Piotr Henryk Skarzynski, Katarzyna Beata Cywka, Emilia Anna Czaplicka, Henryk Skarzynski
Objectives
This study evaluates the safety and efficacy of the Bonebridge BCI 601 and 602 bone conduction implants in our largest cohort to date of 355 patients. The patients had a wide age range and exhibited conductive, mixed, or single-sided deafness (SSD).
Design
All patients underwent Bonebridge implantation. Pre- and post-implantation evaluations included pure-tone audiometry, speech recognition tests, and free-field audiometry. Word recognition was measured using the Polish Monosyllabic Word Test, while speech reception in noise was assessed using the Polish Sentence Matrix Test. Subjective benefit was assessed using the APHAB questionnaire. Follow-up tests were performed 3–6 months after activation.
Results
Revision surgery was required in 17 patients (4.8%) due to complications, including implant removal in 5 cases. Reimplantation was successful in 4 of these. The APHAB questionnaire showed improved hearing function and all hearing tests also showed significant improvement.
Conclusion
Active bone conduction implantation is an effective method for the rehabilitation of conductive hearing loss, mixed hearing loss, and unilateral deafness. This large cohort study confirms significant hearing improvement and subjective benefits. The low complication rate supports the reliability of the Bonebridge system.
{"title":"The Bonebridge Active Bone Conduction Hearing Implant: Safety, Effectiveness and Outcomes Based on 355 Patients","authors":"Piotr Henryk Skarzynski, Katarzyna Beata Cywka, Emilia Anna Czaplicka, Henryk Skarzynski","doi":"10.1111/coa.70050","DOIUrl":"10.1111/coa.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study evaluates the safety and efficacy of the Bonebridge BCI 601 and 602 bone conduction implants in our largest cohort to date of 355 patients. The patients had a wide age range and exhibited conductive, mixed, or single-sided deafness (SSD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>All patients underwent Bonebridge implantation. Pre- and post-implantation evaluations included pure-tone audiometry, speech recognition tests, and free-field audiometry. Word recognition was measured using the Polish Monosyllabic Word Test, while speech reception in noise was assessed using the Polish Sentence Matrix Test. Subjective benefit was assessed using the APHAB questionnaire. Follow-up tests were performed 3–6 months after activation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Revision surgery was required in 17 patients (4.8%) due to complications, including implant removal in 5 cases. Reimplantation was successful in 4 of these. The APHAB questionnaire showed improved hearing function and all hearing tests also showed significant improvement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Active bone conduction implantation is an effective method for the rehabilitation of conductive hearing loss, mixed hearing loss, and unilateral deafness. This large cohort study confirms significant hearing improvement and subjective benefits. The low complication rate supports the reliability of the Bonebridge system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 2","pages":"255-261"},"PeriodicalIF":1.5,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Loader, Hana Stohlawetz, Elisabeth Sterrer, Niya Kiryakova, Franz Windisch, Peter Franz
Objective
To evaluate the surgical placement options, complication rates and audiological outcomes with two generations of a transcutaneous active bone conduction implant.
Design and Setting
This retrospective chart review analysed all BCI601 and BCI602 implant surgeries performed in the period from March 2015 to April 2023 at a single centre. Surgical site of implantation, complication data and audiological outcomes including functional gain and speech performance in quiet were assessed.
Results
Fifty surgical cases were extracted and analysed (BCI601 = 24, BCI602 = 26). The 4-PTA improved by 24.3 dB on average; speech in quiet improved by 33.9% at 65 dB SPL and by 34.8% at 80 dB SPL between aided and unaided conditions overall. The BCI602 had significantly better word recognition scores at 80 dB than the BCI601 (p = 0.0076). One case of wound revision and two explanations have been recorded during the observation period. The use of lifts was significantly reduced with the smaller BCI602 implant.
Conclusion
While the newer BCI602 variant of the implant provides more placement options due to the reduced drilling depth compared to the BCI601, both versions provide a low postoperative risk of complications and significant functional outcomes.
