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2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献

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Evaluation of gait parameter estimation accuracy: a comparison between commercial IMU and optical capture motion system 步态参数估计精度的评价:商用IMU与光学捕捉运动系统的比较
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856475
Luisa Ruiz-Ruiz, Fernando Seco Granja, A. R. Jiménez, Sara Garcia, J. J. García
In the elderly, there are several pathologies that can be identified from gait parameters such as frailty, fall risk and cognitive decline. Gait analysis is a successful method for the detection and diagnosis of gait-related diseases, being Inertial Measurement Units (IMUs) one of the most widely used (low cost, accuracy and portability). In this work, we analyse the accuracy of gait parameters estimation using a commercial IMU (Physilog 6S from GaitUp) versus the Optitrack System as gold standard. We carry out an in-depth comparison of the gait parameters obtained using the manufacturer software (GaitUp Lab) and our own algorithms based on an inertial navigation with zero velocity update at stance algorithm (INS- ZUPT). Several tests were performed by 2 healthy subjects walking in different ways (normal, high step, dragging the feet and feet drop).
在老年人中,有几种病理可以从步态参数中识别出来,如虚弱、跌倒风险和认知能力下降。步态分析是一种检测和诊断步态相关疾病的成功方法,是惯性测量单元(imu)中应用最广泛的一种(成本低、精度高、便携性好)。在这项工作中,我们分析了使用商用IMU(来自GaitUp的Physilog 6S)与Optitrack系统作为金标准的步态参数估计的准确性。基于惯性导航零速度姿态更新算法(INS- ZUPT),我们对使用制造商软件(GaitUp Lab)和我们自己的算法获得的步态参数进行了深入的比较。2名健康受试者以不同的步行方式(正常、高步、拖脚和落脚)进行多项测试。
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引用次数: 3
On the Detection of High-Quality, High-Density Electromyograms During 80m Sprints: a Case Study 在80米短跑中检测高质量、高密度的肌电图:一个案例研究
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856504
Riccardo Nicola, G. L. Cerone, M. Caruso, Rachele Rossanigo, A. Cereatti, T. Vieira
Surface electromyograms (EMGs) have been often used to study muscle function in locomotor activities. Typically, EMGs are sampled with a single pair of electrodes, providing information on the timing and degree of muscle excitation. Additional information may be obtained when sampling EMGs with multiple electrodes from the same, target muscles. Studies using high-density EMGs (HD-EMGs) in locomotor activities are limited to laboratory settings and low speed tasks, likely due to the technical shortcomings in the commercially available systems for high-density recordings. This issue is further aggravated when kinematics data are necessary for associating EMGs with events of interest during the movement cycle. By combining two systems, ad hoc developed for the on-field recording of kinematics data and HD-EMGs, here we present single-case results during extreme-speed locomotion-the 80 m sprint on an official, athletic track. Our aim was to verify whether descriptors of quality documented in the EMG literature during well-controlled, isometric contractions, apply to the HD-EMGs we detected and segmented with respect to the running cycles. From a single, elite sprinter, we were able to obtain HD-EMGs with negligible movement artifacts and with temporal profiles typically characterizing action potentials of single motor units. Our results would seem to advocate the possibility of using HD-EMG to study muscle function during highly dynamic contractions outside the laboratory settings.
