{"title":"Saroglitazar: One Molecule for Managing Two Diseases, Type 2 Diabetes and Hypertriglyceridemia","authors":"D. Hasnani, V. Chavda","doi":"10.5603/dk.a2022.0048","DOIUrl":"https://doi.org/10.5603/dk.a2022.0048","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88811690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ghosal, Radhika M. Joshi, Rahul N. Iyer, S. Adsule
{"title":"Survey to Specify SGLT2 Inhibitor Choice in T2DM Management","authors":"S. Ghosal, Radhika M. Joshi, Rahul N. Iyer, S. Adsule","doi":"10.5603/dk.a2022.0042","DOIUrl":"https://doi.org/10.5603/dk.a2022.0042","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78460042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rizal Fahly, Fabiola M. S. Adam, H. Rasyid, A. Aman, S. Bakri, Idar Mappangara, A. A. Zainuddin
{"title":"Relationship between TG/HDL-C Ratio and TyG Index with Chronic Inflammation in People with Prediabetes: A Cross-Sectional Study","authors":"Rizal Fahly, Fabiola M. S. Adam, H. Rasyid, A. Aman, S. Bakri, Idar Mappangara, A. A. Zainuddin","doi":"10.5603/dk.a2022.0047","DOIUrl":"https://doi.org/10.5603/dk.a2022.0047","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74706484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impaired Brain Insulin Signalling,a Potential Cause of Obesity: A Review of Literature","authors":"M. Bukowska","doi":"10.5603/dk.a2022.0040","DOIUrl":"https://doi.org/10.5603/dk.a2022.0040","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89856650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardio-Renal Benefits of GLP-1 Receptor Agonists vs. SGLT-2 Inhibitors in Type 2 Diabetes: Are They Juxtaposed?","authors":"A. Singh, Viral N Shah","doi":"10.5603/dk.a2022.0037","DOIUrl":"https://doi.org/10.5603/dk.a2022.0037","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85392748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Hyseni, S. Elezi, X. Krasniqi, Rozafa Olloni Nikaj, Vjollca Dedushaj Fazliu, Zana Vela Gaxha, A. Bakalli
Objective: Diabetes mellitus is a major cardiovascular risk factor. Diabetic complications in the cardiovascular system randomly appear following long standing diabetes. However, newly diagnosed diabetes can also be associated with cardiac problems. The aim of this study was to compare patients with newly diagnosed type 2 diabetes mellitus (T2DM) to healthy controls in regard to echocardiography features, specifically left ventricular global longitudinal strain (LV GLS). Materials and methods: This was a prospective cross-sectional study conducted on 94 patients, 52 patients with newly diagnosed T2DM that formed the first group and 42 healthy subjects, without history of diabetes mellitus and/or cardiovascular disease, which formed the second group. Results: Patients with newly diagnosed T2DM had mean glucose level of 16.37 ± 7.43 mmol/L and HbA1c of 8.57 ± 2.31 %. The groups did not differ in regard to age, gender, smoking, arterial hypertension or heart rate at the time of examination. The ratio between early mitral inflow velocity and mitral annu lar early diastolic velocity (E/e’) of the septal wall was significantly lower in patients with newly diagnosed T2DM (6.21 ± 3.14 vs. 7.8 ± 2.45, p = 0.009). The LV GLS resulted lower in patients with newly diagnosed T2DM compared to the healthy subjects (|–19.36|% ± 2.98 vs. |–20.43|% ± 1.99. p = 0.049). Of note, the LV GLS values are expressed as absolute numbers. The ratio of patients with LV GLS strain <|–18.8|% was significantly higher in patients with newly diagnosed T2DM (42.31% vs. 21.43%, p = 0.03). Conclusions: LV GLS may serve as an important echo cardiographic parameter to detect early myocardial changes in asymptomatic patients with newly diagnosed T2DM. (Clin Diabetol 2022, 11; 4: 245–250)
目的:糖尿病是心血管疾病的主要危险因素。糖尿病心血管系统并发症随长期糖尿病随机出现。然而，新诊断的糖尿病也可能与心脏问题有关。本研究的目的是比较新诊断的2型糖尿病(T2DM)患者与健康对照者的超声心动图特征，特别是左心室整体纵向应变(LV GLS)。材料与方法:本研究是一项前瞻性横断面研究，94例患者，52例新诊断T2DM患者构成第一组，42例无糖尿病和/或心血管疾病史的健康受试者构成第二组。结果:新诊断T2DM患者平均血糖水平为16.37±7.43 mmol/L, HbA1c为8.57±2.31%。这些组在年龄、性别、吸烟、动脉高血压或检查时的心率方面没有差异。新诊断T2DM患者二尖瓣早期流入速度与二尖瓣环早期舒张速度(E/ E’)之比(6.21±3.14∶7.8±2.45,p = 0.009)明显降低。新诊断T2DM患者的LV GLS较健康受试者低(-19.36 %±2.98 vs -20.43 %±1.99)。P = 0.049)。值得注意的是，LV GLS值以绝对值表示。新诊断T2DM患者中LV GLS株<| -18.8 |%的比例显著高于T2DM患者(42.31% vs. 21.43%， p = 0.03)。结论:左室GLS可作为新诊断T2DM无症状患者早期心肌改变的重要超声心动图参数。(临床糖尿病杂志，2022,11;4: 245 - 250)
