Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.013
Huafeng Zhang, Jia Zhao, L. Xia, Shang-Wen Yang, Xuezhong Chen
The clinical pathological data of a patient large cell undifferentiated bladder carcinoma was retrospectively analyzed and understand. The clinical and imaging findings of large cell undifferentiated bladder carcinoma was nonspecific. Diagnosis depended on the pathological and immuno-histochemical staining. The tumor is aggressive with high risk of recurrence.It is mainly treated with radical resection. Key words: Urinary bladder; Undifferentiated carcinoma; Large cell carcinoma
{"title":"A case report of large cell undifferentiated carcinoma of the urinary bladder","authors":"Huafeng Zhang, Jia Zhao, L. Xia, Shang-Wen Yang, Xuezhong Chen","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.013","url":null,"abstract":"The clinical pathological data of a patient large cell undifferentiated bladder carcinoma was retrospectively analyzed and understand. The clinical and imaging findings of large cell undifferentiated bladder carcinoma was nonspecific. Diagnosis depended on the pathological and immuno-histochemical staining. The tumor is aggressive with high risk of recurrence.It is mainly treated with radical resection. \u0000 \u0000Key words: \u0000Urinary bladder; Undifferentiated carcinoma; Large cell carcinoma","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43258490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.014
Ting Huang, Li Fang, Yue Cheng
Flexible ureteroscopic incision and drainage is an innovative surgical option for renal parapelvic cysts these years. Finding the thinnest part of the renal parapelvic cyst is the key point of the surgery. This paper reports two patients with renal parapelvic cysts treated with flexible ureteroscopic incision and drainage combined with All-Seeing needle. The operations were successful and had good outcomes with the two-year follow-up. Key words: Kidney disease, cystic; Peripelvic cyst; Flexible ureterscope; All-Seeing needle
{"title":"Two cases report of treatment of renal parapelvic cysts with incision and drainage by flexible ureteroscope combined with the All-Seeing needle","authors":"Ting Huang, Li Fang, Yue Cheng","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.014","url":null,"abstract":"Flexible ureteroscopic incision and drainage is an innovative surgical option for renal parapelvic cysts these years. Finding the thinnest part of the renal parapelvic cyst is the key point of the surgery. This paper reports two patients with renal parapelvic cysts treated with flexible ureteroscopic incision and drainage combined with All-Seeing needle. The operations were successful and had good outcomes with the two-year follow-up. \u0000 \u0000Key words: \u0000Kidney disease, cystic; Peripelvic cyst; Flexible ureterscope; All-Seeing needle","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42688327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.003
Liyuan Wu, Fei-ya Yang, L. Mou, Qinxin Zhao, Hongjiang Song, Xuesong Li, Qian Zhang, B. Shi, N. Xing
Objective To explore the feasibility and clinical effect of laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder. Methods Forty-one patients who underwent laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder from July 2013 to August 2019. There were 31 cases performed in Beijing Chaoyang hospital and 10 cases in National Cancer Center. Mean age was 59(range 44-78) years, mean BMI was 25.3(range 20.1-34.7)kg/m2 , and mean CCI was 3 (range 2-6). No urethral stricture or urinary incontinence was found by preoperative examination. No distant metastasis was identified by bone scans, chest X-ray and sonography. Cystoscopy or TURBT was performed on all patients and biopsy was taken to confirm the diagnosis. Preoperative pathology showed 30 cases (73.2%) of MIBC, 9 cases of NMIBC (22.0%) and 2 cases (4.9%) of in-situ cancer. Laparoscopic radical cystectomy and lymphadenectomy were performed under general anesthesia. Urinary diversion was completed in the peritoneal cavity, by intercepting the terminal ileum about 60 cm, and taking the proximal ileum 10 cm as input loop on the right side with proximal to distal way, and the middle 40 cm ileum was detubated. After u-shaped suture, the ileum was folded back and stitched into a sphere building a novel orthotopic neobladder with bilateral isoperistaltic afferent limbs. The prognosis of perioperative data and