Pub Date : 2021-12-01DOI: 10.1007/s12609-021-00440-0
S. Zelasko, Brittany O’Steen, Elizabeth U. Parker, M. Kilgore, J. Scheel
{"title":"Formalized Radiologic-Pathologic Curriculum in Breast Imaging for Breast Imaging Fellows and Residents: how we do it","authors":"S. Zelasko, Brittany O’Steen, Elizabeth U. Parker, M. Kilgore, J. Scheel","doi":"10.1007/s12609-021-00440-0","DOIUrl":"https://doi.org/10.1007/s12609-021-00440-0","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"405 - 413"},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42726973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-23DOI: 10.1007/s12609-021-00437-9
D. Lam, Elizabeth U. Parker, Janice N. Kim, R. Yung, M. Flanagan
{"title":"A Multidisciplinary Approach to Managing Uncertainty","authors":"D. Lam, Elizabeth U. Parker, Janice N. Kim, R. Yung, M. Flanagan","doi":"10.1007/s12609-021-00437-9","DOIUrl":"https://doi.org/10.1007/s12609-021-00437-9","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"365 - 380"},"PeriodicalIF":0.9,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48385746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-12DOI: 10.1007/s12609-021-00436-w
Quan D. Nguyen, Jing He
{"title":"Invasive Ductal Carcinoma NST and Special Subtypes: Radiology-Pathology Correlation","authors":"Quan D. Nguyen, Jing He","doi":"10.1007/s12609-021-00436-w","DOIUrl":"https://doi.org/10.1007/s12609-021-00436-w","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"347 - 364"},"PeriodicalIF":0.9,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46197739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-10DOI: 10.1007/s12609-021-00428-w
E. Pollack, M. O'Keefe
{"title":"Breast Imaging in Special Populations: Indications and Findings in Pregnant and Lactating, Male, and Transgender Patients","authors":"E. Pollack, M. O'Keefe","doi":"10.1007/s12609-021-00428-w","DOIUrl":"https://doi.org/10.1007/s12609-021-00428-w","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"268 - 281"},"PeriodicalIF":0.9,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42728905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1007/s12609-021-00435-x
Marina J Corines, Melissa Krystel-Whittemore, Melissa Murray, Victoria Mango
Purpose of review: The purpose is to present a case series of rare diagnoses and unusual presentations of breast lesions with radiologic-pathologic correlation from a major cancer center, and to review the recent literature on each entity with a focus on radiology-pathology concordance. We present our findings and experience from cases of metastatic small cell lung carcinoma to the breast, IgG-4 related breast disease, breast implant associated anaplastic large cell lymphoma, granular cell tumor, pleomorphic sarcoma, adenomyoepithelioma, post-radiation angiosarcoma, and breast carcinoma after risk-reducing total mastectomy.
Recent findings: It is essential for physicians to have knowledge of rare breast diagnoses and unusual breast disease presentations to formulate a complete differential diagnosis, recognize radiological-pathological concordance of these entities and provide appropriate patient care.
Summary: Current literature on these rare described entities exists mainly as case reports, case series and small-scale studies. By sharing our findings, we hope to educate trainees in radiology, pathology and other fields across the continuum of care in radiologic-pathologic correlation, while also augmenting the existing literature on these rare entities.
{"title":"Uncommon Tumors and Uncommon Presentations of Cancer in the Breast.","authors":"Marina J Corines, Melissa Krystel-Whittemore, Melissa Murray, Victoria Mango","doi":"10.1007/s12609-021-00435-x","DOIUrl":"https://doi.org/10.1007/s12609-021-00435-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose is to present a case series of rare diagnoses and unusual presentations of breast lesions with radiologic-pathologic correlation from a major cancer center, and to review the recent literature on each entity with a focus on radiology-pathology concordance. We present our findings and experience from cases of metastatic small cell lung carcinoma to the breast, IgG-4 related breast disease, breast implant associated anaplastic large cell lymphoma, granular cell tumor, pleomorphic sarcoma, adenomyoepithelioma, post-radiation angiosarcoma, and breast carcinoma after risk-reducing total mastectomy.</p><p><strong>Recent findings: </strong>It is essential for physicians to have knowledge of rare breast diagnoses and unusual breast disease presentations to formulate a complete differential diagnosis, recognize radiological-pathological concordance of these entities and provide appropriate patient care.</p><p><strong>Summary: </strong>Current literature on these rare described entities exists mainly as case reports, case series and small-scale studies. By sharing our findings, we hope to educate trainees in radiology, pathology and other fields across the continuum of care in radiologic-pathologic correlation, while also augmenting the existing literature on these rare entities.</p>","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 4","pages":"331-346"},"PeriodicalIF":0.9,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798716/pdf/nihms-1828761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10480190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-27DOI: 10.1007/s12609-021-00434-y
E. Oluyemi, Ani Peshtani, Marissa J. White, A. Cimino-Mathews
{"title":"Radiologic and Pathologic Correlation of Invasive Lobular Carcinoma of the Breast","authors":"E. Oluyemi, Ani Peshtani, Marissa J. White, A. Cimino-Mathews","doi":"10.1007/s12609-021-00434-y","DOIUrl":"https://doi.org/10.1007/s12609-021-00434-y","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"319 - 330"},"PeriodicalIF":0.9,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45173586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-27DOI: 10.1007/s12609-021-00432-0
Niketa Kataria, D. Lam, Elizabeth U. Parker
{"title":"Radiology–Pathology Correlation: Inflammatory Conditions of the Breast","authors":"Niketa Kataria, D. Lam, Elizabeth U. Parker","doi":"10.1007/s12609-021-00432-0","DOIUrl":"https://doi.org/10.1007/s12609-021-00432-0","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"282 - 295"},"PeriodicalIF":0.9,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47326988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-01Epub Date: 2021-05-04DOI: 10.1007/s12609-021-00416-0
Jodi A Kagihara, Elena Shagisultanova, Anosheh Afghahi, Jennifer R Diamond
Purpose of review: In this review, we discuss targets of interest in Triple-negative breast cancer (TNBC), approved targeted agents and the results of the clinical trials that led to their approval. Additionally, we review ongoing clinical trials evaluating the use of novel targeted agents in the treatment of TNBC.
