Pub Date : 2019-09-18DOI: 10.2174/2213240606666190423122358
P. Y. Ajmal, R. Bhangare, M. Tiwari, S. Sahu
A major class of nitro-explosives being used in military and commercial purposes belongs to organic compounds containing nitro (NO2) groups like nitrobenzene, nitrotoluenes, and nitramines. Apart from being energetic materials, these substances are inherently toxic to human beings. These substances may find their way into different environmental matrices from the site of their military or commercial applications. They are present in nature at ultra-trace levels. Chromatographic techniques have been widely used for the detection and quantification of nitro-explosives from various environmental matrices. The current study involves a comparison of the performance of liquid and gas chromatography with and without pre-concentration techniques like Solid Phase Micro-extraction (SPME) to detect ultra-trace levels nitrobenzene and nitrotoluenes in water. The addition of SPME to chromatographic techniques significantly improves the quality of the analysis in terms of ease and sensitivity. Both SPME-HPLC and SPME-GC are equally competent techniques for the analysis of nitroaromatic explosives from water. Detection limits were improved by upto 5 orders of magnitude by these methods. The methodology for determining nitroaromatic explosives in water samples has been optimized and validated after trying four different methods and comparing their performance. GC and HPLC techniques used alone cannot be sensitive enough to detect these compounds at ultra-trace levels. Both SPME-HPLC-UV and SPME-GC-FID are equally competent techniques. SPME method has been proved to be an excellent tool with no requirement of any tedious sample preparation and chemical processing of the samples.
{"title":"Analysis of Nitroaromatics: A Comparison Between Gas Chromatography, Liquid Chromatography and their Hyphenation with Solid Phase Micro-Extraction","authors":"P. Y. Ajmal, R. Bhangare, M. Tiwari, S. Sahu","doi":"10.2174/2213240606666190423122358","DOIUrl":"https://doi.org/10.2174/2213240606666190423122358","url":null,"abstract":"\u0000\u0000A major class of nitro-explosives being used in military and commercial\u0000purposes belongs to organic compounds containing nitro (NO2) groups like nitrobenzene, nitrotoluenes,\u0000and nitramines. Apart from being energetic materials, these substances are inherently\u0000toxic to human beings. These substances may find their way into different environmental matrices\u0000from the site of their military or commercial applications. They are present in nature at ultra-trace\u0000levels.\u0000\u0000\u0000\u0000Chromatographic techniques have been widely used for the detection and quantification\u0000of nitro-explosives from various environmental matrices. The current study involves a comparison\u0000of the performance of liquid and gas chromatography with and without pre-concentration techniques\u0000like Solid Phase Micro-extraction (SPME) to detect ultra-trace levels nitrobenzene and nitrotoluenes\u0000in water.\u0000\u0000\u0000\u0000The addition of SPME to chromatographic techniques significantly improves the quality\u0000of the analysis in terms of ease and sensitivity. Both SPME-HPLC and SPME-GC are equally\u0000competent techniques for the analysis of nitroaromatic explosives from water. Detection limits\u0000were improved by upto 5 orders of magnitude by these methods.\u0000\u0000\u0000\u0000The methodology for determining nitroaromatic explosives in water samples has\u0000been optimized and validated after trying four different methods and comparing their performance.\u0000GC and HPLC techniques used alone cannot be sensitive enough to detect these compounds\u0000at ultra-trace levels. Both SPME-HPLC-UV and SPME-GC-FID are equally competent techniques.\u0000SPME method has been proved to be an excellent tool with no requirement of any tedious\u0000sample preparation and chemical processing of the samples.\u0000","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78637303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-18DOI: 10.2174/2213240606666190619120733
T. Hanai
The retention mechanism in reversed-phase liquid chromatography was quantitatively described using log P (octanol-water partition coefficient). The hydrophobic (lipophilic) interaction liquid chromatography was then used to measure the hydrophobicity of a variety of compounds. Furthermore, the technique has been used as an analytical method to determine molecular properties during the drug discovery process. However, log P values cannot be applied to other chromatographic techniques. Therefore, the direct calculation of molecular interactions was proposed to describe the general retention mechanisms in chromatography. The retention mechanisms in reversed-phase liquid chromatography were quantitatively described in silico by using simple model compounds and phases. The competitive interactions between a bonded-phase and a solvent phase clearly demonstrated the retention mechanisms in reversed-phase liquid chromatography. Chromatographic behavior of acidic drugs on a pentyl-, an octyl-, and a hexenyl-phase was quantitatively described in the in silico analysis. Their retention was based on their hydrophobicity, and hydrogen bonding and electrostatic interaction were selectivity of the hexenyl-phase. This review focuses on the quantitative explanation of the retention mechanisms in reversed-phase liquid chromatography and the practical applications in drug discovery.