目的：评价两代经皮活性骨传导植入物的手术位置选择、并发症发生率和听力学结果。设计和背景：本回顾性图表分析了2015年3月至2023年4月在同一中心进行的所有BCI601和BCI602植入手术。评估手术植入部位、并发症数据和听力学结果，包括安静时的功能增益和言语表现。结果：共收集分析手术病例50例（BCI601 = 24, BCI602 = 26）。4-PTA平均提高24.3 dB；总体而言，在辅助和非辅助条件下，安静语音在65 dB SPL下提高了33.9%，在80 dB SPL下提高了34.8%。BCI602在80 dB时的单词识别得分显著高于BCI601 （p = 0.0076）。观察期间记录1例伤口修复，2例解释。使用较小的BCI602种植体可显著减少提升术的使用。结论：与BCI601相比，新型BCI602假体由于钻孔深度减少，提供了更多的植入选择，两种假体术后并发症风险低，功能效果显著。
{"title":"Surgical Site Comparison of Two Active Implantable Transcutaneous Bone Conduction Hearing Aid Generations","authors":"Benjamin Loader, Hana Stohlawetz, Elisabeth Sterrer, Niya Kiryakova, Franz Windisch, Peter Franz","doi":"10.1111/coa.70038","DOIUrl":"10.1111/coa.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the surgical placement options, complication rates and audiological outcomes with two generations of a transcutaneous active bone conduction implant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design and Setting</h3>\u0000 \u0000 <p>This retrospective chart review analysed all BCI601 and BCI602 implant surgeries performed in the period from March 2015 to April 2023 at a single centre. Surgical site of implantation, complication data and audiological outcomes including functional gain and speech performance in quiet were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty surgical cases were extracted and analysed (BCI601 = 24, BCI602 = 26). The 4-PTA improved by 24.3 dB on average; speech in quiet improved by 33.9% at 65 dB SPL and by 34.8% at 80 dB SPL between aided and unaided conditions overall. The BCI602 had significantly better word recognition scores at 80 dB than the BCI601 (<i>p</i> = 0.0076). One case of wound revision and two explanations have been recorded during the observation period. The use of lifts was significantly reduced with the smaller BCI602 implant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While the newer BCI602 variant of the implant provides more placement options due to the reduced drilling depth compared to the BCI601, both versions provide a low postoperative risk of complications and significant functional outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"153-158"},"PeriodicalIF":1.5,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We reviewed the prospects of Artificial Intelligence (AI) and its usage in facial plastic surgery.
Methods
Literature search was performed using PubMed, Medline, Google and Google Scholar search engines between 2000 and 2025 years.
Results
AI is poised to impact the threefold missions of patient care, education and research. It plays a role in aiding clinician decision-making, serving as virtual conversational agents for patient engagement, and forecasting surgical outcomes. Primary areas of AI exploration in the medical field include machine learning (ML), neural networks (NN) and natural language processing (NLP). ML models have demonstrated the ability to detect facial features such as larger nasofrontal and nasolabial angles, correlating with increased attractiveness post-cosmetic rhinoplasty. Efficient resource allocation can be achieved through ML models guiding the analysis of post-operative free flap viability in facial skin cancer reconstruction. During online patient consultations, AI virtual assistants (AIVA) utilising NLP comprehend human speech intent, responding through dialogue. Unsupervised ML in facial analysis software is currently employed for correctly diagnosing rare diseases by recognising dysmorphic craniofacial features in two-dimensional photographs. AI also finds application in assessing post-operative outcomes, as well as in surgical training and research.
Conclusion
The use of AI in healthcare is on the rise, contributing to advancements in pre-operative assessments, predicting prognoses, managing patients and monitoring postoperative progress. Surgeons are encouraged to explore collaboration with data scientists to shape the evolution of AI, aiming to enhance surgical efficiency, improve patient outcomes and potentially alleviate the workload associated with repetitive administrative duties.
