Self-emulsifying drug delivery systems (SEDDS) can increase the solubility and bioavailability of poorly soluble drugs. The inability of 35% to 40% of new pharmaceuticals to dissolve in water presents a serious challenge for the pharmaceutical industry. As a result, there must be dosage proportionality, considerable intra- and inter-subject variability, poor solubility, and limited lung bioavailability. As a result, it is critical that drugs intended for oral administration be highly soluble. This can be improved through a variety of means, including salt generation and the facilitation of solid and complicated dispersion. Surfactants, lubricants, and cosolvents may occasionally be found in SEDDS or isotropic blends. Lipophilic drugs, whose absorption is limited by their dissolution rate, have been used to demonstrate the effectiveness of various formulations and techniques. These particles can form microemulsions and suitable oil-inwater emulsions with minimal agitation and dilution by the water phase as they pass through the gastrointestinal tract. This study summarises the numerous advances, biopharmaceutical components, variations, production techniques, characterisation approaches, limitations, and opportunities for SEDDS. With this context in mind, this review compiles a current account of biopharmaceutical advancements, such as the application of quality by design (QbD) methodologies to optimise drug formulations in different excipients with controllable ratios, the presence of regulatory roadblocks to progress, and the future consequences of SEDDS, encompassing composition, evaluation, diverse dosage forms, and innovative techniques for in vitro converting liquid SEDDS to solid forms.
{"title":"Self-Emulsifying Drug Delivery Systems: Concept to Applications, Regulatory Issues, Recent Patents, Current Challenges and Future Directions.","authors":"Rajib Lochan Maharana, Suryakanta Swain, Santosh Kumar Mahapatra, Bikash Ranjan Jena","doi":"10.2174/0113892010296223240612050639","DOIUrl":"https://doi.org/10.2174/0113892010296223240612050639","url":null,"abstract":"<p><p>Self-emulsifying drug delivery systems (SEDDS) can increase the solubility and bioavailability of poorly soluble drugs. The inability of 35% to 40% of new pharmaceuticals to dissolve in water presents a serious challenge for the pharmaceutical industry. As a result, there must be dosage proportionality, considerable intra- and inter-subject variability, poor solubility, and limited lung bioavailability. As a result, it is critical that drugs intended for oral administration be highly soluble. This can be improved through a variety of means, including salt generation and the facilitation of solid and complicated dispersion. Surfactants, lubricants, and cosolvents may occasionally be found in SEDDS or isotropic blends. Lipophilic drugs, whose absorption is limited by their dissolution rate, have been used to demonstrate the effectiveness of various formulations and techniques. These particles can form microemulsions and suitable oil-inwater emulsions with minimal agitation and dilution by the water phase as they pass through the gastrointestinal tract. This study summarises the numerous advances, biopharmaceutical components, variations, production techniques, characterisation approaches, limitations, and opportunities for SEDDS. With this context in mind, this review compiles a current account of biopharmaceutical advancements, such as the application of quality by design (QbD) methodologies to optimise drug formulations in different excipients with controllable ratios, the presence of regulatory roadblocks to progress, and the future consequences of SEDDS, encompassing composition, evaluation, diverse dosage forms, and innovative techniques for in vitro converting liquid SEDDS to solid forms.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-20DOI: 10.2174/0113892010306005240605072550
Rohitas Deshmukh
Pain and swelling in the joints, increased synovial thickness, and bone and cartilage degeneration are all symptoms of Rheumatoid Arthritis (RA). Anti-rheumatic medications, which are used in conventional treatment plans for RA, need high doses, frequent administration, and long-term use, all of which increase the risk of major adverse effects and low patient compliance. Drug Delivery Systems (DDS) have been developed for RA treatment in an effort to avoid these obstacles and improve clinical efficacy. There have been many successful experimental RA models using these techniques. There has been a notable uptick in the study of RA nanotherapies as a prospective improvement over conventional systemic therapy. In order to overcome the limits of traditional treatments, researchers have begun looking into nanotherapeutic approaches, notably drug-delivery nanosystems. The precise delivery and concentration of therapeutic drugs in the affected regions are made possible by the passive or active targeting of systemic administration. Several new DDS for treating RA have been addressed here. Therefore, nanoscale drug delivery devices increase drug solubility and bioavailability while decreasing the need for higher doses.
