Aim of the study Resection of tumours of the oral cavity has significant consequences relating to function and aesthetic properties. Advancements in surgical techniques and microvascular surgery have enabled reconstructive outcomes to reach those of pre-surgery levels with good functional and aesthetic results. However, reconstructive options are not without complications. Material and methods We report the outcome of 23 patients with large tumours of the oral cavity or floor of the mouth, who underwent resection of the tumour and parts of the mandible without bony reconstruction. The patient population consisted of 19 oropharyngeal carcinomas and four floor of the mouth cancers, all of which had stage cT4 (six female and 17 male patients), and with an average patient age of 59.8 years. The pre- and postoperative ability to open the mouth, level of pain while masticating, mastication function pre and post-surgery, and the aesthetic outcome post-surgery were measured. Results The results obtained were deemed pleasantly acceptable by the patients, from aesthetic, functional, and analgesic points of view. Discussion A thorough preoperative work up is required and discussion with a multidisciplinary team is a necessity. This treatment option is more acceptable to the patient than would be expected and provides a satisfactory functional and aesthetic outcome. Therefore, we believe that partial mandibulectomy without bony reconstruction is an acceptable management option for a carefully selected group of patients who may not be suitable for the extensive surgery involved with bony reconstruction.
{"title":"Partial mandibulectomy without bony reconstruction in patients with oropharyngeal or mouth cancer","authors":"T. Schrom, F. Bast, S. Knipping","doi":"10.5114/wo.2019.87575","DOIUrl":"https://doi.org/10.5114/wo.2019.87575","url":null,"abstract":"Aim of the study Resection of tumours of the oral cavity has significant consequences relating to function and aesthetic properties. Advancements in surgical techniques and microvascular surgery have enabled reconstructive outcomes to reach those of pre-surgery levels with good functional and aesthetic results. However, reconstructive options are not without complications. Material and methods We report the outcome of 23 patients with large tumours of the oral cavity or floor of the mouth, who underwent resection of the tumour and parts of the mandible without bony reconstruction. The patient population consisted of 19 oropharyngeal carcinomas and four floor of the mouth cancers, all of which had stage cT4 (six female and 17 male patients), and with an average patient age of 59.8 years. The pre- and postoperative ability to open the mouth, level of pain while masticating, mastication function pre and post-surgery, and the aesthetic outcome post-surgery were measured. Results The results obtained were deemed pleasantly acceptable by the patients, from aesthetic, functional, and analgesic points of view. Discussion A thorough preoperative work up is required and discussion with a multidisciplinary team is a necessity. This treatment option is more acceptable to the patient than would be expected and provides a satisfactory functional and aesthetic outcome. Therefore, we believe that partial mandibulectomy without bony reconstruction is an acceptable management option for a carefully selected group of patients who may not be suitable for the extensive surgery involved with bony reconstruction.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"35 1","pages":"146 - 150"},"PeriodicalIF":0.0,"publicationDate":"2019-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74631974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The consequence of total laryngectomy is complete loss or disorder of smell. The change may affect daily life and decrease the standard of living of people after larynx removal. A study was carried out in a group of 19 people in order to demonstrate whether applying nasal airflow-inducing maneuvers improves smell. The research was conducted during rehabilitation by the seaside in 2018. The group included 6 women and 13 men. There were two tests. The first was done before presentation of nasal airflow-inducing maneuvers. The group received 10 fragrances and were asked to identify them. Next nasal airflow-inducing maneuvers were presented and a training session was carried out. The second test was performed. According to the analysis of results, in most participants their odor sensation improved, but to different levels. Smell exercise in necessary in rehabilitation of patients after larynx removal. A person who can conduct olfactory therapy can be a speech therapist.