{"title":"Artificial Intelligence in Facial Plastic Procedures","authors":"Nuray Bayar Muluk","doi":"10.1111/coa.70052","DOIUrl":"10.1111/coa.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We reviewed the prospects of Artificial Intelligence (AI) and its usage in facial plastic surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Literature search was performed using PubMed, Medline, Google and Google Scholar search engines between 2000 and 2025 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AI is poised to impact the threefold missions of patient care, education and research. It plays a role in aiding clinician decision-making, serving as virtual conversational agents for patient engagement, and forecasting surgical outcomes. Primary areas of AI exploration in the medical field include machine learning (ML), neural networks (NN) and natural language processing (NLP). ML models have demonstrated the ability to detect facial features such as larger nasofrontal and nasolabial angles, correlating with increased attractiveness post-cosmetic rhinoplasty. Efficient resource allocation can be achieved through ML models guiding the analysis of post-operative free flap viability in facial skin cancer reconstruction. During online patient consultations, AI virtual assistants (AIVA) utilising NLP comprehend human speech intent, responding through dialogue. Unsupervised ML in facial analysis software is currently employed for correctly diagnosing rare diseases by recognising dysmorphic craniofacial features in two-dimensional photographs. AI also finds application in assessing post-operative outcomes, as well as in surgical training and research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The use of AI in healthcare is on the rise, contributing to advancements in pre-operative assessments, predicting prognoses, managing patients and monitoring postoperative progress. Surgeons are encouraged to explore collaboration with data scientists to shape the evolution of AI, aiming to enhance surgical efficiency, improve patient outcomes and potentially alleviate the workload associated with repetitive administrative duties.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Support, Not Supplant: Preserving Human-Centred Care in the Integration of Artificial Intelligence Into Multidisciplinary Decision-Making","authors":"Emma Watts, Kristien Boelaert, Neil Sharma","doi":"10.1111/coa.70044","DOIUrl":"10.1111/coa.70044","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"180-181"},"PeriodicalIF":1.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fangxing Yin, Haris Ali, Alaa Abdelhalim, Hassan A. Elhassan
Objective
Identify and summarise the evidence on the efficacy of low-dose verapamil use for adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
Methods
Two reviewers independently searched the data sources until the 28th of December 2023. From 262 studies identified, PRISMA guidelines were implemented to include three randomised controlled trials that used verapamil for patients diagnosed with CRSwNP. Primary endpoints were extracted, including quality-of-life questionnaires and imaging gradings.
Results
Across 116 participants, all three studies showed statistically significant improvement in the subjective scores of patients who experienced symptoms in the verapamil group. The mean differences between the two intervention groups and placebo in SNOT-22 were −19.17 (95% CI: −30.76 to −7.58) and −27.7 (95% CI: −49.36 to −6.05). On the objective metrics, statistically significant improvement in TNPS or LMS between groups was seen in two out of the three studies (0.01 [p = 0.001], −5.2 [p = 0.02]).
Conclusion
Although verapamil usage resulted in significant improvements in the subjective and objective measurements of the severity of CRSwNP, the current evidence is insufficient to support widespread usage of verapamil for CRSwNP. Further studies should focus on recruiting a clinically significant number of patients, while ensuring robustness and homogeneity in the methodological design.
{"title":"Is Verapamil Effective for Treating Patients With Chronic Rhinosinusitis With Nasal Polyps? A Systematic Review","authors":"Fangxing Yin, Haris Ali, Alaa Abdelhalim, Hassan A. Elhassan","doi":"10.1111/coa.70041","DOIUrl":"10.1111/coa.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Identify and summarise the evidence on the efficacy of low-dose verapamil use for adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two reviewers independently searched the data sources until the 28th of December 2023. From 262 studies identified, PRISMA guidelines were implemented to include three randomised controlled trials that used verapamil for patients diagnosed with CRSwNP. Primary endpoints were extracted, including quality-of-life questionnaires and imaging gradings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Across 116 participants, all three studies showed statistically significant improvement in the subjective scores of patients who experienced symptoms in the verapamil group. The mean differences between the two intervention groups and placebo in SNOT-22 were −19.17 (95% CI: −30.76 to −7.58) and −27.7 (95% CI: −49.36 to −6.05). On the objective metrics, statistically significant improvement in TNPS or LMS between groups was seen in two out of the three studies (0.01 [<i>p</i> = 0.001], −5.2 [<i>p</i> = 0.02]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although verapamil usage resulted in significant improvements in the subjective and objective measurements of the severity of CRSwNP, the current evidence is insufficient to support widespread usage of verapamil for CRSwNP. Further studies should focus on recruiting a clinically significant number of patients, while ensuring robustness and homogeneity in the methodological design.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"17-24"},"PeriodicalIF":1.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anita García Petersen, Kasra Zainali-Gill, Carsten Schade Larsen, Christian Nielsen, Therese Ovesen
Objective
Chronic rhinosinusitis (CRS) is prevalent and causes a great negative impact on quality of life. Primary antibody deficiency (PAD) is highly prevalent with CRS compared to the background population. There are efficient treatment options to consider when CRS is a symptom of PAD. The condition seems to be underdiagnosed.
Design
A prospective cohort study investigating adults with CRS for PAD.
Results
One hundred and thirty-eight patients were included in the study. Mean age was 49 years. Twenty-nine (21%) had hypogammaglobulinemia. Nine of 83 (11%) patients had insufficient response to pneumovax polysaccharide vaccine, but insufficient clinical history for diagnosis of Specific Antibody Deficiency (SPAD). Four patients met the clinical criteria for PAD; one had Common Variable Immune Deficiency (CVID), one had IgA deficiency, and two had IgG subclass deficiency. No clinical characteristic was predictive of PAD, and severity of CRS was not indicative of hypogammaglobulinemia or insufficient vaccine response.
