Pub Date : 2014-03-17DOI: 10.1080/2164232X.2014.883289
M. Kadir, N. Mansor, M. Yusof, C. Sumby
A reaction between monoamide ligand namely N-6-[(4-pyridylamino)carbonyl]-pyridine-2-carboxylic acid methyl ester (L4) and zinc chloride has been attempted in order to generate a carboxylate complex suitable for anion inclusion. This reaction gives rise to a formation of discrete complex with general formula [ZnCl2(L4)2]. Complex [ZnCl2(L4)2] crystallizes in the monoclinic space group, P21/c, with one zinc(II) center, one molecule of ligand L4, one coordinated chloride and one methanol molecule in the asymmetric unit. The extended structure of this molecule shows that the zinc atom is coordinated by four donors: two L4 and two chloride anions. The zinc atom adopts distorted tetrahedral geometry with the angles between the donors in the range 103.62(11)-122.74(8)°. In this study, the amide cavity is bound with methanol through hydrogen-bonding interactions. The methanol molecules is hydrogen bonded to the amide moiety with bond lengths O30-H8···O12 and N17-H17···O30 of 1.988 and 2.078 Å, respectively.
{"title":"Synthesis and crystal structure of N-6-[(4-pyridylamino)carbonyl]-pyridine-2-carboxylic acid methyl ester zinc complex","authors":"M. Kadir, N. Mansor, M. Yusof, C. Sumby","doi":"10.1080/2164232X.2014.883289","DOIUrl":"https://doi.org/10.1080/2164232X.2014.883289","url":null,"abstract":"A reaction between monoamide ligand namely N-6-[(4-pyridylamino)carbonyl]-pyridine-2-carboxylic acid methyl ester (L4) and zinc chloride has been attempted in order to generate a carboxylate complex suitable for anion inclusion. This reaction gives rise to a formation of discrete complex with general formula [ZnCl2(L4)2]. Complex [ZnCl2(L4)2] crystallizes in the monoclinic space group, P21/c, with one zinc(II) center, one molecule of ligand L4, one coordinated chloride and one methanol molecule in the asymmetric unit. The extended structure of this molecule shows that the zinc atom is coordinated by four donors: two L4 and two chloride anions. The zinc atom adopts distorted tetrahedral geometry with the angles between the donors in the range 103.62(11)-122.74(8)°. In this study, the amide cavity is bound with methanol through hydrogen-bonding interactions. The methanol molecules is hydrogen bonded to the amide moiety with bond lengths O30-H8···O12 and N17-H17···O30 of 1.988 and 2.078 Å, respectively.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"61 1","pages":"32 - 37"},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83787160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-17DOI: 10.1080/2164232X.2013.868325
N. F. Curtis, J. Wikaira
The structure of 1RS,4SR,7SR,10RS-(1,4,7,10-tetraazacyclopentadecane)copper(II) tetrachlorozincate, determined at 120 K, is reported: C11H26Cl4CuN4Zn, orthorhombic, P b c a (Hall−P 2ac 2ab); a, 14.0675(7); b, 14.4206(6); c, 18.2106(10) Å. The cation has approximate two-fold symmetry, with the CuN4 group tetrahedrally twisted, with NH groups alternating on opposite sides of the N4 group around the ring. The five-membered chelate rings have gauche conformations and the eight-membered chelate ring has an extended twist conformation. The anion and cation are linked into chains by hydrogen bonds and weak Cu···Cl interactions.
