Pub Date : 2024-04-23DOI: 10.1007/s00062-024-01404-4
B. Csippa, Levente Sándor, Gábor Závodszky, I. Szikora, György Paál
{"title":"Comparison of Flow Reduction Efficacy of Nominal and Oversized Flow Diverters Using a Novel Measurement-assisted in Silico Method.","authors":"B. Csippa, Levente Sándor, Gábor Závodszky, I. Szikora, György Paál","doi":"10.1007/s00062-024-01404-4","DOIUrl":"https://doi.org/10.1007/s00062-024-01404-4","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"51 17","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-23DOI: 10.1007/s00062-024-01412-4
S. Chirumbolo, S. Pandolfi, L. Valdenassi, Marianna Chierchia, M. Franzini
{"title":"Complications During Ozone Therapy as a Result of Malpractice and Lack of Guidelines.","authors":"S. Chirumbolo, S. Pandolfi, L. Valdenassi, Marianna Chierchia, M. Franzini","doi":"10.1007/s00062-024-01412-4","DOIUrl":"https://doi.org/10.1007/s00062-024-01412-4","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"23 12","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-22DOI: 10.1007/s00062-024-01408-0
P. Dhillon, Vinicius Carraro do Nascimento, L. de Villiers, Hal Rice
{"title":"Endovascular Thrombectomy for Extensive Infarction (ASPECTS 0-2) in Acute Ischemic Stroke.","authors":"P. Dhillon, Vinicius Carraro do Nascimento, L. de Villiers, Hal Rice","doi":"10.1007/s00062-024-01408-0","DOIUrl":"https://doi.org/10.1007/s00062-024-01408-0","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"22 25","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.1007/s00062-024-01407-1
Mehmet Salih Yildirim, Victor Ulrich Schmidbauer, Alexander Micko, Lisa Lechner, Michael Weber, Julia Furtner, Stefan Wolfsberger, Intesar-Victoria Malla Houech, Anna Cho, Gregor Dovjak, Gregor Kasprian, Daniela Prayer, Wolfgang Marik
Purpose
Pre-surgical information about tumor consistency could facilitate neurosurgical planning. This study used multi-dynamic-multi-echo (MDME)-based relaxometry for the quantitative determination of pituitary tumor consistency, with the aim of predicting lesion resectability.
Methods
Seventy-two patients with suspected pituitary adenomas, who underwent preoperative 3 T MRI between January 2020 and January 2022, were included in this prospective study. Lesion-specific T1-/T2-relaxation times (T1R/T2R) and proton density (PD) metrics were determined. During surgery, data about tumor resectability were collected. A Receiver Operating Characteristic (ROC) curve analysis was performed to investigate the diagnostic performance (sensitivity/specificity) for discriminating between easy- and hard-to-remove by aspiration (eRAsp and hRAsp) lesions. A Mann-Whitney-U-test was done for group comparison.
Results
A total of 65 participants (mean age, 54 years ± 15, 33 women) were enrolled in the quantitative analysis. Twenty-four lesions were classified as hRAsp, while 41 lesions were assessed as eRAsp. There were significant differences in T1R (hRAsp: 1221.0 ms ± 211.9; eRAsp: 1500.2 ms ± 496.4; p = 0.003) and T2R (hRAsp: 88.8 ms ± 14.5; eRAsp: 137.2 ms ± 166.6; p = 0.03) between both groups. The ROC analysis revealed an area under the curve of 0.72 (95% CI: 0.60–0.85) at p = 0.003 for T1R (cutoff value: 1248 ms; sensitivity/specificity: 78%/58%) and 0.66 (95% CI: 0.53–0.79) at p = 0.03 for T2R (cutoff value: 110 ms; sensitivity/specificity: 39%/96%).
Conclusion
MDME-based relaxometry enables a non-invasive, pre-surgical characterization of lesion consistency and, therefore, provides a modality with which to predict tumor resectability.
