C. Poleggi, D. Restelli, Alfredo Luongo, Federica Cocuzza, Francesca Campanella, Mennili Sara, A. Currò, A. Recupero, M. Scarano
Anomalous origin of coronary artery (CA) is rare and does not generally lead to myocardial infarction. We re- port a case of a 61-year-old man presented with paroxysmal supraventricular tachycardia and atypical chest pain. After arrhythmia subsided, ECG showed T wave abnormalities and transient cardiac enzymes were found to be elevated. Coronary angiography demostrated an anomalous origin of the left circumfl ex artery (LCx) from the right sinus of Valsalva but no obstructive atherosclerotic coronary lesions. The possible rela- tion between the congenital coronary anomaly and the clinical manifestations of the patient is discussed.
{"title":"Anomalous origin of the left circumflex artery from right sinus of Valsalva: a rare case but with great clinical relevance","authors":"C. Poleggi, D. Restelli, Alfredo Luongo, Federica Cocuzza, Francesca Campanella, Mennili Sara, A. Currò, A. Recupero, M. Scarano","doi":"10.33678/cor.2022.063","DOIUrl":"https://doi.org/10.33678/cor.2022.063","url":null,"abstract":"Anomalous origin of coronary artery (CA) is rare and does not generally lead to myocardial infarction. We re- port a case of a 61-year-old man presented with paroxysmal supraventricular tachycardia and atypical chest pain. After arrhythmia subsided, ECG showed T wave abnormalities and transient cardiac enzymes were found to be elevated. Coronary angiography demostrated an anomalous origin of the left circumfl ex artery (LCx) from the right sinus of Valsalva but no obstructive atherosclerotic coronary lesions. The possible rela- tion between the congenital coronary anomaly and the clinical manifestations of the patient is discussed.","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46653112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
COVID-19 infection was declared a pandemic in March 2020 and is responsible for high morbidity and morta-lity around the globe. Although the most common clinical presentation is respiratory, cardiac complications are common and create new challenges for healthcare. We discuss two mildly symptomatic outpatients with COVID-19 presenting with acute ST-elevation myocardial infarction (STEMI) and high coronary thrombus burden without atherosclerotic plaque. Our report describes two different therapeutic approaches that illustrate the challenges encountered in the management of disseminated coronary thrombosis in patients with STEMI and COVID-19. Clinicians should be aware of the high pro-coagulant state caused by COVID-19, even in mildly symptomatic outpatients, and aggressive pharmacological therapy may be an effective alter- native treatment option to percutaneous coronary intervention.
{"title":"Beware of the Unexpected: Acute Coronary Thrombosis Following the Mildly Symptomatic COVID-19 Infection and Two Different Therapeutic Options","authors":"M. Gul, S. Inci","doi":"10.33678/cor.2022.074","DOIUrl":"https://doi.org/10.33678/cor.2022.074","url":null,"abstract":"COVID-19 infection was declared a pandemic in March 2020 and is responsible for high morbidity and morta-lity around the globe. Although the most common clinical presentation is respiratory, cardiac complications are common and create new challenges for healthcare. We discuss two mildly symptomatic outpatients with COVID-19 presenting with acute ST-elevation myocardial infarction (STEMI) and high coronary thrombus burden without atherosclerotic plaque. Our report describes two different therapeutic approaches that illustrate the challenges encountered in the management of disseminated coronary thrombosis in patients with STEMI and COVID-19. Clinicians should be aware of the high pro-coagulant state caused by COVID-19, even in mildly symptomatic outpatients, and aggressive pharmacological therapy may be an effective alter- native treatment option to percutaneous coronary intervention.","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42976743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Kara, Ahmet Özderya, Gulay Uzun, E. Kalaycıoğlu, M. Sayın, T. Turan
