Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.13
Sunjun Lee, Won-Seok Choi
Alzheimer's disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are activated in the AD brain and AD models. However, the exact role of microglia has not been established. We thus investigated the role of microglia in AD models using a primary culture and an ex-vivo assay. We showed that oligomerized Aβ is toxic to neurons in the primary culture. In the ex-vivo assay, a microglial cell line removed amyloid plaques in the brain of 5XFAD (AD model) mice. To verify if microglia can be protective for the neuron, we co-cultured neurons with primary microglia and treated them with Aβ. The loss of neurons, induced by amyloid toxicity, was attenuated by co-cultured microglia. Taken together, our data suggest that microglia promote neuronal survival by phagocytic clearance of Aβ in AD models.
{"title":"Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta.","authors":"Sunjun Lee, Won-Seok Choi","doi":"10.4068/cmj.2022.58.1.13","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.13","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common cause of neurodegeneration. It is characterized by deposits of amyloid beta (Aβ) plaques and impaired memory. Microglia are associated with AD. They are activated in the AD brain and AD models. However, the exact role of microglia has not been established. We thus investigated the role of microglia in AD models using a primary culture and an ex-vivo assay. We showed that oligomerized Aβ is toxic to neurons in the primary culture. In the ex-vivo assay, a microglial cell line removed amyloid plaques in the brain of 5XFAD (AD model) mice. To verify if microglia can be protective for the neuron, we co-cultured neurons with primary microglia and treated them with Aβ. The loss of neurons, induced by amyloid toxicity, was attenuated by co-cultured microglia. Taken together, our data suggest that microglia promote neuronal survival by phagocytic clearance of Aβ in AD models.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/4a/cmj-58-13.PMC8813657.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.59
Hyung Ki Jeong
https://doi.org/10.4068/cmj.2022.58.1.59 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:59-60 Corresponding Author: Hyung Ki Jeong Division of Cardiology, Department of Internal Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Korea Tel: +82-63-859-2526, Fax: +82-63-852-8480, E-mail: jhk30334@hanmail.net Article History: Received April 21, 2021 Revised April 26, 2021 Accepted April 27, 2021 FIG. 1. (A) Electrocardiography (ECG) documented by Apple watch (Apple Inc, Cupertino, CA, USA). It demonstrated regular narrow QRS tachycardia, heart rates 240 beats per minutes. (B) A twelve leads ECG of the regular narrow QRS tachycardia which was induced during electrophysiologic study. It demonstrated long RP interval with cycle length of 310 ms. Supraventricular Tachycardia Detected by Smart Watch
{"title":"Supraventricular Tachycardia Detected by Smart Watch.","authors":"Hyung Ki Jeong","doi":"10.4068/cmj.2022.58.1.59","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.59","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.59 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:59-60 Corresponding Author: Hyung Ki Jeong Division of Cardiology, Department of Internal Medicine, Wonkwang University School of Medicine, 895 Muwang-ro, Iksan 54538, Korea Tel: +82-63-859-2526, Fax: +82-63-852-8480, E-mail: jhk30334@hanmail.net Article History: Received April 21, 2021 Revised April 26, 2021 Accepted April 27, 2021 FIG. 1. (A) Electrocardiography (ECG) documented by Apple watch (Apple Inc, Cupertino, CA, USA). It demonstrated regular narrow QRS tachycardia, heart rates 240 beats per minutes. (B) A twelve leads ECG of the regular narrow QRS tachycardia which was induced during electrophysiologic study. It demonstrated long RP interval with cycle length of 310 ms. Supraventricular Tachycardia Detected by Smart Watch","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"59-60"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/87/cmj-58-59.PMC8813655.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
