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Thermodynamic properties and moisture sorption isotherms of two pharmaceutical compounds 两种药物化合物的热力学性质和吸湿等温线
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7702
Amel Zammouri, M. B. Zid, N. Kechaou, N. B. Mihoubi
This investigation examines and compares the water sorption isotherms and the thermodynamic properties of two pharmaceutical preparations (Hypril and Azix) intended to be manufactured with the same process plant and equipment. The moisture equilibrium isotherms were determined at 50, 60 and 70 °C using a gravimetric technique. Five isotherm models were explored for their fitting to the experimental data. Azix showed sigmoid type II isotherms while Hypril showed type III isotherms according to the BET classification. All investigated models fitted well the water sorption isotherms of Hypril. By contrast, only GAB and Adam and Shove equations gave appropriate fit to the experimental data of Azix. For both formulations, the isosteric heat and the differential entropy decreased sharply with the increase of equilibrium moisture content to minimum values and thereafter remain constant. In the case of Azix, the integral enthalpy decreased with equilibrium moisture content while the integral entropy increased until reaching a constant value. Contrariwise, Hypril showed decreasing of the integral enthalpy and entropy with the equilibrium moisture content. Keywords: sorption isotherm, enthalpy, entropy, spreading pressure, pharmaceutical formulations  
本研究检查并比较了两种药物制剂(Hypril和Azix)的吸水等温线和热力学性质,这两种药物制剂打算用相同的工艺装置和设备生产。水分平衡等温线在50,60和70°C时用重量法测定。探讨了五种等温线模型与实验数据的拟合。根据BET分类,Azix为s型II型等温线,Hypril为III型等温线。所有模型都能很好地拟合Hypril的吸水等温线。相比之下,只有GAB方程和Adam和push方程能较好地拟合Azix的实验数据。对于这两种公式,等静热和微分熵随着平衡含水率的增加而急剧下降到最小值,然后保持不变。在Azix的情况下,随着平衡水分含量的增加,积分焓降低,而积分熵增加,直到达到恒定值。相反,Hypril的积分焓和熵随平衡含水率的增加而减小。关键词:吸附等温线,焓,熵,扩散压力,药物配方
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引用次数: 3
Investigation of influence of pre-treatment and low-temperature on drying kinetics, sorption properties, shrinkage and color of brown seaweeds (Saccharina Latissima) 预处理和低温对褐海藻(Saccharina Latissima)干燥动力学、吸附性能、收缩率和颜色的影响
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7694
I. Tolstorebrov, T. Eikevik, I. Petrova, Yulia Shokina, M. Bantle
Drying kinetics of Saccharina latissima (raw and blanched) at low temperatures (10.0, 25.0 and 38.0 °C) was studied. The effective moisture diffusivity coefficient varied due to temperature alterations in the range between 1.4 and 4.5 10-10 m2/s for raw and 0.91 and 2.56 10-10 m2/s for blanched seaweeds. Significant changes in structural properties and chemical composition resulted in a much longer drying time of blanched seaweeds, when compared with raw. Drying temperature of 38.0 °C resulted in more brown color, when compared with other samples. Sorption characteristics of dried raw seaweeds depended on salt content and showed high accumulation of moisture at relative humidity of air of 80.0 %. The blanched seaweeds showed linear accumulation of moisture within increasing of relative humidity of drying air from 20.0 to 80.0 %, but high level of hysteresis was determined between sorption and desorption isotherms. The shrinkage development within dewatering of blanched and raw samples was also studied. Keywords: brown seaweeds, drying kinetics, sorption isotherms, color 
研究了低热(10.0℃、25.0℃和38.0℃)条件下甘蔗糖精(生料和焯水)的干燥动力学。随着温度的变化,生海藻的有效水分扩散系数在1.4 ~ 4.5 10 ~ 10 m2/s之间,而焯水海藻的有效水分扩散系数在0.91 ~ 2.56 10 ~ 10 m2/s之间。与未加工的海藻相比,漂白后的海藻在结构特性和化学成分上发生了显著的变化,导致其干燥时间大大延长。干燥温度为38.0°C时,与其他样品相比,颜色偏棕。干燥生海藻的吸附特性与含盐量有关,在空气相对湿度为80.0%时表现出较高的水分积累。在干燥空气相对湿度从20.0%增加到80.0%的范围内,漂白后的海藻水分呈线性积累,但在吸附和解吸等温线之间存在较大的滞后性。研究了漂后和生样在脱水过程中的收缩发展。关键词:褐藻,干燥动力学,吸附等温线,颜色
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引用次数: 0
Flat plate solar air heater with helical integrated fins for drying processe 用于干燥过程的螺旋集成翅片平板太阳能空气加热器
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7767
I. Farkas, M. A. Al-Neama
In this study, an experimental investigation was carried out on solar system consists of many main components; solar air collector, drying chamber and air blower. Manufacturing and an analysis of two active double-pass solar air collector integrated with unfinned and helical finned absorbers have been carried out. The helical fins increased the standers solar collector (unfinned) efficiency by about 6%. In five hours for 2 kg of apple slices drying, the final weight of the dried product is 1.237 kg using an unfinned solar collector, while 1.039 kg using helical finned solar collector. Keywords: solar drying, air heater, thermal performance, helical fins.
