manifestation of Lyme disease. We report a 61-year old female, who was admitted to the emergency de- partment with the complaints of syncope, dizziness and generalized fatigue. Physical examination revealed normal findings. The patient's electrocardiogram on admission revealed a newly diagnosed bradycardia due to third degree of AV block with40/min ventricular rate. The patient was admitted to the coronary care unit and was placed a transvenous pacemaker. Lyme serology and Western blot were positive for Borrelia antibodies. The symptoms and AV block resolved completely after doxycycline therapy.
{"title":"A rare cause of complete atrioventricular block: Lyme carditis","authors":"M. Aydın, S. Bulur, Y. Türker, K. Süner, A. Şahin, H. Özhan","doi":"10.5923/J.CMD.20120203.02","DOIUrl":"https://doi.org/10.5923/J.CMD.20120203.02","url":null,"abstract":"Lyme disease is a tick-borne spirochete infection that may affect the heart. Cardiac manifestations include conduction disturbances and other pathologies of the heart. Disturbance of atrioventricular (AV) node conduction is the most common cardiac manifestation of Lyme disease. We report a 61-year old female, who was admitted to the emergency de- partment with the complaints of syncope, dizziness and generalized fatigue. Physical examination revealed normal findings. The patient's electrocardiogram on admission revealed a newly diagnosed bradycardia due to third degree of AV block with40/min ventricular rate. The patient was admitted to the coronary care unit and was placed a transvenous pacemaker. Lyme serology and Western blot were positive for Borrelia antibodies. The symptoms and AV block resolved completely after doxycycline therapy.","PeriodicalId":101352,"journal":{"name":"Clinical medicine and diagnostics","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125161329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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