{"title":"Preparation and structure of 1RS,4SR,7SR,10RS- (1,4,7,10-tetraazacyclopentadecane)copper(II) tetrachlorozincate","authors":"N. F. Curtis, J. Wikaira","doi":"10.1080/2164232X.2013.868325","DOIUrl":"https://doi.org/10.1080/2164232X.2013.868325","url":null,"abstract":"The structure of 1RS,4SR,7SR,10RS-(1,4,7,10-tetraazacyclopentadecane)copper(II) tetrachlorozincate, determined at 120 K, is reported: C11H26Cl4CuN4Zn, orthorhombic, P b c a (Hall−P 2ac 2ab); a, 14.0675(7); b, 14.4206(6); c, 18.2106(10) Å. The cation has approximate two-fold symmetry, with the CuN4 group tetrahedrally twisted, with NH groups alternating on opposite sides of the N4 group around the ring. The five-membered chelate rings have gauche conformations and the eight-membered chelate ring has an extended twist conformation. The anion and cation are linked into chains by hydrogen bonds and weak Cu···Cl interactions.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"109 3","pages":"3 - 6"},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91461471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-17DOI: 10.1080/2164232X.2013.871620
Ya-Ping Duan, W. Xia, P. Tang, Dong‐sheng Li, W. Dong, Jack Y. Lu
The reactions of Co II or Ni II acetate with azobenzene-3,3′-dicarboxylic acid (3,3′-H2AZDB) and 1,2-bis(4-pyridyl)ethylene (bpe) afforded two isomorphic compounds [M 2(3,3′-AZDB)2(bpe)2]n (M=Co (1) and Ni (2)) under hydrothermal conditions. They were characterized by elemental analysis, IR spectra, thermogravimetric analysis and single-crystal X-ray diffraction technique. The structures of compounds 1 and 2 have similar 3-D 3-fold interpenetrating structures in which each 3-D net displayed a 6-connected pcu network consisting of M 2+-AZDB2− layers and bpe pillars. Variable-temperature magnetic-susceptibility measurements revealed the occurrence of weak antiferromagnetic interactions between the Co(II) atoms in 1.
{"title":"The first 3-fold interpenetrating framework containing both azobenzene-3,3′-dicarboxylicate and 1,2-bis(4-pyridyl)ethylene","authors":"Ya-Ping Duan, W. Xia, P. Tang, Dong‐sheng Li, W. Dong, Jack Y. Lu","doi":"10.1080/2164232X.2013.871620","DOIUrl":"https://doi.org/10.1080/2164232X.2013.871620","url":null,"abstract":"The reactions of Co II or Ni II acetate with azobenzene-3,3′-dicarboxylic acid (3,3′-H2AZDB) and 1,2-bis(4-pyridyl)ethylene (bpe) afforded two isomorphic compounds [M 2(3,3′-AZDB)2(bpe)2]n (M=Co (1) and Ni (2)) under hydrothermal conditions. They were characterized by elemental analysis, IR spectra, thermogravimetric analysis and single-crystal X-ray diffraction technique. The structures of compounds 1 and 2 have similar 3-D 3-fold interpenetrating structures in which each 3-D net displayed a 6-connected pcu network consisting of M 2+-AZDB2− layers and bpe pillars. Variable-temperature magnetic-susceptibility measurements revealed the occurrence of weak antiferromagnetic interactions between the Co(II) atoms in 1.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"39 1","pages":"122 - 127"},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77105054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-17DOI: 10.1080/2164232X.2014.883489
R. Hakimelahi, M. Mousazadeh
d-H2Pen-binding behavior to [VO(acac)2] at pH=7.00, 7.50 and 10.0 has been studied in thermodynamic viewpoint using UV/VIS spectroscopy. The optical absorption spectra of [VO(acac)2] were analyzed in order to obtain binding constants and stoichiometries using SQUAD software. The estimation of binding constant at various temperatures enabled us to calculate all of the thermodynamic parameters of binding using the van't Hoff equation. Studies of described reactions at pH=7.00, 7.50 and 10.0 show exothermic, endothermic and exothermic modality, respectively. d-penicillamine is a potentially tridentate ligand, but the pKa for the ‒ COOH, NH3 and S‒ H groups are 1.99–2.00, 8.0 and 10.6, respectively, as a result S‒H can not release proton at pH=7.00 and pH=7.50, so the coordination of S is not possible except at strong alkali mediums. At pH=7.00, d-H2Pen converts [VO(acac)2] to a vanadyl Schiff base complex (coordination mode is N2O2). At pH=7.50, d-H2Pen is converted to HPen− and the exchange of acac− with HPen− produces VO(HPen)2. It is clear that the coordination is formed via amine nitrogen and carboxylate oxygen. At pH=10.0, the main product is a vanadyl complex with the (S2O2) coordination mode. Studies in different ionic strengths of KCl confirm these products according to the number of ions in each medium. The formation constants of the products of VO(acac)2 with d-penicillamine at pH=7.00 and 7.50 are independent of ionic strength, but a Debye–Huckel-type equation was established for the dependence of the formation constant on ionic strength at pH=10.0.