Conclusion
Immunoglobulin testing should be a routine part of the diagnostic work-up in chronic rhinosinusitis before considering biologics, as primary antibody deficiency is an under-recognised but treatable cause of refractory disease.
{"title":"Primary Antibody Deficiency in Patients With Chronic Rhinosinusitis: A Call for Immunologic Evaluation Prior to Biologic Therapy","authors":"Anita García Petersen, Kasra Zainali-Gill, Carsten Schade Larsen, Christian Nielsen, Therese Ovesen","doi":"10.1111/coa.70045","DOIUrl":"10.1111/coa.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Chronic rhinosinusitis (CRS) is prevalent and causes a great negative impact on quality of life. Primary antibody deficiency (PAD) is highly prevalent with CRS compared to the background population. There are efficient treatment options to consider when CRS is a symptom of PAD. The condition seems to be underdiagnosed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>A prospective cohort study investigating adults with CRS for PAD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and thirty-eight patients were included in the study. Mean age was 49 years. Twenty-nine (21%) had hypogammaglobulinemia. Nine of 83 (11%) patients had insufficient response to pneumovax polysaccharide vaccine, but insufficient clinical history for diagnosis of Specific Antibody Deficiency (SPAD). Four patients met the clinical criteria for PAD; one had Common Variable Immune Deficiency (CVID), one had IgA deficiency, and two had IgG subclass deficiency. No clinical characteristic was predictive of PAD, and severity of CRS was not indicative of hypogammaglobulinemia or insufficient vaccine response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Immunoglobulin testing should be a routine part of the diagnostic work-up in chronic rhinosinusitis before considering biologics, as primary antibody deficiency is an under-recognised but treatable cause of refractory disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"144-152"},"PeriodicalIF":1.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Local allergic rhinitis (LAR) is a rhinitis subtype characterised by an IgE-mediated response in the nasal mucosa. Although the nasal provocation test (NPT) is the diagnostic gold standard, it is impractical in many centres. Consequently, patients are often misclassified as having non-allergic rhinitis, delaying appropriate treatment. This study evaluated the role of nasal cytology in the classifying and monitoring paediatric allergic rhinitis (AR), distinguishing probable LAR (pLAR), and guiding treatment.
Methods
This retrospective study analysed data from 255 patients diagnosed with chronic rhinitis between March and June 2024. After applying exclusion criteria (recent allergy treatment, nasal deformities, incomplete records), 48 patients were included and grouped as pLAR (n = 11) or AR (n = 37). Nasal eosinophilia and atopy markers were assessed with clinical symptoms, before and after treatment.
Results
The mean age was 10.5 years (range: 3–17), with 64.6% male. AR was diagnosed in 77% and pLAR in 23%. Asthma was the most common comorbidity (37.5%). Persistent, moderate-severe symptoms were seen in 68.8%, with pollen sensitivity present in 76.3%. After treatment, both VAS scores and nasal eosinophil rates (NEOS%) significantly decreased in both groups (p < 0.05). NEOS% was higher in patients with atopic dermatitis and lower in those with adenoidal hypertrophy. AEC and NEOS% were positively correlated (p < 0.001), suggesting a link between systemic and local eosinophilia.
Conclusions
Patients with pLAR showed clinical and laboratory improvement similar to AR following treatment. Nasal cytology may be a useful diagnostic and monitoring tool in children with chronic rhinitis.