表面肌电图(EMGs)常用于研究运动活动中的肌肉功能。通常,肌电图是用一对电极采样,提供肌肉兴奋的时间和程度的信息。当用多个电极从相同的目标肌肉取样肌电信号时,可以获得额外的信息。在运动活动中使用高密度肌电信号(hd - emg)的研究仅限于实验室设置和低速任务,可能是由于商用高密度记录系统的技术缺陷。当需要运动学数据将肌电信号与运动周期中感兴趣的事件联系起来时,这个问题进一步加剧。通过结合两种专门用于现场记录运动学数据和hd - emg的系统,我们在这里展示了极端速度运动(在官方田径跑道上进行80米短跑)的单一案例结果。我们的目的是验证在控制良好的等距收缩过程中,肌电图文献中记录的质量描述符是否适用于我们根据运行周期检测和分割的hd肌电图。从一个优秀的短跑运动员身上,我们能够获得可以忽略的运动伪影的hd - emg,以及单个运动单元的典型动作电位的时间特征。我们的结果似乎提倡在实验室环境外使用HD-EMG研究高动态收缩期间肌肉功能的可能性。
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引用次数: 0
Monitoring of the Viscoelastic Behaviour of Bacterial Biofilms Exploiting an Accurate QCM System 利用精确QCM系统监测细菌生物膜的粘弹性行为
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856431
A. Fort, Elia Landi, Anna Lo Grasso, M. Mugnaini, E. Panzardi, V. Vignoli, Fariba Fahmideh Mahdizadeh, A. Magnani
The presence of bacteria forming biofilm is pervasive in our daily life and may lead to beneficial effects or, more frequently, to adverse consequences. The monitoring of the biofilm formation process and of the related physical parameters, is essential not only for the investigation of the biofilm internal structure but also because it offers the possibility to take prompt actions to either control or counteract the growth process. In this paper the measurement problem related to the real-time monitoring of biofilm growth through Quartz Crystal Microbalance (QCM) is analyzed. After a theoretical analysis, experimental data are discussed, consisting in the long-term monitoring of the activity of Pseudomonas fluorescens bacteria. The developed prototype measurement system is based on a Mecham bridge oscillator topology and allows to accurately monitor the quartz resonance frequency and the motional resistance in real time. In particular, the bacteria adhesion process, the biofilm growth and the complex impact which has on the QCM response, related to the soft particles and media attached on the quartz surface is analyzed. The presented results demonstrate the suitability of the developed system for this kind of applications. The excellent stability and frequency resolution of the measurement system allows for the analysis of biological processes and is a useful tool for collecting information concerning the physical characteristics of the observed biological media.
形成生物膜的细菌在我们的日常生活中无处不在,可能会产生有益的影响,但更常见的是,会产生不利的后果。监测生物膜的形成过程和相关的物理参数,不仅对研究生物膜的内部结构至关重要,而且因为它提供了迅速采取行动控制或抵消生长过程的可能性。本文分析了利用石英晶体微天平(QCM)实时监测生物膜生长的测量问题。经过理论分析,讨论了实验数据,包括长期监测荧光假单胞菌的活性。开发的原型测量系统基于Mecham桥振荡器拓扑结构,可以实时准确地监测石英谐振频率和运动电阻。特别分析了石英表面附着的软颗粒和介质对细菌粘附过程、生物膜生长及其对QCM响应的复杂影响。结果表明,所开发的系统适合此类应用。测量系统的优异稳定性和频率分辨率允许对生物过程进行分析,并且是收集有关所观察生物介质的物理特性信息的有用工具。
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引用次数: 1
Comparison of U -NET backbones for morphometric measurements of white blood cell 白细胞形态测量用U -NET主干的比较
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856479
Imran Ahmed, D. L. Carní, E. Balestrieri, F. Lamonaca
Measurements of Morphometric Parameters of Blood Cells (MPBC) playa key role in haematological examination, and it is considered as one of the principal needs for clinicians in the diagnosis of various diseases in human and animals. Obliviously, the correctness of the diagnosis, and, as a consequence, the effectiveness of clinician actions is highly dependent on the accuracy of MPBC measurements. In this context, deep learning based MPBC measurement systems are a promising solution. In recent studies, researchers have applied semantic segmentation with various backbone networks for white blood cell measurements. Vice versa, few investigations were done about the achieved accuracy. Indeed, accurate segmentation of white blood cell remains a challenging task because of the complex nature of cell images, staining techniques, and imaging conditions which strongly affects the accuracy of the MPBC measurements. This paper presents a comparison among the segmentation performance carried out by U-Net deep learning algorithm with different backbones typically used for MPBC. The goal is to make a first step towards a whole MPBC measurement system capable of evaluating the effects of the influencing magnitudes, attenuate them (if possible), and evaluate the accuracy of the measurements. The aims are to increase measurement reliability and to give clinicians further information to take their decisions.