Objectıve: The effect of exercise-based cardiac rehabilitation (CR) on systemic infl ammation was not well established in patients with coronary artery disease (CAD). Neutrophil/lymphocyte (N/L) ratio has emerged as a new infl ammation marker and elevated levels were found to be associated with worse clinical outcome in patients with CAD. Also, poor impaired health-related quality of life (HRQL) is an independent predictor of morbi-mortality in patients with CAD. The purpose of this study is to determine the effect of exercise-based CR on N/L ratio and HRQL in patients with CAD. Methods: We enrolled 200 stable CAD out-patients referred for Phase III CR program by their physicians (CR group). We compared them with 100 stable CAD out-patients who did not have access to CR because of travel distance or comorbid conditions that limited exercise (non-CR group). Results: There was not a statistically signifi cant difference in the baseline clinical and biochemical characteristics between the groups. Although N/L ratio-post and CRP-post values were lower than the N/L ratio-pre and CRP-pre in CR & non-CR groups ( p <0.001 & p : 0.007 and p <0.001 & p <0.001), in the CR group N/L ratio-post and CRP-post values were lower than the non-CR group ( p <0.001 & p <0.001 and p <0.001 & p <0.001). Mac-New HRQL total-postscores were higher in the non-CR group ( p <0.001). Conclusions: Exercise-based CR program improves N/L ratio values and HRQL in patients with stable CAD. A
{"title":"The Effect of Exercise-Based Cardiac Rehabilitation on Neutrophil to Lymphocyte Ratio in Patients with Coronary Artery Disease","authors":"F. Kara, Ahmet Özderya, Gulay Uzun, E. Kalaycıoğlu, M. Sayın, T. Turan","doi":"10.33678/cor.2022.081","DOIUrl":"https://doi.org/10.33678/cor.2022.081","url":null,"abstract":"Objectıve: The effect of exercise-based cardiac rehabilitation (CR) on systemic infl ammation was not well established in patients with coronary artery disease (CAD). Neutrophil/lymphocyte (N/L) ratio has emerged as a new infl ammation marker and elevated levels were found to be associated with worse clinical outcome in patients with CAD. Also, poor impaired health-related quality of life (HRQL) is an independent predictor of morbi-mortality in patients with CAD. The purpose of this study is to determine the effect of exercise-based CR on N/L ratio and HRQL in patients with CAD. Methods: We enrolled 200 stable CAD out-patients referred for Phase III CR program by their physicians (CR group). We compared them with 100 stable CAD out-patients who did not have access to CR because of travel distance or comorbid conditions that limited exercise (non-CR group). Results: There was not a statistically signifi cant difference in the baseline clinical and biochemical characteristics between the groups. Although N/L ratio-post and CRP-post values were lower than the N/L ratio-pre and CRP-pre in CR & non-CR groups ( p <0.001 & p : 0.007 and p <0.001 & p <0.001), in the CR group N/L ratio-post and CRP-post values were lower than the non-CR group ( p <0.001 & p <0.001 and p <0.001 & p <0.001). Mac-New HRQL total-postscores were higher in the non-CR group ( p <0.001). Conclusions: Exercise-based CR program improves N/L ratio values and HRQL in patients with stable CAD. A","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49518389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
of these drugs effectively reduces blood pressure and heart rate, which improves the cardiovascular prognosis of selected patients. The article is devoted to the indications of these drugs in patients both in the treatment of uncomplicated hypertension and in secondary prevention in patients with ischemic heart disease. The emphasis is placed especially on the position of beta-blockers. Klíčová slova:
{"title":"(Why to use fixed dose perindopril, bisoprolol combination in hypertonics with CHD?)","authors":"O. Petrák","doi":"10.33678/cor.2023.004","DOIUrl":"https://doi.org/10.33678/cor.2023.004","url":null,"abstract":"of these drugs effectively reduces blood pressure and heart rate, which improves the cardiovascular prognosis of selected patients. The article is devoted to the indications of these drugs in patients both in the treatment of uncomplicated hypertension and in secondary prevention in patients with ischemic heart disease. The emphasis is placed especially on the position of beta-blockers. Klíčová slova:","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44112863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josef Laštůvka, M. Porzer, M. Branny, L. Pleva, J. Mrózek, P. Kukla, T. Grézl
{"title":"(Pseudoaneurysm of radial artery as a complication of selective coronary catheterization)","authors":"Josef Laštůvka, M. Porzer, M. Branny, L. Pleva, J. Mrózek, P. Kukla, T. Grézl","doi":"10.33678/cor.2022.042","DOIUrl":"https://doi.org/10.33678/cor.2022.042","url":null,"abstract":"","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44870655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Osmonov, A. Nazarov, M. Unal, Ishenbai Moldotashev, N. Usubaliev, A. Sorokin, Dmitry Lezhnin