在本研究中,对由许多主要组成部分组成的太阳系进行了实验研究;太阳能集风器、干燥室和鼓风机。对两种非翅片和螺旋翅片太阳能吸收体双通型太阳能集热器进行了制造和分析。螺旋翅片使立式太阳能集热器(非翅片)的效率提高了约6%。2公斤苹果片在5小时内干燥,使用无翅片太阳能集热器干燥产品的最终重量为1.237公斤,而使用螺旋翅片太阳能集热器干燥产品的最终重量为1.039公斤。关键词:太阳能干燥,空气加热器,热性能,螺旋翅片。
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引用次数: 1
Thermal stability of amorphous sugar matrix, dried from methanol, as an amorphous solid dispersion carrier 无定形糖基质的热稳定性,从甲醇中干燥,作为无定形固体分散载体
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7716
K. Imamura, Koji Takeda, K. Yamamoto, H. Imanaka, N. Ishida
Developing a technique to disperse hydrophobic ingredients homogeneously in a water-soluble solid matrix (solid dispersion) is one of the topics that have been extensively investigated in the pharmaceutical and food industries. Recently, we have devised a novel solid dispersion technique (surfactant-free solid dispersion), in which a preliminarily amorphized sugar was dissolved in an organic media containing hydrophobic component, without using any surface active substances, and then vacuum dried into the amorphous solid mixture [Food Chem., 197 (2016) 1136; Mol. Pharm., 14 (2017) 791]. In this study, the physicochemical properties, especially thermal stability of the surfactant-free amorphous solid dispersion, were investigated. keywords: solid dispersion; amorphous sugar; surfactant-free; vacuum drying; glass transition temperature
开发一种将疏水成分均匀分散在水溶性固体基质(固体分散)中的技术是制药和食品工业广泛研究的课题之一。最近,我们设计了一种新的固体分散技术(无表面活性剂固体分散),将初步无定形的糖溶解在含有疏水成分的有机介质中,不使用任何表面活性物质,然后真空干燥成无定形固体混合物[食品化学]。, 197 (2016) 1136;摩尔。制药。农业学报,14(2017):791]。研究了无表面活性剂的非晶态固体分散体的物理化学性质,特别是热稳定性。关键词:固体分散体;非晶糖;surfactant-free;真空干燥;玻璃化转变温度
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引用次数: 1
CT-scanning of the drying process of Eucalyptus nitens 桉树干燥过程的ct扫描
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7380
J. Couceiro, Lars Hansson, A. Ambroz, D. Sandberg
The drying of Eucalyptus nitens is a troublesome process as the species is extremely prone to drying defects. This paper reports ongoing research to improve the understanding of surface checking and cell collapse in Chilean grown Eucalyptus nitens during drying. Computed tomography (CT) scanning was used as a powerful tool for studying the internal changes in the wood-material during the drying process. Different levels of temperatures have been tested with the same equilibrium moisture content (EMC) conditions and low air velocity. The results confirm that a low drying temperature and a low air velocity, which results in a slow rate of drying, reduce internal cell collapse  and surface checking . Keywords: Cell collapse; computed tomography; surface checks; wood drying; internal checks
桉树的干燥是一个麻烦的过程,因为该物种极易出现干燥缺陷。本文报道了正在进行的研究,以提高对智利生长的桉树在干燥过程中的表面检查和细胞崩溃的理解。计算机断层扫描(CT)是研究木材干燥过程中内部变化的有力工具。在相同的平衡含水率(EMC)条件和低风速条件下,测试了不同的温度水平。结果表明,低干燥温度和低空气流速,导致干燥速度慢,减少内部细胞崩溃和表面检查。关键词:细胞塌缩;计算机断层扫描;表面检查;木材干燥;内部检查
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引用次数: 0
Application of microwaves in the convective drying of ceramic 微波在陶瓷对流干燥中的应用
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7749
K. Rajewska, A. Pawłowski
The paper demonstrates microwave and convective drying processes in different combinations of kaolin cylindrical samples in laboratory scale. Analysis of the kinetics and sample temperature evolution show that the moment of application and electromagnetic field duration have the biggest influence on characteristics of the drying curve and quality of dried material. Dried samples were subjected to strength tests using the Brazilian method in order to determine the relation between its quality and different drying programs. Keywords: ceramic, convective drying, microwave drying, strength test. 