postoperative satisfaction regarding continence were analyzed, continence was defined as 0-1 pad/day. The 41 patients were divided into two groups to compare the difference in term of operation time and blood loss between the first 21 patients and the last 20 patients. Results Mean total operative time was 324.9 mins (range 210-480) mins, and mean estimated blood loss was 177.6(range 50-700) ml. There were significant statistical differences in term of total operation time, construction time and blood loss between the first 21 patients and the next 20 patients (P<0.05). Postoperative pathological results were urothelial carcinoma in 40 cases (2 in situ carcinoma) and small cell carcinoma in 1 case. Mean number of dissected lymph nodes was 19 (range 11-58), with 7 cases(17.1%)of positive lymph nodes, and 3 cases(7.3%)had positive surgical margin. At a mean follow up of 17.6(range 2-64) months, 36 patients (87.8%) survived, including 2 patients (4.9%) with metastasis and 1 patient (2.4%) with recurrence, and 5 cases (12.2%)died. All patients were able to urinate without catheterization. Thirty-seven patients (90.2%) were satisfied with voiding control during the daytime (0-1 urinal pad), and 29 patients (70.7%) were satisfied with voiding control at nighttime (0-1 urinal pad) by the follow-up 12 months after the operation. Conclusions Total laparoscopic radical cystectomy combined with Xing's orthotopic ileum neobladder is a simple method with fewer postoperative complications and a satisfactory continence rate. Key words: Urin
{"title":"The feasibility and efficacy of total laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder","authors":"Liyuan Wu, Fei-ya Yang, L. Mou, Qinxin Zhao, Hongjiang Song, Xuesong Li, Qian Zhang, B. Shi, N. Xing","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.003","url":null,"abstract":"Objective \u0000To explore the feasibility and clinical effect of laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder. \u0000 \u0000 \u0000Methods \u0000Forty-one patients who underwent laparoscopic radical cystectomy with intracorporeal Xing's orthotopic neobladder from July 2013 to August 2019. There were 31 cases performed in Beijing Chaoyang hospital and 10 cases in National Cancer Center. Mean age was 59(range 44-78) years, mean BMI was 25.3(range 20.1-34.7)kg/m2 , and mean CCI was 3 (range 2-6). No urethral stricture or urinary incontinence was found by preoperative examination. No distant metastasis was identified by bone scans, chest X-ray and sonography. Cystoscopy or TURBT was performed on all patients and biopsy was taken to confirm the diagnosis. Preoperative pathology showed 30 cases (73.2%) of MIBC, 9 cases of NMIBC (22.0%) and 2 cases (4.9%) of in-situ cancer. Laparoscopic radical cystectomy and lymphadenectomy were performed under general anesthesia. Urinary diversion was completed in the peritoneal cavity, by intercepting the terminal ileum about 60 cm, and taking the proximal ileum 10 cm as input loop on the right side with proximal to distal way, and the middle 40 cm ileum was detubated. After u-shaped suture, the ileum was folded back and stitched into a sphere building a novel orthotopic neobladder with bilateral isoperistaltic afferent limbs. The prognosis of perioperative data and postoperative satisfaction regarding continence were analyzed, continence was defined as 0-1 pad/day. The 41 patients were divided into two groups to compare the difference in term of operation time and blood loss between the first 21 patients and the last 20 patients. \u0000 \u0000 \u0000Results \u0000Mean total operative time was 324.9 mins (range 210-480) mins, and mean estimated blood loss was 177.6(range 50-700) ml. There were significant statistical differences in term of total operation time, construction time and blood loss between the first 21 patients and the next 20 patients (P<0.05). Postoperative pathological results were urothelial carcinoma in 40 cases (2 in situ carcinoma) and small cell carcinoma in 1 case. Mean number of dissected lymph nodes was 19 (range 11-58), with 7 cases(17.1%)of positive lymph nodes, and 3 cases(7.3%)had positive surgical margin. At a mean follow up of 17.6(range 2-64) months, 36 patients (87.8%) survived, including 2 patients (4.9%) with metastasis and 1 patient (2.4%) with recurrence, and 5 cases (12.2%)died. All patients were able to urinate without catheterization. Thirty-seven patients (90.2%) were satisfied with voiding control during the daytime (0-1 urinal pad), and 29 patients (70.7%) were satisfied with voiding control at nighttime (0-1 urinal pad) by the follow-up 12 months after the operation. \u0000 \u0000 \u0000Conclusions \u0000Total laparoscopic radical cystectomy combined with Xing's orthotopic ileum neobladder is a simple method with fewer postoperative complications and a satisfactory continence rate. \u0000 \u0000 \u0000Key words: \u0000Urin","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44069055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.016
