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Mentalizing psychiatric training 精神病学培训的心理化
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-02-06 DOI: 10.1111/acps.13662
Peter Fonagy

In their remarkable paper, Castellini et al1 provide us with not so much a survey but a census of psychiatric trainees in Italy with a remarkable response rate of over 80% compared with a more quotidian comparison group of medical trainees at a similar point of their professional development. The comprehensiveness of their approach permits a tentative conclusion about the average mental state of psychiatric residents—it seems young doctors do not generally go into the mental health specialty to address their own psychological needs; trainee psychiatrists are, on average, less neurotic, notwithstanding above-average childhood adversity. The report also adds to the growing literature that trainees who feel supported and mentally well will perform better in the workplace in the long run,2 at least in terms of symptoms of burnout.

The study, being cross-sectional and relying solely on self-report data, inherently restricts the extent to which we can confidently infer causality from the observed associations. However, with the authors' indication that future longitudinal data might be provided, it is worthwhile to cautiously consider the implications of the reported correlations. For this purpose, we shall make the generous assumption that these correlations represent authentic associations and are not skewed by factors like recall bias, social desirability bias or the impact of any unmeasured confounding variables. The correlations, albeit tentative, provide a starting point for deeper investigation into the factors contributing to burnout and the potential avenues for intervention, while fully recognising their limitations we can acknowledge the value they add to the ongoing discourse on mental health and resilience in medical training.

Work-related burnout syndrome, characterised by the triad of emotional exhaustion, cynicism and low sense of professional efficacy3 has been associated with stress-related health problems,4 broken personal relationships,5 inadequate patient care6 and reduced learning capacity.7 Medical doctors experience higher rates of burnout syndrome than the general population5 likely because a critical factor in the development of burnout is the sustained mismatch between job demands and resources available. Training years, more than any other stage in physicians' career, are characterised by this type of imbalance due to long and irregular work hours8 and high levels of responsibility combined with lack of professional experience.9 Psychiatry itself adds several very specific stressors such as perceived stigma of this profession, demanding therapeutic relationships, personal threats from violent patients and the risk of patient suicide.10

The repor

22 认识到社会系统如何促进或阻碍心理化,为制定有利于心理化的教育和制度框架提供了重要机会,从而有助于预防与工作相关的倦怠。承认个人的心理化能力受到各种系统的影响,意味着有效的干预措施可能需要是多方面的。在培训方面,尤其是针对精神科受训人员的培训,如果要可持续地提高心理调节能力,就必须同时解决多个系统的问题。这种方法不仅仅是个别辅导。它包括教育调整以及更广泛的机构宣传活动。通过这样做,培训计划可以创造一种环境,不仅可以提高学员的心理调节能力,还可以在教育走廊和机构框架内培养一种理解、共情和有效沟通的文化,使个人在其中学习和成熟,进一步塑造专业技能。认识到心智能力并非存在于真空中,这意味着要真正培养心智能力,我们的干预措施可能需要贯穿个人生活的多个方面。认识到大学或医院在培养或抑制心智能力方面所起的作用,可能会对我们有所帮助。23 更广泛的文化和社会背景也起着关键作用。一个社会如何看待精神病学也会产生影响。每种文化都有其独特的表达和解释情绪的词汇,这些词汇是由规范、价值观和共同信仰形成的。尤其是社会习俗,既可以成为我们心理化能力的催化剂,也可以成为我们心理化能力的障碍。了解这些文化维度对于制定有效的策略和干预措施至关重要,这些策略和干预措施要对实习精神科医生的不同背景和经历保持敏感,最终带来更好的心理健康结果和更有效的培训项目。本出版物中表达的观点仅代表作者本人,不代表国家健康与护理研究所或健康与社会护理部的观点。
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引用次数: 0
Key psychosocial issues in medical care 医疗护理中的关键社会心理问题
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-02-01 DOI: 10.1111/acps.13667
Giovanni A. Fava, Chiara Patierno, Nicoletta Sonino, Fiammetta Cosci

Objective

The aim of this review is to illustrate an innovative framework for assessing the psychosocial aspects of medical disorders within the biopsychosocial model. It is based on clinimetrics, the science of clinical measurements. It may overcome the limitations of DSM-5 in identifying highly individualized responses at the experiential, behavioral, and interpersonal levels.

Method

A critical review of the clinimetric formulations of the biopsychosocial model in the setting of medical disease was performed. References were identified through searches from PubMed for English articles on human subjects published from January 1982 to October 2023.