目的 手术前了解肿瘤的一致性有助于制定神经外科手术计划。本研究采用基于多动态多回波(MDME)的弛豫测量法对垂体瘤的一致性进行定量测定,旨在预测病变的可切除性。方法这项前瞻性研究纳入了在2020年1月至2022年1月期间接受术前3 T磁共振成像检查的72例疑似垂体腺瘤患者。研究确定了病变特异性T1/T2松弛时间(T1R/T2R)和质子密度(PD)指标。在手术过程中,收集了有关肿瘤可切除性的数据。进行了接收者操作特征曲线(ROC)分析,以研究区分易切除病灶和难切除病灶(ERAsp和hRAsp)的诊断性能(灵敏度/特异性)。结果 共有 65 名参与者(平均年龄为 54 岁±15 岁,33 名女性)参与了定量分析。24 个病灶被归类为 hRAsp,41 个病灶被评估为 eRAsp。两组的 T1R(hRAsp:1221.0 ms ± 211.9;eerasp:1500.2 ms ± 496.4;p = 0.003)和 T2R(hRAsp:88.8 ms ± 14.5;eerasp:137.2 ms ± 166.6;p = 0.03)有明显差异。ROC 分析显示,在 p = 0.003 时,T1R(临界值:1248 ms;敏感性/特异性:78%/58%)的曲线下面积为 0.72(95% CI:0.60-0.85);在 p = 0.003 时,T2R(临界值:1248 ms;敏感性/特异性:78%/58%)的曲线下面积为 0.66(95% CI:0.53-0.79)。结论:基于 MDME 的弛豫测量可在手术前对病变的一致性进行无创鉴定,因此是预测肿瘤可切除性的一种方法。
{"title":"Multi-Dynamic-Multi-Echo-based MRI for the Pre-Surgical Determination of Sellar Tumor Consistency: a Quantitative Approach for Predicting Lesion Resectability","authors":"Mehmet Salih Yildirim, Victor Ulrich Schmidbauer, Alexander Micko, Lisa Lechner, Michael Weber, Julia Furtner, Stefan Wolfsberger, Intesar-Victoria Malla Houech, Anna Cho, Gregor Dovjak, Gregor Kasprian, Daniela Prayer, Wolfgang Marik","doi":"10.1007/s00062-024-01407-1","DOIUrl":"https://doi.org/10.1007/s00062-024-01407-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Pre-surgical information about tumor consistency could facilitate neurosurgical planning. This study used multi-dynamic-multi-echo (MDME)-based relaxometry for the quantitative determination of pituitary tumor consistency, with the aim of predicting lesion resectability.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Seventy-two patients with suspected pituitary adenomas, who underwent preoperative 3 T MRI between January 2020 and January 2022, were included in this prospective study. Lesion-specific T1-/T2-relaxation times (T1R/T2R) and proton density (PD) metrics were determined. During surgery, data about tumor resectability were collected. A Receiver Operating Characteristic (ROC) curve analysis was performed to investigate the diagnostic performance (sensitivity/specificity) for discriminating between easy- and hard-to-remove by aspiration (eRAsp and hRAsp) lesions. A Mann-Whitney-U-test was done for group comparison.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 65 participants (mean age, 54 years ± 15, 33 women) were enrolled in the quantitative analysis. Twenty-four lesions were classified as hRAsp, while 41 lesions were assessed as eRAsp. There were significant differences in T1R (hRAsp: 1221.0 ms ± 211.9; eRAsp: 1500.2 ms ± 496.4; <i>p</i> = 0.003) and T2R (hRAsp: 88.8 ms ± 14.5; eRAsp: 137.2 ms ± 166.6; <i>p</i> = 0.03) between both groups. The ROC analysis revealed an area under the curve of 0.72 (95% CI: 0.60–0.85) at <i>p</i> = 0.003 for T1R (cutoff value: 1248 ms; sensitivity/specificity: 78%/58%) and 0.66 (95% CI: 0.53–0.79) at <i>p</i> = 0.03 for T2R (cutoff value: 110 ms; sensitivity/specificity: 39%/96%).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>MDME-based relaxometry enables a non-invasive, pre-surgical characterization of lesion consistency and, therefore, provides a modality with which to predict tumor resectability.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"51 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.1007/s00062-024-01402-6
A. Khanafer, P. von Gottberg, P. Albiña-Palmarola, T. Liebig, M. Forsting, O. Ganslandt, H. Henkes
Purpose
Recent observational studies have indicated the efficacy of stent retriever devices for the treatment of posthemorrhagic cerebral vasospasm (CVS), both by deployment and on-site withdrawal into the microcatheter (stent angioplasty, SA) and deployment followed by retraction through the target vessel similar to thrombectomy (StentRetraction to reLieve Arterial Cerebral vaSospasm caused by SAH, Stent-ReLACSS). This article reports the findings with each application of pRESET and pRELAX in the treatment of CVS.
Methods
We retrospectively enrolled 25 patients with severe CVS following aneurysmal subarachnoid hemorrhage. For the SA group, a stent retriever or a pRELAX was temporarily deployed into a narrow vessel segment and retrieved into the microcatheter after 3 min. For the Stent-ReLACSS group, a pRELAX was temporarily deployed into a narrow vessel and pulled back unfolded into the internal carotid artery. If intra-arterial vasodilators were administered, they were given exclusively after mechanical vasospasmolysis to maximize the effectiveness of the stent treatment.