Xin Du, B. Hong, Qiang Zhao, Yongpeng Ji, Yong Yang, Ning Zhang
Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma. Key words: Carcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker
{"title":"Progress in detection and clinical application of circulating tumor cells in renal cell carcinoma","authors":"Xin Du, B. Hong, Qiang Zhao, Yongpeng Ji, Yong Yang, Ning Zhang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.016","url":null,"abstract":"Renal cell carcinoma is one of the common malignant tumors in genitourinary cancer. 20%-30% of patients have distant metastases. However, current biomarkers used for diagnosis, recurrence monitoring, and prognosis assessment are still uncertain. Circulating tumor cells (CTCs) are tumor cells that are detached from the primary tumor or metastases, and invade and presenting in peripheral blood vessels. Therefore, CTCs is regarded as a key step in the process of tumor metastasis. However, current studies on CTCs of renal cell carcinoma are facing with problems such as inconsistent detection methods and limited clinical applications. This article reviews the progress in the detection and clinical application of CTCs of renal cell carcinoma. \u0000 \u0000Key words: \u0000Carcinoma, renal cell; Circulating tumor cells (CTCs); Biomarker","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42289638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.005
Ming Zhao, Daqian Liu, X. Teng, Xiulong Zhong, Yonghua Wang, Haitao Niu, Xin-sheng Wang
Objective To investigate the relationship between preoperative albumin-to-alkaline phosphatase ratio and overall survival (OS) after radical cystectomy of bladder cancer. Methods The clinical date of patients with bladder cancer who underwent radical cystectomy and urinary diversion and confirmed by pathology from Jan 2007 to Dec 2015 were analyzed retrospectively, with 140 cases undergoing laparoscopic surgery and 26 cases undergoing open surgery. There were 148 males and 18 females, aged was 33-85 years, with an average age of (65.1±9.4) years. There were 55 cases of cutaneous ureterostomy, 96 cases of Brick diversion with ileum, and 15 cases of ileal neobladder. The AAPR range 0.03-1.67, with an average 0.62±0.23, and body mass index (BMI) was 16.79-32.65 kg/m2, with an average of (24.00±3.32) kg/m2. There were 33 cases with hydronephrosis and 133 no hydronephrosis, 31 cases with hypertension and 135 cases no hypertension, and 14 cases with diabetes and 152 cases no diabetes. Four cases were classified as grade 0, 65 cases as grade 1, 86 cases as grade 2, and 11 cases as grade 3. Based on the preoperative AAPR(0.62±0.23), they were divided into three groups, with 55 cases in the low AAPR (0.42±0.09)group, 55 cases in the middle AAPR(0.58±0.05)group, and 56 cases in the high AAPR(0.86±0.21)group. Cox proportional hazards regression methodology were used to evaluate the relationship between preoperative AAPR and overall survival. Survival analysis was conducted using the Kaplan-Meier method and compared with the log-rank test. Results 166 patients were followed up for 1-144 months, with a median of 63 months, and 71 cases died and 95 survived. The median serum AAPR level in all cases was 0.59(range 0.03-1.67). Results of univariate Cox regression model revealed that AAPR(HR=0.09, 95%CI 0.022-0.391, P=0.001), high AAPR (HR=0.40, 95%CI 0.216-0.742, P=0.003), age (HR=2.42, 95%CI 1.294-4.531, P=0.006), tumor size (HR=2.11, 95%CI 1.112-4.014, P=0.023), pT3 stage (HR=8.93, 95%CI 3.173-25.114, P<0.001), pT4 stage(HR=10.39, 95%CI 3.110-34.707, P<0.001), pN1 stage(HR=2.80, 95%CI 1.422-5.531, P=0.003), pN3 stage(HR=17.06, 95%CI 2.192-132.863, P=0.007), pathological grade (HR=0.30, 95%CI 0.113-0.817, P=0.019), hydronephrosis (HR=2.36, 95%CI 1.406-3.939, P=0.001), adjuvant chemotherapy (HR=2.66, 95%CI 1.674-4.247, P<0.001)were associated with OS. Compared with patients in the lowest of AAPR, the risk for death in the highest AAPR group decreased about 59%(HR=0.406, 95%CI 0.200-0.822, P=0.012)after adjustment for age, BMI, tumor size, number of tumor, T category, N category, pathological grade, hydronephrosis, ASA level, adjuvant chemotherapy in multiple Cox regression models. Each unit increase in the AAPR was associated with about 80% decreased risk of death (HR=0.199, 95%CI 0.051-0.779, P=0.020)after adjusting for the confounding variables. After adjusting for age, BMI, tumor size, number of tumor, T category, N category, pathological grade,
