Pub Date : 2026-01-01Epub Date: 2026-01-27DOI: 10.1007/s40496-025-00421-7
Arwa Daghrery, Igor Paulino Mendes Soares, Alexandre H Dos Reis-Prado, Isaac J de Souza Araújo, Renan Dal-Fabbro, Marco C Bottino
Purpose of review: To compile recent advances in scaffold-guided periodontal regeneration (SGPR) enabled by 3D printing, focusing on innovations in materials, multiphasic/anisotropic design, image-guided personalization, and the spatiotemporal delivery of therapeutic cues.
Recent findings: Composite scaffold systems, extracellular matrix (ECM)-mimetic hydrogels, and ion-releasing ceramics (e.g., Mg/Sr/Ca-phosphates, bioactive glass, among others) enhance osteogenesis, periodontal ligament (PDL) formation, and angiogenesis. Melt electrowriting, extrusion, and inkjet printing enable the creation of patient-specific, multiphasic and anisotropic scaffolds that mimic cementum-PDL-bone interfaces. Controlled release of ions, growth factors, genes, and antimicrobials modulate immunity and microenvironments. Emerging directions include in situ and 4D bioprinting, immuno-instructive and prevascularized constructs, and CAD models derived from clinical imaging, which are essential for manufacturing personalized scaffolds and grafts.
Summary: 3D printing is advancing SGPR toward functional, personalized therapies; however, its translation depends on reliable vascularization, immune modulation, long-term mechanics, scalable manufacturing, and clear regulatory and safety pathways. Standardized workflows, hybrid/4D printing, machine-learning-guided design, and rigorous clinical studies are essential to accelerate clinical adoption.
综述目的：综述基于3D打印的支架引导牙周再生（SGPR）的最新进展，重点介绍材料、多相/各向异性设计、图像引导个性化以及治疗线索的时空传递方面的创新。最近的研究发现：复合支架系统、细胞外基质（ECM）模拟水凝胶和离子释放陶瓷（例如Mg/Sr/ ca -phosphate，生物活性玻璃等）促进骨生成、牙周韧带（PDL）形成和血管生成。熔体电书写、挤压和喷墨打印可以创造出患者特异性的、多相的和各向异性的支架，模拟骨水泥- pdl -骨界面。离子、生长因子、基因和抗菌剂的控制释放调节免疫和微环境。新兴方向包括原位和4D生物打印，免疫引导和预血管化构建，以及基于临床成像的CAD模型，这对于制造个性化支架和移植物至关重要。总结：3D打印正在推动SGPR朝着功能性、个性化的方向发展；然而，它的转化依赖于可靠的血管化、免疫调节、长期机制、可扩展的制造以及明确的监管和安全途径。标准化的工作流程、混合/4D打印、机器学习引导设计和严格的临床研究对于加快临床应用至关重要。
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Pub Date : 2024-07-24DOI: 10.1007/s40496-024-00382-3
Sumeyye Gundogdu, Dilay Erbahceci, Alp Abidin Ateşçi, M. Kaval
{"title":"Endodontic Treatment Approach in Patients with Chronic Kidney Disease","authors":"Sumeyye Gundogdu, Dilay Erbahceci, Alp Abidin Ateşçi, M. Kaval","doi":"10.1007/s40496-024-00382-3","DOIUrl":"https://doi.org/10.1007/s40496-024-00382-3","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":"44 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.1007/s40496-024-00381-4
P. Emecen-Huja, B. Leblebicioglu
{"title":"Peri-Implant Wound Healing and Clinical Outcomes","authors":"P. Emecen-Huja, B. Leblebicioglu","doi":"10.1007/s40496-024-00381-4","DOIUrl":"https://doi.org/10.1007/s40496-024-00381-4","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-08DOI: 10.1007/s40496-024-00379-y
Alp Akyol, İpek Akyol, Kasım Emre Ergün, N. Buduneli
{"title":"Oral Health and Oral Mucosa as A Graft Material for Urinary System: A Narrative Review","authors":"Alp Akyol, İpek Akyol, Kasım Emre Ergün, N. Buduneli","doi":"10.1007/s40496-024-00379-y","DOIUrl":"https://doi.org/10.1007/s40496-024-00379-y","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":"130 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-17DOI: 10.1007/s40496-024-00378-z
M. Dioguardi, F. Spirito, Giovanna Iacovelli, D. Sovereto, Enrica Laneve, G. A. Caloro, A. Ballini, Angelo Martella, Lorenzo Lo Muzio
{"title":"Abfraction Theory: Controversy Analysis, Scoping Review","authors":"M. Dioguardi, F. Spirito, Giovanna Iacovelli, D. Sovereto, Enrica Laneve, G. A. Caloro, A. Ballini, Angelo Martella, Lorenzo Lo Muzio","doi":"10.1007/s40496-024-00378-z","DOIUrl":"https://doi.org/10.1007/s40496-024-00378-z","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":"71 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1007/s40496-024-00375-2
N. De Angelis, E. Colombo, C. Yumang, C. Canepa, D. Baldi, F. Bagnasco, P. Pesce
{"title":"Socket Preservation in Dentistry: a Comprehensive Review on Efficacy, Tissue Volume Maintenance, and Economic Considerations with Focus on Membrane Types and Bone Regeneration Dynamics","authors":"N. De Angelis, E. Colombo, C. Yumang, C. Canepa, D. Baldi, F. Bagnasco, P. Pesce","doi":"10.1007/s40496-024-00375-2","DOIUrl":"https://doi.org/10.1007/s40496-024-00375-2","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.1007/s40496-024-00374-3
S. Shetty, Shibani Shetty, S. Venkatesh
{"title":"Tissue Engineering in Oral and Maxillofacial Rehabilitation—Current Status and Future Prospects","authors":"S. Shetty, Shibani Shetty, S. Venkatesh","doi":"10.1007/s40496-024-00374-3","DOIUrl":"https://doi.org/10.1007/s40496-024-00374-3","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":"244 4‐5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140704007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.1007/s40496-024-00369-0
Sabrina Carvalho Gomes, L. M. Miller, Luana Xavier, F. Bitencourt
{"title":"The Mouth as a Reservoir of SARS-CoV-2","authors":"Sabrina Carvalho Gomes, L. M. Miller, Luana Xavier, F. Bitencourt","doi":"10.1007/s40496-024-00369-0","DOIUrl":"https://doi.org/10.1007/s40496-024-00369-0","url":null,"abstract":"","PeriodicalId":10731,"journal":{"name":"Current Oral Health Reports","volume":"35 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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