血细胞形态参数(MPBC)的测量在血液学检查中起着关键作用,被认为是临床医生诊断人类和动物各种疾病的主要需求之一。显然,诊断的正确性,以及临床医生行动的有效性高度依赖于MPBC测量的准确性。在这种情况下,基于深度学习的MPBC测量系统是一个很有前途的解决方案。在最近的研究中,研究人员将语义分割与各种骨干网络应用于白细胞测量。反之亦然,对所获得的准确性进行的调查很少。事实上,白细胞的准确分割仍然是一项具有挑战性的任务,因为细胞图像、染色技术和成像条件的复杂性强烈影响MPBC测量的准确性。本文比较了U-Net深度学习算法在MPBC中常用的不同主干网下的分割性能。目标是朝着整个MPBC测量系统迈出第一步,该系统能够评估影响幅度的影响,衰减它们(如果可能的话),并评估测量的准确性。目的是提高测量的可靠性,并为临床医生提供进一步的信息来做出决定。
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引用次数: 2
Estimating Spatial Gait Parameters from the Planar Covariation of Lower Limb Elevation Angles: a Pilot Study 从下肢仰角的平面共变估计空间步态参数:一项初步研究
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856500
Simone Ranaldi, S. Conforto, C. D. Marchis
When characterizing human gait control strategies, theories based on the modularity of the neuromuscular system have been proven to be powerful in providing a compact description of the gait patterns. The planar covariation law of lower limb elevation angles has been proposed as a compact, modular description of gait kinematics. In this paper, we exploit this model for characterizing healthy subjects' spatial gait parameters during walking at different speeds, one self-selected and one slightly slower than the subject's comfortable pace. Different geometrical features have been calculated over the gait loop, that is the planar loop defined by the covariation of the thigh, shank and foot elevation angles. A correlation analysis has been carried out between these features and classical gait spatial parameters (step length, step width, stride length and foot clearance) by training a linear regressor on the dataset comprising both speeds. The results from this analysis have highlighted a correlation with some spatial gait parameters across the two speed conditions, indicating that this compact description of kinematics unravels a significant biomechanical meaning. These results can be exploited to guide the control mechanisms of external assistive devices, such as prostheses or exoskeletons, based purely on the measurement of few relevant kinematic quantities of the lower limb segments.
在描述人类步态控制策略时,基于神经肌肉系统模块化的理论已被证明在提供步态模式的紧凑描述方面是强大的。提出了下肢仰角平面共变规律,作为一种紧凑、模块化的步态运动学描述。在本文中,我们利用该模型来表征健康受试者在不同速度下的空间步态参数,一个是自我选择的,一个是略慢于受试者舒适的步伐。在步态环上计算了不同的几何特征,即由大腿、小腿和足的仰角共变定义的平面环。通过在包含两种速度的数据集上训练线性回归器,对这些特征与经典步态空间参数(步长、步宽、步长和足间隙)进行相关性分析。该分析结果强调了在两种速度条件下与一些空间步态参数的相关性,表明这种紧凑的运动学描述揭示了重要的生物力学意义。这些结果可以用来指导外部辅助装置的控制机制,如假体或外骨骼,纯粹基于下肢部分的几个相关运动学量的测量。
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引用次数: 1
The Impact of Ankle-Foot Orthoses on Spatio-Temporal Gait Parameters in Drop-Foot Patients 踝足矫形器对落脚患者时空步态参数的影响
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856440
F. Amitrano, A. Coccia, G. Pagano, L. Dileo, E. Losavio, G. Tombolini, G. D'Addio
Drop foot syndrome represents a deficit in locomotion, resulting from pathologies such as stroke, brain or spinal cord injury and other neurological diseases. In order to improve the quality of life of people suffering from this impairment, a widely used orthopaedic support is the “ankle foot orthosis-AFO”. This aid is applied externally to patients with drop foot syndrome in order to support plantar flexion after heel strike and subsequently allow the foot to be extended. The purpose of this study is to investigate the effect and clinical relevance of the use of an AFO on walking ability in patients suffering Drop-Foot syndrome. The experimental procedures to collect data consisted of gait analysis sessions performed with the Mobility Lab system by APDM, based on Inertial Measurement Units (IMUs) data. The analysis was carried out on a group of 19 patients with unilateral Drop-Foot syndrome, by means of ANOVA statistical test, to verify the differences among limbs and the effects of the use of the AFO. Results show a significant difference, between the affected and contralateral limb, in the following spatio-temporal metrics: Foot Clearance at Mid-Swing, Stance Duration and Swing Duration. Moreover, the considered AFO does not produce significant improvements on these parameters. The Step Duration differs significantly among limbs and improves when walking with AFO. Finally, the use of the orthotic device in the analysed population produces a significant change also in the following parameters: Gait Cycle Time and Cadence.