{"title":"Applying nasal airflow – inducing maneuvers with patients with hyposmia after total laryngectomy","authors":"Agnieszka Hamerlińska","doi":"10.5114/wo.2019.86688","DOIUrl":"https://doi.org/10.5114/wo.2019.86688","url":null,"abstract":"The consequence of total laryngectomy is complete loss or disorder of smell. The change may affect daily life and decrease the standard of living of people after larynx removal. A study was carried out in a group of 19 people in order to demonstrate whether applying nasal airflow-inducing maneuvers improves smell. The research was conducted during rehabilitation by the seaside in 2018. The group included 6 women and 13 men. There were two tests. The first was done before presentation of nasal airflow-inducing maneuvers. The group received 10 fragrances and were asked to identify them. Next nasal airflow-inducing maneuvers were presented and a training session was carried out. The second test was performed. According to the analysis of results, in most participants their odor sensation improved, but to different levels. Smell exercise in necessary in rehabilitation of patients after larynx removal. A person who can conduct olfactory therapy can be a speech therapist.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"18 1","pages":"141 - 145"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84588183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim of the study The aim of the study was to determine the psychological factors that will help reduce the level of stress in people supporting leukaemia patients. Material and methods The study group consisted of 100 close relatives supporting leukaemia patients (66 women and 34 men). The study included close relatives who supported patients with the diagnosis of leukaemia. A standardized interview and the questionnaires CISS, SES, SOC-29, STAI, and the Questionnaire of Perceived Control of Life were used in the study. Results The research results show that 65% of the respondents indicate the illness of a close relative as the main source of stress. Among the respondents, the emotion-oriented style (β = 0.301, p = 0.008) and anxious personality (β = 0.560, p = 0.000) proved to be predictors of stress. Stress is counteracted by a sense of coherence (β = –0.294, p = 0.028). Conclusions In respect of struggling with stress by people supporting leukaemia patients, releasing accumulated tension and formulating negative emotions are the key issues. The strengthening of the sense of coherence will also be crucial.
研究的目的研究的目的是确定心理因素，这些因素将有助于降低支持白血病患者的人的压力水平。材料与方法研究对象为100例支持白血病患者的近亲属，其中女性66例，男性34例。研究对象包括支持白血病诊断的患者的近亲。采用标准化访谈法，采用问卷CISS、SES、SOC-29、STAI和生活感知控制问卷。结果研究结果显示，65%的受访者表示近亲的疾病是主要的压力来源。在被调查者中，情绪导向型人格(β = 0.301, p = 0.008)和焦虑型人格(β = 0.560, p = 0.000)被证明是压力的预测因子。压力被连贯性抵消(β = -0.294, p = 0.028)。结论支持白血病患者的人在应对压力时，释放累积的紧张情绪，形成负面情绪是关键。加强一致性也将是至关重要的。
{"title":"Predictors of stress in close relatives supporting patients with leukaemia","authors":"Anna Kaczmarska-Tabor, H. Wrona-Polańska","doi":"10.5114/wo.2019.85883","DOIUrl":"https://doi.org/10.5114/wo.2019.85883","url":null,"abstract":"Aim of the study The aim of the study was to determine the psychological factors that will help reduce the level of stress in people supporting leukaemia patients. Material and methods The study group consisted of 100 close relatives supporting leukaemia patients (66 women and 34 men). The study included close relatives who supported patients with the diagnosis of leukaemia. A standardized interview and the questionnaires CISS, SES, SOC-29, STAI, and the Questionnaire of Perceived Control of Life were used in the study. Results The research results show that 65% of the respondents indicate the illness of a close relative as the main source of stress. Among the respondents, the emotion-oriented style (β = 0.301, p = 0.008) and anxious personality (β = 0.560, p = 0.000) proved to be predictors of stress. Stress is counteracted by a sense of coherence (β = –0.294, p = 0.028). Conclusions In respect of struggling with stress by people supporting leukaemia patients, releasing accumulated tension and formulating negative emotions are the key issues. The strengthening of the sense of coherence will also be crucial.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"21 1","pages":"110 - 114"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74595765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Lewandowska, E. Nalejska, Łukasz Żołna, Aleksandra Chrząstek, B. Żurawski, M. Wiśniewska, Manuela Las-Jankowska, K. Roszkowski, J. Kowalewski
Aim of the study The main purpose of this study was to assess detection of mutations in the epidermal growth factor receptor (EGFR) gene in circulating tumor DNA (ctDNA) as a tool for EGFR tyrosine kinase inhibitor (TKI) monitoring therapy. Material and methods The study was conducted using 20 samples from 7 adenocarcinoma patients treated with TKIs. Blood samples for ctDNA analysis were collected in 2015–2016. ctDNA was isolated using the QIAamp Circulating Nucleic Acid Kit (Qiagen) and analyzed using the ctEGFR Mutation Detection Kit (EntroGen). Results The most common exon 19 deletion and p.Leu858Arg mutation in exon 21 of the EGFR gene were detected. We observed a correlation between stabilization of patient condition and the lack of p.Thr790Met mutation detection in ctEGFR during TKI treatment (2 out of 7 patients). We also observed a correlation between progression of the disease and p.Thr790Met mutation detection in ctEGFR (3 out of 7 cases). We did not detect ctDNA p.Thr790Metp in two patients in whom progression occurred shortly thereafter. Last but not least, we noticed that good organization during plasma collection and transportation (average time of 6 minutes and 30 seconds) allows to use K2EDTA tubes. Conclusions When tissue is limited or insufficient, analysis of the ctEGFR mutational status can be considered as an alternative tool for qualifying patients with non-small cell lung cancer (NSCLC) for TKI therapy, also as a potential monitoring tool. The plasma p.Thr790Met-negative result needs to be verified for the presence of p.Thr790Met-positive tumor tissue.
