Chonnam Medical Journal最新文献

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A Rare Case of Acute Pancreatitis with Concomitant Ulcerative Colitis 急性胰腺炎并发溃疡性结肠炎1例

Chonnam Medical Journal

Pub Date : 2022-05-01 DOI: 10.4068/cmj.2022.58.2.83

Kyoung-Hoon Yoo, K. Choi, Tae Hyeon Kim, H. Chon

https://doi.org/10.4068/cmj.2022.58.2.83 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:83-84 Corresponding Author: Hyung Ku Chon Department of Internal Medicine, Wonkwang University School of Medicine and Hospital, 895 Muwang-ro, Iksan 54538, Korea Tel: +82-63-859-2564, Fax: +82-63-855-2025, E-mail: gipb2592@wku.ac.kr Article History: Received February 19, 2022 Revised April 5, 2022 Accepted April 17, 2022 FIG. 1. Abdominal computed tomography reveals (A) diffuse edematous swelling of the pancreas, “sausage like” appearance of the pancreas with a low attenuating halo (white arrows) and (B) diffuse bowel wall thickening involving the rectum (open white arrow).

https://doi.org/10.4068/cmj.2022.58.2.83 C全南医学杂志，2022全南医学J 2022;58:83-84通讯作者:Hyung Ku Chon内科，原光大学医学院，895 Muwang-ro, Iksan 54538，韩国电话:+82-63-859-2564，传真:+82-63-855-2025,E-mail: gipb2592@wku.ac.kr文章历史:收到2022年2月19日修订2022年4月5日接受2022年4月17日图1。腹部计算机断层扫描显示(A)胰腺弥漫性水肿肿胀，胰腺呈“香肠样”外观，伴低衰减晕(白色箭头);(B)肠壁弥漫性增厚，累及直肠(白色开口箭头)。

引用次数: 0

Radiation Ileitis Leading to Enterovesical Fistula 放射性回肠炎导致肠膀胱瘘

Chonnam Medical Journal

Pub Date : 2022-05-01 DOI: 10.4068/cmj.2022.58.2.77

A. Hokama, Moemi Kanemoto, Keita Hagiwara, Akihito Ikemura, Erika Koga, Shigehito Tameda, Yuiko Oishi, Souhei Tabata, Kouya Miyazato, J. Fujita

https://doi.org/10.4068/cmj.2022.58.2.77 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:77-78 Corresponding Author: Akira Hokama Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Tel: +81-988951144, Fax: +81-988951414, E-mail: hokama-a@med.u-ryukyu.ac.jp Article History: Received January 16, 2022 Revised January 21, 2022 Accepted January 24, 2022 FIG. 1. A radiographic study using gastrographin showed the markedly stenotic ileum with ‘saw tooth’ appearance (arrow). FIG. 2. Cystography disclosed the enhancing material draining from the bladder (arrowhead) to the diseased ileum (arrow), consistent with the enterovesical fistula. Radiation Ileitis Leading to Enterovesical Fistula Akira Hokama*, Moemi Kanemoto, Keita Hagiwara, Akihito Ikemura, Erika Koga, Shigehito Tameda, Yuiko Oishi, Souhei Tabata, Kouya Miyazato, and Jiro Fujita Departments of Endoscopy and Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan,

https://doi.org/10.4068/cmj.2022.58.2.77 C全南医学杂志，2022全南医学杂志，2022;58:77-78通讯作者:北山明，琉球大学医学研究生院内镜部，207上原，西原，冲绳903-0215，日本电话:+81-988951144，传真:+81-988951414,E-mail: hokama-a@med.u-ryukyu.ac.jp文章历史:收到1月16日，2022年1月21日修订，2022年1月24日接受图1。胃造影显示回肠明显狭窄，呈“锯齿”状(箭头)。图2所示。膀胱造影显示增强物质从膀胱(箭头)引流至病变回肠(箭头)，符合肠膀胱瘘。日本冲绳琉球大学医学研究生院内镜与感染、呼吸、消化医学科，北山明*、金本茂美、萩原庆太、池村明仁、古贺丽丽、田田茂仁、大石由子、田田南平、宫内广也、藤田二郎

引用次数: 0

Our Dedicated Effort to Save a COVID-19 Confirmed Patient with Myocardial Infarction 我们为拯救COVID-19确诊心肌梗死患者所做的不懈努力