下垂足综合症是一种运动障碍,由中风、脑或脊髓损伤以及其他神经系统疾病等病理引起。为了改善患有这种损伤的人的生活质量,一种广泛使用的矫形支持是“踝足矫形器- afo”。这种辅助装置用于下垂足综合征患者的外部,以便在脚跟撞击后支持足底屈曲,随后允许足部伸展。本研究的目的是探讨使用AFO对落脚综合征患者行走能力的影响及其临床意义。收集数据的实验程序包括基于惯性测量单元(imu)数据,通过APDM移动实验室系统进行步态分析。对19例单侧下垂足综合征患者进行分析,采用方差分析(ANOVA)统计检验,验证四肢间差异及使用AFO的效果。结果显示,受影响肢体和对侧肢体在以下时空指标上存在显著差异:摇摆中期足部间隙、站立持续时间和摇摆持续时间。此外,所考虑的AFO不会对这些参数产生显著的改进。步长在四肢之间有显著差异,在有AFO行走时得到改善。最后,在分析人群中使用矫形器也会在以下参数上产生显著变化:步态周期时间和节奏。
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引用次数: 1
Comparison of Hierarchical and Partitional Clustering in Multi-Source Phonocardiography 多源心音图的分层聚类与局部聚类比较
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856547
N. Giordano, S. Rosati, M. Knaflitz, G. Balestra
Phonocardiography (PCG) has proved a valuable tool over the years to monitor the status of at-risk patients for some cardiovascular diseases. Its multi-source version, consisting of the simultaneous recording of multiple acoustic signals from different points of the patient's chest, is currently under research as a solution to develop wearable devices based on PCG and bring PCG to the patient's domicile. When a high number of PCG signals are available, to define the most suitable auscultation area, depending on the clinical question, clustering comes into the picture. In this work, we applied agglomerative hierarchical clustering and k-means to multi-source PCG recordings. A similarity metrics based on the correlation of the signals was used to compare the signals based on their morphological characteristics. The two clustering methods resulted in a Rand Index averagely higher than 0.84, showing a high level of agreement and validating the usage of clustering for the application of interest. Hierarchical clustering allowed for obtaining a better trade-off between the intra-cluster variability and the inter-cluster distance. Adding to its deterministic nature, it should be considered as preferrable with respect to k-means. This work moves one step further to the development a reliable wearable device based on digital auscultation for the monitoring of the patient at its domicile.