{"title":"Quantitative Explanation of Retention Mechanisms in Reversed-phase Mode Liquid Chromatography, and Utilization of Typical Reversed-phase Liquid Chromatography for Drug Discovery","authors":"T. Hanai","doi":"10.2174/2213240606666190619120733","DOIUrl":"https://doi.org/10.2174/2213240606666190619120733","url":null,"abstract":"\u0000\u0000The retention mechanism in reversed-phase liquid chromatography was quantitatively\u0000described using log P (octanol-water partition coefficient). The hydrophobic (lipophilic) interaction\u0000liquid chromatography was then used to measure the hydrophobicity of a variety of compounds.\u0000Furthermore, the technique has been used as an analytical method to determine molecular\u0000properties during the drug discovery process. However, log P values cannot be applied to other\u0000chromatographic techniques. Therefore, the direct calculation of molecular interactions was proposed\u0000to describe the general retention mechanisms in chromatography. The retention mechanisms\u0000in reversed-phase liquid chromatography were quantitatively described in silico by using simple\u0000model compounds and phases. The competitive interactions between a bonded-phase and a solvent\u0000phase clearly demonstrated the retention mechanisms in reversed-phase liquid chromatography.\u0000Chromatographic behavior of acidic drugs on a pentyl-, an octyl-, and a hexenyl-phase was quantitatively\u0000described in the in silico analysis. Their retention was based on their hydrophobicity, and\u0000hydrogen bonding and electrostatic interaction were selectivity of the hexenyl-phase. This review\u0000focuses on the quantitative explanation of the retention mechanisms in reversed-phase liquid\u0000chromatography and the practical applications in drug discovery.\u0000","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"199 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82089110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-25DOI: 10.2174/2213240606666190725104244
A. Tripathi, Jigni Mishra, Anuja Bhardwaj, K. Misra, Sarada S K Sagi
Quercetin (3’,3’,4,5,7-pentahydroxyflavonol), a natural flavonoid found in fruits, vegetables, beverages, and other phytoproducts, exerts multiple health benefits including a reduction in hypoxia-induced oxidative stress, inflammation, lipid peroxidation, allergic disorders, neurodegenerative disorders, and cardiovascular diseases. Despite knowledge of such therapeutic efficacy of quercetin to human health, there is limited literature available that sheds light on an organ-wise distribution of quercetin. Therefore, the current study was performed to accurately estimate the distribution of quercetin in its supplemented form in different tissues of a mammalian model, i.e., male Sprague Dawley (SD) rats. The rats were exposed to different durations (1 h, 3 h, 6 h, and 12 h) of hypoxia in a simulated hypobaric hypoxia chamber, with parameters maintained at 8 % O2 and 282 mm Hg, following which they were sacrificed. Plasma and different tissue samples were duly collected. A high-performance thin layer chromatography (HPTLC) approach was employed for the first time, using our own reported method, along with an optimized sample preparation procedure for quercetin determination. Briefly, the samples were developed in a mobile phase constituted of ethyl acetate, dichloromethane, methanol, formic acid, and glacial acetic acid. Distinct bands of quercetin in resultant HPTLC profiles verified that the amount of quercetin varied among different tissues, with varying durations to hypoxia exposure. Quercetin was substantially retained in vital organs namely, lungs, liver, and heart for relatively longer durations. The present study established HPTLC as an efficient and high throughput tool, leading to a satisfactory evaluation of the amount of quercetin present in various tissue samples under hypoxia.