Results

Clinimetric methods of classification have been found to deserve special attention in four major areas: allostatic load (the cumulative cost of fluctuating and heightened neural or neuroendocrine responses to environmental stressors); health attitudes and behavior; persistent somatization; demoralization and irritable mood. This type of assessment, integrated with traditional psychiatric nosography, may disclose pathophysiological links and provide clinical characterizations that demarcate major prognostic and therapeutic differences among patients who otherwise seem deceptively similar because they have the same medical diagnosis. It may be of value in a number of medical situations, such as: high level of disability or compromised quality of life in relation to what is expected by disease status; delayed or partial recovery; insufficient participation in self-management and/or rehabilitation; failure to resume healthy role after convalescence; unhealthy lifestyle; high attendance of medical facilities disproportionate to detectable disease; lack of treatment adherence; illness denial.

Conclusions

The clinimetric approach to the assessment of key psychosocial variables may lead to unique individual profiles, that take into account both biology and biography. It may offer new opportunities for integrating psychosocial and medical perspectives.

本综述旨在说明在生物-心理-社会模式中评估内科疾病的心理-社会方面的创新框架。该框架以临床测量学(clinimetrics)为基础。它可以克服 DSM-5 在识别经验、行为和人际层面高度个性化反应方面的局限性。
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引用次数: 0
Sleep medicines are often prescribed for older adults (≥75 years) without appropriate dosing instructions: A nationwide retrospective register study in Finland 老年人(≥75 岁)经常在没有适当剂量说明的情况下服用睡眠药物:芬兰全国范围内的回顾性登记研究。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-24 DOI: 10.1111/acps.13661
Sini-Tuulia Eronen, Terhi Kurko, Sirkka-Liisa Kivelä, Tiina Paunio, Marja Airaksinen, Tomi Rantamäki

Background

Sleep medicines should be prescribed cautiously, accompanied by instructions that ensure appropriate use and reduce risks. This is especially important for older adults, for whom many of these medicines are classified as potentially inappropriate medicines.

Methods

We investigated the use and appropriateness of dosing instructions for sleep medicines (described in the Finnish National Current Care Guideline for Insomnia) prescribed for older adults (≥75 years) and dispensed with instruction label in pharmacies. The retrospective reimbursement register data for year 2020 by the Social Insurance Institution of Finland was used as the data source (1,080,843 purchases by 143,886 individuals of which 565,228 purchases were pharmacy dispenses). The appropriateness of the pharmacy dosing instructions containing keyword(s) referring to insomnia treatment was examined according to the prescribed dose, time of intake, frequency of use, and warnings/remarks. A random sample of 1000 instructions was used to manually analyze the phrasing and appropriateness.

Outcomes

We focused our analysis on 58.1% (328,285 purchases by 87,396 individuals) of the pharmacy dispenses, which contained dosing instructions referring insomnia treatment. Of these, zopiclone and mirtazapine were the most prescribed drugs (134,631 and 112,463 purchases, respectively). Dose and time of intake were specified in most of the instructions (98.4% and 83.4%, respectively), whereas frequency of use was specified in 57.3%. A small percentage of the instructions included warnings/remarks (2.8%). Overall, only 2.1% of the instructions contained information about a single dose, time of intake, temporary use, and warnings/remarks and were thus defined as sufficient. Notably, 47.7% (n = 515,615) of all the purchases in our dataset were dispensed via automated multi-dose dispensing systems, which is aimed for long-term treatment.

Interpretation

It is common to prescribe sleep medicines for older adults without appropriate dosing instructions, particularly excluding warnings against long-term, regular use. Actions to change the current prescribing practices are warranted.

背景:应谨慎开具睡眠药物处方,并附有使用说明,以确保合理使用并降低风险。这一点对老年人尤为重要,因为对他们来说,许多此类药物都被归类为潜在的不适当药物:我们调查了药房为老年人(≥75 岁)处方并附有说明书标签的睡眠药物(在《芬兰国家失眠症现行护理指南》中有所描述)的使用情况和剂量说明的适当性。数据来源是芬兰社会保险机构 2020 年的回顾性报销登记数据(143886 人购买了 1,080,843 次药品,其中 565,228 次为药房配药)。根据处方剂量、服用时间、使用频率和警告/备注,对包含失眠治疗关键词的药房配药说明的适当性进行了研究。我们随机抽取了 1000 份说明书,对其措辞和适当性进行了人工分析:我们重点分析了 58.1%(87396 人购买 328285 次)的药房配药,这些配药包含失眠治疗的剂量说明。其中,佐匹克隆和米氮平是处方量最大的药物(分别为 134,631 次和 112,463 次)。大部分说明书(分别为 98.4%和 83.4%)都说明了服用剂量和时间,57.3%的说明书说明了使用频率。小部分说明书包含警告/备注(2.8%)。总体而言,只有 2.1%的说明书包含单次剂量、服用时间、临时使用和警告/备注等信息,因此被定义为足够。值得注意的是,在我们的数据集中,47.7%(n=515,615)的购买者是通过自动多剂量配药系统配药的,而这种配药系统是针对长期治疗的:为老年人开具睡眠药物处方时,没有适当的剂量说明,特别是不包括禁止长期、定期使用的警告,是很常见的现象。有必要采取行动改变目前的处方做法。
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引用次数: 0
Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort 双相情感障碍患者代谢综合征的发病率和预测因素:FACE-BD队列纵向研究。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-24 DOI: 10.1111/acps.13655
O. Godin, E. Olié, G. Fond, B. Aouizerate, V. Aubin, F. Bellivier, R. Belzeaux, P. Courtet, C. Dubertret, E. Haffen, A. Lefrere, P. M. Llorca, M. Polosan, P. Roux, L. Samalin, R. Schwan, the FondaMental Academic Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators, M. Leboyer, B. Etain