多年来,心音图(PCG)已被证明是监测某些心血管疾病高危患者状态的宝贵工具。它的多源版本,包括同时记录来自患者胸部不同位置的多个声学信号,目前正在研究中,作为开发基于PCG的可穿戴设备的解决方案,并将PCG带到患者的住所。当有大量的PCG信号可用时,根据临床问题确定最合适的听诊区域,聚类就出现了。在这项工作中,我们将聚类分层聚类和k-means应用于多源PCG记录。采用基于信号相关性的相似性度量,根据信号的形态特征对信号进行比较。两种聚类方法的Rand指数平均高于0.84,显示出高度的一致性,并验证了聚类对兴趣应用的使用。分层聚类允许在簇内可变性和簇间距离之间获得更好的权衡。再加上它的确定性,相对于k-means,它应该被认为是更可取的。这项工作进一步发展了一种可靠的基于数字听诊的可穿戴设备,用于在其住所监测患者。
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引用次数: 1
Application of mHealth Technologies to Improve Self-Control of Children and Adolescents with Type 1 Diabetes 应用移动健康技术提高1型糖尿病儿童和青少年自我控制能力
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856485
N. Zholdas, M. Mansurova, Magzhan Sarsembayev, O. Postolache, A. Shomanov, T. Sarsembayeva
Our research has shown that the use of mobile technologies (mHealth) to improve self-control of children and adolescents with diabetes, as well as for parental control, gives positive results. A functional implemented in a mobile application has been developed that contains recommendations from endocrinologists based on the analysis of data from sensors, taking into account the individual characteristics of the patient's body. Digital health profiles of patients with diabetes mellitus, containing the values of state indicators obtained from various sensors, mobile phones, medical watches and fitness bracelets, make it possible to develop systems for monitoring and supporting personalized decision-making. By observing a patient's digital profile, clinicians can determine some of the possible causes of deviations in glucose readings in predetermined time segments. During the project, under the close supervision of endocrinologists and a pediatrician, patient data were collected, such as continuous monitoring glucose sensor values, fitness bracelet records, anthropometric data, disease and family history data, eating behavior data, HbAl c (glycated hemoglobin) level data in beginning and end of the study to assess carbohydrate metabolism compensation, FA (fructosamine) level data twice during the study period in order to short-term assess the degree of carbohydrate metabolism compensation, general blood analysis and general urine analysis data in order to additionally assess the reliability of previous tests for data analysis.
我们的研究表明,使用移动技术(移动健康)来提高患有糖尿病的儿童和青少年的自我控制能力,以及父母的控制,产生了积极的结果。在移动应用程序中实现了一个功能,该功能包含内分泌学家基于传感器数据分析的建议,并考虑到患者身体的个体特征。糖尿病患者的数字健康概况,包含从各种传感器、移动电话、医疗手表和健身手环获得的状态指标值,使开发监测和支持个性化决策的系统成为可能。通过观察患者的数字档案,临床医生可以确定在预定时间段内血糖读数偏差的一些可能原因。项目期间,在内分泌科医生和儿科医生的密切监督下,收集患者数据,如持续监测血糖传感器值、健身手环记录、人体测量数据、疾病和家族史数据、饮食行为数据、研究开始和结束时的HbAl c(糖化血红蛋白)水平数据,以评估碳水化合物代谢代偿。研究期间两次FA(果糖胺)水平数据,以短期评估碳水化合物代谢代偿程度,一般血液分析和一般尿液分析数据,以额外评估以往测试数据分析的可靠性。
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引用次数: 0
Reliability analysis of muscle stiffness estimation in varied loading levels by using dynamic myotonometric measurements 在不同负荷水平下用动态肌测法估计肌肉刚度的可靠性分析
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856463
S. Banerjee, A. Arunachalakasi, S. Ramakrishnan
Measurement of skeletal muscle stiffness can provide a noninvasive estimation of its contraction level. Myotonometry is a novel technique for estimating muscle stiffness using digital palpation method. In this study, the reliability of myotonometric measurements with varied loading conditions is explored. For this purpose, eight healthy young participants (6 male, age 25.00 ± 3.94 years) are recruited to perform isometric elbow flexion tasks. Myotonometric signal is recorded from the biceps brachii muscle belly at resting and at isometric no-load, isometric 3 kg, and isometric 6 kg loading conditions from both hands. Three observations are made per trial and Dynamic Stiffness (DS) values are calculated from the recorded signals. Modified Bland and Altman's method and subsequent interclass correlation coefficients (ICCs) are determined for DS in each loading configuration. Point biserial correlation analysis has been performed to explore the effect of incremental loading on DS. Excellent agreement between the observations has been found for all the loading configurations with high ICC scores of more than 0.9. DS is observed to vary linearly with the increasing loading intensity with the R value of 0.73 for the right and 0.92 for the left hand. The results demonstrate that myotonometric measurements give reliable measurements of muscle stiffness in sub maximal contractions. Linear variation of DS with increasing loading intensity is observed for both hands, although the variation is more consistent in the left hand. The results of the present study might be clinically relevant in noninvasively estimating the muscle contraction level and designing better rehabilitative strategies.