{"title":"Distribution of Quercetin in Different Organs of Male Sprague Dawley Rats Under Hypoxia: A High-Performance Thin Layer Chromatography Approach","authors":"A. Tripathi, Jigni Mishra, Anuja Bhardwaj, K. Misra, Sarada S K Sagi","doi":"10.2174/2213240606666190725104244","DOIUrl":"https://doi.org/10.2174/2213240606666190725104244","url":null,"abstract":"\u0000\u0000Quercetin (3’,3’,4,5,7-pentahydroxyflavonol), a natural flavonoid found in\u0000fruits, vegetables, beverages, and other phytoproducts, exerts multiple health benefits including a reduction\u0000in hypoxia-induced oxidative stress, inflammation, lipid peroxidation, allergic disorders,\u0000neurodegenerative disorders, and cardiovascular diseases.\u0000\u0000\u0000\u0000Despite knowledge of such therapeutic efficacy of quercetin to human health, there is\u0000limited literature available that sheds light on an organ-wise distribution of quercetin. Therefore, the\u0000current study was performed to accurately estimate the distribution of quercetin in its supplemented\u0000form in different tissues of a mammalian model, i.e., male Sprague Dawley (SD) rats.\u0000\u0000\u0000\u0000The rats were exposed to different durations (1 h, 3 h, 6 h, and 12 h) of hypoxia\u0000in a simulated hypobaric hypoxia chamber, with parameters maintained at 8 % O2 and 282 mm\u0000Hg, following which they were sacrificed. Plasma and different tissue samples were duly collected.\u0000A high-performance thin layer chromatography (HPTLC) approach was employed for the first time,\u0000using our own reported method, along with an optimized sample preparation procedure for quercetin\u0000determination. Briefly, the samples were developed in a mobile phase constituted of ethyl acetate,\u0000dichloromethane, methanol, formic acid, and glacial acetic acid.\u0000\u0000\u0000\u0000Distinct bands of quercetin in resultant HPTLC profiles verified that the\u0000amount of quercetin varied among different tissues, with varying durations to hypoxia exposure.\u0000Quercetin was substantially retained in vital organs namely, lungs, liver, and heart for relatively\u0000longer durations.\u0000\u0000\u0000\u0000The present study established HPTLC as an efficient and high throughput tool, leading to\u0000a satisfactory evaluation of the amount of quercetin present in various tissue samples under hypoxia.\u0000","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84961861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.2174/2213240606666190709100858
I. Zenkevich, Nino G. Todua, A. Mikaia
Background Application of simple regularities and general principles along with direct use of reference gas chromatography retention index data for reliable structure determination of compounds can be enhanced by determination of new regularities that are specific to certain structural elements. Objective Revelation and interpretation of an anomaly in the elution order of alkyl esters of alkoxycarbonyl derivatives of glycine and alanine on standard and semi-standard non-polar phases. Method Preliminary derivatization of amino acids to alkyl esters of N-alkoxycarbonyl analogs and interpretation of their gas chromatographic characteristics. Results Alkyl esters of N-alkoxycarbonyl derivatives of alanine (Alkyl = C2H5, n- and iso-C3H7) elute prior to the same derivatives of glycine, despite the presence of an additional methyl group at C(2) in the molecule. Elution order is reversed for methyl esters of N-methoxycarbonyl derivatives. Conclusion It is established that the peculiar behavior of alkyl esters of N-alkoxycarbonyl derivatives of glycine and alanine agrees with the concepts of gas chromatography and the known retention index regularities of organic compounds. A decrease of retention index values is a result of an introduction of an additional methyl group to a carbon atom connected to two polar fragments in a molecule like CH2XY. The dependence of the difference of retention index values for homologs of the types of CH3-CHXY and CH2XY vs. the total mass of fragments (X + Y) is similar to those for other sub-groups of analytes.