{"title":"Prognostic value of albumin-to-alkaline phosphatase ratio before radical cystectomy in patients with bladder cancer","authors":"Ming Zhao, Daqian Liu, X. Teng, Xiulong Zhong, Yonghua Wang, Haitao Niu, Xin-sheng Wang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.005","url":null,"abstract":"Objective \u0000To investigate the relationship between preoperative albumin-to-alkaline phosphatase ratio and overall survival (OS) after radical cystectomy of bladder cancer. \u0000 \u0000 \u0000Methods \u0000The clinical date of patients with bladder cancer who underwent radical cystectomy and urinary diversion and confirmed by pathology from Jan 2007 to Dec 2015 were analyzed retrospectively, with 140 cases undergoing laparoscopic surgery and 26 cases undergoing open surgery. There were 148 males and 18 females, aged was 33-85 years, with an average age of (65.1±9.4) years. There were 55 cases of cutaneous ureterostomy, 96 cases of Brick diversion with ileum, and 15 cases of ileal neobladder. The AAPR range 0.03-1.67, with an average 0.62±0.23, and body mass index (BMI) was 16.79-32.65 kg/m2, with an average of (24.00±3.32) kg/m2. There were 33 cases with hydronephrosis and 133 no hydronephrosis, 31 cases with hypertension and 135 cases no hypertension, and 14 cases with diabetes and 152 cases no diabetes. Four cases were classified as grade 0, 65 cases as grade 1, 86 cases as grade 2, and 11 cases as grade 3. Based on the preoperative AAPR(0.62±0.23), they were divided into three groups, with 55 cases in the low AAPR (0.42±0.09)group, 55 cases in the middle AAPR(0.58±0.05)group, and 56 cases in the high AAPR(0.86±0.21)group. Cox proportional hazards regression methodology were used to evaluate the relationship between preoperative AAPR and overall survival. Survival analysis was conducted using the Kaplan-Meier method and compared with the log-rank test. \u0000 \u0000 \u0000Results \u0000166 patients were followed up for 1-144 months, with a median of 63 months, and 71 cases died and 95 survived. The median serum AAPR level in all cases was 0.59(range 0.03-1.67). Results of univariate Cox regression model revealed that AAPR(HR=0.09, 95%CI 0.022-0.391, P=0.001), high AAPR (HR=0.40, 95%CI 0.216-0.742, P=0.003), age (HR=2.42, 95%CI 1.294-4.531, P=0.006), tumor size (HR=2.11, 95%CI 1.112-4.014, P=0.023), pT3 stage (HR=8.93, 95%CI 3.173-25.114, P<0.001), pT4 stage(HR=10.39, 95%CI 3.110-34.707, P<0.001), pN1 stage(HR=2.80, 95%CI 1.422-5.531, P=0.003), pN3 stage(HR=17.06, 95%CI 2.192-132.863, P=0.007), pathological grade (HR=0.30, 95%CI 0.113-0.817, P=0.019), hydronephrosis (HR=2.36, 95%CI 1.406-3.939, P=0.001), adjuvant chemotherapy (HR=2.66, 95%CI 1.674-4.247, P<0.001)were associated with OS. Compared with patients in the lowest of AAPR, the risk for death in the highest AAPR group decreased about 59%(HR=0.406, 95%CI 0.200-0.822, P=0.012)after adjustment for age, BMI, tumor size, number of tumor, T category, N category, pathological grade, hydronephrosis, ASA level, adjuvant chemotherapy in multiple Cox regression models. Each unit increase in the AAPR was associated with about 80% decreased risk of death (HR=0.199, 95%CI 0.051-0.779, P=0.020)after adjusting for the confounding variables. After adjusting for age, BMI, tumor size, number of tumor, T category, N category, pathological grade, ","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44231496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.001
Jian Huang
