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Type III procollagen N-peptide correlates with beta-2-microglobulin in myelomatosis. 骨髓瘤中III型前胶原n肽与β -2微球蛋白相关。
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01243.X
H. Hasselbalch, O. Bjerrum, P. Junker
The serum concentration of the N-terminal peptide of type III procollagen (PIIINP) was determined in 32 patients with myelomatosis (MM). Four subjects were studied at the time of diagnosis and the remaining patients at variable intervals from diagnosis. Serum concentration of beta-2-microglobulin (B2m) was measured in 31 patients. Serial measurements of both substances were performed in 20 patients. Serum PIIINP was increased in MM as compared with healthy control subjects (P < 0.001). Patients with active disease had significantly higher propeptide values (median 7.4; range 3.8-11.2) as compared to those with stable disease (median 4.3; range 2.2-9.6) (P < 0.009). A highly significant correlation existed between circulating PIIINP and B2m (P < 0.001). It is concluded that MM elicits a stromal reaction as reflected by parallel increases in serum PIIINP and serum B2m. In subsets of patients, e.g. those with non-secretory myeloma and in patients with smouldering disease, serum PIIINP may even be superior to B2m as an indicator of disease activity.
测定32例骨髓瘤病(MM)患者血清III型前胶原n端肽(PIIINP)的浓度。四名受试者在诊断时进行研究，其余患者在诊断后的可变时间间隔进行研究。测定31例患者血清β -2微球蛋白(B2m)浓度。对20例患者进行了两种物质的连续测量。与健康对照组相比，MM组血清PIIINP增高(P < 0.001)。活动性疾病患者的前肽值明显较高(中位7.4;范围3.8-11.2)，与疾病稳定的患者相比(中位4.3;范围2.2 ~ 9.6)(P < 0.009)。循环PIIINP与B2m之间存在高度显著相关(P < 0.001)。结论是MM引起基质反应，反映在血清PIIINP和血清B2m平行增加。在患者亚群中，如非分泌性骨髓瘤患者和阴燃性疾病患者，血清PIIINP作为疾病活动性指标甚至可能优于B2m。
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引用次数: 2
Further comparative experience with the Roche Cobas Argos Analyser. 进一步比较罗氏科巴斯Argos分析仪的经验。
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01247.X
S. Wilson, G. Pillay, N. Hindley, S. Gelderbloem, P. Jacobs
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引用次数: 0
Laboratory diagnosis and assessment of myelodysplasia 骨髓发育不良的实验室诊断和评估
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01253.X
D. Oscier
{"title":"Laboratory diagnosis and assessment of myelodysplasia","authors":"D. Oscier","doi":"10.1111/J.1365-2257.1995.TB01253.X","DOIUrl":"https://doi.org/10.1111/J.1365-2257.1995.TB01253.X","url":null,"abstract":"","PeriodicalId":10285,"journal":{"name":"Clinical and laboratory haematology","volume":"48 1","pages":"271-272"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76869985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular pathogenesis of myeloproliferative disorders 骨髓增生性疾病的分子发病机制
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01264.X
A. Green
{"title":"Molecular pathogenesis of myeloproliferative disorders","authors":"A. Green","doi":"10.1111/J.1365-2257.1995.TB01264.X","DOIUrl":"https://doi.org/10.1111/J.1365-2257.1995.TB01264.X","url":null,"abstract":"","PeriodicalId":10285,"journal":{"name":"Clinical and laboratory haematology","volume":"82 1","pages":"295-297"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78057395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Investigation of neonatal blood disorders 新生儿血液病的调查
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01254.X
I. Hann
{"title":"Investigation of neonatal blood disorders","authors":"I. Hann","doi":"10.1111/J.1365-2257.1995.TB01254.X","DOIUrl":"https://doi.org/10.1111/J.1365-2257.1995.TB01254.X","url":null,"abstract":"","PeriodicalId":10285,"journal":{"name":"Clinical and laboratory haematology","volume":"29 3 1","pages":"273-276"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85759912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type III procollagen N-peptide correlates with beta-2-microglobulin in myelomatosis. 骨髓瘤中III型前胶原n肽与β -2微球蛋白相关。