https://doi.org/10.4068/cmj.2022.58.1.52 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:52-53 Corresponding Author: Akira Hokama Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Tel: +81-988951144, Fax: +81-988951414, E-mail: hokama-a@med.u-ryukyu.ac.jp Article History: Received November 17, 2021 Revised December 1, 2021 Accepted December 2, 2021 FIG. 1. (A) An abdominal computed tomography scan disclosed circumferential mural thickening involving the ascending and transverse colon. Note the stricture at the hepatic flexure (arrow) and mesenteric inflammation. (B) Gastrographin enema radiograph disclosed shortening of the ascending colon with surface irregularity and marked stricture at the hepatic flexure (arrow). Paradoxical Reaction to Antitubercular Treatment Causing Colonic Obstruction Akira Hokama*, Yuiko Oishi, Erika Koga, Sayuri Takehara, and Jiro Fujita Departments of Endoscopy and Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
{"title":"Paradoxical Reaction to Antitubercular Treatment Causing Colonic Obstruction.","authors":"Akira Hokama, Yuiko Oishi, Erika Koga, Sayuri Takehara, Jiro Fujita","doi":"10.4068/cmj.2022.58.1.52","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.52","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.52 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:52-53 Corresponding Author: Akira Hokama Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Tel: +81-988951144, Fax: +81-988951414, E-mail: hokama-a@med.u-ryukyu.ac.jp Article History: Received November 17, 2021 Revised December 1, 2021 Accepted December 2, 2021 FIG. 1. (A) An abdominal computed tomography scan disclosed circumferential mural thickening involving the ascending and transverse colon. Note the stricture at the hepatic flexure (arrow) and mesenteric inflammation. (B) Gastrographin enema radiograph disclosed shortening of the ascending colon with surface irregularity and marked stricture at the hepatic flexure (arrow). Paradoxical Reaction to Antitubercular Treatment Causing Colonic Obstruction Akira Hokama*, Yuiko Oishi, Erika Koga, Sayuri Takehara, and Jiro Fujita Departments of Endoscopy and Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"52-53"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/d8/cmj-58-52.PMC8813645.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.61
Kyung Hoon Cho, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong
https://doi.org/10.4068/cmj.2022.58.1.61 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:61-62 Corresponding Author: Young Joon Hong Division of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Korea Tel: +82-62-220-5778, Fax: +82-62-223-3105, E-mail: hyj200@hanmail.net Article History: Received January 6, 2021 Revised January 22, 2021 Accepted January 23, 2021 FIG. 1. Coronary angiography. (A, B) Left coronary angiogram shows a short left anterior descending artery (LAD) arising from the left main coronary artery and a big diagonal branch with severe stenosis (arrow) and unfavorable angulation (arrowhead). (C, D) Right coronary angiogram shows a long LAD originating from the right coronary sinus separately from the right coronary artery (arrow) and continuing as mid LAD (arrowhead). (E, F) Left coronary angiograms shows successful revascularization of the big diagonal branch of a short left anterior descending artery (arrow). (A, E) Anterior posterior cranial view. (B, F) Left anterior oblique caudal view. (C, D) Right anterior oblique view. Intervention of a Large Diagonal Branch for Acute Myocardial Infarction in a Patient with a New Variant of the Dual Left Anterior Descending Artery