{"title":"Association between Newly Diagnosed Type 2 Diabetes Mellitus and Left Ventricular Global Longitudinal Strain: A Single Center, Cross-Sectional Study","authors":"V. Hyseni, S. Elezi, X. Krasniqi, Rozafa Olloni Nikaj, Vjollca Dedushaj Fazliu, Zana Vela Gaxha, A. Bakalli","doi":"10.5603/dk.a2022.0029","DOIUrl":"https://doi.org/10.5603/dk.a2022.0029","url":null,"abstract":"Objective: Diabetes mellitus is a major cardiovascular risk factor. Diabetic complications in the cardiovascular system randomly appear following long standing diabetes. However, newly diagnosed diabetes can also be associated with cardiac problems. The aim of this study was to compare patients with newly diagnosed type 2 diabetes mellitus (T2DM) to healthy controls in regard to echocardiography features, specifically left ventricular global longitudinal strain (LV GLS). Materials and methods: This was a prospective cross-sectional study conducted on 94 patients, 52 patients with newly diagnosed T2DM that formed the first group and 42 healthy subjects, without history of diabetes mellitus and/or cardiovascular disease, which formed the second group. Results: Patients with newly diagnosed T2DM had mean glucose level of 16.37 ± 7.43 mmol/L and HbA1c of 8.57 ± 2.31 %. The groups did not differ in regard to age, gender, smoking, arterial hypertension or heart rate at the time of examination. The ratio between early mitral inflow velocity and mitral annu lar early diastolic velocity (E/e’) of the septal wall was significantly lower in patients with newly diagnosed T2DM (6.21 ± 3.14 vs. 7.8 ± 2.45, p = 0.009). The LV GLS resulted lower in patients with newly diagnosed T2DM compared to the healthy subjects (|–19.36|% ± 2.98 vs. |–20.43|% ± 1.99. p = 0.049). Of note, the LV GLS values are expressed as absolute numbers. The ratio of patients with LV GLS strain <|–18.8|% was significantly higher in patients with newly diagnosed T2DM (42.31% vs. 21.43%, p = 0.03). Conclusions: LV GLS may serve as an important echo cardiographic parameter to detect early myocardial changes in asymptomatic patients with newly diagnosed T2DM. (Clin Diabetol 2022, 11; 4: 245–250)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85457816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Diabetes is a chronic and common global dis-ease that requires particular care behaviors for the rest of life. People with diabetes can be trained to achieve optimal self-care. The present study was conducted to determine the effect of stage-matched educational intervention on behavior change and glycemic control in elderly patients with diabetes. Matherials and methods: In this controlled clinical trial, 110 type 2 elderly patients with diabetes were selected randomly from health centers in Malard city, Iran, and were assigned to the control and experimental group equally. Data collection instruments were: demographics questions, scales to assess transtheoretical model constructs and stage of change, and blood samples for determining FBS and HbA1c. The mentioned variables were measured before, 1, and 3 months after the stage-matched educational intervention. The educational intervention consisted of 2 group intensive training sessions of about 45 minutes and daily messages via mobile phone for 3 months. The educational topics were about healthy diet and caring behaviors. Data were analyzed using SPSS 25.0 and independent & paired t-test, chi-square, one-way ANOVA, and ANCOVA. The significance level was con sidered less than 0.05. Results: The mean age of study participants was (66.5 ± 3.91) years. Also, the average duration of diabetes was (7.18 ± 4.21) years, and 50% had a Junior high school education. A significant decrease was found in mean FBS (from 187 ± 43.4 to 136.42 ± 36.34, p < 0.05) and HbA1c (from 8.28 ± 1.26 to 7.26 ± ± 1.10, p < 0.05) in the experimental group, and also the mean of self-care behaviors in the experimental group increased significantly from baseline (from 1.51 ± ± 1.71 to 1.45 ± 0.92, p < 0.05). Conclusions: Educational intervention based on the stages-of-change model can improve glycemic control and behaviors related to controlling diabetes, so it is necessary to pay attention to essential psychological variables in designing educational interventions in order to control blood glucose in patients with diabetes. (Clin Diabetol 2022, 11; 4: 232–238)