Introduction

Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.

Methods

Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort and followed-up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow-up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow-up. We applied inverse probability-of-censoring weighting method to minimize selection bias due to loss during follow-up.

Results

Among individuals without MetS at baseline (n = 1521), 19.3% developed MetS during follow-up. Multivariable analyses showed that incident MetS during follow-up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7–3.0, p < 0.0001), older age (OR = 2.14, 95% CI = 1.40–3.25, p = 0.0004), presence of a mood recurrence during follow-up (OR = 1.91, 95% CI = 1.22–3.00, p = 0.0049), prolonged exposure to second-generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, p = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00–1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98–1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00–1.08), independently of the associations observed for baseline MetS components.

Conclusion

We observed a high incidence of MetS during a 3 years follow-up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.

简介代谢综合征(MetS)是包括腹部肥胖、高血糖、高血压和血脂异常在内的一组疾病。代谢综合征在双相情感障碍(BD)患者中发病率很高,估计全球发病率为 32.6%。有关双相情感障碍患者MetS发病情况的纵向数据很少,而且样本量较小。本研究的目的是估计1521名躁狂症患者组成的大型纵向队列中MetS的发病率,并确定MetS发病的临床和生物学预测因素:方法:从方达精神科双相情感障碍高级专家中心(FACE-BD)队列中招募参与者,并对其进行为期3年的随访。MetS是根据国际糖尿病联盟的标准定义的。基线时没有 MetS,但在随访期间出现 MetS 的人被视为出现 MetS。我们采用逻辑回归模型来估算各因素与随访期间发生的 MetS 之间的调整后几率及其相应的 95% 置信区间 (CI)。我们采用了反删减概率加权法,以最大限度地减少随访过程中因失访造成的选择偏差:在基线时没有 MetS 的人群(n = 1521)中,19.3% 在随访期间患上 MetS。多变量分析显示,随访期间发生的 MetS 与男性性别显著相关(OR = 2.2,95% CI = 1.7-3.0,P 结论:我们观察到 MetS 的发生率很高:我们观察到,在 3 年的随访中,BD 患者的 MetS 发生率很高(19.3%)。找出预测因素有助于制定早期干预措施,预防或治疗早期 MetS。
{"title":"Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the FACE-BD cohort","authors":"O. Godin,&nbsp;E. Olié,&nbsp;G. Fond,&nbsp;B. Aouizerate,&nbsp;V. Aubin,&nbsp;F. Bellivier,&nbsp;R. Belzeaux,&nbsp;P. Courtet,&nbsp;C. Dubertret,&nbsp;E. Haffen,&nbsp;A. Lefrere,&nbsp;P. M. Llorca,&nbsp;M. Polosan,&nbsp;P. Roux,&nbsp;L. Samalin,&nbsp;R. Schwan,&nbsp;the FondaMental Academic Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators,&nbsp;M. Leboyer,&nbsp;B. Etain","doi":"10.1111/acps.13655","DOIUrl":"10.1111/acps.13655","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort and followed-up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow-up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow-up. We applied inverse probability-of-censoring weighting method to minimize selection bias due to loss during follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among individuals without MetS at baseline (<i>n</i> = 1521), 19.3% developed MetS during follow-up. Multivariable analyses showed that incident MetS during follow-up was significantly associated with male sex (OR = 2.2, 95% CI = 1.7–3.0, <i>p</i> &lt; 0.0001), older age (OR = 2.14, 95% CI = 1.40–3.25, <i>p</i> = 0.0004), presence of a mood recurrence during follow-up (OR = 1.91, 95% CI = 1.22–3.00, <i>p</i> = 0.0049), prolonged exposure to second-generation antipsychotics (OR = 1.56, 95% CI = 0.99, 2.45, <i>p</i> = 0.0534), smoking status at baseline (OR = 1.30, 95% CI = 1.00–1.68), lifetime alcohol use disorders (OR = 1.33, 95% CI = 0.98–1.79), and baseline sleep disturbances (OR = 1.04, 95% CI = 1.00–1.08), independently of the associations observed for baseline MetS components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We observed a high incidence of MetS during a 3 years follow-up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139544969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights and improvements: A critical analysis of methodological limitations in the investigation of smoking and valproic acid in treatment-resistant schizophrenia 见解与改进:对耐药精神分裂症患者吸烟和丙戊酸调查方法局限性的批判性分析。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-23 DOI: 10.1111/acps.13659
Marisa Bezerra de Araujo, Guilherme Nobre Nogueira, Pedro Lucas Santana da Silveira, Sergio Andre de Souza Júnior, Fabio Gomes de Matos e Souza, Luisa Weber Bisol
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引用次数: 0
Can digital self-harm relate to suicidal thoughts and behaviors beyond physical self-harm? 除了身体自残之外,数字自残还与自杀想法和行为有关吗?
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-22 DOI: 10.1111/acps.13658
Juan Wang, Ziqian Wei, Luxia Jia, Jiaao Yu, Yuanyuan Wang, Yaxuan Meng, Yi Feng, Runsen Chen