{"title":"Intervention of a Large Diagonal Branch for Acute Myocardial Infarction in a Patient with a New Variant of the Dual Left Anterior Descending Artery.","authors":"Kyung Hoon Cho, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong","doi":"10.4068/cmj.2022.58.1.61","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.61","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.61 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:61-62 Corresponding Author: Young Joon Hong Division of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Korea Tel: +82-62-220-5778, Fax: +82-62-223-3105, E-mail: hyj200@hanmail.net Article History: Received January 6, 2021 Revised January 22, 2021 Accepted January 23, 2021 FIG. 1. Coronary angiography. (A, B) Left coronary angiogram shows a short left anterior descending artery (LAD) arising from the left main coronary artery and a big diagonal branch with severe stenosis (arrow) and unfavorable angulation (arrowhead). (C, D) Right coronary angiogram shows a long LAD originating from the right coronary sinus separately from the right coronary artery (arrow) and continuing as mid LAD (arrowhead). (E, F) Left coronary angiograms shows successful revascularization of the big diagonal branch of a short left anterior descending artery (arrow). (A, E) Anterior posterior cranial view. (B, F) Left anterior oblique caudal view. (C, D) Right anterior oblique view. Intervention of a Large Diagonal Branch for Acute Myocardial Infarction in a Patient with a New Variant of the Dual Left Anterior Descending Artery","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"61-62"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/7b/cmj-58-61.PMC8813660.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.64
Soyoon Hwang, Hyun-Ha Chang, Sohyun Bae, Yu Kyung Kim, Jungmin Kim
https://doi.org/10.4068/cmj.2022.58.1.64 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:64-65 Corresponding Author: Hyun-Ha Chang Department of Internal Medicine, School of Medicine, Kyungpook National University, 680 gukchaebosang-ro, Jung-gu, Daegu 41944, Korea Tel: +82-53-200-6553, Fax: +82-53-424-5542, E-mail: changhha@knu.ac.kr Article History: Received August 17, 2021 Revised September 10, 2021 Accepted September 15, 2021 A Case of Resembling Hemolytic Uremic Syndrome Caused by Escherichia fergusonii in an Immunocompetent Adult Soyoon Hwang, Hyun-Ha Chang*, Sohyun Bae, Yu Kyung Kim, and Jungmin Kim Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Departments of Clinical Pathology and Microbiology, School of Medicine, Kyungpook National University, Daegu, Korea
{"title":"A Case of Resembling Hemolytic Uremic Syndrome Caused by <i>Escherichia fergusonii</i> in an Immunocompetent Adult.","authors":"Soyoon Hwang, Hyun-Ha Chang, Sohyun Bae, Yu Kyung Kim, Jungmin Kim","doi":"10.4068/cmj.2022.58.1.64","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.64","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.64 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:64-65 Corresponding Author: Hyun-Ha Chang Department of Internal Medicine, School of Medicine, Kyungpook National University, 680 gukchaebosang-ro, Jung-gu, Daegu 41944, Korea Tel: +82-53-200-6553, Fax: +82-53-424-5542, E-mail: changhha@knu.ac.kr Article History: Received August 17, 2021 Revised September 10, 2021 Accepted September 15, 2021 A Case of Resembling Hemolytic Uremic Syndrome Caused by Escherichia fergusonii in an Immunocompetent Adult Soyoon Hwang, Hyun-Ha Chang*, Sohyun Bae, Yu Kyung Kim, and Jungmin Kim Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Departments of Clinical Pathology and Microbiology, School of Medicine, Kyungpook National University, Daegu, Korea","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"64-65"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/3e/cmj-58-64.PMC8813659.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
https://doi.org/10.4068/cmj.2022.58.1.48 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:48-49 Corresponding Author: Akira Hokama Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Tel: +81-98-895-1144, Fax: +81-98-895-1414, E-mail: hokama-a@med.u-ryukyu.ac.jp Article History: Received September 20, 2021 Revised October 4, 2021 Accepted October 6, 2021 FIG. 2. (A) Colonoscopy showed massive fresh blood and an exposed vessel (arrow) in the rectum. (B) Closer observation disclosed a nipple-like pulsatile vessel without surrounding ulceration, consistent with Dieulafoy lesion. (C) Hemostatic clips were deployed to the Dieulafoy lesion (arrow), achieving successful hemostasis. FIG. 1. An enhanced computed tomography scan disclosed active extravasation (arrow) in the rectum. Rectal Dieulafoy Lesion Erika Koga, Satoshi Ashimine, Atsushi Iraha, and Akira Hokama* Departments of Endoscopy, Urology, and Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