{"title":"The Role of Nasal Cytology in the Phenotyping and Monitoring of Chronic Rhinitis in Children","authors":"Damla Baysal Bakır, Özge Atay, Halime Yağmur, Gizem Kabadayı, Dilek Tezcan, Suna Asilsoy, Nevin Uzuner","doi":"10.1111/coa.70040","DOIUrl":"10.1111/coa.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Local allergic rhinitis (LAR) is a rhinitis subtype characterised by an IgE-mediated response in the nasal mucosa. Although the nasal provocation test (NPT) is the diagnostic gold standard, it is impractical in many centres. Consequently, patients are often misclassified as having non-allergic rhinitis, delaying appropriate treatment. This study evaluated the role of nasal cytology in the classifying and monitoring paediatric allergic rhinitis (AR), distinguishing probable LAR (pLAR), and guiding treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study analysed data from 255 patients diagnosed with chronic rhinitis between March and June 2024. After applying exclusion criteria (recent allergy treatment, nasal deformities, incomplete records), 48 patients were included and grouped as pLAR (<i>n</i> = 11) or AR (<i>n</i> = 37). Nasal eosinophilia and atopy markers were assessed with clinical symptoms, before and after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age was 10.5 years (range: 3–17), with 64.6% male. AR was diagnosed in 77% and pLAR in 23%. Asthma was the most common comorbidity (37.5%). Persistent, moderate-severe symptoms were seen in 68.8%, with pollen sensitivity present in 76.3%. After treatment, both VAS scores and nasal eosinophil rates (NEOS%) significantly decreased in both groups (<i>p</i> < 0.05). NEOS% was higher in patients with atopic dermatitis and lower in those with adenoidal hypertrophy. AEC and NEOS% were positively correlated (<i>p</i> < 0.001), suggesting a link between systemic and local eosinophilia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with pLAR showed clinical and laboratory improvement similar to AR following treatment. Nasal cytology may be a useful diagnostic and monitoring tool in children with chronic rhinitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"136-143"},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rakesh R. Bright, Madhavi Kandagaddala, Lisa Mary Cherian, Regi Kurien, Vedantam Rupa, Belavendra Antonisamy, Aparna Irodi, Lalee Varghese
Objective
To describe the radiological anatomy of patients with inverted papilloma (IP) and to evaluate the association between radiological findings and disease recurrence.
Methods
Retrospective observational study of patients with inverted papilloma who underwent surgery between January 2010 and December 2019. Patients were grouped as primary and recurrent cases, and later at follow-up, depending on disease status, they were subcategorized into ‘primary with no recurrence’ (PnR), ‘primary with recurrence’ (PwR), ‘recurrent with no further recurrence’ (RnR) and ‘recurrent with further recurrence’ (RwR) groups. Radiological and surgical data were collected and analysed.
Results
Among the 117 patients, zygomatic recess was anatomically the most prevalent maxillary recess. Palatonasal was the most commonly affected recess in both primary and recurrent groups. Within the maxillary sinus, the most common sites of recurrence were the lateral wall and floor. Anterior ethmoid (p = 0.047), frontal recess (p = 0.017) and frontal sinus (p = 0.026) showed significantly higher radiological involvement in recurrent cases compared to primary cases. Among the recurrent cases, involvement of posterior ethmoid (p = 0.030), frontal recess (p = 0.017), intraorbital extraconal compartment (p = 0.036) and Krouse stage T4 (p = 0.002) were significantly higher in those with repeated disease recurrence (RwR).
Conclusion
In recurrent IP, predictors of repeated recurrence include the site of initial recurrence being the frontal recess/sinus region, involvement of the posterior ethmoid, frontal recess and intraorbital extraconal compartment, and Krouse stage T4 at the time of diagnosis.
{"title":"Sinonasal Inverted Papilloma—Relevance of Radiological Anatomy in Disease Recurrence","authors":"Rakesh R. Bright, Madhavi Kandagaddala, Lisa Mary Cherian, Regi Kurien, Vedantam Rupa, Belavendra Antonisamy, Aparna Irodi, Lalee Varghese","doi":"10.1111/coa.70046","DOIUrl":"10.1111/coa.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe the radiological anatomy of patients with inverted papilloma (IP) and to evaluate the association between radiological findings and disease recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective observational study of patients with inverted papilloma who underwent surgery between January 2010 and December 2019. Patients were grouped as primary and recurrent cases, and later at follow-up, depending on disease status, they were subcategorized into ‘primary with no recurrence’ (PnR), ‘primary with recurrence’ (PwR), ‘recurrent with no further recurrence’ (RnR) and ‘recurrent with further recurrence’ (RwR) groups. Radiological and surgical data were collected and analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 117 patients, zygomatic recess was anatomically the most prevalent maxillary recess. Palatonasal was the most commonly affected recess in both primary and recurrent groups. Within the maxillary sinus, the most common sites of recurrence were the lateral wall and floor. Anterior ethmoid (<i>p</i> = 0.047), frontal recess (<i>p</i> = 0.017) and frontal sinus (<i>p</i> = 0.026) showed significantly higher radiological involvement in recurrent cases compared to primary cases. Among the recurrent cases, involvement of posterior ethmoid (<i>p</i> = 0.030), frontal recess (<i>p</i> = 0.017), intraorbital extraconal compartment (<i>p</i> = 0.036) and Krouse stage T4 (<i>p</i> = 0.002) were significantly higher in those with repeated disease recurrence (RwR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In recurrent IP, predictors of repeated recurrence include the site of initial recurrence being the frontal recess/sinus region, involvement of the posterior ethmoid, frontal recess and intraorbital extraconal compartment, and Krouse stage T4 at the time of diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"127-135"},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seong Hoon Bae, Taeuk Cheon, Soo-Keun Kong, In Seok Moon
Introduction
Patulous Eustachian tube disorder (PET) causes disabling symptoms due to abnormal tubal patency. Eustachian tube plugging is a surgical option, but the optimal surgical position and plug material remain undetermined. To evaluate the success rate and complications of Eustachian tube plugging according to surgical position (sitting vs. supine) and plug material (silicone vs. angiocatheter).