Background

Digital self-harm (DiSH) is a recently identified self-harm distinct from physical self-harm (PSH, also known as non-suicidal self-injury, NSSI). Although prior research has shown that DiSH was associated with suicidal thoughts and behaviors (STBs), it was still unclear whether DiSH has a unique association with STBs after controlling for PSH.

Method

A cross-sectional survey was conducted on Chinese college students. The lifetime prevalence of DiSH and PSH, the functions of DiSH, recent suicide experiences (including suicide ideation, plans, and attempts), anxiety and depression were examined. A total of 5281 participants were analyzed.

Results

A total of 10.83% of participants had ever engaged in DiSH, and 1.59% of participants reported histories of both DiSH and PSH. Among participants with a history of PSH, 30.11% engaged in DiSH. Engagement in DiSH was significantly associated with suicide ideation (SI), suicide plans (SPs), and suicide attempts (SAs). More importantly, participants who engaged in both DiSH and PSH showed higher odds of SI and SPs compared to those who had only engaged in PSH. Regarding the functions of DiSH, using DiSH for self-punishment was associated with SI and SPs, and using DiSH for sensation seeking was associated with SPs and SAs. Similar results were found for the association between DiSH and anxiety and depression.

Conclusions

Our findings suggest that DiSH has a unique association with the risks of STBs beyond PSH. Early identification and intervention for DiSH are crucial, even for individuals who already engage in PSH.

背景:数字自残(DiSH)是最近发现的一种有别于物理自残(PSH,又称非自杀性自伤,NSSI)的自残行为。尽管之前的研究表明,DiSH 与自杀想法和行为(STBs)有关,但在控制 PSH 后,DiSH 是否与 STBs 有独特的关联仍不清楚:方法:对中国大学生进行了横断面调查。方法:对中国大学生进行了一项横断面调查,研究了DiSH和PSH的终生患病率、DiSH的功能、最近的自杀经历(包括自杀意念、自杀计划和自杀未遂)、焦虑和抑郁。共对 5281 名参与者进行了分析:共有 10.83% 的参与者曾有过 DiSH 行为,1.59% 的参与者报告说既有过 DiSH 行为,也有过 PSH 行为。在曾有过 PSH 的参与者中,30.11% 的人参与过 DiSH。参与 DiSH 与自杀意念(SI)、自杀计划(SPs)和自杀未遂(SAs)明显相关。更重要的是,与只参与过 PSH 的参与者相比,同时参与过 DiSH 和 PSH 的参与者出现 SI 和 SPs 的几率更高。关于DiSH的功能,使用DiSH进行自我惩罚与SI和SP有关,而使用DiSH寻求感觉与SP和SA有关。DiSH与焦虑和抑郁之间的关系也发现了类似的结果:我们的研究结果表明,除 PSH 外,DiSH 与 STBs 风险也有独特的关联。早期识别和干预 DiSH 至关重要,即使对于那些已经参与 PSH 的人也是如此。
{"title":"Can digital self-harm relate to suicidal thoughts and behaviors beyond physical self-harm?","authors":"Juan Wang,&nbsp;Ziqian Wei,&nbsp;Luxia Jia,&nbsp;Jiaao Yu,&nbsp;Yuanyuan Wang,&nbsp;Yaxuan Meng,&nbsp;Yi Feng,&nbsp;Runsen Chen","doi":"10.1111/acps.13658","DOIUrl":"10.1111/acps.13658","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Digital self-harm (DiSH) is a recently identified self-harm distinct from physical self-harm (PSH, also known as non-suicidal self-injury, NSSI). Although prior research has shown that DiSH was associated with suicidal thoughts and behaviors (STBs), it was still unclear whether DiSH has a unique association with STBs after controlling for PSH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A cross-sectional survey was conducted on Chinese college students. The lifetime prevalence of DiSH and PSH, the functions of DiSH, recent suicide experiences (including suicide ideation, plans, and attempts), anxiety and depression were examined. A total of 5281 participants were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 10.83% of participants had ever engaged in DiSH, and 1.59% of participants reported histories of both DiSH and PSH. Among participants with a history of PSH, 30.11% engaged in DiSH. Engagement in DiSH was significantly associated with suicide ideation (SI), suicide plans (SPs), and suicide attempts (SAs). More importantly, participants who engaged in both DiSH and PSH showed higher odds of SI and SPs compared to those who had only engaged in PSH. Regarding the functions of DiSH, using DiSH for <i>self-punishment</i> was associated with SI and SPs, and using DiSH for <i>sensation seeking</i> was associated with SPs and SAs. Similar results were found for the association between DiSH and anxiety and depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that DiSH has a unique association with the risks of STBs beyond PSH. Early identification and intervention for DiSH are crucial, even for individuals who already engage in PSH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lithium use and bone health in women with bipolar disorder: A cross-sectional study 双相情感障碍女性患者的锂使用与骨骼健康:一项横断面研究。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-19 DOI: 10.1111/acps.13660
Lana J. Williams, Bruno Agustini, Amanda L. Stuart, Julie A. Pasco, Jason M. Hodge, Rasika M. Samarasinghe, Ottar Bjerkeset, Shae E. Quirk, Heli Koivumaa-Honkanen, Risto Honkanen, Jeremi Heikkinen, Michael Berk