The clinical research is an important cornerstone of medical innovation and development. In the past decade, there have been some breakthrough achievements in the field of urological clinical research internationally. However, there is still a large gap between Chinese urological clinical research and the international level. Urologists across China should improve the clinical research to a new level of awareness, starting with the idea of patients’expectation being our concern, and making clinical research our priority. The multi-center clinical research should be the priority, involving the real-world study, prospective randomized controlled trails, translational medicine, and artificial intelligence, etc. The standardized method must be adopted and the integrity of scientific research should be concerned in the process of clinical research. The clinical research results should not only be published in the international journals, but more importantly be published in the domestic journals. The proposal of "publishing the studies on the land of our motherland" should be vigorously advocated. Key words: Clinical research; Multicenter; Real-world study; Prospective randomized contro-lled trails; Translational medicine; Artificial intelligence; Research integrity
{"title":"Accelerating the development of Chinese urology in clinical research by taking the advantages and making cooperation","authors":"Jian Huang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.001","url":null,"abstract":"The clinical research is an important cornerstone of medical innovation and development. In the past decade, there have been some breakthrough achievements in the field of urological clinical research internationally. However, there is still a large gap between Chinese urological clinical research and the international level. Urologists across China should improve the clinical research to a new level of awareness, starting with the idea of patients’expectation being our concern, and making clinical research our priority. The multi-center clinical research should be the priority, involving the real-world study, prospective randomized controlled trails, translational medicine, and artificial intelligence, etc. The standardized method must be adopted and the integrity of scientific research should be concerned in the process of clinical research. The clinical research results should not only be published in the international journals, but more importantly be published in the domestic journals. The proposal of \"publishing the studies on the land of our motherland\" should be vigorously advocated. \u0000 \u0000Key words: \u0000Clinical research; Multicenter; Real-world study; Prospective randomized contro-lled trails; Translational medicine; Artificial intelligence; Research integrity","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47900397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.012
Tao Yang, Hong Xie, Xiaoyong Hu, Jianwen Huang
Duplex kidney and ureter abnormality are one of the most common malformation in urinary system, with most of patients present no apparent symptom, and only a few patients being complicated by ureter obstruction and serious hydronephrosis, which is difficult to differentiate with renal cyst. Therefore a case with duplex kidney and ureter abnormality was reported to provide information for clinical practice. Key words: Ureteral disease; Duplex kidney and ureter abnormality; Hydronephrosis
{"title":"A case report of duplex kidney and ureter abnormality accompanied with lower giant hydronephrosis","authors":"Tao Yang, Hong Xie, Xiaoyong Hu, Jianwen Huang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.012","url":null,"abstract":"Duplex kidney and ureter abnormality are one of the most common malformation in urinary system, with most of patients present no apparent symptom, and only a few patients being complicated by ureter obstruction and serious hydronephrosis, which is difficult to differentiate with renal cyst. Therefore a case with duplex kidney and ureter abnormality was reported to provide information for clinical practice. \u0000 \u0000Key words: \u0000Ureteral disease; Duplex kidney and ureter abnormality; Hydronephrosis","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42431562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.015
Jian-xiang Xie, Jia-xi Li, C. Du
The purpose of this study is to study the clinical characteristics of spermatic cord tumor. The clinical data of a case of varicocele in our hospital were analyzed retrospectively. In this case, the patients with varicocele had a good recovery after operation. Varicocele is a rare case. The best mode of treatment is surgical resection and follow-up after operation. Key words: Spermatic cord; Spermatic schwannoma; Benign mass