{"title":"Detection of somatic mutations in ctDNA derived from adenocarcinoma patients – EGFR tyrosine kinase inhibitor monitoring preliminary study","authors":"M. Lewandowska, E. Nalejska, Łukasz Żołna, Aleksandra Chrząstek, B. Żurawski, M. Wiśniewska, Manuela Las-Jankowska, K. Roszkowski, J. Kowalewski","doi":"10.5114/wo.2019.85879","DOIUrl":"https://doi.org/10.5114/wo.2019.85879","url":null,"abstract":"Aim of the study The main purpose of this study was to assess detection of mutations in the epidermal growth factor receptor (EGFR) gene in circulating tumor DNA (ctDNA) as a tool for EGFR tyrosine kinase inhibitor (TKI) monitoring therapy. Material and methods The study was conducted using 20 samples from 7 adenocarcinoma patients treated with TKIs. Blood samples for ctDNA analysis were collected in 2015–2016. ctDNA was isolated using the QIAamp Circulating Nucleic Acid Kit (Qiagen) and analyzed using the ctEGFR Mutation Detection Kit (EntroGen). Results The most common exon 19 deletion and p.Leu858Arg mutation in exon 21 of the EGFR gene were detected. We observed a correlation between stabilization of patient condition and the lack of p.Thr790Met mutation detection in ctEGFR during TKI treatment (2 out of 7 patients). We also observed a correlation between progression of the disease and p.Thr790Met mutation detection in ctEGFR (3 out of 7 cases). We did not detect ctDNA p.Thr790Metp in two patients in whom progression occurred shortly thereafter. Last but not least, we noticed that good organization during plasma collection and transportation (average time of 6 minutes and 30 seconds) allows to use K2EDTA tubes. Conclusions When tissue is limited or insufficient, analysis of the ctEGFR mutational status can be considered as an alternative tool for qualifying patients with non-small cell lung cancer (NSCLC) for TKI therapy, also as a potential monitoring tool. The plasma p.Thr790Met-negative result needs to be verified for the presence of p.Thr790Met-positive tumor tissue.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"2016 1","pages":"87 - 91"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86643296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrycja Modzelewska, Sylwia Chludzińska, J. Lewko, J. Reszeć
Obesity is a new risk factor, to which more and more research is devoted, related to the development of cancer. Many studies of recent years have drawn attention to the role of adipose tissue as an important internal endocrine organ. In the adipose tissue proteins are produced, referred to by the common name as adipokines. In the case of obesity, the neoplasm cells are constantly stimulated by pro-inflammatory cytokines and adipokines, among which leptin dominates. The studies show that leptin can affect the cancer cells through numerous phenomena, e.g. inflammation, cell proliferation, suppression of apoptosis and angiogenesis. In this literature review we examined the role of leptin in the development of the individual cancers: breast cancer, colorectal cancer, prostate cancer, ovarian cancer, endometrial cancer and brain neoplasms: glioma and meningioma. However, leptin has very complicated mechanisms of action which require better understanding in certain types of cancer.