Introduction

Several psychiatric disorders and medications used to treat them appear to be independently associated with skeletal deficits. As there is increasing evidence that lithium possesses skeletal protective properties, we aimed to investigate the association between lithium use and bone health in a group of women with bipolar disorder.

Method

Women with bipolar disorder (n = 117, 20+ years) were recruited from south-eastern Australia. Bipolar disorder was confirmed using a clinical interview (SCID-I/NP). Bone mineral density (BMD; g/cm2) was measured at the spine, hip and total body using dual-energy x-ray absorptiometry and low bone mass determined by BMD T-score of <−1.0. Weight and height were measured, socioeconomic status (SES) determined and information on medication use and lifestyle factors self-reported. Linear and logistic regression were used to test associations between lithium and (i) BMD and (ii) low bone mass, respectively.

Results

Thirty-five (29.9%) women reported current lithium use. Lithium users and non-users differed in regard to SES and BMD; otherwise, groups were similar. After adjustments, mean BMD among lithium users was 5.1% greater at the spine (1.275 [95% CI 1.229–1.321] vs. 1.214 [1.183–1.244] g/cm2, p = 0.03), 4.2% greater at the total hip (0.979 [0.942–1.016] vs. 0.938 [0.910–0.966] g/cm2, p = 0.03) and 2.2% greater at the total body (1.176 [1.148–1.205] vs. 1.150 [1.129–1.171] g/cm2, p = 0.08) compared to participants not receiving lithium. Lithium users were also less likely to have low bone mass (22.9% vs. 43.9%, p = 0.031). Associations persisted after adjustment for confounders.

Conclusion

These data suggest lithium is associated with greater BMD and reduced risk of low bone mass in women with bipolar disorder. Research into the underlying mechanisms is warranted.