本文对不同组合的高岭土圆柱形样品进行了微波和对流干燥实验。动力学和样品温度演化分析表明,施加力矩和电磁场持续时间对干燥曲线特性和干燥物料质量的影响最大。用巴西法对干燥后的试样进行强度试验,以确定不同干燥程序对试样质量的影响。关键词:陶瓷,对流干燥,微波干燥,强度试验。
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引用次数: 0
Drying of acerola residues in a roto-aerated dryer assisted by infrared heating 在红外加热辅助的旋转充气干燥机中干燥针叶花残留物
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7456
P. Silva, G. D. Nogueira, C. Duarte, M. Barrozo
Acerola (Malpighia emarginata D.C.) is a tropical fruit which has attracted recent industrial interest, due to its high levels of bioactive compounds and vitamin C. However, acerola processing generates a substantial amount of wastes, which can represent up to 40% of total processed volume. The drying of acerola residues in a new dryer, developed by our research group, named as roto-aerated dryer, has been investigated. This dryer provides a better fluid-particle contact than the conventional rotatory dryer. A pre-drying system with infrared lamps has been installed in the feed of this new dryer. The effect of the pre-treatment of this fruit residues with ethanol was also investigated. The results shown that the roto-aerated dryer assisted by infrared radiation hybrid combined with a pre-treatment with ethanol is a good alternative for processing fruit residues, aiming their reuse. It was possible to identify conditions under which the phenolic, flavonoid, and antioxidant capacity presented high levels after drying. The main phenolic compounds were idenfied by HPLC.Keywords: Drying; roto-aerated dryer; infrared; acerola  
针叶树(malpiighia marginata dc)是一种热带水果,由于其高含量的生物活性化合物和维生素c,最近引起了工业的兴趣。然而,针叶树加工产生了大量的废物,可占加工总量的40%。本文研究了本课题组研制的一种新型旋转曝气干燥机对针叶花残留物的干燥。这种干燥机提供了一个更好的流体颗粒接触比传统的旋转干燥机。在这台新烘干机的进料中安装了带红外灯的预干燥系统。研究了乙醇预处理对果渣的影响。结果表明,红外辐射混合辅助下的旋转曝气干燥机结合乙醇预处理是处理果渣的一种较好的方法,可实现果渣的重复利用。可以确定干燥后酚类、类黄酮和抗氧化能力较高的条件。用高效液相色谱法对主要酚类化合物进行了鉴定。关键词:干燥;roto-aerated烘干机;红外;针叶
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引用次数: 0
Drying characteristics and mathematical modelling of the drying kinetics of oyster mushroom (Pleurotus ostreatus) 平菇干燥特性及干燥动力学的数学建模
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7847
A. Satimehin, M. Oluwamukomi, V. Enujiugha, M. Bello
This study was conducted to determine the drying characteristics of oyster mushroom (Pleurotus ostreatus) at 50, 60 and 70 °C.  Pleurotus ostreatus were cleaned and dried in a laboratory cabinet dryer. The drying data were fitted to six model equations namely Newton, Pabis and Henderson, Logarithmic, Two-term diffusion, Wang and Singh, as well as Modified Henderson and Pabis equations. The goodness of fit of the models were evaluated by means of the coefficient of determination (R2), root mean square error (RMSE) and reduced chi-square (χ2). The Logarithmic model best describes the drying data and could be used to predict its drying behaviour. Keywords: oyster mushroom; thin-layer drying; characteristics; modelling
