Clinical Neurology and Neurosurgery最新文献

{"title":"Reply to: Correspondence on “Upper respiratory tract infections in myasthenia gravis: Key considerations and future research directions”","authors":"Hussain M. Alqahtani, Mohammed H. Alanazy","doi":"10.1016/j.clineuro.2025.108746","DOIUrl":"10.1016/j.clineuro.2025.108746","url":null,"abstract":"","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108746"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a risk stratification model for stroke recurrence after acute ischemic stroke in young adults: A nomogram-based, multicenter retrospective study","authors":"Zhongzhen Li ,&nbsp;Tian Tian ,&nbsp;Yujia Yan ,&nbsp;Yue Yu ,&nbsp;Jun Liu ,&nbsp;Shusheng Zhang ,&nbsp;Guobin Zhang ,&nbsp;Shaoya Yin","doi":"10.1016/j.clineuro.2025.108763","DOIUrl":"10.1016/j.clineuro.2025.108763","url":null,"abstract":"<div><h3>Objective</h3><div>The prevalence of ischemic stroke in young adults has increased dramatically. However, factors associated with prognosis in this cohort have not been well studied. This study primary aimed to construct and validate a nomogram for predicting stroke recurrence and to achieve risk stratification of young adults after acute ischemic stroke (AIS).</div></div><div><h3>Methods</h3><div>In this retrospective, multicenter study, we identified AIS patients aged 18–50 years in Tianjin Huanhu Hospital (training cohort) and The Affiliated Hospital of Chengde Medical College (validation cohort) from September 2019 to September 2021, respectively. Demographics and clinical characteristics data were systematically collected. A stepwise Cox proportional hazards regression analysis was used to identify the independent predictors of stroke recurrence in the training cohort and employed to construct the best-fit nomogram. Patients were stratified into low-, medium-, and high-risk groups based on the total points. Receiver operating characteristic (ROC) analysis and calibration curves were used to assess the discrimination and calibration of the nomogram. The discriminate value of risk stratification was verified using Kaplan-Meier curves, and external validation was performed with the validation cohort.</div></div><div><h3>Results</h3><div>A total of 467 young adult AIS patients were enrolled in this study. The overall prevalence of young adults in AIS patients was 13.3 % (95 % confidence interval, 12.2 %-14.5 %). Hyperlipidemia (Hazard ratio, 2.4 [1.2–4.9]), current smoking (5.9 [2.7–12.8]), stroke subtype (small-vessel occlusion, 3.7 [1.8–7.6]; stroke of undetermined cause/ others, 14.5 [3.0–70.2]), and stenosis (11.4 [4.5–28.9]) were significant independent predictors of stroke recurrence. A nomogram was constructed with the above predictors and achieved a satisfactory prediction in the validation cohort. Patients were classified into low-, medium-, and high-risk groups based on the total points with the cutoff value of 110.8 and 185.2. The log-rank test showed significant discrimination among the Kaplan-Meier curves of different risk groups (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The nomogram can satisfactory prediction of stroke recurrence-free rate in young adult patients and achieved risk stratification, may help to personalize management of patients.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108763"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of percutaneous treatments for trigeminal neuralgia in multiple sclerosis: A reassessment of insights and concerns.","authors":"Hung Youl Seok","doi":"10.1016/j.clineuro.2025.108780","DOIUrl":"10.1016/j.clineuro.2025.108780","url":null,"abstract":"","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"108780"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of microsurgical resection versus stereotactic radiosurgery for Spetzler-Martin grade III arteriovenous malformations: A multicenter propensity score matched study","authors":"Salem M. Tos ,&nbsp;Bardia Hajikarimloo ,&nbsp;Mahmoud Osama ,&nbsp;Georgios Mantziaris ,&nbsp;Nimer Adeeb ,&nbsp;Sandeep Kandregula ,&nbsp;Hamza Adel Salim ,&nbsp;Basel Musmar ,&nbsp;Christopher Ogilvy ,&nbsp;Douglas Kondziolka ,&nbsp;Adam A. Dmytriw ,&nbsp;Kareem El Naamani ,&nbsp;Ahmed Abdelsalam ,&nbsp;Deepak Kumbhare ,&nbsp;Sanjeev Gummadi ,&nbsp;Cagdas Ataoglu ,&nbsp;Muhammed Amir Essibayi ,&nbsp;Ufuk Erginoglu ,&nbsp;Abdullah Keles ,&nbsp;Sandeep Muram ,&nbsp;Jason Sheehan","doi":"10.1016/j.clineuro.2024.108669","DOIUrl":"10.1016/j.clineuro.2024.108669","url":null,"abstract":"<div><h3>Background</h3><div>Spetzler-Martin (SM) Grade III brain arteriovenous malformations (BAVMs) represent a transitional risk zone between low- and high-grade BAVMs, characterized by diverse angioarchitecture. The primary treatment options are endovascular embolization, microsurgical resection (MS), and stereotactic radiosurgery (SRS). This study compares the efficacy and outcomes of MS and SRS.</div></div><div><h3>Methods</h3><div>We conducted a multicenter, retrospective study involving patients from the MISTA database with SM Grade III BAVMs treated with MS or SRS between 2010 and 2023. Propensity matching was based on age, favorable modified Rankin Score (mRS) at presentation, nidus size, rupture status, location depth, and eloquence.</div></div><div><h3>Results</h3><div>After matching, 60 patients were equally divided between MS and SRS groups. Median age (MS: 45.0 vs. SRS: 42.5 years, p = 0.3) and AVM size (MS: 3.2 vs. SRS: 2.9 cm³, p = 0.6) were similar. MS showed higher obliteration rates (93.3 %) compared to SRS (46.7 %) at the last follow-up (p &lt; 0.001). The median time to obliteration post-SRS was 31.5 months (IQR: 15.3–60.0). SRS obliteration rates were 19 %, 29 %, and 59 % at 24, 36, and 60 months, respectively. Overall complication rates (MS: 30 % vs. SRS: 20 %, p = 0.4) and permanent complications (MS: 10 % vs. SRS: 13.3 %, p &gt; 0.9) were similar. Hemorrhage occurred once in the MS group and none in the SRS (p &gt; 0.9). Favorable outcomes (mRS 0–2) were higher with SRS than MS (93.3 % vs 80.0 %, p = 0.3), with one AVM-related mortality in the MS group.</div></div><div><h3>Conclusion</h3><div>MS and SRS are viable treatments for SM Grade III BAVMs. Treatment choice should be individualized by a multidisciplinary team, considering patient goals.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108669"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current evidence of arterial spin labeling in amyotrophic lateral sclerosis: A systematic review","authors":"Sadegh Ghaderi ,&nbsp;Sana Mohammadi ,&nbsp;Farzad Fatehi","doi":"10.1016/j.clineuro.2024.108691","DOIUrl":"10.1016/j.clineuro.2024.108691","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the utility of arterial spin labeling (ASL) in assessing cerebral blood flow (CBF) changes in amyotrophic lateral sclerosis (ALS), and its potential as a biomarker for early diagnosis.</div></div><div><h3>Methods</h3><div>A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies that employed ASL to compare CBF between ALS patients and healthy controls were included.</div></div><div><h3>Results</h3><div>Seven studies were included. A consistent finding across these studies was hypoperfusion in both the motor and non-motor regions, particularly in the frontotemporal cortex. Hypoperfusion in motor regions was correlated with functional impairment and was observed prior to structural changes, suggesting its potential as an early biomarker. There is limited evidence to suggest that monitoring changes in CBF patterns in the brain. Besides, limited findings showed initial hyperperfusion in regions not yet involved in the pathological process, and progressing hypoperfusion in regions with increasing pathological burden.</div></div><div><h3>Conclusions</h3><div>This review highlights the potential of ASL as a valuable tool for understanding the neurovascular dysfunction in ALS. Further research is required to validate its clinical utility for diagnosing ALS and monitoring disease progression.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108691"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and associated in-hospital mortality of myocardial injury in patients with traumatic brain injury: A systematic review and meta-analysis","authors":"Huaqiang Ding,&nbsp;Xiaofeng Hou,&nbsp;Xinhai Zhang,&nbsp;Jinhui Yu,&nbsp;Jun He,&nbsp;Jiuning Tang,&nbsp;Minruo Chen,&nbsp;Maoyuan Tang,&nbsp;Qifu Ren,&nbsp;Zhi Liu","doi":"10.1016/j.clineuro.2024.108693","DOIUrl":"10.1016/j.clineuro.2024.108693","url":null,"abstract":"<div><h3>Objective</h3><div>Myocardial injury has not been well characterized in traumatic brain injury (TBI). We aimed to assess the pooled incidence of myocardial injury defined by elevated cardiac troponin (cTn) after TBI and explore its association with in-hospital mortality.