简介几种精神障碍和用于治疗精神障碍的药物似乎都与骨骼缺陷有关。有越来越多的证据表明,锂具有保护骨骼的作用,因此,我们旨在研究锂的使用与双相情感障碍女性患者的骨骼健康之间的关系:方法:我们从澳大利亚东南部招募了患有躁郁症的女性(n = 117,20 岁以上)。通过临床访谈(SCID-I/NP)确认双相情感障碍。使用双能 X 射线吸收测量法测量了脊柱、髋部和全身的骨密度(BMD;克/平方厘米),并根据 BMD T 评分确定了低骨量结果:35名(29.9%)女性报告目前使用锂。锂使用者和非锂使用者在社会经济地位和 BMD 方面存在差异;除此之外,各组情况相似。经调整后,锂使用者脊柱的平均 BMD 高 5.1%(1.275 [95% CI 1.229-1.321] vs. 1.214 [1.183-1.244] g/cm2,p = 0.03),全髋的平均 BMD 高 4.2%(0.979 [0.942-1.016] vs. 0.938 [0.910-0.966] g/cm2,p = 0.03),全身(1.176 [1.148-1.205] vs. 1.150 [1.129-1.171] g/cm2,p = 0.08)比未服用锂的参与者高出 2.2%。此外,锂使用者的骨量较低(22.9% vs. 43.9%,p = 0.031)。在对混杂因素进行调整后,相关性依然存在:这些数据表明,锂与双相情感障碍女性患者更高的骨密度和更低的骨量风险有关。有必要对其潜在机制进行研究。
{"title":"Lithium use and bone health in women with bipolar disorder: A cross-sectional study","authors":"Lana J. Williams,&nbsp;Bruno Agustini,&nbsp;Amanda L. Stuart,&nbsp;Julie A. Pasco,&nbsp;Jason M. Hodge,&nbsp;Rasika M. Samarasinghe,&nbsp;Ottar Bjerkeset,&nbsp;Shae E. Quirk,&nbsp;Heli Koivumaa-Honkanen,&nbsp;Risto Honkanen,&nbsp;Jeremi Heikkinen,&nbsp;Michael Berk","doi":"10.1111/acps.13660","DOIUrl":"10.1111/acps.13660","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Several psychiatric disorders and medications used to treat them appear to be independently associated with skeletal deficits. As there is increasing evidence that lithium possesses skeletal protective properties, we aimed to investigate the association between lithium use and bone health in a group of women with bipolar disorder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Women with bipolar disorder (<i>n</i> = 117, 20+ years) were recruited from south-eastern Australia. Bipolar disorder was confirmed using a clinical interview (SCID-I/NP). Bone mineral density (BMD; g/cm<sup>2</sup>) was measured at the spine, hip and total body using dual-energy x-ray absorptiometry and low bone mass determined by BMD T-score of &lt;−1.0. Weight and height were measured, socioeconomic status (SES) determined and information on medication use and lifestyle factors self-reported. Linear and logistic regression were used to test associations between lithium and (i) BMD and (ii) low bone mass, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-five (29.9%) women reported current lithium use. Lithium users and non-users differed in regard to SES and BMD; otherwise, groups were similar. After adjustments, mean BMD among lithium users was 5.1% greater at the spine (1.275 [95% CI 1.229–1.321] vs. 1.214 [1.183–1.244] g/cm<sup>2</sup>, <i>p</i> = 0.03), 4.2% greater at the total hip (0.979 [0.942–1.016] vs. 0.938 [0.910–0.966] g/cm<sup>2</sup>, <i>p</i> = 0.03) and 2.2% greater at the total body (1.176 [1.148–1.205] vs. 1.150 [1.129–1.171] g/cm<sup>2</sup>, <i>p</i> = 0.08) compared to participants not receiving lithium. Lithium users were also less likely to have low bone mass (22.9% vs. 43.9%, <i>p</i> = 0.031). Associations persisted after adjustment for confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These data suggest lithium is associated with greater BMD and reduced risk of low bone mass in women with bipolar disorder. Research into the underlying mechanisms is warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13660","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose response relationship between lithium serum levels during pregnancy and birth outcomes 孕期锂血清水平与分娩结果之间的剂量反应关系。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-18 DOI: 10.1111/acps.13663
Lisanne Schrijver, Astrid M. Kamperman, Hilmar Bijma, Inge L. van Kamp, Richard Wesseloo, Witte J. G. Hoogendijk, Veerle Bergink, Eline M. P. Poels

Introduction

Lithium use during pregnancy reduces the risk of mood episodes in the perinatal period for women with bipolar disorder. Some previous studies found deleterious effects of intrauterine lithium exposure on birth outcomes, yet little is known about a dose response relationship. The current study investigated the influence of maternal lithium serum levels on birth outcomes.

Methods

This retrospective observational cohort study included women with a bipolar spectrum disorder who were referred to a specialized psychiatric and obstetric outpatient clinic from 2003 to 2019 and used lithium during the entire pregnancy. For 101 pregnancies at least one lithium level during pregnancy was available. A weighted average lithium level was calculated for the entire pregnancy, as well as for each trimester. Detailed information on maternal, obstetric and neonatal outcomes were retrieved from the medical records. Linear and logistic regression models were used to investigate the association between weighted average lithium level and pregnancy duration, birth weight percentiles, preterm birth and large for gestational age births (LGA). In subsequent exploratory analyses, we studied the role of thyroid-stimulating hormone (TSH) and thyroxine (T4) as a mediator in the found associations.

Results

The weighted average lithium serum level during pregnancy was negatively associated with pregnancy duration and positively with preterm birth, but not with birth weight percentile or LGA. In exploratory analyses, TSH and T4 did not mediate the association between average lithium serum level and pregnancy duration.

Conclusion

The results of this cohort study during pregnancy indicate a dose response relationship between maternal lithium serum levels and pregnancy duration.