研究了平菇(Pleurotus ostreatus)在50、60和70℃下的干燥特性。在实验室柜式干燥机中对平菇进行了清洗和干燥。将干燥数据拟合到Newton、Pabis和Henderson、对数、两项扩散、Wang和Singh以及修正的Henderson和Pabis方程6个模型方程中。采用决定系数(R2)、均方根误差(RMSE)和简化卡方(χ2)评价模型的拟合优度。对数模型最好地描述了干燥数据,可以用来预测其干燥行为。关键词:平菇;薄层干燥;特征;造型
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引用次数: 3
Enhancing antioxidant property of instant coffee by microencapsulation via spray drying 喷雾干燥微胶囊化提高速溶咖啡抗氧化性能
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.7520
Desi Sakawulan, R. Archer, C. Borompichaichartkul
This study is aimed to improve the antioxidant property of instant coffee by using microencapsulation technique and spray drying. Concentrated coffee extract was mixed with Konjac glucomannan hydrolysate (KGMH) and Maltodextrin (MD). The mixture of coating material and coffee extract was then spray dried at 160 - 180 °C inlet air temperature and at 85-90 °C outlet air temperature. KGMH can preserve retention of phenolic compounds, DPPH scavenging activity and antioxidant activity of FRAP (p<0.05 of instrant coffee better than other treatment. Keywords: Hydrolysed Konjac Glucomannan; Spray Drying; Microencapsulation; Instant Coffee, Antioxidant 
采用微胶囊化技术和喷雾干燥技术提高速溶咖啡的抗氧化性能。将浓缩咖啡提取物与魔芋葡甘露聚糖水解物(KGMH)和麦芽糊精(MD)混合。然后在160 - 180°C的入口空气温度和85-90°C的出口空气温度下喷雾干燥涂层材料和咖啡提取物的混合物。KGMH对速溶咖啡中酚类化合物的保留、DPPH的清除活性和FRAP的抗氧化活性均优于其他处理(p<0.05)。关键词:水解魔芋葡甘露聚糖;喷雾干燥;微型胶囊;速溶咖啡,抗氧化剂
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引用次数: 3
Partial drying of apple fruits to improve freeze/thaw quality during long term frozen storage 在长期冷冻贮藏过程中,对苹果果实进行部分干燥以改善其冻融品质
Pub Date : 2018-09-07 DOI: 10.4995/IDS2018.2018.8372
L. B. Said, S. Bellaga, K. Allaf
Apple samples were submitted to partially drying prior to freezing. Then, quality assessments were achieved in order to evaluate the quality of these various frozen samples during frozen-storage. Significant positive effects of water content were observed on thaw exudate water and total color difference of dehydrofrozen/thawed apples. Total polyphenol content and total flavonoid content losses were important for samples without any dehydration pretreatment. They noticeably decreased when water content decreased during the whole period of storage. Thus, a partial removal of water prior to freezing is a relevant way to maintain the stability of fruit quality during long-term frozen-storage. Keywords: Apple fruits; dehydrofreezing; frozen storage; color; polyphenol
苹果样品在冷冻前进行部分干燥。然后进行质量评价,以评价各种冷冻样品在冷冻贮藏过程中的质量。水分含量对脱氢冷冻/解冻苹果的解冻渗出水和总色差有显著的正影响。对于未进行脱水预处理的样品,总多酚含量和总黄酮含量损失是重要的。在整个贮藏期间,随着含水量的降低,它们明显减少。因此,在冷冻前部分去除水分是在长期冷冻储存中保持水果品质稳定性的一种相关方法。关键词:苹果果实;脱水冷冻;冷冻储存;颜色;多酚
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引用次数: 0
期刊
Proceedings of 21th International Drying Symposium
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