{"title":"Rectal Dieulafoy Lesion.","authors":"Erika Koga, Satoshi Ashimine, Atsushi Iraha, Akira Hokama","doi":"10.4068/cmj.2022.58.1.48","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.48","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.48 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:48-49 Corresponding Author: Akira Hokama Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Tel: +81-98-895-1144, Fax: +81-98-895-1414, E-mail: hokama-a@med.u-ryukyu.ac.jp Article History: Received September 20, 2021 Revised October 4, 2021 Accepted October 6, 2021 FIG. 2. (A) Colonoscopy showed massive fresh blood and an exposed vessel (arrow) in the rectum. (B) Closer observation disclosed a nipple-like pulsatile vessel without surrounding ulceration, consistent with Dieulafoy lesion. (C) Hemostatic clips were deployed to the Dieulafoy lesion (arrow), achieving successful hemostasis. FIG. 1. An enhanced computed tomography scan disclosed active extravasation (arrow) in the rectum. Rectal Dieulafoy Lesion Erika Koga, Satoshi Ashimine, Atsushi Iraha, and Akira Hokama* Departments of Endoscopy, Urology, and Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"48-49"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/e7/cmj-58-48.PMC8813646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.54
In-Jae Kim, Lae-Young Jung
https://doi.org/10.4068/cmj.2022.58.1.54 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:54-56 Corresponding Author: Lae-Young Jung Division of Cardiology, Jeonbuk National University Hospital and Jeonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea Tel: +82-63-250-1389, Fax: +82-63-250-1680, E-mail: lyjung@jbnu.ac.kr Article History: Received November 4, 2021 Revised November 30, 2021 Accepted December 2, 2021 FIG. 1. Chest X-ray (A), echocardiography (B), and chest CT (C-F) findings from the first medical examination. A computed tomography demonstrated foreign material in the RV with an apical wall perforation (arrow head). Extraction or No Extraction? A Case of Long-Term Follow Up of a Patient with Cement Embolism Induced Right Ventricular Perforation without Pericardial Effusion In-Jae Kim and Lae-Young Jung* Division of Cardiology, Jeonbuk National University Hospital and Jeonbuk National University Medical School, Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea
{"title":"Extraction or No Extraction? A Case of Long-Term Follow Up of a Patient with Cement Embolism Induced Right Ventricular Perforation without Pericardial Effusion.","authors":"In-Jae Kim, Lae-Young Jung","doi":"10.4068/cmj.2022.58.1.54","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.54","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.54 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:54-56 Corresponding Author: Lae-Young Jung Division of Cardiology, Jeonbuk National University Hospital and Jeonbuk National University Medical School, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea Tel: +82-63-250-1389, Fax: +82-63-250-1680, E-mail: lyjung@jbnu.ac.kr Article History: Received November 4, 2021 Revised November 30, 2021 Accepted December 2, 2021 FIG. 1. Chest X-ray (A), echocardiography (B), and chest CT (C-F) findings from the first medical examination. A computed tomography demonstrated foreign material in the RV with an apical wall perforation (arrow head). Extraction or No Extraction? A Case of Long-Term Follow Up of a Patient with Cement Embolism Induced Right Ventricular Perforation without Pericardial Effusion In-Jae Kim and Lae-Young Jung* Division of Cardiology, Jeonbuk National University Hospital and Jeonbuk National University Medical School, Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Korea","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/e3/cmj-58-54.PMC8813662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.57
Dong Hyun Choi, Sung Soo Kim, Hyun Kuk Kim, Young Jae Ki, Keun Ho Park, Jae Han Jeong