</div></div><div><h3>Methods</h3><div>We searched Medline, Embase, Cochrane Library, Scopus, and Web of Science from inception to 1 January 2024, for observational studies that assessed the incidence and/or associated in-hospital mortality of elevated cTn in adult TBI patients. The incidence data was reported with proportion with 95 % confidence intervals (CIs) and 95 % prediction intervals (PIs). In-hospital mortality data was synthesized with odds ratios (ORs) with 95 % CIs and 95 % PIs. Subgroup analyses and meta-regression analyses were performed to identify the potential sources of heterogeneity, and the leave-one-out method was performed for sensitivity analysis.</div></div><div><h3>Results</h3><div>We included 16 studies involving 4263 participants in the meta-analysis. The overall pooled incidence of myocardial injury after TBI was 33.3 % (95 % CI, 25.2 %–42.1 %; 95 % PI, 7.3 %-66.7 %; I2 = 95.3 %). Incidence of myocardial injury was 43.4 % (95 % CI, 31.7 %–55.4 %; 95 % PI 7.3 %-84.1 %; I2 = 94.8 %) for moderate to severe TBI. Myocardial injury was associated with higher in-hospital mortality (OR, 5.62; 95 % CI, 3.59–8.78; 95 % PI, 1.35–23.38; I2 = 79.0 %) after TBI.</div></div><div><h3>Conclusion</h3><div>Early myocardial injury was common in adult patients with acute TBI. Furthermore, myocardial injury was associated with increased in-hospital mortality after TBI. High-quality studies are needed to elucidate the true incidence of myocardial injury and its relationship between clinical outcomes in this populations.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108693"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prior use of statins on endovascular thrombectomy outcomes in acute ischemic stroke","authors":"Nader El Seblani ,&nbsp;Saurabh Kalra ,&nbsp;Deepak Kalra ,&nbsp;Fawaz Al-Mufti ,&nbsp;Nandakumar Nagaraja","doi":"10.1016/j.clineuro.2025.108724","DOIUrl":"10.1016/j.clineuro.2025.108724","url":null,"abstract":"<div><h3>Introduction</h3><div>Acute large vessel occlusions (LVOs) account for up to one-third of acute ischemic strokes (AIS) and are associated with high mortality and severe functional deficits. Animal model research suggests that statins may have a protective effect on vessel wall injury during endovascular thrombectomy (EVT). We conducted a retrospective observational study to assess the impact of statin use on clinical outcomes post-EVT in AIS patients with LVOs.</div></div><div><h3>Methods</h3><div>Using the Global Collaborative Network consisting of about 143 million patients in TriNetX database, we identified adult AIS patients who underwent EVT between 2018 and 2023. Patients were categorized based on any statin use (atorvastatin, simvastatin, rosuvastatin, pravastatin, lovastatin, or pitavastatin) in the 3 months before AIS admission. The primary outcome was all-cause mortality at one-week post-EVT. Secondary outcomes included intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), decompressive hemicraniectomy procedure (DHC), and aspiration pneumonia at one-week post-EVT. Propensity score matching balanced relevant medical history, stroke severity, medications, and demographics. Cox proportional hazard regression analysis compared outcomes between statin and non-statin cohorts.</div></div><div><h3>Results</h3><div>We identified 17,774 patients who received EVT for LVO ischemic stroke. A total of 10,678 patients were on statins during 3 months prior to EVT and 7096 patients were not on statins. After 1:1 propensity matching, 2148 patients were included in each group. AIS patients treated with EVT and on statins had lower risk of all-cause mortality [7 % vs. 17 %; HR 0.43, 95 % CI 0.35–0.51], ICH [10 % vs. 15 %; HR 0.64, 95 % CI 0.51–0.74], SAH [3 % vs. 6 %; HR 0.48, 95 % CI 0.35–0.64], and aspiration pneumonia [4 % vs 8 %; HR 0.53, 95 % CI 0.41–0.70] compared to AIS patients treated with EVT but not on statins. Rates of DHC were similar between groups [2 % vs 2 %; HR 0.81; 95 % CI (0.52,1.25)].