The main aim of the research was to do the complex research and stratifi cation of clinical, functional, and surgical risk factors for coronary artery bypass grafting complications development in the preoperative pe- riod. Materials and methods: Data of 97 patients with coronary heart disease aged 31–84 (the mean age 62.9±8.4) after coronary artery bypass grafting (with the artifi cial circulation) have been analyzed. As prognostic criteria were analyzed the patient’s age, a history of the acute myocardial infarction, hospitalization time, number of the placed shunts, aortic compression duration, as well as the duration of the artifi cial circulation
{"title":"Evaluation of Complications Predictors in the Performance of Coronary Artery Bypass Grafting Surgery in the Cardiac Surgery Clinic \"Bicard\"","authors":"D. Osmonov, A. Nazarov, M. Unal, Ishenbai Moldotashev, N. Usubaliev, A. Sorokin, Dmitry Lezhnin","doi":"10.33678/cor.2022.049","DOIUrl":"https://doi.org/10.33678/cor.2022.049","url":null,"abstract":"The main aim of the research was to do the complex research and stratifi cation of clinical, functional, and surgical risk factors for coronary artery bypass grafting complications development in the preoperative pe- riod. Materials and methods: Data of 97 patients with coronary heart disease aged 31–84 (the mean age 62.9±8.4) after coronary artery bypass grafting (with the artifi cial circulation) have been analyzed. As prognostic criteria were analyzed the patient’s age, a history of the acute myocardial infarction, hospitalization time, number of the placed shunts, aortic compression duration, as well as the duration of the artifi cial circulation","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48023435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kotryna Druteikaitė, Simona Bėrontaitė, Gintarė Valterytė, G. Jaruševičius
Prosthetic heart valve thrombosis is one of the most dangerous prosthetic valve complications. Proper monitoring and management of these patients help to prevent this complication. Fluoroscopy is advantageous in cases of thrombosis to assess the function of the prosthetic valve by measuring opening and closing angles. We describe two cases of aortic mechanical valve thrombosis with different mechanisms of thrombus formation. The fi rst case was a 48-year-old woman admitted to the hospital because of shortness of breath during minimal exertion and signifi cantly reduced exercise tolerance. Due to rheumatic heart disease the patient underwent aortic and mitral mechanical prosthesis and has been using warfarin in therapeutic norms. During echocardioscopy aortic prosthesis obstruction and severe tricuspid valve regurgitation were observed. The patient was scheduled for aortic root and TV prosthesis surgery. The second patient also had aortic mechanical valve due to severe aortic stenosis caused by rheumatism and presented with organizing pneumonia and progressing respiratory failure as complications of the COVID-19 infection and was admitted with dyspnea, cough, and weakness. Aortic prosthetic valve thrombosis was diagnosed despite optimal treatment and therapeutic INR.
{"title":"Prosthetic valve thrombosis: literature review and two case reports","authors":"Kotryna Druteikaitė, Simona Bėrontaitė, Gintarė Valterytė, G. Jaruševičius","doi":"10.33678/cor.2022.054","DOIUrl":"https://doi.org/10.33678/cor.2022.054","url":null,"abstract":"Prosthetic heart valve thrombosis is one of the most dangerous prosthetic valve complications. Proper monitoring and management of these patients help to prevent this complication. Fluoroscopy is advantageous in cases of thrombosis to assess the function of the prosthetic valve by measuring opening and closing angles. We describe two cases of aortic mechanical valve thrombosis with different mechanisms of thrombus formation. The fi rst case was a 48-year-old woman admitted to the hospital because of shortness of breath during minimal exertion and signifi cantly reduced exercise tolerance. Due to rheumatic heart disease the patient underwent aortic and mitral mechanical prosthesis and has been using warfarin in therapeutic norms. During echocardioscopy aortic prosthesis obstruction and severe tricuspid valve regurgitation were observed. The patient was scheduled for aortic root and TV prosthesis surgery. The