{"title":"The influence of leptin on the process of carcinogenesis","authors":"Patrycja Modzelewska, Sylwia Chludzińska, J. Lewko, J. Reszeć","doi":"10.5114/wo.2019.85877","DOIUrl":"https://doi.org/10.5114/wo.2019.85877","url":null,"abstract":"Obesity is a new risk factor, to which more and more research is devoted, related to the development of cancer. Many studies of recent years have drawn attention to the role of adipose tissue as an important internal endocrine organ. In the adipose tissue proteins are produced, referred to by the common name as adipokines. In the case of obesity, the neoplasm cells are constantly stimulated by pro-inflammatory cytokines and adipokines, among which leptin dominates. The studies show that leptin can affect the cancer cells through numerous phenomena, e.g. inflammation, cell proliferation, suppression of apoptosis and angiogenesis. In this literature review we examined the role of leptin in the development of the individual cancers: breast cancer, colorectal cancer, prostate cancer, ovarian cancer, endometrial cancer and brain neoplasms: glioma and meningioma. However, leptin has very complicated mechanisms of action which require better understanding in certain types of cancer.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"60 1","pages":"63 - 68"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84523399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Smolarz, D. Samulak, K. Szyłło, Marianna Makowska, H. Romanowicz, Z. Kojs, M. Michalska
Introduction Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor – cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This study aimed to analyze the prevalence of high risk HPV DNA (HR HPV) in females from Poland. Material and methods The study was performed on 280 cervical smear samples. In this work we used the Roche Cobas 4800 HPV test to detect the HR HPV in cervical smear samples. Results 56 patients (20%) proved to be positive regarding HPV-16 DNA and 40 patients (14.28%) regarding HPV-18 DNA. In overall assessment, in 94 patients (33.57%) we detected oncogenic HPV subtypes, other than the two mentioned above. In 90 patients (32.14%) no high risk HPV was detected. Conclusions The Roche Cobas 4800 HPV test is a viable, effective, easy and quick tool in detecting high risk HPV DNA.
{"title":"Cobas 4800 HPV detection in cervical samples of Polish women","authors":"B. Smolarz, D. Samulak, K. Szyłło, Marianna Makowska, H. Romanowicz, Z. Kojs, M. Michalska","doi":"10.5114/wo.2019.85880","DOIUrl":"https://doi.org/10.5114/wo.2019.85880","url":null,"abstract":"Introduction Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor – cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This study aimed to analyze the prevalence of high risk HPV DNA (HR HPV) in females from Poland. Material and methods The study was performed on 280 cervical smear samples. In this work we used the Roche Cobas 4800 HPV test to detect the HR HPV in cervical smear samples. Results 56 patients (20%) proved to be positive regarding HPV-16 DNA and 40 patients (14.28%) regarding HPV-18 DNA. In overall assessment, in 94 patients (33.57%) we detected oncogenic HPV subtypes, other than the two mentioned above. In 90 patients (32.14%) no high risk HPV was detected. Conclusions The Roche Cobas 4800 HPV test is a viable, effective, easy and quick tool in detecting high risk HPV DNA.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"154 1","pages":"92 - 95"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78178375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ukleikins, A. Irmejs, A. Gilis, E. Tauvena, J. Maksimenko, G. Trofimovičs, J. Gardovskis
Introduction Immediate breast reconstructions (IBR) have become an integral part of modern breast cancer management. However, in a small breast unit the spectrum of methods used for IBR could be limited, which could result in poorer results in some cases. The aim of the study is to evaluate the patient satisfaction and aesthetic outcome results in a breast unit where only implant-based IBR were performed. Material and methods During 2009–2016, 64 cases of implant-based IBR were performed in the university hospital. 55 patients completed the questionnaire and 38 underwent evaluation by a plastic surgeon. 33 skin-sparing and 22 nipple-sparing mastectomies were included. The study included 30 two-stage expander/implant and 25 direct-toimplant IBR cases. Results Overall satisfaction was reported by 89% of respondents. 93% were satisfied with appearance in clothes and 82% with appearance in a bra. There was a significant difference with satisfaction in nude appearance between groups with a removed (3%) and a spared nipple (46%). The plastic surgeon evaluated overall outcome as satisfactory in 61% and poor in 39%. Spearman coefficient showed a moderate negative correlation between body mass index (BMI) and aesthetic outcome (p = 0.02), as well as BMI and volume differences between breasts (p = 0.03). Patients evaluated their breast symmetry as satisfactory in 55%, and the plastic surgeon concluded the same in 55% of 38 cases. Conclusions Most of the patients were satisfied with the aesthetic outcome of IBR. Nipple preservation considerably improved satisfaction rates. However, implant-based IBR revealed suboptimal cosmetic results in the subset of cases with increased BMI and other IBR methods should be considered in those cases.