</div></div><div><h3>Conclusion</h3><div>Statin use within 3 months prior to AIS was associated with better survival and lesser intracranial bleeding risks and complications following EVT. Future studies may help examine how the duration or dosages of statins or LDL levels on admission affect outcomes in LVO strokes treated with EVT.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108724"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap: A scoping review of endovascular and microsurgical approaches to anterior ethmoidal dural arteriovenous fistulas","authors":"Samantha Schimmel ,&nbsp;Emma Dunn ,&nbsp;Emma Sargent ,&nbsp;Daryl T. Goldman ,&nbsp;Elliot Pressman ,&nbsp;Waldo Guerrero ,&nbsp;Maxim Mokin ,&nbsp;Siviero Agazzi ,&nbsp;Kunal Vakharia","doi":"10.1016/j.clineuro.2025.108734","DOIUrl":"10.1016/j.clineuro.2025.108734","url":null,"abstract":"<div><h3>Introduction</h3><div>Dural arteriovenous fistulas (dAVF) are abnormal anastomoses between meningeal arteries and dural venous sinuses. Typically, dAVF treatment involves an endovascular or microsurgical approach. Anterior ethmoidal artery (AEA) dAVFs pose unique challenges due to their anatomy and location. We performed a scoping review to characterize pre and postoperative characteristics of AEA dAVFs and elucidate their optimal management.</div></div><div><h3>Methods</h3><div>The authors conducted a comprehensive literature search on PubMed and Embase using Arskey &amp; O’Malley’s scoping review framework. The search strategy included \"anterior,\" \"ethmoidal,\" and \"fistula\" and excluded review articles and studies with unrelated pathology. Data collected included patient demographics, presentation, angiographic features, treatment modalities, and clinical and radiological outcomes.</div></div><div><h3>Results</h3><div>One-hundred and two articles describing 273 patients with an average age of 58.79 years were included. Two-hundred and sixty patients had surgery; 127 (49 %) had endovascular embolization and 133 (51 %) had open surgery. Surgical approach was significantly associated with complete dAVF obliteration (p = 0.003, X²=8.73, N = 206); patients treated endovascularly were less likely to have complete dAVF obliteration (85.9 % for endovascular versus 97.2 % for microsurgery). Additionally, patients with preoperative dAVF rupture had significantly greater rates of postoperative hemorrhage (p = 0.003, X²=11.86, N = 184).</div></div><div><h3>Discussion</h3><div>Surgical techniques and endovascular embolization are commonly used when treating dAVF, and our results highlight that open surgery appears to be superior to endovascular embolization when considering complete AEA dAVF obliteration. Despite advancements in treatment modalities, complications such as stroke, hemorrhage, and recurrence persist, emphasizing the importance of continued research and refinement of therapeutic strategies.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108734"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of intravenous tirofiban in patients with acute ischemic stroke due to large artery atherosclerosis undergoing endovascular thrombectomy: A systematic review and meta-analysis","authors":"Ocílio Ribeiro Gonçalves ,&nbsp;Frederico de Sousa Marinho Mendes Filho ,&nbsp;Filipe Virgilio Ribeiro ,&nbsp;Saul Dominici ,&nbsp;Christian Ken Fukunaga ,&nbsp;Naysha Myllene de Lima Gonçalves ,&nbsp;Kenzo Ogasawara ,&nbsp;Rebeca Oliveira da Silva ,&nbsp;Kelson James Almeida","doi":"10.1016/j.clineuro.2025.108727","DOIUrl":"10.1016/j.clineuro.2025.108727","url":null,"abstract":"<div><h3>Introduction</h3><div>Intravenous tirofiban (IT) is shown to be potentially effective in acute ischemic stroke (AIS) patients submitted to mechanical thrombectomy, despite its safety and efficacy are not well established. However, there is a lack of evidence on the effects of IT on endovascular thrombectomy (EVT) in patients with AIS due to large artery atherosclerosis (LAA).</div></div><div><h3>Objectives</h3><div>To assess the safety and efficacy of IT in AIS patients due to LAA submitted to EVT.