Results
In this study fifteen patients and 49 vessels were treated with SA. All were technically successful without periprocedural complications; however, 8/15 patients (53.3%) required additional treatment of the CVS. A total of 10 patients and 23 vessel segments were treated with Stent-ReLACSS. All maneuvers were technically successful without periprocedural complications and all vessels showed significant angiographic improvement. No recurrent CVS requiring further endovascular treatment occurred in-hospital, and neither territorial ischemia in the treated vessels nor vascular injury were observed in follow-up angiography.
Conclusion
Based on the presented data it appears that Stent-ReLACSS with pRELAX does not pose any additional risks when used to treat CVS and might be superior to SA, especially concerning mid-term and long-term efficacy. The mechanism of action may be an effect on the endothelium rather than mechanical vasodilation. As many patients with CVS are diagnosed too late, prophylactic treatment of high-risk patients (e.g., poor grade, young, female) is potentially viable.
{"title":"Is Stent Retraction to ReLieve Arterial Cerebral VaSospasm Caused by SAH (Stent-ReLACSS) Using PRELAX the Long-awaited Solution for Treatment of Posthemorrhagic Cerebral Vasospasm?","authors":"A. Khanafer, P. von Gottberg, P. Albiña-Palmarola, T. Liebig, M. Forsting, O. Ganslandt, H. Henkes","doi":"10.1007/s00062-024-01402-6","DOIUrl":"https://doi.org/10.1007/s00062-024-01402-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Recent observational studies have indicated the efficacy of stent retriever devices for the treatment of posthemorrhagic cerebral vasospasm (CVS), both by deployment and on-site withdrawal into the microcatheter (stent angioplasty, SA) and deployment followed by retraction through the target vessel similar to thrombectomy (<i>Stent</i> <i>Re</i>traction to re<i>L</i>ieve <i>A</i>rterial <i>C</i>erebral va<i>S</i>ospasm caused by <i>S</i>AH, <i>Stent-ReLACSS</i>). This article reports the findings with each application of pRESET and pRELAX in the treatment of CVS.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We retrospectively enrolled 25 patients with severe CVS following aneurysmal subarachnoid hemorrhage. For the SA group, a stent retriever or a pRELAX was temporarily deployed into a narrow vessel segment and retrieved into the microcatheter after 3 min. For the Stent-ReLACSS group, a pRELAX was temporarily deployed into a narrow vessel and pulled back unfolded into the internal carotid artery. If intra-arterial vasodilators were administered, they were given exclusively after mechanical vasospasmolysis to maximize the effectiveness of the stent treatment.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In this study fifteen patients and 49 vessels were treated with SA. All were technically successful without periprocedural complications; however, 8/15 patients (53.3%) required additional treatment of the CVS. A total of 10 patients and 23 vessel segments were treated with Stent-ReLACSS. All maneuvers were technically successful without periprocedural complications and all vessels showed significant angiographic improvement. No recurrent CVS requiring further endovascular treatment occurred in-hospital, and neither territorial ischemia in the treated vessels nor vascular injury were observed in follow-up angiography.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Based on the presented data it appears that Stent-ReLACSS with pRELAX does not pose any additional risks when used to treat CVS and might be superior to SA, especially concerning mid-term and long-term efficacy. The mechanism of action may be an effect on the endothelium rather than mechanical vasodilation. As many patients with CVS are diagnosed too late, prophylactic treatment of high-risk patients (e.g., poor grade, young, female) is potentially viable.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"101 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The prognosis of untreated spinal arteriovenous malformations (SAVMs) is poor. Embolization plays an important role in the management of intramedullary SAVMs. Delayed aggravation due to spinal venous thrombosis following successful embolization has been reported; however, perioperative management strategies to prevent thrombosis have not been explored. We present our single-center experience of SAVM embolization and perioperative management, including anticoagulation.
Material and Methods
We retrospectively evaluated 18 patients with SAVMs who underwent transarterial embolization. Perioperative anticoagulation therapy was administered to selected patients. We compared the characteristics of the patients, including perioperative management procedures, between those with and without postoperative worsening following embolization.