second patient also had aortic mechanical valve due to severe aortic stenosis caused by rheumatism and presented with organizing pneumonia and progressing respiratory failure as complications of the COVID-19 infection and was admitted with dyspnea, cough, and weakness. Aortic prosthetic valve thrombosis was diagnosed despite optimal treatment and therapeutic INR.","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48976034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Krebsová, Štěpánka Pohlová Kučerová, P. Votýpka, P. Peldová, M. Kulvajtová, Petra Dohnalova, Matěj Bílek, Veronika Stufka, Kristina Rücklová, I. Grossová, Hanka Wünschová, T. Tavacova, J. Haskova, M. Segeťová, A. Gřegořová, V. Zoubková, J. Petrkova, M. Dobias, Michal Makuša, A. Blanková, David Veitr, Hynek Řehulka, I. Šubrt, A. Pilin, P. Tomášek, J. Janoušek, J. Kautzner, M. Máček
Sudden cardiac death (SCD) in individuals younger than 40 years has a heritable cause in a signifi cant subset of cases. Identifi cation of SCD, postmortem genetic analysis along with the cardiological screening in fi rst degree relatives represents an important tool for the primary prevention of cardiac arrest in victim’s relatives and requires multicentric and multidisciplinary collaboration. Between 2016 and 2021 we dealt with totally 133 cases of sudden death, the complex cardiogenetic analysis was performed in 115 cases at the age of 0–59 years with post mortem diagnosis of cardiomyopathy, acute aortic dissection and cases without mor-phological fi nding explaining the cause of death (sudden arrhythmic death or sudden unexplained death). DNA was isolated from post mortem collected tissue samples or relative’s blood and subjected to massively parallel sequencing (SophiaGenetics, Switzerland). Genetic counselling and cardiological examinations were carried out in 328 family members. Highly likely or certain molecular aetiology (i.e. based on presence of ACMG.net classifi cation 4 to 5 variants) was disclosed in 19.8% of analysed cases in RYR2 , KCNH2 , KCNQ1 , SCN5A , FLNC , GLA , TTN , TNNT2, RBM 20, MYBPC3, MYPN, FHL1, TGFBR1, and COL3A1 genes. With cardiogenetic screening we identifi ed 83/328 (26.2%) relatives at risk of life threatening arrhythmias, who were offered individualised care. Conclusion: Our study with postmortem analysis could reveal a pathogenic DNA variant in 19.8% of cases and in 32.6% in cases with positive family history. A relevant number of studied victims had a positive family history, which indicates the importance of family cascade screening in patients with heart failure or malig-nant
{"title":"(Postmortem genetic testing in sudden cardiac death victims and genetic screening of relatives at risk in the Czech Republic)","authors":"A. Krebsová, Štěpánka Pohlová Kučerová, P. Votýpka, P. Peldová, M. Kulvajtová, Petra Dohnalova, Matěj Bílek, Veronika Stufka, Kristina Rücklová, I. Grossová, Hanka Wünschová, T. Tavacova, J. Haskova, M. Segeťová, A. Gřegořová, V. Zoubková, J. Petrkova, M. Dobias, Michal Makuša, A. Blanková, David Veitr, Hynek Řehulka, I. Šubrt, A. Pilin, P. Tomášek, J. Janoušek, J. Kautzner, M. Máček","doi":"10.33678/cor.2022.059","DOIUrl":"https://doi.org/10.33678/cor.2022.059","url":null,"abstract":"Sudden cardiac death (SCD) in individuals younger than 40 years has a heritable cause in a signifi cant subset of cases. Identifi cation of SCD, postmortem genetic analysis along with the cardiological screening in fi rst degree relatives represents an important tool for the primary prevention of cardiac arrest in victim’s relatives and requires multicentric and multidisciplinary collaboration. Between 2016 and 2021 we dealt with totally 133 cases of sudden death, the complex cardiogenetic analysis was performed in 115 cases at the age of 0–59 years with post mortem diagnosis of cardiomyopathy, acute aortic dissection and cases without mor-phological fi nding explaining the cause of death (sudden arrhythmic death or sudden unexplained death). DNA was isolated from post mortem collected tissue samples or relative’s blood and subjected to massively parallel sequencing (SophiaGenetics, Switzerland). Genetic counselling and cardiological examinations were carried out in 328 family members. Highly likely or certain molecular aetiology (i.e. based on presence of ACMG.net classifi cation 4 to 5 variants) was disclosed in 19.8% of analysed cases in RYR2 , KCNH2 , KCNQ1 , SCN5A , FLNC , GLA , TTN , TNNT2, RBM 20, MYBPC3, MYPN, FHL1, TGFBR1, and COL3A1 genes. With cardiogenetic screening we identifi ed 83/328 (26.2%) relatives at risk of life threatening arrhythmias, who were offered individualised care. Conclusion: Our study with postmortem analysis could reveal a pathogenic DNA variant in 19.8% of cases and in 32.6% in cases with positive family history. A relevant number of studied victims had a positive family history, which indicates the importance of family cascade screening in patients with heart failure or malig-nant","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48528604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Santos, Mariana Santos, Margarida Gancho Figueiredo, Mariana Caetano Coelho, S. Almeida, L. Almeida, S. Paula