{"title":"The Effect of Stage-Matched Educational Intervention on Behavior Change and Glycemic Control in Elderly Patients with Diabetes","authors":"Azadeh Hajipour, M. Javadi, I. Mohammadi Zeidi","doi":"10.5603/dk.a2022.0030","DOIUrl":"https://doi.org/10.5603/dk.a2022.0030","url":null,"abstract":"Objective: Diabetes is a chronic and common global dis-ease that requires particular care behaviors for the rest of life. People with diabetes can be trained to achieve optimal self-care. The present study was conducted to determine the effect of stage-matched educational intervention on behavior change and glycemic control in elderly patients with diabetes. Matherials and methods: In this controlled clinical trial, 110 type 2 elderly patients with diabetes were selected randomly from health centers in Malard city, Iran, and were assigned to the control and experimental group equally. Data collection instruments were: demographics questions, scales to assess transtheoretical model constructs and stage of change, and blood samples for determining FBS and HbA1c. The mentioned variables were measured before, 1, and 3 months after the stage-matched educational intervention. The educational intervention consisted of 2 group intensive training sessions of about 45 minutes and daily messages via mobile phone for 3 months. The educational topics were about healthy diet and caring behaviors. Data were analyzed using SPSS 25.0 and independent & paired t-test, chi-square, one-way ANOVA, and ANCOVA. The significance level was con sidered less than 0.05. Results: The mean age of study participants was (66.5 ± 3.91) years. Also, the average duration of diabetes was (7.18 ± 4.21) years, and 50% had a Junior high school education. A significant decrease was found in mean FBS (from 187 ± 43.4 to 136.42 ± 36.34, p < 0.05) and HbA1c (from 8.28 ± 1.26 to 7.26 ± ± 1.10, p < 0.05) in the experimental group, and also the mean of self-care behaviors in the experimental group increased significantly from baseline (from 1.51 ± ± 1.71 to 1.45 ± 0.92, p < 0.05). Conclusions: Educational intervention based on the stages-of-change model can improve glycemic control and behaviors related to controlling diabetes, so it is necessary to pay attention to essential psychological variables in designing educational interventions in order to control blood glucose in patients with diabetes. (Clin Diabetol 2022, 11; 4: 232–238)","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76120400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Okada, K. Kikkawa, Junichi Okada, Kazuya Okada, Eijiro Yamada, Kihachi Ohshima
Address for correspondence: Shuichi Okada Department of Diabetes and Endocrinology, Hidaka Hospital 886 Nakao-machi Takasaki, Gunma 370-0001, Japan phone: +81-27-362-6201; fax: 81-27-362-0217 email: okadash1823@gmail.com Clinical Diabetology 2022, 11; 4: 296–297 DOI: 10.5603/DK.a2022.0035 Received: 5.07.2022 Accepted: 26.07.2022 Shuichi Okada1, Koji Kikkawa1, Junichi Okada2, Kazuya Okada3, Eijiro Yamada4, Kihachi Ohshima1 1Department of Diabetes and Endocrinology, Hidaka Hospital, Gunma, Japan 2Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, New York, USA 3Omagari Kousei Medical Center, Akita, Japan 4Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
{"title":"Renal Threshold for Glucose Re-Absorption in Patients with Latent Autoimmune Diabetes of Adults is Similar to That of Patients with Type 1 Diabetes Mellitus but Lower than That of Patients with Type 2 Diabetes Mellitus","authors":"S. Okada, K. Kikkawa, Junichi Okada, Kazuya Okada, Eijiro Yamada, Kihachi Ohshima","doi":"10.5603/dk.a2022.0035","DOIUrl":"https://doi.org/10.5603/dk.a2022.0035","url":null,"abstract":"Address for correspondence: Shuichi Okada Department of Diabetes and Endocrinology, Hidaka Hospital 886 Nakao-machi Takasaki, Gunma 370-0001, Japan phone: +81-27-362-6201; fax: 81-27-362-0217 email: okadash1823@gmail.com Clinical Diabetology 2022, 11; 4: 296–297 DOI: 10.5603/DK.a2022.0035 Received: 5.07.2022 Accepted: 26.07.2022 Shuichi Okada1, Koji Kikkawa1, Junichi Okada2, Kazuya Okada3, Eijiro Yamada4, Kihachi Ohshima1 1Department of Diabetes and Endocrinology, Hidaka Hospital, Gunma, Japan 2Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, New York, USA 3Omagari Kousei Medical Center, Akita, Japan 4Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74705844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Outcomes of IDF-DAR Practical Guidelines Adaptation for the Management of Type 2 Diabetes: Results from a Real-world Clinical Study in India","authors":"S. Bhattacharyya","doi":"10.5603/dk.a2022.0034","DOIUrl":"https://doi.org/10.5603/dk.a2022.0034","url":null,"abstract":"","PeriodicalId":10386,"journal":{"name":"Clinical Diabetology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85799059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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