Results
Acute postoperative worsening within 1 week occurred in 4 (22.2%) patients. Of these, immediate worsening was observed in one patient as a procedure-related complication. Delayed worsening after 24 h was observed in 3 patients, caused by delayed venous thrombosis with severe back pain. Rescue anticoagulation for delayed worsening improved symptoms in two patients. A comparison between patients with and without acute postoperative worsening revealed significant differences in age (median 46.5 vs. 26.5 years, p = 0.009) and the presence of postoperative back pain (75.0% vs. 0%, p = 0.005); however, there was no significant difference in use of selective anticoagulation (p = 0.274).
Conclusion
The results of this study suggest that SAVM embolization can cause acute worsening due to postoperative venous thrombosis with severe back pain, which may be reversed by anticoagulation therapy. Back pain is an important finding that suggests venous thrombosis, and anticoagulation should be urgently administered.
{"title":"Perioperative Management of Spinal Arteriovenous Malformation Embolization: Delayed Venous Thrombosis and Implications for Severe Back Pain","authors":"Bikei Ryu, Tatsuki Mochizuki, Shogo Shima, Shinsuke Sato, Tatsuya Inoue, Takakazu Kawamata, Yasunari Niimi","doi":"10.1007/s00062-024-01403-5","DOIUrl":"https://doi.org/10.1007/s00062-024-01403-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background and Purpose</h3><p>The prognosis of untreated spinal arteriovenous malformations (SAVMs) is poor. Embolization plays an important role in the management of intramedullary SAVMs. Delayed aggravation due to spinal venous thrombosis following successful embolization has been reported; however, perioperative management strategies to prevent thrombosis have not been explored. We present our single-center experience of SAVM embolization and perioperative management, including anticoagulation.</p><h3 data-test=\"abstract-sub-heading\">Material and Methods</h3><p>We retrospectively evaluated 18 patients with SAVMs who underwent transarterial embolization. Perioperative anticoagulation therapy was administered to selected patients. We compared the characteristics of the patients, including perioperative management procedures, between those with and without postoperative worsening following embolization.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Acute postoperative worsening within 1 week occurred in 4 (22.2%) patients. Of these, immediate worsening was observed in one patient as a procedure-related complication. Delayed worsening after 24 h was observed in 3 patients, caused by delayed venous thrombosis with severe back pain. Rescue anticoagulation for delayed worsening improved symptoms in two patients. A comparison between patients with and without acute postoperative worsening revealed significant differences in age (median 46.5 vs. 26.5 years, <i>p</i> = 0.009) and the presence of postoperative back pain (75.0% vs. 0%, <i>p</i> = 0.005); however, there was no significant difference in use of selective anticoagulation (<i>p</i> = 0.274).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The results of this study suggest that SAVM embolization can cause acute worsening due to postoperative venous thrombosis with severe back pain, which may be reversed by anticoagulation therapy. Back pain is an important finding that suggests venous thrombosis, and anticoagulation should be urgently administered.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"111 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140587162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1007/s00062-024-01405-3
Junhyung Kim, Sang Kyu Park, Joonho Chung
{"title":"Endovascular Treatment of a Wide-necked Bilobulated Bifurcation Aneurysm using the Woven EndoBridge (WEB) Device","authors":"Junhyung Kim, Sang Kyu Park, Joonho Chung","doi":"10.1007/s00062-024-01405-3","DOIUrl":"https://doi.org/10.1007/s00062-024-01405-3","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"111 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140587275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-05DOI: 10.1007/s00062-024-01398-z
Jürgen Panholzer, G. Malsiner‐Walli, Bettina Grün, Ognian Kalev, Michael Sonnberger, Robert Pichler
{"title":"Correction to: Multiparametric Analysis Combining DSC-MR Perfusion and [18F]FET-PET is Superior to a Single Parameter Approach for Differentiation of Progressive Glioma from Radiation Necrosis.","authors":"Jürgen Panholzer, G. Malsiner‐Walli, Bettina Grün, Ognian Kalev, Michael Sonnberger, Robert Pichler","doi":"10.1007/s00062-024-01398-z","DOIUrl":"https://doi.org/10.1007/s00062-024-01398-z","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":"5 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2023-06-15DOI: 10.1007/s00062-023-01321-y
Yash Verma, Sairam Ramesh, Arosh S Perera Molligoda Arachchige
{"title":"7 T Versus 3 T in the Diagnosis of Small Unruptured Intracranial Aneurysms: Reply to Radojewski et al.","authors":"Yash Verma, Sairam Ramesh, Arosh S Perera Molligoda Arachchige","doi":"10.1007/s00062-023-01321-y","DOIUrl":"10.1007/s00062-023-01321-y","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"51-52"},"PeriodicalIF":2.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9634120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}