{"title":"A case report of spermatic neuroblastoma","authors":"Jian-xiang Xie, Jia-xi Li, C. Du","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.015","url":null,"abstract":"The purpose of this study is to study the clinical characteristics of spermatic cord tumor. The clinical data of a case of varicocele in our hospital were analyzed retrospectively. In this case, the patients with varicocele had a good recovery after operation. Varicocele is a rare case. The best mode of treatment is surgical resection and follow-up after operation. \u0000 \u0000Key words: \u0000Spermatic cord; Spermatic schwannoma; Benign mass","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48864171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.006
Jun Xiao, Gan Yu, Huixia Zhou, Henglong Hu, Xueyou Ma, Yanan Wang, Chunguang Yang, Zhiquan Hu, Shaogang Wang, Z. Ye, Zhihua Wang
Objective To summarize the preliminary experience of extraperitoneal laparoscopic radical prostatectomy (C.R.P.C. four-step) for localized prostate cancer and the outcomes based on early follow-up. Methods A total of 102 prostate cancer patients were screened by prostate specific antigen (PSA) and diagnosed by prostate magnetic resonance imaging and prostatic puncture biopsy with cT1c-cT3b, with average age of (67±5) years old, average preoperative total PSA value of (45.32±18.33) ng/ml, and average prostate volume was (42±12)cm3. All these patients underwent extraperitoneal laparoscopic radical prostatectomy by the four-step technique, abbreviating as C. R.P.C.[C: control DVC (dorsal deep venous complex). R: recognize three anatomical layers (prostate and bladder junction, seminal vesicle, and Denonvilliers’fascia surface). P: preserve urethral sphincter and bladder neck. C: continuous anastomosis between urethra and bladder neck (4 key needles at 3, 5, 7 and 9 o’clock)]. The operative time, estimated blood loss, length of hospital stay and postoperative complications were recorded, and the postoperative PSA was followed up. Results All the 102 cases were successfully treated by laparoscopic radical prostatectomy. The operative time was from 55 to 156 min (mean 92 min), and the estimated blood loss was from 55 to 185 ml (mean 105 ml). There was no case converted of open surgery, only one case received blood transfusion for postoperative hemorrhage (0.98%), and positive surgical margin was found in 15 case (14.70%) by pathological examination. Postoperative urinary extravasation within one week occurred in 2 (1.96%) cases, and resolved after tensioning the catheter and prolonging the indwelling time. During the follow-up period of 12 to 45 months, 2 cases were incontinent (grade Ⅰ-Ⅱ), and the other cases(98.04%) had no incontinence or dysuria . However, 11 cases(10.78%) developed to biochemical recurrence within 6 months after the operation. Conclusions The C. R.P.C. four-step technique of lparoscopic radical prostatectomy is easily to be grasped and performed by the greenhand urologists, and was efficient and safe. Key words: Prostatic neoplasms; Radical prostatectomy; Extraperitoneal laparoscopy; Prostate cancer; Four-step method; Curative effect
目的总结腹腔镜下四步根治性前列腺切除术治疗局限性前列腺癌的初步经验及早期随访的效果。方法对102例前列腺癌患者进行前列腺特异抗原(PSA)筛查，经前列腺磁共振成像和前列腺穿刺活检诊断，检测结果为cT1c-cT3b，平均年龄(67±5)岁，平均术前总PSA值(45.32±18.33)ng/ml，平均前列腺体积(42±12)cm3。所有患者均行腹腔外腹腔镜根治性前列腺切除术，采用四步技术，简称为c.r.p.c. [C: control DVC (dorsal deep venous complex)]。R:识别三个解剖层(前列腺与膀胱交界处、精囊、德农维利氏筋膜表面)。保尿道括约肌及膀胱颈。C:尿道与膀胱颈间连续吻合(3、5、7、9点钟方向4根键针)。记录手术时间、预计出血量、住院时间及术后并发症，并随访术后PSA。结果102例患者均成功行腹腔镜根治性前列腺切除术。手术时间55 ~ 156 min(平均92 min)，估计失血量55 ~ 185 ml(平均105 ml)。无中转开腹手术，术后出血输血1例(0.98%)，病理检查手术切缘阳性15例(14.70%)。术后1周内发生尿外渗2例(1.96%)，经拉紧导尿管并延长留置时间后，尿外渗得以缓解。随访12 ~ 45个月，2例出现尿失禁(级别Ⅰ~Ⅱ)，其余98.04%无尿失禁或排尿困难。术后6个月内生化复发11例(10.78%)。结论腹腔镜根治性前列腺切除术的四步法易于泌尿外科新手掌握和操作，安全有效。关键词:前列腺肿瘤;根治性前列腺切除术;Extraperitoneal腹腔镜检查;前列腺癌;四个步骤的方法;疗效