Chonnam Medical Journal

Pub Date : 2022-05-01 DOI: 10.4068/cmj.2022.58.2.85

S. Oh, Min Chul Kim, D. Sim, Y. Hong, Ju Han Kim, Youngkeun Ahn, M. Jeong

F IG . 1. During the hospitalization to the intensive care unit, ventricular fibrillation with sudden cardiac arrest occurred. After electrical defibrillation, the patient was successfully resusci-tated. A 73-year-old COVID-19 confirmed female was brought to our tertiary cardiovascular center because of acute myocardial infarction (AMI). Since cardiac arrest occurred with ventricular fibrillation (Fig. 1), an urgent coronary angiogram (CAG) was planned. Before CAG, all cathlab team members wore personal protective equipment (Fig. 2, Supplemental Video 1). CAG showed critical stenoses at both proximal and distal portions of left circumflex coronary artery (LCX) (Fig. 3A, Supplemental Video 2). After a 2.5×15 mm balloon was pre-dilated, we implanted two drug-eluting stents

图。1. 在重症监护病房住院期间，发生心室颤动并心脏骤停。经电除颤后，患者成功复苏。一名确诊为COVID-19的73岁女性因急性心肌梗死(AMI)被送往三级心血管中心。由于心脏骤停并心室颤动(图1)，计划进行紧急冠状动脉造影(CAG)。在CAG之前，所有cathlab团队成员都佩戴了个人防护装备(图2，补充视频1)。CAG显示左旋冠状动脉(LCX)近端和远端都存在严重狭窄(图3A，补充视频2)。在2.5×15 mm球囊预扩张后，我们植入了两个药物洗脱支架

引用次数: 0

Jejunal Arteriovenous Malformation Detected by Video Capsule Endoscopy 视频胶囊内镜检测空肠动静脉畸形

Chonnam Medical Journal

Pub Date : 2022-05-01 DOI: 10.4068/cmj.2022.58.2.75

Atsushi Iraha, Y. Irei, T. Kinjo, Yuiko Oishi, T. Ohira, Tetsu Kinjo, A. Hokama, Noritake Kosuge, Naoki Wada, M. Takatsuki, J. Fujita

A 61-year-old man visited a clinic because of melena. He had taken amlodipine for hypertension but no antiplatelet drugs. After esophagogastroduodenoscopy (EGD) and colonoscopy were negative, he was referred to our hospital for overt small bowel bleeding. A physical examination showed stable vital signs and

一名61岁的男子因黑素瘤就诊。他曾服用氨氯地平治疗高血压，但未服用抗血小板药物。经食管胃十二指肠镜和结肠镜检查均为阴性后，因明显的小肠出血转介至我院。体检显示生命体征稳定

引用次数: 0

Cutaneous Metastasis from Cholangiocarcinoma 胆管癌的皮肤转移

Chonnam Medical Journal

Pub Date : 2022-05-01 DOI: 10.4068/cmj.2022.58.2.79

Y. Kajihara

https://doi.org/10.4068/cmj.2022.58.2.79 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:79-80 Corresponding Author: Yusaku Kajihara Department of Gastroenterology, Fuyoukai Murakami Hospital, 3-3-14 Hamada, Aomori 030-0843, Japan Tel: +81-17-729-8888, Fax: +81-17-729-8887, E-mail: yukajihara-gi@umin.ac.jp Article History: Received January 31, 2022 Revised February 8, 2022 Accepted February 9, 2022 FIG. 1. (A) An erythematous ulcerated nodule measuring 4×3 cm. (B) Histological evaluation (hematoxylin and eosin staining) revealing malignant glands in the subcutaneous area. FIG. 2. Computed tomography coronal view showing cholangiocarcinoma (arrows) and a liver metastasis (arrowheads). Cutaneous Metastasis from Cholangiocarcinoma

https://doi.org/10.4068/cmj.2022.58.2.79 C全南医学杂志，2022全南医学杂志，2022;58:79-80通讯作者:梶原友作电话:+81-17-729-8888，传真:+81-17-729-8887,E-mail: yukajihara-gi@umin.ac.jp文章历史:收稿日期:2022年1月31日修改日期:2022年2月8日接收日期:2022年2月9日(A)溃疡性红斑结节，直径4×3 cm。(B)组织学评价(苏木精和伊红染色)显示皮下区域的恶性腺体。图2所示。计算机断层扫描冠状面显示胆管癌(箭头)和肝转移(箭头)。胆管癌的皮肤转移