简介孕期使用锂可降低躁郁症妇女围产期情绪发作的风险。之前的一些研究发现,宫内锂暴露会对出生结果产生有害影响,但对剂量反应关系却知之甚少。本研究调查了母体锂血清水平对分娩结局的影响:这项回顾性观察队列研究纳入了 2003 年至 2019 年期间转诊至精神科和产科专科门诊并在整个孕期使用锂的双相情感障碍女性。其中 101 名孕妇在怀孕期间至少使用过一次锂。我们计算了整个孕期以及每个孕期的加权平均锂含量。有关孕产妇、产科和新生儿结局的详细信息均来自医疗记录。我们使用线性和逻辑回归模型来研究加权平均锂含量与孕期、出生体重百分位数、早产和大胎龄新生儿(LGA)之间的关系。在随后的探索性分析中,我们研究了促甲状腺激素(TSH)和甲状腺素(T4)作为中介因素在所发现的关联中的作用:结果:孕期加权平均锂血清水平与孕期长短呈负相关,与早产呈正相关,但与出生体重百分位数或 LGA 无关。在探索性分析中,促甲状腺激素(TSH)和甲状腺素(T4)并不介导平均锂血清水平与妊娠持续时间之间的关系:这项孕期队列研究的结果表明,母体锂血清水平与妊娠持续时间之间存在剂量反应关系。
{"title":"Dose response relationship between lithium serum levels during pregnancy and birth outcomes","authors":"Lisanne Schrijver,&nbsp;Astrid M. Kamperman,&nbsp;Hilmar Bijma,&nbsp;Inge L. van Kamp,&nbsp;Richard Wesseloo,&nbsp;Witte J. G. Hoogendijk,&nbsp;Veerle Bergink,&nbsp;Eline M. P. Poels","doi":"10.1111/acps.13663","DOIUrl":"10.1111/acps.13663","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Lithium use during pregnancy reduces the risk of mood episodes in the perinatal period for women with bipolar disorder. Some previous studies found deleterious effects of intrauterine lithium exposure on birth outcomes, yet little is known about a dose response relationship. The current study investigated the influence of maternal lithium serum levels on birth outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective observational cohort study included women with a bipolar spectrum disorder who were referred to a specialized psychiatric and obstetric outpatient clinic from 2003 to 2019 and used lithium during the entire pregnancy. For 101 pregnancies at least one lithium level during pregnancy was available. A weighted average lithium level was calculated for the entire pregnancy, as well as for each trimester. Detailed information on maternal, obstetric and neonatal outcomes were retrieved from the medical records. Linear and logistic regression models were used to investigate the association between weighted average lithium level and pregnancy duration, birth weight percentiles, preterm birth and large for gestational age births (LGA). In subsequent exploratory analyses, we studied the role of thyroid-stimulating hormone (TSH) and thyroxine (T4) as a mediator in the found associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The weighted average lithium serum level during pregnancy was negatively associated with pregnancy duration and positively with preterm birth, but not with birth weight percentile or LGA. In exploratory analyses, TSH and T4 did not mediate the association between average lithium serum level and pregnancy duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of this cohort study during pregnancy indicate a dose response relationship between maternal lithium serum levels and pregnancy duration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of the original major depression inventory with a modified version: A Danish validation study 原始重度抑郁量表与修订版的比较:丹麦验证研究。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-16 DOI: 10.1111/acps.13656
Henrik Schou Pedersen, Karl Bang Christensen, Anders Prior, Kaj Sparle Christensen

Background

The Major Depression Inventory (MDI) is a patient-reported outcome measure used by general practitioners to assist with diagnosing and evaluation of the severity of a patient's depression. However, recent studies have questioned the structural validity of the MDI.

Objectives

We proposed a modified version (mMDI) of the MDI with fewer response categories and four rephrased items and aimed to compare the psychometric properties of the changes in a joint cohort of patients from general practice and mental health associations.

Methods

We used Rasch analysis, confirmatory factor analysis, and the area under the receiver operating curve (AUROC) to assess the validity and reliability of the two versions. Equipercentile linking was used to compute cut-off points for the mMDI.

Results

For both versions, local dependence was found between the three item pairs (loss of interest, lack of energy), (lack of self-confidence, feelings of guilt), and (concentration problems, feeling restless/slowed down). The mMDI displayed lower measurement error in the upper end of the scale and better item level fit for three of the four reformulated items compared to the MDI. For the MDI, 5.3% of the respondents gave improbable responses; the corresponding number was 3.4% for the mMDI. The mMDI displayed better fit to a one-factor model compared to the MDI. When comparing the correlation of the scales with the WHO-5 instrument, the corresponding AUROC estimates for the mMDI and MDI were found to be 0.93 (0.92; 0.96) and 0.91 (0.87; 0.94), respectively. The cut-off points for mild, moderate, and severe depression in the mMDI were found to be 17, 20, and 23, respectively.