Clinical and laboratory haematology
Pub Date : 1995-09-01
H C Hasselbalch, O W Bjerrum, P Junker

The serum concentration of the N-terminal peptide of type III procollagen (PIIINP) was determined in 32 patients with myelomatosis (MM). Four subjects were studied at the time of diagnosis and the remaining patients at variable intervals from diagnosis. Serum concentration of beta-2-microglobulin (B2m) was measured in 31 patients. Serial measurements of both substances were performed in 20 patients. Serum PIIINP was increased in MM as compared with healthy control subjects (P < 0.001). Patients with active disease had significantly higher propeptide values (median 7.4; range 3.8-11.2) as compared to those with stable disease (median 4.3; range 2.2-9.6) (P < 0.009). A highly significant correlation existed between circulating PIIINP and B2m (P < 0.001). It is concluded that MM elicits a stromal reaction as reflected by parallel increases in serum PIIINP and serum B2m. In subsets of patients, e.g. those with non-secretory myeloma and in patients with smouldering disease, serum PIIINP may even be superior to B2m as an indicator of disease activity.

测定32例骨髓瘤病(MM)患者血清III型前胶原n端肽(PIIINP)的浓度。四名受试者在诊断时进行研究，其余患者在诊断后的可变时间间隔进行研究。测定31例患者血清β -2微球蛋白(B2m)浓度。对20例患者进行了两种物质的连续测量。与健康对照组相比，MM组血清PIIINP增高(P < 0.001)。活动性疾病患者的前肽值明显较高(中位7.4;范围3.8-11.2)，与疾病稳定的患者相比(中位4.3;范围2.2 ~ 9.6)(P < 0.009)。循环PIIINP与B2m之间存在高度显著相关(P < 0.001)。结论是MM引起基质反应，反映在血清PIIINP和血清B2m平行增加。在患者亚群中，如非分泌性骨髓瘤患者和阴燃性疾病患者，血清PIIINP作为疾病活动性指标甚至可能优于B2m。
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引用次数: 0
Further comparative experience with the Roche Cobas Argos Analyser. 进一步比较罗氏科巴斯Argos分析仪的经验。
Clinical and laboratory haematology
Pub Date : 1995-09-01
S Wilson, G S Pillay, N Hindley, S Gelderbloem, P Jacobs
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引用次数: 0
The organization of a peripheral blood stem cell laboratory 外周血干细胞实验室的组织
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01260.X
N. Russell
{"title":"The organization of a peripheral blood stem cell laboratory","authors":"N. Russell","doi":"10.1111/J.1365-2257.1995.TB01260.X","DOIUrl":"https://doi.org/10.1111/J.1365-2257.1995.TB01260.X","url":null,"abstract":"","PeriodicalId":10285,"journal":{"name":"Clinical and laboratory haematology","volume":"283 1","pages":"286-287"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83111102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Haematology self-assessment exercise. 血液学自我评估练习。
Clinical and laboratory haematology
Pub Date : 1995-09-01
C Fegan, D K Bowen
{"title":"Haematology self-assessment exercise.","authors":"C Fegan,&nbsp;D K Bowen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10285,"journal":{"name":"Clinical and laboratory haematology","volume":"17 3","pages":"255-7"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19694013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficiencies and limitations of automated white cell differentials 白细胞自动鉴别的效率和局限性
Clinical and laboratory haematology
Pub Date : 1995-09-01 DOI: 10.1111/J.1365-2257.1995.TB01257.X
C. S. Scott
{"title":"The efficiencies and limitations of automated white cell differentials","authors":"C. S. Scott","doi":"10.1111/J.1365-2257.1995.TB01257.X","DOIUrl":"https://doi.org/10.1111/J.1365-2257.1995.TB01257.X","url":null,"abstract":"","PeriodicalId":10285,"journal":{"name":"Clinical and laboratory haematology","volume":"31 1","pages":"280-281"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74637924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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