https://doi.org/10.4068/cmj.2022.58.1.57 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:57-58 Corresponding Author: Sung Soo Kim Department of Cardiovascular Medicine, Chosun University Medical School, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea Tel: +82-62-220-3240, Fax: +82-62-650-5116, E-mail: kholywater@gmail.com Article History: Received September 23, 2021 Revised October 15, 2021 Accepted October 23, 2021 FIG. 2. Coronary angiography reveals total occlusion of proximal left anterior descending coronary artery (LAD) (arrow) (A) and a normal right coronary artery (B). Percutaneous coronary intervention with everolimus-eluting stent implantation (3.0×38 mm, Synergy XD, Boston Scientific, Marlborough, MA) in the proximal LAD is performed (triangle) (C). FIG. 1. Initial 12-lead electrocardiography shows ST elevation and a Q wave in leads V1-V4, as well as a premature ventricular beat. Unusual Case of Interventricular Septal Dissection with Defects Following Anterior Myocardial Infarction Dong Hyun Choi, Sung Soo Kim*, Hyun Kuk Kim, Young Jae Ki, Keun Ho Park, and Jae Han Jeong Departments of Cardiovascular Medicine and Cardiovascular Surgery, Chosun University Medical School, Gwangju, Korea
{"title":"Unusual Case of Interventricular Septal Dissection with Defects Following Anterior Myocardial Infarction.","authors":"Dong Hyun Choi, Sung Soo Kim, Hyun Kuk Kim, Young Jae Ki, Keun Ho Park, Jae Han Jeong","doi":"10.4068/cmj.2022.58.1.57","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.57","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.57 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:57-58 Corresponding Author: Sung Soo Kim Department of Cardiovascular Medicine, Chosun University Medical School, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea Tel: +82-62-220-3240, Fax: +82-62-650-5116, E-mail: kholywater@gmail.com Article History: Received September 23, 2021 Revised October 15, 2021 Accepted October 23, 2021 FIG. 2. Coronary angiography reveals total occlusion of proximal left anterior descending coronary artery (LAD) (arrow) (A) and a normal right coronary artery (B). Percutaneous coronary intervention with everolimus-eluting stent implantation (3.0×38 mm, Synergy XD, Boston Scientific, Marlborough, MA) in the proximal LAD is performed (triangle) (C). FIG. 1. Initial 12-lead electrocardiography shows ST elevation and a Q wave in leads V1-V4, as well as a premature ventricular beat. Unusual Case of Interventricular Septal Dissection with Defects Following Anterior Myocardial Infarction Dong Hyun Choi, Sung Soo Kim*, Hyun Kuk Kim, Young Jae Ki, Keun Ho Park, and Jae Han Jeong Departments of Cardiovascular Medicine and Cardiovascular Surgery, Chosun University Medical School, Gwangju, Korea","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"57-58"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/5e/cmj-58-57.PMC8813650.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.1
Mohammad Amin Amini, Jamshid Karimi, Seyed Saman Talebi, Hosein Piri
There is no denying that the massive spread of COVID-19 around the world has worried everyone. The virus can cause mild to severe symptoms in various organs, especially the lungs. The virus affects oxidative stress in the cells. Reactive Oxygen Species modulator 1 (ROMO1) is one of the most important mitochondrial proteins that plays a critical regulatory role in the production of Reactive Oxygen Species (ROS). According to the studies, COVID-19 can promote oxidative stress through some important pathways, for instance, TNF-α and NF-κB routes. Furthermore, ROMO1 is closely related to these pathways and its dysfunction may affect these routes, then promote oxidative stress, and ultimately cause tissue damage, especially in the lungs. Another factor to consider is that the TNF-α and NF-κB pathways are associated with ROMO1, COVID-19, and oxidative stress. To summarize, it is hypothesized that COVID-19 may increase oxidative stress by affecting ROMO1. Understanding the exact molecular mechanisms of ROMO1 in the pathogenesis of COVID-19 can pave the way to find better therapeutic strategies.