{"title":"The application and outcomes of C. R.P.C. four-step radical prostatectomy under extraperitoneal laparoscopy","authors":"Jun Xiao, Gan Yu, Huixia Zhou, Henglong Hu, Xueyou Ma, Yanan Wang, Chunguang Yang, Zhiquan Hu, Shaogang Wang, Z. Ye, Zhihua Wang","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.006","url":null,"abstract":"Objective \u0000To summarize the preliminary experience of extraperitoneal laparoscopic radical prostatectomy (C.R.P.C. four-step) for localized prostate cancer and the outcomes based on early follow-up. \u0000 \u0000 \u0000Methods \u0000A total of 102 prostate cancer patients were screened by prostate specific antigen (PSA) and diagnosed by prostate magnetic resonance imaging and prostatic puncture biopsy with cT1c-cT3b, with average age of (67±5) years old, average preoperative total PSA value of (45.32±18.33) ng/ml, and average prostate volume was (42±12)cm3. All these patients underwent extraperitoneal laparoscopic radical prostatectomy by the four-step technique, abbreviating as C. R.P.C.[C: control DVC (dorsal deep venous complex). R: recognize three anatomical layers (prostate and bladder junction, seminal vesicle, and Denonvilliers’fascia surface). P: preserve urethral sphincter and bladder neck. C: continuous anastomosis between urethra and bladder neck (4 key needles at 3, 5, 7 and 9 o’clock)]. The operative time, estimated blood loss, length of hospital stay and postoperative complications were recorded, and the postoperative PSA was followed up. \u0000 \u0000 \u0000Results \u0000All the 102 cases were successfully treated by laparoscopic radical prostatectomy. The operative time was from 55 to 156 min (mean 92 min), and the estimated blood loss was from 55 to 185 ml (mean 105 ml). There was no case converted of open surgery, only one case received blood transfusion for postoperative hemorrhage (0.98%), and positive surgical margin was found in 15 case (14.70%) by pathological examination. Postoperative urinary extravasation within one week occurred in 2 (1.96%) cases, and resolved after tensioning the catheter and prolonging the indwelling time. During the follow-up period of 12 to 45 months, 2 cases were incontinent (grade Ⅰ-Ⅱ), and the other cases(98.04%) had no incontinence or dysuria . However, 11 cases(10.78%) developed to biochemical recurrence within 6 months after the operation. \u0000 \u0000 \u0000Conclusions \u0000The C. R.P.C. four-step technique of lparoscopic radical prostatectomy is easily to be grasped and performed by the greenhand urologists, and was efficient and safe. \u0000 \u0000 \u0000Key words: \u0000Prostatic neoplasms; Radical prostatectomy; Extraperitoneal laparoscopy; Prostate cancer; Four-step method; Curative effect","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45407050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.3760/CMA.J.ISSN.1000-6702.2020.02.009
Zijian Tian, H. Hou, S. Lai, Shengjie Liu, Xingbo Long, Miao Wang, Jianye Wang, Ming Liu
Objective To analyze effects of androgen deprivation therapy on lipid metabolism and nutritional status in patients with prostate cancer. Methods The clinical data of 255 elderly patients (≥ 65 years old) with prostate cancer who received endocrine therapy and complete follow-up data from January 2010 to December 2018 were analyzed retrospectively. The median age of the 255 patients was 76 years(65-92). The average PSA of patients was (58.15±9.62) ng/ml, where 101 patients had PSA 20 ng/ml. All patients were diagnosed pathologically by prostate biopsy. As for Gleason score, Gleason score≤6, Gleason score=7 and Gleason score≥ 8 had 62, 103 and 90 patients, respectively. Endocrine therapy included maximum androgen blockade (197 cases) and drug castration (58 cases), and continued for at least 1 year. Among them, 123 cases had complete blood lipid index data, and the subgroup analysis was based on the age of 80 years old, including 98 cases aged 65 to 80 years old and 25 cases over 80 years old. A total of 186 cases had complete data of total protein and albumin, of which 147 cases were 65 years old and 80 years old and 39 cases were more than 80 years old. Before treatment, cholesterol was (4.08±0.87)mmol/L, including (4.14±0.86) mmol/L in the 65-80 years old group, (3.82±0.88) mmol/L in >80 years old group; triglyceride was (1.23 ±0.56) mmol/L, 65-80 age group was (1.26±0.56) mmol/L and >80 years old group was (1.11±0.57) mmol/L; High density lipoprotein cholesterol was(1.09±0.24)mmol/L, 65-80 age group was (1.10±0.25) mmol/L and >80 years group was (1.04±0.21) mmol/L. Low density lipoprotein cholesterol was (2.50±0.78)mmol/L, 65~80 age group was (2.55±0.77)mmol/L and (2.34±0.83) mmol/L in >80 years old group.The total protein before endocrine therapy was (63.81±5.93) g/L, including (63.95±5.79) g/L in the 65-80 years old group, (63.30±6.49) g/L in >80 years old group. In terms of pre-treatment albumin (39.68±3.50) g/L, including (39.82±3.60) g/L in the 65-80 years old group and (39.21±3.12) g/L in >80 years old group. The differences of various indexes before and after treatment were analyzed. Results The results of