Background: Acute coronary syndrome (ACS) and atrial fi brillation (AF) are common in the Portuguese population. In some cases, AF fi rst episode can occur in ACS context. Nevertheless, the impact of new-onset AF (nAF) in the setting of ACS seems to be associated with a poor prognosis. Objectives: To understand different characteristic in nAF patients with ACS and to evaluate the predictors of nAF. Methods: Multicenter retrospective study based on the Acute Coronary Syndrome Portuguese National Registry, including 29 851 patients admitted for ACS between 1/10/2010–4/09/2019, classifi ed according to the presence or absence of nAF during the hospitalization. Patients with previous AF were excluded. Results: nAF was identifi ed in 1067 patients (4.1%), mostly older, presenting more non-cardiovascular comorbidities, decreased left ventricular ejection fraction (LVEF) and a more complex coronary disease. nAF pa- tients received more anti-arrhythmic therapy, but just 21.5% had triple anti-thrombotic therapy and 30.3% had dual anti-thrombotic therapy. This group also presented high rates of in-hospital complications and death. Multiple logistic regression revealed that age >75 years old, previous stroke, higher Killip–Kimball class, haemoglobin <12g/dL and LVEF <50% were predictors of nAF in the setting of ACS. CHA 2 DS 2 -VASc score was a predictor of nAF in the setting of ACS (odds ratio 2.07, p <0.001), of cardiovascular re-admission ( p <0.001) and all-cause of re-admission ( p <0.001) at one year follow-up. Conclusions: Patients with nAF in the setting of ACS have a worse prognosis when compared to sinus rhythm patients. CHA 2 DS 2 -VASc score used for thromboembolic risk
{"title":"New onset of atrial fibrillation in acute coronary syndromes","authors":"H. Santos, Mariana Santos, Margarida Gancho Figueiredo, Mariana Caetano Coelho, S. Almeida, L. Almeida, S. Paula","doi":"10.33678/cor.2022.052","DOIUrl":"https://doi.org/10.33678/cor.2022.052","url":null,"abstract":"Background: Acute coronary syndrome (ACS) and atrial fi brillation (AF) are common in the Portuguese population. In some cases, AF fi rst episode can occur in ACS context. Nevertheless, the impact of new-onset AF (nAF) in the setting of ACS seems to be associated with a poor prognosis. Objectives: To understand different characteristic in nAF patients with ACS and to evaluate the predictors of nAF. Methods: Multicenter retrospective study based on the Acute Coronary Syndrome Portuguese National Registry, including 29 851 patients admitted for ACS between 1/10/2010–4/09/2019, classifi ed according to the presence or absence of nAF during the hospitalization. Patients with previous AF were excluded. Results: nAF was identifi ed in 1067 patients (4.1%), mostly older, presenting more non-cardiovascular comorbidities, decreased left ventricular ejection fraction (LVEF) and a more complex coronary disease. nAF pa- tients received more anti-arrhythmic therapy, but just 21.5% had triple anti-thrombotic therapy and 30.3% had dual anti-thrombotic therapy. This group also presented high rates of in-hospital complications and death. Multiple logistic regression revealed that age >75 years old, previous stroke, higher Killip–Kimball class, haemoglobin <12g/dL and LVEF <50% were predictors of nAF in the setting of ACS. CHA 2 DS 2 -VASc score was a predictor of nAF in the setting of ACS (odds ratio 2.07, p <0.001), of cardiovascular re-admission ( p <0.001) and all-cause of re-admission ( p <0.001) at one year follow-up. Conclusions: Patients with nAF in the setting of ACS have a worse prognosis when compared to sinus rhythm patients. CHA 2 DS 2 -VASc score used for thromboembolic risk","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44109761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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