不可否认，新冠肺炎疫情在全球范围内的大规模传播让每个人都感到担忧。这种病毒可以在各个器官，特别是肺部，引起轻微到严重的症状。病毒影响细胞的氧化应激。活性氧调节因子1 (Reactive Oxygen Species modulator 1, ROMO1)是线粒体中最重要的蛋白之一，在活性氧(Reactive Oxygen Species, ROS)的产生中起关键的调节作用。研究表明，COVID-19可通过TNF-α、NF-κB等重要途径促进氧化应激。此外，ROMO1与这些通路密切相关，其功能障碍可能影响这些通路，进而促进氧化应激，最终导致组织损伤，尤其是肺组织损伤。另一个需要考虑的因素是TNF-α和NF-κB通路与ROMO1、COVID-19和氧化应激相关。综上所述，我们假设COVID-19可能通过影响ROMO1来增加氧化应激。了解ROMO1在COVID-19发病机制中的确切分子机制可以为寻找更好的治疗策略铺平道路。
{"title":"The Association of COVID-19 and Reactive Oxygen Species Modulator 1 (ROMO1) with Oxidative Stress.","authors":"Mohammad Amin Amini, Jamshid Karimi, Seyed Saman Talebi, Hosein Piri","doi":"10.4068/cmj.2022.58.1.1","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.1","url":null,"abstract":"<p><p>There is no denying that the massive spread of COVID-19 around the world has worried everyone. The virus can cause mild to severe symptoms in various organs, especially the lungs. The virus affects oxidative stress in the cells. Reactive Oxygen Species modulator 1 (ROMO1) is one of the most important mitochondrial proteins that plays a critical regulatory role in the production of Reactive Oxygen Species (ROS). According to the studies, COVID-19 can promote oxidative stress through some important pathways, for instance, TNF-α and NF-κB routes. Furthermore, ROMO1 is closely related to these pathways and its dysfunction may affect these routes, then promote oxidative stress, and ultimately cause tissue damage, especially in the lungs. Another factor to consider is that the TNF-α and NF-κB pathways are associated with ROMO1, COVID-19, and oxidative stress. To summarize, it is hypothesized that COVID-19 may increase oxidative stress by affecting ROMO1. Understanding the exact molecular mechanisms of ROMO1 in the pathogenesis of COVID-19 can pave the way to find better therapeutic strategies.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/9b/cmj-58-1.PMC8813649.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39803537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.43
Sun-Seog Kweon, Il Yun, Changkyun Choi, So-Yeon Ryu, Jun Hwi Cho, Min-Ho Shin
COVID-19 vaccine hesitancy will likely increase in the unvaccinated general population because of several vaccine safety issues that arose during priority vaccination. To investigate the potential rate of COVID-19 vaccine hesitancy in the unvaccinated population and evaluate factors that affect the attitude towards vaccine acceptance, a cross-sectional survey was performed. A telephone survey was conducted in 1,357 people older than 18 years; 99 were excluded from the analysis because they had already been vaccinated (n=58) or hesitated (n=41) after an official call. The COVID-19 vaccine hesitancy rate was 21.9% and was highest among those aged under 30 years (33.4%) and lowest among those aged 65 years and over (8.7%). Age, occupation, and perceived confidence in vaccine safety and efficacy were associated with vaccine hesitancy. These findings suggest that public health authorities should strengthen the spread of correct information, especially in the younger population, to increase vaccination rates.
{"title":"Factors Associated with COVID-19 Vaccine Hesitancy in Korea.","authors":"Sun-Seog Kweon, Il Yun, Changkyun Choi, So-Yeon Ryu, Jun Hwi Cho, Min-Ho Shin","doi":"10.4068/cmj.2022.58.1.43","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.43","url":null,"abstract":"<p><p>COVID-19 vaccine hesitancy will likely increase in the unvaccinated general population because of several vaccine safety issues that arose during priority vaccination. To investigate the potential rate of COVID-19 vaccine hesitancy in the unvaccinated population and evaluate factors that affect the attitude towards vaccine acceptance, a cross-sectional survey was performed. A telephone survey was conducted in 1,357 people older than 18 years; 99 were excluded from the analysis because they had already been vaccinated (n=58) or hesitated (n=41) after an official call. The COVID-19 vaccine hesitancy rate was 21.9% and was highest among those aged under 30 years (33.4%) and lowest among those aged 65 years and over (8.7%). Age, occupation, and perceived confidence in vaccine safety and efficacy were associated with vaccine hesitancy. These findings suggest that public health authorities should strengthen the spread of correct information, especially in the younger population, to increase vaccination rates.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ac/5e/cmj-58-43.PMC8813654.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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