Methods
This retrospective study included 50 ears from 42 patients who underwent Eustachian tube plugging between May 2019 and May 2025. Surgical outcomes and complications were assessed up to 3 months postoperatively.
Results
The overall complete remission (CR) rate was 70.0%, and 88.0% of patients experienced clinical improvement. Obstructive Eustachian tube dysfunction occurred in 14.6% of ears, exclusively in CR cases. No tympanic membrane perforation was observed. The sitting position showed a higher CR rate (80.0%) compared to supine (60.0%) in short-term outcome.
Conclusion
Sitting-position surgery may improve CR outcomes due to real-time symptom feedback. Angiocatheters are effective but prone to extrusion. Plugging is a promising procedure for PET with a favourable safety profile.
{"title":"Optimal Eustachian Tube Plugging Method for Patulous Eustachian Tube Disorder","authors":"Seong Hoon Bae, Taeuk Cheon, Soo-Keun Kong, In Seok Moon","doi":"10.1111/coa.70043","DOIUrl":"10.1111/coa.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patulous Eustachian tube disorder (PET) causes disabling symptoms due to abnormal tubal patency. Eustachian tube plugging is a surgical option, but the optimal surgical position and plug material remain undetermined. To evaluate the success rate and complications of Eustachian tube plugging according to surgical position (sitting vs. supine) and plug material (silicone vs. angiocatheter).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 50 ears from 42 patients who underwent Eustachian tube plugging between May 2019 and May 2025. Surgical outcomes and complications were assessed up to 3 months postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall complete remission (CR) rate was 70.0%, and 88.0% of patients experienced clinical improvement. Obstructive Eustachian tube dysfunction occurred in 14.6% of ears, exclusively in CR cases. No tympanic membrane perforation was observed. The sitting position showed a higher CR rate (80.0%) compared to supine (60.0%) in short-term outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sitting-position surgery may improve CR outcomes due to real-time symptom feedback. Angiocatheters are effective but prone to extrusion. Plugging is a promising procedure for PET with a favourable safety profile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"121-126"},"PeriodicalIF":1.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sam P. J. van Dijk, Carolien C. H. M. Maas, Ali Alshangi, M. H. Elise van Driel, Eline A. Feitsma, Caroline M. J. van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B. Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P. Peeters, Tessa M. van Ginhoven, The Hypoparathyroidism Study Group of the Thyroid Network
Background
The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.
Methods
This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.
Results
Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after surgery. Multivariable logistic regression analysis showed that ΔPTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism-corrected C-index: 0.88, 95% CI: 0.84–0.92) with moderately calibrated predictions.
Conclusions
The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.
{"title":"Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy","authors":"Sam P. J. van Dijk, Carolien C. H. M. Maas, Ali Alshangi, M. H. Elise van Driel, Eline A. Feitsma, Caroline M. J. van Kinschot, Ivona Lončar, Charlotte van Noord, Linetta B. Koppert, Schelto Kruijff, David van Klaveren, Cornelis Verhoef, Robin P. Peeters, Tessa M. van Ginhoven, The Hypoparathyroidism Study Group of the Thyroid Network","doi":"10.1111/coa.70039","DOIUrl":"10.1111/coa.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after surgery. Multivariable logistic regression analysis showed that ΔPTH the day after surgery, corrected calcium the day after surgery, and not identifying at least one parathyroid during surgery were strong predictors for persistent hypoparathyroidism. The discriminative ability of the model was excellent (optimism-corrected C-index: 0.88, 95% CI: 0.84–0.92) with moderately calibrated predictions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The model proposed in this study could be used to perform an individual assessment of patients at risk for persistent hypoparathyroidism after total thyroidectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 1","pages":"111-120"},"PeriodicalIF":1.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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