{"title":"The specification of the production of three different complexes via thermodynamic investigations between vanadyl (IV) bis(acetylacetonate) and D-penicillamine at three various pHs","authors":"R. Hakimelahi, M. Mousazadeh","doi":"10.1080/2164232X.2014.883489","DOIUrl":"https://doi.org/10.1080/2164232X.2014.883489","url":null,"abstract":"d-H2Pen-binding behavior to [VO(acac)2] at pH=7.00, 7.50 and 10.0 has been studied in thermodynamic viewpoint using UV/VIS spectroscopy. The optical absorption spectra of [VO(acac)2] were analyzed in order to obtain binding constants and stoichiometries using SQUAD software. The estimation of binding constant at various temperatures enabled us to calculate all of the thermodynamic parameters of binding using the van't Hoff equation. Studies of described reactions at pH=7.00, 7.50 and 10.0 show exothermic, endothermic and exothermic modality, respectively. d-penicillamine is a potentially tridentate ligand, but the pKa for the ‒ COOH, NH3 and S‒ H groups are 1.99–2.00, 8.0 and 10.6, respectively, as a result S‒H can not release proton at pH=7.00 and pH=7.50, so the coordination of S is not possible except at strong alkali mediums. At pH=7.00, d-H2Pen converts [VO(acac)2] to a vanadyl Schiff base complex (coordination mode is N2O2). At pH=7.50, d-H2Pen is converted to HPen− and the exchange of acac− with HPen− produces VO(HPen)2. It is clear that the coordination is formed via amine nitrogen and carboxylate oxygen. At pH=10.0, the main product is a vanadyl complex with the (S2O2) coordination mode. Studies in different ionic strengths of KCl confirm these products according to the number of ions in each medium. The formation constants of the products of VO(acac)2 with d-penicillamine at pH=7.00 and 7.50 are independent of ionic strength, but a Debye–Huckel-type equation was established for the dependence of the formation constant on ionic strength at pH=10.0.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"17 1","pages":"52 - 56"},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88626850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-17DOI: 10.1080/2164232X.2014.883291
Yahia Z. Hamada, Nabil Bayakly, M. Shafi, S. Painter, Vanessa Taylor, J. Greene, Khalid Rosli
Formation of the metal complexes of aspartic acid (Asp) with the chromium metal ion (Cr3+) in solutions using potentiometric titrations is presented within a wide pH range (∼3.5 to ∼10.5) at 25°C and I=0.10 M NaNO3. Concentration distribution diagrams revealed that the main complex formed within this pH range is the bis Cr 3+ complex. Literature stability constant values for the Cr–Asp complexes were used to construct concentration distribution diagrams. Complexes taken into consideration were the simple one-to-one complex, the bis-complex, and the bis-mono-protonated complex, namely, Cr–Asp, Cr(Asp)2, and Cr(Asp)2H. The corresponding Log β values of these complexes were 12.46, 21.86, and 24.30, respectively. UV–Vis spectra demonstrate Cr 3+–Asp binding. The UV–Vis spectra were collected from a system that reached a high level of equilibrium state (50 days’ equilibrium time).