测量骨骼肌的刚度可以提供一个无创的估计其收缩水平。肌张力测量是一种利用数字触诊法估计肌肉僵硬度的新技术。本研究探讨了不同负荷条件下肌力测量的可靠性。为此,我们招募了8名健康的年轻参与者(6名男性,年龄25.00±3.94岁)进行等距肘关节屈曲任务。在静息和等距空载、等距3公斤和等距6公斤负荷条件下,从双手记录肱二头肌腹部的肌测信号。每次试验进行三次观测,并根据记录的信号计算动态刚度(DS)值。改进的Bland和Altman方法和随后的类间相关系数(ICCs)被确定在每个加载配置的DS。点双列相关分析探讨了增量加载对DS的影响。对于ICC分数大于0.9的所有加载配置,观察结果之间的一致性非常好。DS随载荷强度的增加呈线性变化,右侧R值为0.73,左侧R值为0.92。结果表明,肌张力测量提供了可靠的测量肌肉的刚度在亚最大收缩。双手DS随载荷强度的增加呈线性变化,但左手DS的变化更为一致。本研究结果可能对无创评估肌肉收缩水平和设计更好的康复策略具有临床意义。
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引用次数: 0
Development and Experimental Validation of an Artificial Neural Network Model of a Microwave Microstrip Resonator for Humidity Sensing 微波微带湿度传感人工神经网络模型的研制与实验验证
Pub Date : 2022-06-22 DOI: 10.1109/MeMeA54994.2022.9856501
Z. Marinković, G. Gugliandolo, A. Quattrocchi, G. Campobello, G. Crupi, N. Donato
The focus of this paper is on the modeling of a gas sensor based on a microwave microstrip resonator aimed for humidity detection. This is because humidity sensors have been widely applied in different fields, like healthcare, environmental monitoring, meteorology, and industrial processes. The propagative structure of a microwave resonator sensor is covered with a humidity sensing layer whose frequency dielectric properties vary with the change of humidity, causing changes in the sensor microwave properties. The frequency- and humidity- dependent behavior of the reflection coefficient of the studied sensor is modelled by using artificial neural networks (ANNs). To achieve a model which will reliably and accurately predict the reflection coefficient, the prior knowledge input (PKI) approach is implemented. The data used for the model development have been acquired by measuring the reflection coefficient in the frequency range (3.4 ÷ 5.6) GHz and for different relative humidity values, in the range (0 ÷ 83) %rh. The ANN-based model has been developed and experimentally validated, allowing an accurate reproduction of the measured properties of such sensor under test and prediction even at an operating condition not used during the ANN training. This demonstrates the good capabilities of the achieved model to learn and generalize.
本文重点研究了一种基于微波微带谐振腔的湿度检测气体传感器的建模。这是因为湿度传感器已广泛应用于不同领域,如医疗保健,环境监测,气象和工业过程。在微波谐振器传感器的传播结构上覆盖一层湿度传感层,其频率介电特性随湿度的变化而变化,从而引起传感器微波特性的变化。利用人工神经网络建立了传感器反射系数随频率和湿度变化的模型。为了获得一个能够可靠、准确地预测反射系数的模型,采用了先验知识输入(PKI)方法。用于模型开发的数据是通过测量频率范围(3.4 ÷ 5.6) GHz和不同相对湿度值范围(0 ÷ 83) %rh的反射系数获得的。基于人工神经网络的模型已经开发并经过实验验证,即使在人工神经网络训练期间未使用的操作条件下,也可以在测试和预测中准确再现此类传感器的测量特性。这证明了所实现的模型具有良好的学习和泛化能力。
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引用次数: 1
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2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)
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