{"title":"Unusual Regularity in GC Retention of Simple Amino Acid Derivatives.","authors":"I. Zenkevich, Nino G. Todua, A. Mikaia","doi":"10.2174/2213240606666190709100858","DOIUrl":"https://doi.org/10.2174/2213240606666190709100858","url":null,"abstract":"Background\u0000Application of simple regularities and general principles along with direct use of reference gas chromatography retention index data for reliable structure determination of compounds can be enhanced by determination of new regularities that are specific to certain structural elements.\u0000\u0000\u0000Objective\u0000Revelation and interpretation of an anomaly in the elution order of alkyl esters of alkoxycarbonyl derivatives of glycine and alanine on standard and semi-standard non-polar phases.\u0000\u0000\u0000Method\u0000Preliminary derivatization of amino acids to alkyl esters of N-alkoxycarbonyl analogs and interpretation of their gas chromatographic characteristics.\u0000\u0000\u0000Results\u0000Alkyl esters of N-alkoxycarbonyl derivatives of alanine (Alkyl = C2H5, n- and iso-C3H7) elute prior to the same derivatives of glycine, despite the presence of an additional methyl group at C(2) in the molecule. Elution order is reversed for methyl esters of N-methoxycarbonyl derivatives.\u0000\u0000\u0000Conclusion\u0000It is established that the peculiar behavior of alkyl esters of N-alkoxycarbonyl derivatives of glycine and alanine agrees with the concepts of gas chromatography and the known retention index regularities of organic compounds. A decrease of retention index values is a result of an introduction of an additional methyl group to a carbon atom connected to two polar fragments in a molecule like CH2XY. The dependence of the difference of retention index values for homologs of the types of CH3-CHXY and CH2XY vs. the total mass of fragments (X + Y) is similar to those for other sub-groups of analytes.","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"2000 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82798268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.2174/2213240606666181226143757
Ranjith Arimboor, K. R. Menon, N. Babu, Haneesh Chandran
Increased consumer demand for curry leaves free from pesticides demands fast and reliable analytical methods for the analysis of pesticide residues.The optimization of a QuEChERS based sample preparation technique with improved analytical accuracy by removing interfering matrix components for LC-MS/MS analysis of pesticide residues from curry leaves.A modified QuEChERS solid phase extraction method was developed and validated for the analysis of 26 pesticides in fresh and dried curry leaves. The effects of the sample preparation steps and column retention time on the matrix suppression of analyte ions were also evaluated.Validation parameters were found within an acceptable range. The matrix effect evaluation studies showed that the QuEChERS sample preparation was able to minimize the ion suppression of analytes due to co-eluting matrix of components and that a d-SPE clean up step had major role in reducing matrix effect. The gradient mobile phase with longer retention time for analytes resulted in comparatively lesser matrix effects than the isocratic mobile phase of non-polar nature. Even after the clean up, a considerable number of compounds had more than 20% reduction in their MS response in the gradient mobile phase.This study emphasized the need of proper sample clean up before a LC-MS/MS analysis and the usage of matrix matched standards and mobile phase that ultimately results in an appropriate analyte separation in reasonable retention times.
{"title":"A Modified QuEChERS Extraction and LC-MS/MS Method for the Determination of Pesticide Residues in Curry Leaves (Murraya koenigii)","authors":"Ranjith Arimboor, K. R. Menon, N. Babu, Haneesh Chandran","doi":"10.2174/2213240606666181226143757","DOIUrl":"https://doi.org/10.2174/2213240606666181226143757","url":null,"abstract":"Increased consumer demand for curry leaves free from pesticides demands fast and reliable analytical methods for the analysis of pesticide residues.The optimization of a QuEChERS based sample preparation technique with improved analytical accuracy by removing interfering matrix components for LC-MS/MS analysis of pesticide residues from curry leaves.A modified QuEChERS solid phase extraction method was developed and validated for the analysis of 26 pesticides in fresh and dried curry leaves. The effects of the sample preparation steps and column retention time on the matrix suppression of analyte ions were also evaluated.Validation parameters were found within an acceptable range. The matrix effect evaluation studies showed that the QuEChERS sample preparation was able to minimize the ion suppression of analytes due to co-eluting matrix of components and that a d-SPE clean up step had major role in reducing matrix effect. The gradient mobile phase with longer retention time for analytes resulted in comparatively lesser matrix effects than the isocratic mobile phase of non-polar nature. Even after the clean up, a considerable number of compounds had more than 20% reduction in their MS response in the gradient mobile phase.This study emphasized the need of proper sample clean up before a LC-MS/MS analysis and the usage of matrix matched standards and mobile phase that ultimately results in an appropriate analyte separation in reasonable retention times.","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82158857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.2174/2213240606666190410152956
Carina Maria Bello de Carvalho, Scorsatto R. Ortiz, R. Limberger
Dating of ballpoint pen manuscripts in forensic documents is still a challenge for experts. Methods of ink dating consider solvent evaporation through time, especially 2- phenoxyethanol (2-PE). The objective of the researchers was to perform a continued study with pen ink strokes of ballpoint pens commercialized in Brazil, to characterize the ageing profile of 15 brands of blue and black pens. Solvent composition analysis of ballpoint pen ink lines written in white and recycled paper was performed by gas chromatography/mass spectrometry, to quantify 2-PE, in recently written lines and in lines aged 4, 18, 27 and 36 months. The results showed that the pens had initial quantities of 2-PE smaller than in the Europe despite of having similar ageing behavior. Such kind of paper had more influence on aged pen strokes than in the recently applied pen strokes. Light and heat accelerated ageing. Some pens stopped ageing at 18, 27 and 36 months. The results obtained were promising for elucidation of the ageing behavior of pen ink lines in tropical weather, but further statistical treatments could be done to adequate interpretation in real cases.