{"title":"Body mass index and nipple preservation are major contributors to satisfaction and aesthetic outcome rates after implant-based immediate breast reconstruction","authors":"S. Ukleikins, A. Irmejs, A. Gilis, E. Tauvena, J. Maksimenko, G. Trofimovičs, J. Gardovskis","doi":"10.5114/wo.2019.85881","DOIUrl":"https://doi.org/10.5114/wo.2019.85881","url":null,"abstract":"Introduction Immediate breast reconstructions (IBR) have become an integral part of modern breast cancer management. However, in a small breast unit the spectrum of methods used for IBR could be limited, which could result in poorer results in some cases. The aim of the study is to evaluate the patient satisfaction and aesthetic outcome results in a breast unit where only implant-based IBR were performed. Material and methods During 2009–2016, 64 cases of implant-based IBR were performed in the university hospital. 55 patients completed the questionnaire and 38 underwent evaluation by a plastic surgeon. 33 skin-sparing and 22 nipple-sparing mastectomies were included. The study included 30 two-stage expander/implant and 25 direct-toimplant IBR cases. Results Overall satisfaction was reported by 89% of respondents. 93% were satisfied with appearance in clothes and 82% with appearance in a bra. There was a significant difference with satisfaction in nude appearance between groups with a removed (3%) and a spared nipple (46%). The plastic surgeon evaluated overall outcome as satisfactory in 61% and poor in 39%. Spearman coefficient showed a moderate negative correlation between body mass index (BMI) and aesthetic outcome (p = 0.02), as well as BMI and volume differences between breasts (p = 0.03). Patients evaluated their breast symmetry as satisfactory in 55%, and the plastic surgeon concluded the same in 55% of 38 cases. Conclusions Most of the patients were satisfied with the aesthetic outcome of IBR. Nipple preservation considerably improved satisfaction rates. However, implant-based IBR revealed suboptimal cosmetic results in the subset of cases with increased BMI and other IBR methods should be considered in those cases.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"64 1","pages":"96 - 99"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77187511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Łukasz Kowalczyk, Marcin Braun, B. Tomasik, Dominika Piasecka, Dominika Michno, J. Fijuth, D. Jesionek-Kupnicka, R. Kordek
Ossifying fasciitis is a very rare disease of reactive character; however, it can mimic malignant lesions, especially osteosarcoma. We report a case of a 30-year-old woman, who experienced a rapidly growing painful lesion of the left knee joint, preceded by a trauma. The tumor was resected, and the histopathological image suggested a malignant lesion with features of an osteosarcoma. A detailed correlation with a clinicopathological and radiological analysis led to the final diagnosis of ossifying fasciitis at an extraordinary site of patellar retinaculum. Our case shows that the close similarity between ossifying fasciitis and osteosarcoma may be challenging.
{"title":"Ossifying fasciitis at an extraordinary site – a case report and analysis of diagnostic pitfalls","authors":"Łukasz Kowalczyk, Marcin Braun, B. Tomasik, Dominika Piasecka, Dominika Michno, J. Fijuth, D. Jesionek-Kupnicka, R. Kordek","doi":"10.5114/wo.2019.85884","DOIUrl":"https://doi.org/10.5114/wo.2019.85884","url":null,"abstract":"Ossifying fasciitis is a very rare disease of reactive character; however, it can mimic malignant lesions, especially osteosarcoma. We report a case of a 30-year-old woman, who experienced a rapidly growing painful lesion of the left knee joint, preceded by a trauma. The tumor was resected, and the histopathological image suggested a malignant lesion with features of an osteosarcoma. A detailed correlation with a clinicopathological and radiological analysis led to the final diagnosis of ossifying fasciitis at an extraordinary site of patellar retinaculum. Our case shows that the close similarity between ossifying fasciitis and osteosarcoma may be challenging.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"23 1","pages":"121 - 125"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79076453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Przemysław M. Krzaczek, M. Mitura-Lesiuk, Joanna Zawitkowska, Beata Petkowicz, B. Wilczynska, K. Drabko
Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 23% of all cancers diagnosed in this age group. The last stage of radical treatment is remission maintenance, during which hospitalization is not necessary. The lesions occurring in the oral cavity caused by medications and chemotherapy may also be directly related to hematological and systemic disorders. The aim of this study was to examine the levels of selected pro- and anti-inflammatory cytokines in saliva and serum of both patients undergoing remission maintenance and those after the cessation of therapy who reported to the hematology clinic of the Pediatric University Hospital in Lublin. The results were later analyzed in relation to the frequency of oral lesions and subjective intensity of oral complaints. The study revealed significant differences in salivary and serum concentrations of TNF-α and IL-10 between test and control groups. Oral lesions were more frequent in patients receiving therapy compared to the control group. Subjective afflictions described by the Visual Analog Scale (VAS) mean values were highest in the control group.