</div></div><div><h3>Methods</h3><div>Pubmed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were systematically searched for studies that involved patients enrolled to take IT in AIS caused by LAA. The statistical analysis was performed using Risk Ratio (RR) with 95 % confidence intervals and the Mantel-Haenszel method of random-effects model to evaluate both efficacy and safety. Heterogeneity was assessed using I² statistics and Cochran Q test. This meta-analysis evaluated a modified Rankin scale (mRS) between 0 and 2, successful reperfusion, symptomatic intracranial hemorrhage (sICH), and mortality in 90 days. The statistical analyses for this study were performed using R software (version 4.4.1.)</div></div><div><h3>Results</h3><div>A total of 8 studies were analyzed, and a total of 2607 patients were included. In the meta-analysis, the IT group was associated with a higher proportion of patients in mRS 0–2 (RR 1.16; 95 % CI 1.04–1.29; I² = 0 %). There was no difference between the groups regarding successful reperfusion (RR 1.03; 95 % CI 0.98–1.09; I² = 64.2 %) and sICH (RR 0.83; 95 % CI 0.55–1.26; I² = 22.9 %), although tirofiban was associated with a lower mortality in 90 days (RR 0.70; 95 % CI 0.60–0.82; I² = 0 %).</div></div><div><h3>Conclusion</h3><div>This meta-analysis highlights the positive effects of adjuvant IT for AIS patients due to LAA submitted to EVT. It has been shown to improve functional outcomes and lower mortality rates in this population and to be a reliable medication in this setting.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108727"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury","authors":"Zhiqiang Tang ,&nbsp;Shuyun Xu ,&nbsp;Shucheng Zhao ,&nbsp;Zhihui Luo ,&nbsp;Yuanli Tang ,&nbsp;Yuanjun Zhang","doi":"10.1016/j.clineuro.2024.108648","DOIUrl":"10.1016/j.clineuro.2024.108648","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the clinical significance of long non-coding RNA, myocardial infarction-associated transcript (MIAT), in patients with traumatic brain injury (TBI).</div></div><div><h3>Methods</h3><div>Retrospective inclusion of TBI patients meeting clinical criteria with complete data, alongside healthy controls. RT-qPCR was used to detect the expression of the serum MIAT. Based on the Glasgow Coma Scale (GCS) scores, patients were categorized into mild, moderate, and severe TBI groups. The potential risk factors for severity were examined using logistic regression analysis. The one-year prognosis for TBI was determined using the Glasgow Outcome Scale (GOS) score. The correlation of MIAT levels with GCS scores and GOS scores was determined using Pearson correlation analysis. The effect of MIAT on the severity and poor prognosis was assessed using the receiver operating characteristic curve. Lastly, the dual-luciferase reporter assay confirmed the relationship between the MIAT and miR-221–3p.</div></div><div><h3>Results</h3><div>110 patients with TBI and 106 healthy controls were included. Serum MIAT levels were strikingly higher in patients with TBI compared to controls, whereas miR-221–3p levels were lower. As the severity of TBI increases, the expression of MIAT gradually elevated. A notable negative correlation was observed between serum MIAT levels and both the GCS and GOS scores. MIAT levels were effective in distinguishing patients with moderate TBI from those with mild or severe TBI, with a sensitivity of 82.35 % and 88.64 % and a specificity of 86.67 % and 86.27 %. Furthermore, elevated MIAT levels, with a sensitivity of 85.00 % and a specificity of 75.56 %, can predict the clinical outcomes of patients with TBI. miR-221–3p levels were negatively correlated with MIAT expression in patients with TBI, and MIAT directly targeted miR-221–3p.</div></div><div><h3>Conclusion</h3><div>Serum MIAT could serve as a diagnostic marker of severity and may predict poor prognosis in patients with TBI. This study proposes fresh perspectives on the pursuit of biomarkers and the management of patients with TBI.</div></div>","PeriodicalId":10385,"journal":{"name":"Clinical Neurology and Neurosurgery","volume":"249 ","pages":"Article 108648"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}