{"title":"Reactions of Cr3+ with aspartic acid within a wide pH range","authors":"Yahia Z. Hamada, Nabil Bayakly, M. Shafi, S. Painter, Vanessa Taylor, J. Greene, Khalid Rosli","doi":"10.1080/2164232X.2014.883291","DOIUrl":"https://doi.org/10.1080/2164232X.2014.883291","url":null,"abstract":"Formation of the metal complexes of aspartic acid (Asp) with the chromium metal ion (Cr3+) in solutions using potentiometric titrations is presented within a wide pH range (∼3.5 to ∼10.5) at 25°C and I=0.10 M NaNO3. Concentration distribution diagrams revealed that the main complex formed within this pH range is the bis Cr 3+ complex. Literature stability constant values for the Cr–Asp complexes were used to construct concentration distribution diagrams. Complexes taken into consideration were the simple one-to-one complex, the bis-complex, and the bis-mono-protonated complex, namely, Cr–Asp, Cr(Asp)2, and Cr(Asp)2H. The corresponding Log β values of these complexes were 12.46, 21.86, and 24.30, respectively. UV–Vis spectra demonstrate Cr 3+–Asp binding. The UV–Vis spectra were collected from a system that reached a high level of equilibrium state (50 days’ equilibrium time).","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"1 1","pages":"46 - 51"},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86440301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-17DOI: 10.1080/2164232X.2014.883290
R. Ahmed, T. A. Hamdan, A. Numan, M. J. Al-Jeboori, H. Potgieter
New biscarboxylato zwitterionic ligands, namely bis(N-carboxylatoethyl)-4,4′-dipyridinum) L1 and bis(N-carboxylatopropyl)-)-4,4′-dipyridinum) L2, were synthesized from the reaction of 4,4′-dipyridine with 3-bromopropanoic acid and 4-bromobutanoic acid, respectively. The reaction of these ligands and the azido coligand with some metal ions resulted in the formation of polymeric complexes of general formulae [Cr2(Ln)(N3)4]Cl2·H2O and [M2(Ln)(N3)4] xH2O, where (M=Mn (II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II); n=1, 2; x=1, 1, 1, 1, 0, 1, and 1, respectively.) The oxygens of the carboxylato group are coordinated to the metal ion in a bidentate fashion. The mode of bonding and overall geometry of the complexes were determined through IR, UV–VIS, NMR and mass spectral studies, magnetic moment measurements, elemental analysis, metal content, chloride content and conductance. These studies revealed the formation of polymeric assemblies of six-coordinate complexes with distorted octahedral geometries about metal centers.
{"title":"Formation of polymeric assemblies of six-coordinate metal complexes with mixed bridges of dicarboxylato-azido moieties","authors":"R. Ahmed, T. A. Hamdan, A. Numan, M. J. Al-Jeboori, H. Potgieter","doi":"10.1080/2164232X.2014.883290","DOIUrl":"https://doi.org/10.1080/2164232X.2014.883290","url":null,"abstract":"New biscarboxylato zwitterionic ligands, namely bis(N-carboxylatoethyl)-4,4′-dipyridinum) L1 and bis(N-carboxylatopropyl)-)-4,4′-dipyridinum) L2, were synthesized from the reaction of 4,4′-dipyridine with 3-bromopropanoic acid and 4-bromobutanoic acid, respectively. The reaction of these ligands and the azido coligand with some metal ions resulted in the formation of polymeric complexes of general formulae [Cr2(Ln)(N3)4]Cl2·H2O and [M2(Ln)(N3)4] xH2O, where (M=Mn (II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II); n=1, 2; x=1, 1, 1, 1, 0, 1, and 1, respectively.) The oxygens of the carboxylato group are coordinated to the metal ion in a bidentate fashion. The mode of bonding and overall geometry of the complexes were determined through IR, UV–VIS, NMR and mass spectral studies, magnetic moment measurements, elemental analysis, metal content, chloride content and conductance. These studies revealed the formation of polymeric assemblies of six-coordinate complexes with distorted octahedral geometries about metal centers.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"15 1","pages":"38 - 45"},"PeriodicalIF":0.0,"publicationDate":"2014-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89354724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-14DOI: 10.1080/2164232X.2014.883287
Durba Ganguly, Ratul Sarkar, R. Santra, Tathagata Deb, T. Sen, Saurabh Das
A major drawback of azo compounds is their associated toxicity, often carcinogenic, which is related to the reduction of the azo bond. This study intends to re-investigate this behavior by studying 5-amino-2-((3-hydroxy-4-((3-hydroxyphenyl) phenyl) diazenyl) phenol (AHPD), a compound containing two azo bonds. Interaction of AHPD and its dimeric Cu(II) complex with bacterial strains Escherichia coli and Staphylococcus aureus revealed the complex was less toxic. Reductive cleavage of the azo bond in AHPD and the complex followed using cytochrome c reductase (a model azo-reductase) as well as azo-reductase enzymes obtained from bacterial cell extracts. Degradation of the azo bond was less in the complex allowing us to correlate the observed cytotoxicity. Cyclic voltammetry on AHPD and the complex support observations of enzyme assay experiments. These were particularly useful in realizing the formation of amines as an outcome of the reductive cleavage of azo bonds in AHPD that could not be identified through an enzyme assay. Results suggest that complex formation of azo compounds could be a means to control the formation of amines responsible for cytotoxicity. Studies carried out on bacterial cells for mere simplicity bear significance for multicellular organisms and could be important for human beings involved with the preparation and utilization of azo dyes.