关节疼痛和肿胀、滑膜厚度增加、骨和软骨退化都是类风湿关节炎(RA)的症状。类风湿关节炎的传统治疗方案中使用的抗风湿药物需要大剂量、频繁用药和长期使用,所有这些都会增加出现重大不良反应和患者依从性低的风险。为了避免这些障碍并提高临床疗效,人们开发了用于治疗 RA 的给药系统(DDS)。许多成功的 RA 实验模型都使用了这些技术。作为对传统系统疗法的一种前瞻性改进,对 RA 纳米疗法的研究明显增加。为了克服传统疗法的局限性,研究人员已开始研究纳米治疗方法,特别是给药纳米系统。通过系统给药的被动或主动靶向性,可以在受影响区域精确输送和浓缩治疗药物。本文介绍了几种用于治疗 RA 的新型 DDS。因此,纳米级给药装置可提高药物溶解度和生物利用度,同时减少对高剂量的需求。
{"title":"Drug Targeting and Nanotherapeutic Advancement in the Treatment of Rheumatoid Arthritis: Recent Progress in Drug Delivery Systems.","authors":"Rohitas Deshmukh","doi":"10.2174/0113892010306005240605072550","DOIUrl":"https://doi.org/10.2174/0113892010306005240605072550","url":null,"abstract":"<p><p>Pain and swelling in the joints, increased synovial thickness, and bone and cartilage degeneration are all symptoms of Rheumatoid Arthritis (RA). Anti-rheumatic medications, which are used in conventional treatment plans for RA, need high doses, frequent administration, and long-term use, all of which increase the risk of major adverse effects and low patient compliance. Drug Delivery Systems (DDS) have been developed for RA treatment in an effort to avoid these obstacles and improve clinical efficacy. There have been many successful experimental RA models using these techniques. There has been a notable uptick in the study of RA nanotherapies as a prospective improvement over conventional systemic therapy. In order to overcome the limits of traditional treatments, researchers have begun looking into nanotherapeutic approaches, notably drug-delivery nanosystems. The precise delivery and concentration of therapeutic drugs in the affected regions are made possible by the passive or active targeting of systemic administration. Several new DDS for treating RA have been addressed here. Therefore, nanoscale drug delivery devices increase drug solubility and bioavailability while decreasing the need for higher doses.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The process of wound healing is intricate and requires close coordination; any disruption to this process can have catastrophic results. It is hypothesized that chronic wounds that do not heal or that cease healing entirely can be caused by a combination of host factors and bacteria that are present in a wound bed or wound bed environment. There is currently a lack of understanding regarding the role that the cutaneous microbiome plays in the healing process of wounds, despite the fact that methods that do not rely on culture have revealed the role that the gut microbiome plays in human health and illness. In order to keep the host immune system in check, protect the epithelial barrier function, and ward off harmful microbes, skin commensals play a crucial role. This review compiles the research on the effects of microbiome modifications on wound healing and tissue regeneration from both clinical and pre-clinical investigations on a variety of chronic skin wounds. It is now clear that human skin commensals, symbionts, and pathogens all play a part in the inflammatory response, which in turn suggests a number of ways to treat wounds that are infected and not healing. To fully understand the function of the human skin microbiome in both short-term and long-term wound healing, additional study is required to reconcile the conflicting and contentious results of previous investigations.