Conclusion

The proposed changes of the MDI are psychometrically sound upgrades of the original.

背景:重度抑郁量表(MDI)是一种由患者报告的结果测量方法,全科医生使用它来协助诊断和评估患者抑郁的严重程度。然而,最近的研究对 MDI 的结构有效性提出了质疑:目的:我们提出了一个改良版的 MDI(mMDI),减少了回答类别,并对四个项目进行了重新表述,旨在对来自全科医生和心理健康协会的联合组群患者的心理测量特性进行比较:我们使用拉施分析、确证因子分析和接收者操作曲线下面积(AUROC)来评估两个版本的有效性和可靠性。结果:两个版本都发现了局部依赖性:在这两个版本中,三个项目对(失去兴趣、缺乏活力)、(缺乏自信、内疚感)和(注意力不集中、感到不安/迟钝)之间都存在局部依赖性。与心理健康指数相比,心理健康指数在量表高端的测量误差较小,在四个重新制定的项目中,有三个项目的项目水平拟合度较高。在心理健康指数中,5.3% 的受访者给出了不可能的回答;而在移动心理健康指数中,相应的数字为 3.4%。与计量吸入器指数相比,移动式计量吸入器指数更适合单因素模型。在比较量表与 WHO-5 工具的相关性时,发现 mMDI 和 MDI 的相应 AUROC 估计值分别为 0.93 (0.92; 0.96) 和 0.91 (0.87; 0.94)。在 mMDI 中,轻度、中度和重度抑郁的临界点分别为 17、20 和 23:结论:从心理测量学的角度来看,所建议的 MDI 变更是对原有 MDI 的升级。
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引用次数: 0
Embracing evolutionary theories of autism: Implications for psychiatry 自闭症的进化理论:对精神病学的影响。
IF 6.7 2区 医学 Q1 Medicine Pub Date : 2024-01-15 DOI: 10.1111/acps.13653
Tanya L. Procyshyn, Alex Tsompanidis, Simon Baron-Cohen

Autism is one of most common disabilities, with recent estimates that 1 in 36 children1 have an autism diagnosis and late diagnoses in adults also increasing. The DSM-5 diagnostic criteria for autism now include sensory sensitivities alongside the long-established criteria of social and communication challenges and repetitive and restrictive behaviours and interests. Most clinicians no longer view autism as something to be cured or treated, instead providing support for the challenges that autistic people experience and treatments or interventions for any co-occurring conditions, while respecting their unique differences and strengths. As the prevalence of autism, who is being diagnosed with autism, and clinical understanding of autism are changing, so are perspectives on what it means to be autistic.

One field aiming to shift scientific perspectives on how we think about autism is evolutionary psychiatry,2 a relatively new discipline that now has its own special interest group within the Royal College of Psychiatrists in the UK as well as dedicated textbooks. Like the related field of evolutionary medicine, evolutionary psychiatry sets its focus beyond biomedical causes (e.g., genetic and environmental factors), instead asking the “ultimate” question of why neurodevelopmental and psychiatric conditions have persisted in the human population over time. At first glance, autism presents an evolutionary paradox3: it is a highly heritable condition that affects “reproductive success” yet is relatively prevalent. Evolutionary psychiatry proposes possibilities that move us away from viewing autism as a disorder or disease to one that considers the role of crucial adaptations that have shaped the evolution of the human brain and our complex cognitive abilities. In this article, we consider several evolutionary explanations of autism, the supporting evidence, and how embracing an evolutionary perspective could influence clinical practice in psychiatry.

Most evolutionary theories conceptualise autism as a specialised neurocognitive profile characterised by a trade-off between costs (social cognition) and benefits (non-social cognition). The empathising-systemizing theory4 was the first to suggest this, framing autism as enhanced motivation to systemize (the ability to analyse the variables in a system and derive the underlying rules that govern it) paired with challenges in empathising (the ability to imagine another person's thoughts and feelings and respond with an appropriate emotion). The link between autism and occupations that require a high level of systemizing ability5—such as science, technology, engineering, and mathematics—provides further support for the theory that autism reflects a brain specialised in rule-based thinking. Similarly, the “diametric model” of autism6 highlights e

对于临床医生来说,通过进化的视角来理解自闭症的优势和挑战,可以为神经变异者提供支持和便利,使他们能够在不同的环境中茁壮成长。由于对自闭症的生物医学理解方面的进展尚未对临床实践产生变革性影响,进化精神病学可能为理解自闭症提供一个仍然建立在科学基础上的新框架。
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引用次数: 0
期刊
Acta Psychiatrica Scandinavica
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