{"title":"Synthesis and characterization of 5-amino-2-((3-hydroxy-4-((3-hydroxyphenyl) phenyl) diazenyl) phenol and its Cu(II) complex – a strategy toward developing azo complexes for reduction of cytotoxicity","authors":"Durba Ganguly, Ratul Sarkar, R. Santra, Tathagata Deb, T. Sen, Saurabh Das","doi":"10.1080/2164232X.2014.883287","DOIUrl":"https://doi.org/10.1080/2164232X.2014.883287","url":null,"abstract":"A major drawback of azo compounds is their associated toxicity, often carcinogenic, which is related to the reduction of the azo bond. This study intends to re-investigate this behavior by studying 5-amino-2-((3-hydroxy-4-((3-hydroxyphenyl) phenyl) diazenyl) phenol (AHPD), a compound containing two azo bonds. Interaction of AHPD and its dimeric Cu(II) complex with bacterial strains Escherichia coli and Staphylococcus aureus revealed the complex was less toxic. Reductive cleavage of the azo bond in AHPD and the complex followed using cytochrome c reductase (a model azo-reductase) as well as azo-reductase enzymes obtained from bacterial cell extracts. Degradation of the azo bond was less in the complex allowing us to correlate the observed cytotoxicity. Cyclic voltammetry on AHPD and the complex support observations of enzyme assay experiments. These were particularly useful in realizing the formation of amines as an outcome of the reductive cleavage of azo bonds in AHPD that could not be identified through an enzyme assay. Results suggest that complex formation of azo compounds could be a means to control the formation of amines responsible for cytotoxicity. Studies carried out on bacterial cells for mere simplicity bear significance for multicellular organisms and could be important for human beings involved with the preparation and utilization of azo dyes.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"1 1","pages":"13 - 22"},"PeriodicalIF":0.0,"publicationDate":"2014-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76732997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-14DOI: 10.1080/2164232X.2013.873992
J. Marques, Vera L. M. Silva, Artur M. S. Silva, Mario Monteiro Marques, S. Braga
The ruthenium(II) complex [Ru([9]aneS 3)(phpz)Cl 2] (1) ([9]aneS 3=trithiacyclononane, phpz=5-(2- hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole]) was readily isolated by reacting [Ru([9]aneS 3)(DMSO)Cl 2] with one equivalent of the ligand phpz. A combination of MS, FT–IR and solution NMR studies (1-D and 2-D) was employed to determine the structural formula of the complex 1, in which phpz coordinates in a monodentate mode to Ru(II) by a simple replacement of the leaving group DMSO of the precursor. The cytotoxic properties of 1 in vitro were investigated by determination of the half-maximal growth inhibition on the human prostate (PC-3) and breast cancer cells (MDA-MB-231).