blood lipid data analysis of 123 cases showed that, there were increased significant differences(P 0.05). The results of data analysis of 186 cases of total protein and albumin showed that, the total protein after treatment was (62.81±7.34) g/L, which was not significantly different from that before treatment (P>0.05). The total protein in 65-80 years old group after treatment was (62.36±7.36) g/L, which decrease and have statistical significantly different from that before treatment (P 80 years old group after treatment was (64.49±7.12) g/L, it was higher than that before treatment, but the difference was not statistically significant (P>0.05). The level of albumin after endocrine therapy was (38.34±4.48) g/L, which was significantly different from that before treatment (P 80 years old group after treatment were (38.32±4
{"title":"Effects of endocrine therapy on lipid metabolism and nutritional status in elderly patients with prostate cancer","authors":"Zijian Tian, H. Hou, S. Lai, Shengjie Liu, Xingbo Long, Miao Wang, Jianye Wang, Ming Liu","doi":"10.3760/CMA.J.ISSN.1000-6702.2020.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6702.2020.02.009","url":null,"abstract":"Objective \u0000To analyze effects of androgen deprivation therapy on lipid metabolism and nutritional status in patients with prostate cancer. \u0000 \u0000 \u0000Methods \u0000The clinical data of 255 elderly patients (≥ 65 years old) with prostate cancer who received endocrine therapy and complete follow-up data from January 2010 to December 2018 were analyzed retrospectively. The median age of the 255 patients was 76 years(65-92). The average PSA of patients was (58.15±9.62) ng/ml, where 101 patients had PSA 20 ng/ml. All patients were diagnosed pathologically by prostate biopsy. As for Gleason score, Gleason score≤6, Gleason score=7 and Gleason score≥ 8 had 62, 103 and 90 patients, respectively. Endocrine therapy included maximum androgen blockade (197 cases) and drug castration (58 cases), and continued for at least 1 year. Among them, 123 cases had complete blood lipid index data, and the subgroup analysis was based on the age of 80 years old, including 98 cases aged 65 to 80 years old and 25 cases over 80 years old. A total of 186 cases had complete data of total protein and albumin, of which 147 cases were 65 years old and 80 years old and 39 cases were more than 80 years old. Before treatment, cholesterol was (4.08±0.87)mmol/L, including (4.14±0.86) mmol/L in the 65-80 years old group, (3.82±0.88) mmol/L in >80 years old group; triglyceride was (1.23 ±0.56) mmol/L, 65-80 age group was (1.26±0.56) mmol/L and >80 years old group was (1.11±0.57) mmol/L; High density lipoprotein cholesterol was(1.09±0.24)mmol/L, 65-80 age group was (1.10±0.25) mmol/L and >80 years group was (1.04±0.21) mmol/L. Low density lipoprotein cholesterol was (2.50±0.78)mmol/L, 65~80 age group was (2.55±0.77)mmol/L and (2.34±0.83) mmol/L in >80 years old group.The total protein before endocrine therapy was (63.81±5.93) g/L, including (63.95±5.79) g/L in the 65-80 years old group, (63.30±6.49) g/L in >80 years old group. In terms of pre-treatment albumin (39.68±3.50) g/L, including (39.82±3.60) g/L in the 65-80 years old group and (39.21±3.12) g/L in >80 years old group. The differences of various indexes before and after treatment were analyzed. \u0000 \u0000 \u0000Results \u0000The results of blood lipid data analysis of 123 cases showed that, there were increased significant differences(P 0.05). The results of data analysis of 186 cases of total protein and albumin showed that, the total protein after treatment was (62.81±7.34) g/L, which was not significantly different from that before treatment (P>0.05). The total protein in 65-80 years old group after treatment was (62.36±7.36) g/L, which decrease and have statistical significantly different from that before treatment (P 80 years old group after treatment was (64.49±7.12) g/L, it was higher than that before treatment, but the difference was not statistically significant (P>0.05). The level of albumin after endocrine therapy was (38.34±4.48) g/L, which was significantly different from that before treatment (P 80 years old group after treatment were (38.32±4","PeriodicalId":10343,"journal":{"name":"Chinese Journal of Urology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42770213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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