{"title":"Unravelling the Microbiome's Role in Healing Diabetic Wounds","authors":"Sanchit Dhankhar, Nitika Garg, Samrat Chauhan, Monika Saini, Thakur Gurjeet Singh, Randhir Singh","doi":"10.2174/0113892010307032240530071003","DOIUrl":"https://doi.org/10.2174/0113892010307032240530071003","url":null,"abstract":"\u0000\u0000The process of wound healing is intricate and requires close coordination; any disruption\u0000to this process can have catastrophic results. It is hypothesized that chronic wounds that do\u0000not heal or that cease healing entirely can be caused by a combination of host factors and bacteria\u0000that are present in a wound bed or wound bed environment. There is currently a lack of understanding\u0000regarding the role that the cutaneous microbiome plays in the healing process of\u0000wounds, despite the fact that methods that do not rely on culture have revealed the role that the\u0000gut microbiome plays in human health and illness. In order to keep the host immune system in\u0000check, protect the epithelial barrier function, and ward off harmful microbes, skin commensals\u0000play a crucial role. This review compiles the research on the effects of microbiome modifications\u0000on wound healing and tissue regeneration from both clinical and pre-clinical investigations on a\u0000variety of chronic skin wounds. It is now clear that human skin commensals, symbionts, and\u0000pathogens all play a part in the inflammatory response, which in turn suggests a number of ways\u0000to treat wounds that are infected and not healing. To fully understand the function of the human\u0000skin microbiome in both short-term and long-term wound healing, additional study is required to\u0000reconcile the conflicting and contentious results of previous investigations.\u0000","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.2174/0113892010302534240530073118
Sun Zhu, Huiyan Jiang, Zhaoshuo Diao, Qiu Luan, Yaming Li, Xuena Li, Yan Pei
Cancer metastasis usually means that cancer cells spread to other tissues or organs, and the condition worsens. Identifying whether cancer has metastasized can help doctors infer the progression of a patient's condition and is an essential prerequisite for devising treatment plans. Fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (18F -FDG PET/CT) is an advanced cancer diagnostic imaging technique that provides both metabolic and structural information. In cancer metastasis recognition tasks, effectively integrating metabolic and structural information stands as a key technology to enhance feature representation and recognition performance. This paper proposes a cancer metastasis identification network based on dynamic coordinated metabolic attention and structural attention to address these challenges. Specifically, metabolic and structural features are extracted by incorporating a dynamic coordinated attention module (DCAM) into two branches of ResNet networks, thereby amalgamating high metabolic spatial information from PET images with texture structure information from CT images, and dynamically adjusting this process through iterations. Next, to improve the efficacy of feature expression, a multi-receptive field feature fusion module (MRFM) is included in order to execute multi-receptive field fusion of semantic features. To validate the effectiveness of our proposed model, experiments were conducted on both a private lung lymph nodes dataset and a public soft tissue sarcomas dataset The accuracy of our method reached 76.0% and 75.1% for the two datasets, respectively, demonstrating an improvement of 6.8% and 5.6% compared to ResNet, thus affirming the efficacy of our method.
{"title":"CoF-DResNet: Cancer Metastasis Recognition Network based on Dynamic\u0000Coordinated Metabolic Attention and Structural Attention","authors":"Sun Zhu, Huiyan Jiang, Zhaoshuo Diao, Qiu Luan, Yaming Li, Xuena Li, Yan Pei","doi":"10.2174/0113892010302534240530073118","DOIUrl":"https://doi.org/10.2174/0113892010302534240530073118","url":null,"abstract":"\u0000\u0000Cancer metastasis usually means that cancer cells spread to other tissues\u0000or organs, and the condition worsens. Identifying whether cancer has metastasized can help\u0000doctors infer the progression of a patient's condition and is an essential prerequisite for devising\u0000treatment plans. Fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography\u0000(18F -FDG PET/CT) is an advanced cancer diagnostic imaging technique that provides\u0000both metabolic and structural information.\u0000\u0000\u0000\u0000In cancer metastasis recognition tasks, effectively integrating metabolic and structural\u0000information stands as a key technology to enhance feature representation and recognition performance.\u0000This paper proposes a cancer metastasis identification network based on dynamic\u0000coordinated metabolic attention and structural attention to address these challenges. Specifically,\u0000metabolic and structural features are extracted by incorporating a dynamic coordinated attention\u0000module (DCAM) into two branches of ResNet networks, thereby amalgamating high metabolic\u0000spatial information from PET images with texture structure information from CT images, and\u0000dynamically adjusting this process through iterations.\u0000\u0000\u0000\u0000Next, to improve the efficacy of feature expression, a multi-receptive field feature\u0000fusion module (MRFM) is included in order to execute multi-receptive field fusion of semantic\u0000features.\u0000\u0000\u0000\u0000To validate the effectiveness of our proposed model, experiments were conducted on\u0000both a private lung lymph nodes dataset and a public soft tissue sarcomas dataset\u0000\u0000\u0000\u0000The accuracy of our method reached 76.0% and 75.1% for the two datasets, respectively,\u0000demonstrating an improvement of 6.8% and 5.6% compared to ResNet, thus affirming the\u0000efficacy of our method.\u0000","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}