{"title":"Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells","authors":"J. Marques, Vera L. M. Silva, Artur M. S. Silva, Mario Monteiro Marques, S. Braga","doi":"10.1080/2164232X.2013.873992","DOIUrl":"https://doi.org/10.1080/2164232X.2013.873992","url":null,"abstract":"The ruthenium(II) complex [Ru([9]aneS 3)(phpz)Cl 2] (1) ([9]aneS 3=trithiacyclononane, phpz=5-(2- hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole]) was readily isolated by reacting [Ru([9]aneS 3)(DMSO)Cl 2] with one equivalent of the ligand phpz. A combination of MS, FT–IR and solution NMR studies (1-D and 2-D) was employed to determine the structural formula of the complex 1, in which phpz coordinates in a monodentate mode to Ru(II) by a simple replacement of the leaving group DMSO of the precursor. The cytotoxic properties of 1 in vitro were investigated by determination of the half-maximal growth inhibition on the human prostate (PC-3) and breast cancer cells (MDA-MB-231).","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"1 1","pages":"12 - 7"},"PeriodicalIF":0.0,"publicationDate":"2014-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88296285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-14DOI: 10.1080/2164232X.2014.883288
H. Mansouri‐Torshizi, S. Shahraki, Z. Nezami, A. Ghahghaei, Sahebeh Najmedini, A. Divsalar, Hamed Ghaemi, A. Saboury
Two Pd(II) and Pt(II) complexes ([Pt(bpy)(pr-dtc)]Br and [Pd(bpy)(pr-dtc)]Br, where bpy=2, 2′-bipyridine and pr-dtc = n-propyldithiocarbamate) were synthesized and characterized by elemental analysis (CHN), molar conductivity measurements, Fourier transform infrared, 1H nuclear magnetic resonance and UV–visible techniques. In these complexes, the dithiocarbamato ligand coordinates to Pt(II) or Pd(II) center as bidentate with two sulfur atoms. The binding of these complexes to calf thymus DNA (CT-DNA) was investigated using various physicochemical methods such as spectrophotometric, spectrofluorometric and gel filtration technique. The experimental results indicate that Pt(II) and Pd(II) complexes interact with CT-DNA in the intercalative mode. Both complexes unexpectedly denatured DNA at low concentration. Gel filtration studies indicated that the binding of complexes with DNA is strong enough and does not break readily. The cytotoxic activity of these metal complexes has been tested against human cell tumor lines (K562) and revealed much lower 50% cytotoxic concentration (Cc50) less than that of cisplatin. Several binding and thermodynamic parameters are also described.
{"title":"Platinum(II)/palladium(II) complexes with n-propyldithiocarbamate and 2,2′-bipyridine: synthesis, characterization, biological activity and interaction with calf thymus DNA","authors":"H. Mansouri‐Torshizi, S. Shahraki, Z. Nezami, A. Ghahghaei, Sahebeh Najmedini, A. Divsalar, Hamed Ghaemi, A. Saboury","doi":"10.1080/2164232X.2014.883288","DOIUrl":"https://doi.org/10.1080/2164232X.2014.883288","url":null,"abstract":"Two Pd(II) and Pt(II) complexes ([Pt(bpy)(pr-dtc)]Br and [Pd(bpy)(pr-dtc)]Br, where bpy=2, 2′-bipyridine and pr-dtc = n-propyldithiocarbamate) were synthesized and characterized by elemental analysis (CHN), molar conductivity measurements, Fourier transform infrared, 1H nuclear magnetic resonance and UV–visible techniques. In these complexes, the dithiocarbamato ligand coordinates to Pt(II) or Pd(II) center as bidentate with two sulfur atoms. The binding of these complexes to calf thymus DNA (CT-DNA) was investigated using various physicochemical methods such as spectrophotometric, spectrofluorometric and gel filtration technique. The experimental results indicate that Pt(II) and Pd(II) complexes interact with CT-DNA in the intercalative mode. Both complexes unexpectedly denatured DNA at low concentration. Gel filtration studies indicated that the binding of complexes with DNA is strong enough and does not break readily. The cytotoxic activity of these metal complexes has been tested against human cell tumor lines (K562) and revealed much lower 50% cytotoxic concentration (Cc50) less than that of cisplatin. Several binding and thermodynamic parameters are also described.","PeriodicalId":10590,"journal":{"name":"Complex Metals","volume":"12 1","pages":"23 - 31"},"PeriodicalIF":0.0,"publicationDate":"2014-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84094594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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