引用次数: 0

Gold Threads on Chest Radiograph 胸片上的金线

Chonnam Medical Journal

Pub Date : 2022-05-01 DOI: 10.4068/cmj.2022.58.2.87

Y. Kajihara

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. FIG. 1. Chest radiograph showing numerous short, hyper-dense, thread-like fragments in the chest and neck. FIG. 2. Computed tomography confirming multiple fine metallic subcutaneous densities. Gold Threads on Chest Radiograph

这是一篇在知识共享署名非商业许可(http://creativecommons.org/licenses/ by-nc/4.0)的条款下发布的开放获取文章，该许可允许在任何媒介上不受限制地进行非商业使用、分发和复制，前提是正确引用原创作品。图1所示。胸片显示胸部和颈部有大量短而高密度的线状碎片。图2所示。计算机断层扫描证实皮下多发细金属密度。胸片上的金线

引用次数: 0

Prognostic Significance of the Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Neuroendocrine Carcinoma. 中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值在神经内分泌癌中的预后意义。

Chonnam Medical Journal

Pub Date : 2022-01-01 Epub Date: 2022-01-25 DOI: 10.4068/cmj.2022.58.1.29

Hyeon-Jong Kim, Kang Han Lee, Hyun Jeong Shim, Eu Chang Hwang, Yoo-Duk Choi, Hyunjin Bang, Sang Hee Cho, Ik-Joo Chung, Jun Eul Hwang, Myung Ah Lee, Woo Kyun Bae

Extra-pulmonary neuroendocrine carcinoma is a rare and aggressive cancer. Although several biological and histological markers have been suggested as prognostic factors for this cancer, the prognostic importance of systemic inflammatory markers, including the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio, is unclear. This study aimed to evaluate the association between systemic inflammatory markers and the prognosis of extra-pulmonary neuroendocrine carcinoma. We retrospectively analyzed the clinical data of 85 patients with unresectable or metastatic extra-pulmonary neuroendocrine carcinoma who received platinum-based chemotherapy as first-line chemotherapy from August 2007 to November 2019. We used time-dependent receiver operating characteristic curve analysis to determine the cut-off values. The cut-off values for the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were 3.0 and 158.5, respectively. There was no significant difference in the Eastern Cooperative Oncology Group performance status score, Ki-67 index, or response to chemotherapy between groups. The high neutrophil-lymphocyte ratio group showed significantly worse overall survival (high vs. low, median 11.1 vs. 21.0 months, log-rank p=0.004) and shorter median progression-free survival, but the latter was not statistically significant. The high platelet-lymphocyte ratio group also showed significantly worse progression-free survival and overall survival than the low platelet-lymphocyte ratio group (high vs. low: median 5.6 vs. 9.8 months, log-rank p=0.047 and median 13.8 vs. 21.0 months, log-rank p=0.013, respectively). In multivariable analysis, a high neutrophil-lymphocyte ratio was an independent prognostic factor for overall survival. The neutrophil-lymphocyte ratio is a potent and readily available prognostic factor for extra-pulmonary neuroendocrine carcinoma.

肺外神经内分泌癌是一种罕见的恶性肿瘤。尽管一些生物学和组织学标志物已被认为是这种癌症的预后因素，但系统性炎症标志物(包括中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率)对预后的重要性尚不清楚。本研究旨在评估全身炎症标志物与肺外神经内分泌癌预后的关系。回顾性分析2007年8月至2019年11月接受铂类化疗作为一线化疗的85例不可切除或转移性肺外神经内分泌癌患者的临床资料。我们使用随时间变化的受者工作特性曲线分析来确定截止值。中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值的临界值分别为3.0和158.5。东部肿瘤合作组的表现状态评分、Ki-67指数及化疗反应在两组间无显著差异。高中性粒细胞-淋巴细胞比率组的总生存期明显较差(高vs低，中位11.1 vs 21.0个月，log-rank p=0.004)，中位无进展生存期较短，但后者无统计学意义。高血小板-淋巴细胞比率组的无进展生存期和总生存期也明显低于低血小板-淋巴细胞比率组(高与低:中位数5.6 vs 9.8个月，log-rank p=0.047;中位数13.8 vs 21.0个月，log-rank p=0.013)。在多变量分析中，高中性粒细胞-淋巴细胞比率是总生存的独立预后因素。中性粒细胞与淋巴细胞比值是肺外神经内分泌癌的一个有效且容易获得的预后因素。