Recent findings: TNBC accounts for 15-20% of all breast cancer cases and is associated with worse clinical outcomes. Patients have a higher risk of metastatic recurrence and inferior overall survival compared to other breast cancer subtypes. Cytotoxic chemotherapy has historically been the mainstay of treatment for TNBC. In recent years, we have seen a surge in clinical trials investigating the use of targeted agents in TNBC and now have approval for targeted therapies in select patients. Inhibitors of PARP (olaparib and talazoparib), PD-L1 (atezolizumab) and an antibody drug conjugate targeting Trop-2 (sacituzumab govitecan-hziy) are now approved for the use in select groups of patients with TNBC.
Summary: Various novel targeted agents as monotherapy, dual targeted combinations, and chemotherapy combinations are currently under investigation. The results are promising and may significantly improve patient outcomes in TNBC.
{"title":"Moving Towards Targeted Therapies for Triple-Negative Breast Cancer.","authors":"Jodi A Kagihara, Elena Shagisultanova, Anosheh Afghahi, Jennifer R Diamond","doi":"10.1007/s12609-021-00416-0","DOIUrl":"10.1007/s12609-021-00416-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>In this review, we discuss targets of interest in Triple-negative breast cancer (TNBC), approved targeted agents and the results of the clinical trials that led to their approval. Additionally, we review ongoing clinical trials evaluating the use of novel targeted agents in the treatment of TNBC.</p><p><strong>Recent findings: </strong>TNBC accounts for 15-20% of all breast cancer cases and is associated with worse clinical outcomes. Patients have a higher risk of metastatic recurrence and inferior overall survival compared to other breast cancer subtypes. Cytotoxic chemotherapy has historically been the mainstay of treatment for TNBC. In recent years, we have seen a surge in clinical trials investigating the use of targeted agents in TNBC and now have approval for targeted therapies in select patients. Inhibitors of PARP (olaparib and talazoparib), PD-L1 (atezolizumab) and an antibody drug conjugate targeting Trop-2 (sacituzumab govitecan-hziy) are now approved for the use in select groups of patients with TNBC.</p><p><strong>Summary: </strong>Various novel targeted agents as monotherapy, dual targeted combinations, and chemotherapy combinations are currently under investigation. The results are promising and may significantly improve patient outcomes in TNBC.</p>","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 3","pages":"216-226"},"PeriodicalIF":1.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386298/pdf/nihms-1713830.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-27DOI: 10.1007/s12609-021-00424-0
C. Weltz, E. Port
{"title":"Surgical Risk Reduction, Breast Cancer and Childbearing","authors":"C. Weltz, E. Port","doi":"10.1007/s12609-021-00424-0","DOIUrl":"https://doi.org/10.1007/s12609-021-00424-0","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"113 - 118"},"PeriodicalIF":0.9,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12609-021-00424-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49029780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-18DOI: 10.1007/s12609-021-00426-y
M. Davis, L. Newman
{"title":"Oncologic Anthropology: An Interdisciplinary Approach to Understanding the Association Between Genetically Defined African Ancestry and Susceptibility for Triple Negative Breast Cancer","authors":"M. Davis, L. Newman","doi":"10.1007/s12609-021-00426-y","DOIUrl":"https://doi.org/10.1007/s12609-021-00426-y","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"13 1","pages":"247 - 258"},"PeriodicalIF":0.9,"publicationDate":"2021-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12609-021-00426-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44160971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}