{"title":"Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia","authors":"Przemysław M. Krzaczek, M. Mitura-Lesiuk, Joanna Zawitkowska, Beata Petkowicz, B. Wilczynska, K. Drabko","doi":"10.5114/wo.2019.85878","DOIUrl":"https://doi.org/10.5114/wo.2019.85878","url":null,"abstract":"Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 23% of all cancers diagnosed in this age group. The last stage of radical treatment is remission maintenance, during which hospitalization is not necessary. The lesions occurring in the oral cavity caused by medications and chemotherapy may also be directly related to hematological and systemic disorders. The aim of this study was to examine the levels of selected pro- and anti-inflammatory cytokines in saliva and serum of both patients undergoing remission maintenance and those after the cessation of therapy who reported to the hematology clinic of the Pediatric University Hospital in Lublin. The results were later analyzed in relation to the frequency of oral lesions and subjective intensity of oral complaints. The study revealed significant differences in salivary and serum concentrations of TNF-α and IL-10 between test and control groups. Oral lesions were more frequent in patients receiving therapy compared to the control group. Subjective afflictions described by the Visual Analog Scale (VAS) mean values were highest in the control group.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"54 1","pages":"81 - 86"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85803891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim of the study The aim of the study was to investigate whether there are differences in the various dimensions of the health locus of control between oncological and non-oncological patients and to determine whether there is a relationship between the level of health locus of control and the type, duration of disease and gender. Material and methods The study was conducted at the Department of Hematology and the 1st Department of Cardiology of the University Hospital in Krakow. 204 patients were enrolled. Our own questionnaire developed for this purpose and the Multidimensional Health Locus of Control scale were used. The US normalization group and the Polish standardization groups of the chronically ill patients were used for comparative analysis. Results Analysis showed significant differences between women and men in the Internal control scale (p < 0.02). The respondents from both groups showed lower scores in the Internal locus of control and much higher scores in the dimension Powerful Others. In the group of oncological patients, a negative correlation was found between the Internal scale of health locus of control and the duration of the disease (p = 0.007). There was a significant difference between oncological and non-oncological patients in the Powerful Others scale (p < 0.004). Conclusions The results suggest that oncologically ill patients could be more convinced that others are responsible for their health when compared to non-oncological patients. The longer the disease persists in oncological patients, the weaker is their internal motivation to achieve good treatment results.
{"title":"Comparison of health locus of control in oncological and non-oncological patients","authors":"Katarzyna Gibek, T. Sacha","doi":"10.5114/wo.2019.85638","DOIUrl":"https://doi.org/10.5114/wo.2019.85638","url":null,"abstract":"Aim of the study The aim of the study was to investigate whether there are differences in the various dimensions of the health locus of control between oncological and non-oncological patients and to determine whether there is a relationship between the level of health locus of control and the type, duration of disease and gender. Material and methods The study was conducted at the Department of Hematology and the 1st Department of Cardiology of the University Hospital in Krakow. 204 patients were enrolled. Our own questionnaire developed for this purpose and the Multidimensional Health Locus of Control scale were used. The US normalization group and the Polish standardization groups of the chronically ill patients were used for comparative analysis. Results Analysis showed significant differences between women and men in the Internal control scale (p < 0.02). The respondents from both groups showed lower scores in the Internal locus of control and much higher scores in the dimension Powerful Others. In the group of oncological patients, a negative correlation was found between the Internal scale of health locus of control and the duration of the disease (p = 0.007). There was a significant difference between oncological and non-oncological patients in the Powerful Others scale (p < 0.004). Conclusions The results suggest that oncologically ill patients could be more convinced that others are responsible for their health when compared to non-oncological patients. The longer the disease persists in oncological patients, the weaker is their internal motivation to achieve good treatment results.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"34 1","pages":"115 - 120"},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74412197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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