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引用次数: 2

Riedel's Lobe of the Liver. 里德尔的肝叶。

Chonnam Medical Journal

Pub Date : 2022-01-01 Epub Date: 2022-01-25 DOI: 10.4068/cmj.2022.58.1.50

Yusaku Kajihara

https://doi.org/10.4068/cmj.2022.58.1.50 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:50-51 Corresponding Author: Yusaku Kajihara Department of Gastroenterology, Fuyoukai Murakami Hospital, 3-3-14 Hamada, Aomori 030-0843, Japan Tel: +81-17-729-8888, Fax: +81-17-729-8887, E-mail: yukajihara-gi@umin.ac.jp Article History: Received January 28, 2021 Revised February 3, 2021 Accepted February 9, 2021 FIG. 1. Downward elongation of the liver (arrows), ending at the level of the iliac crest. FIG. 2. The transverse diameter and the greatest anteroposterior diameter on the level with the upper pole of the right kidney. Riedel’s Lobe of the Liver

引用次数: 2

Dominant Dystrophic Epidermolysis Bullosa with a Mutation in COL7A1 Confirmed by Diagnostic Exome Sequencing. 诊断外显子组测序证实COL7A1突变的显性营养不良大疱性表皮松解症。

Chonnam Medical Journal

Pub Date : 2022-01-01 Epub Date: 2022-01-25 DOI: 10.4068/cmj.2022.58.1.66

Sang-Hyeon Won, Kyung-Nam Bae, Jin-Hwa Son, Kihyuk Shin, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim

https://doi.org/10.4068/cmj.2022.58.1.66 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:66-67 Corresponding Author: Moon-Bum Kim Department of Dermatology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea Tel: +82-51-240-7338, Fax: +82-51-245-9467, E-mail: drkmp@hanmail.net Article History: Received November 10, 2021 Revised December 14, 2021 Accepted December 15, 2021 FIG. 1. Erythematous to purpuric scarring and milia on both lower legs, elbows, and the dorsa of hands and feet (A-E). Nail dystrophy on both fingernails and toenails (D, E). Dominant Dystrophic Epidermolysis Bullosa with a Mutation in COL7A1 Confirmed by Diagnostic Exome Sequencing Sang-Hyeon Won, Kyung-Nam Bae, Jin-Hwa Son, Kihyuk Shin, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, and Moon-Bum Kim* Department of Dermatology, School of Medicine, Pusan National University, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

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引用次数: 0

The Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation. 组蛋白乙酰化在间充质干细胞分化中的作用。

Chonnam Medical Journal

Pub Date : 2022-01-01 Epub Date: 2022-01-25 DOI: 10.4068/cmj.2022.58.1.6

Sujeong Jang, Jinsu Hwang, Han-Seong Jeong

The mechanism and action concerning epigenetic modifications, especially that of histone modifications, are not fully understood. However, it is clear that histone modifications play an essential role in several biological processes that are involved in cell proliferation and differentiation. In this article, we focused on how histone acetylation may result in differentiation into mesenchymal stem cells as well as histone acetylation function. Moreover, histone acetylation followed by the action of histone deacetylase inhibitors, which can result in the differentiation of stem cells into other types of cells such as adipocytes, chondrocytes, osteocytes, neurons, and other lineages, were also reviewed.

表观遗传修饰的机制和作用，特别是组蛋白修饰的机制和作用尚不完全清楚。然而，很明显，组蛋白修饰在涉及细胞增殖和分化的几个生物学过程中起着重要作用。在本文中，我们主要关注组蛋白乙酰化如何导致间充质干细胞分化以及组蛋白乙酰化的功能。此外，组蛋白乙酰化之后的组蛋白去乙酰化酶抑制剂的作用，可以导致干细胞分化为其他类型的细胞，如脂肪细胞、软骨细胞、骨细胞、神经元和其他谱系，也进行了综述。

引用次数: 5

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Chonnam Medical Journal

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