{"title":"Manuscripts from Different Brands of Ballpoint Pens – GC/MS Ageing Profile in Brazilian Tropical Weather","authors":"Carina Maria Bello de Carvalho, Scorsatto R. Ortiz, R. Limberger","doi":"10.2174/2213240606666190410152956","DOIUrl":"https://doi.org/10.2174/2213240606666190410152956","url":null,"abstract":"\u0000\u0000Dating of ballpoint pen manuscripts in forensic documents is still a challenge\u0000for experts. Methods of ink dating consider solvent evaporation through time, especially 2-\u0000phenoxyethanol (2-PE).\u0000\u0000\u0000\u0000The objective of the researchers was to perform a continued study with pen ink strokes\u0000of ballpoint pens commercialized in Brazil, to characterize the ageing profile of 15 brands of blue\u0000and black pens.\u0000\u0000\u0000\u0000Solvent composition analysis of ballpoint pen ink lines written in white and recycled\u0000paper was performed by gas chromatography/mass spectrometry, to quantify 2-PE, in recently\u0000written lines and in lines aged 4, 18, 27 and 36 months.\u0000\u0000\u0000\u0000The results showed that the pens had initial quantities of 2-PE smaller than in the Europe\u0000despite of having similar ageing behavior. Such kind of paper had more influence on aged pen\u0000strokes than in the recently applied pen strokes. Light and heat accelerated ageing. Some pens\u0000stopped ageing at 18, 27 and 36 months.\u0000\u0000\u0000\u0000The results obtained were promising for elucidation of the ageing behavior of pen ink\u0000lines in tropical weather, but further statistical treatments could be done to adequate interpretation\u0000in real cases.\u0000","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78647654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-11DOI: 10.2174/2213240605666181109154409
M. Mariani, A. Penissi
Fil: Mariani, Maria Laura Lucia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Histologia y Embriologia de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Instituto de Histologia y Embriologia de Mendoza Dr. Mario H. Burgos; Argentina
线程:Mariani, Maria Laura Lucia。国家科学技术研究委员会。科学技术中心Conicet - Mendoza。门多萨组织与胚胎研究所Mario H. Burgos博士。库约国立大学。医学科学学院。门多萨组织学和胚胎学研究所Mario H. Burgos博士;阿根廷
{"title":"Development and Validation of a Novel HPLC Method for the Analysis and Quantification of Dehydroleucodine in Plant Extracts","authors":"M. Mariani, A. Penissi","doi":"10.2174/2213240605666181109154409","DOIUrl":"https://doi.org/10.2174/2213240605666181109154409","url":null,"abstract":"Fil: Mariani, Maria Laura Lucia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Histologia y Embriologia de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Instituto de Histologia y Embriologia de Mendoza Dr. Mario H. Burgos; Argentina","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81625780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-11DOI: 10.2174/2213240605666180912144153
P. Porwal, S. Sawant, S. Tambe
{"title":"Effect of Organic Modifier on Elution Behavior of Voriconazole in Supercritical Fluid Chromatography: Development of Validated SFC Method","authors":"P. Porwal, S. Sawant, S. Tambe","doi":"10.2174/2213240605666180912144153","DOIUrl":"https://doi.org/10.2174/2213240605666180912144153","url":null,"abstract":"","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87492800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-11DOI: 10.2174/2213240605666180810104156
M. L. Alonso, N. Ayarza, I. S. Román, L. Bartolomé, R. Alonso
{"title":"Analytical Methodologies Used in Nanoparticles Remediation Processes for Monitoring of Organic Pollutants. An Overview","authors":"M. L. Alonso, N. Ayarza, I. S. Román, L. Bartolomé, R. Alonso","doi":"10.2174/2213240605666180810104156","DOIUrl":"https://doi.org/10.2174/2213240605666180810104156","url":null,"abstract":"","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81193139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-11DOI: 10.2174/2213240605666180913100054
C. Waterlot, A. Ghinet, E. Lipka
{"title":"Core-shell Particles: A Way to Greening Liquid Chromatography in Environmental Applications","authors":"C. Waterlot, A. Ghinet, E. Lipka","doi":"10.2174/2213240605666180913100054","DOIUrl":"https://doi.org/10.2174/2213240605666180913100054","url":null,"abstract":"","PeriodicalId":10826,"journal":{"name":"Current chromatography","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76395123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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