Pub Date : 2017-06-23DOI: 10.2174/1875692115666170508152128
R. Finelli, A. V. Pascale, P. Marotta, A. Guida, M. Ciccarelli
{"title":"Tackling Cardiovascular Risk: New Evidence from Personalized Medicine","authors":"R. Finelli, A. V. Pascale, P. Marotta, A. Guida, M. Ciccarelli","doi":"10.2174/1875692115666170508152128","DOIUrl":"https://doi.org/10.2174/1875692115666170508152128","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72515703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DOI: 10.2174/1875692115666170508153322 Abstract: In the last decades, aging of population is becoming even more prevalent, with consequent increasing requirement in health assistance and services. Physical and social environments can affect health directly, or through barriers or incentives conditioning opportunities, decisions and behavior. Moreover, the relationship with environment varies according to several personal characteristics including family background, sex and ethnicity. The impact of these factors is often skewed by these characteristics, leading to inequalities in health. In almost all countries, the older population is predominantly female. The prevalence and incidence of Cardiovascular Diseases (CVD) are reported to be lower in women than in men, increasing with age in both genders, but at advanced ages women outnumber men. Gender-differences in the contribution of various pathophysiological processes, combined with suboptimal recognition of female specificities, may explain sexdifferences in presentation and outcomes of CVD and also partially explain the differences in cardiovascular drug therapy related to gender, where other behavioral and cultural factors can be involved. Starting by the conflicting data in literature, the aim of this article is to summarize the gender differences available on the use of the main cardiovascular drugs, and the possible explanation for these disparities. Till date, data on gender differences in cardiovascular therapy are still controversial, and overall no established factors have been identified to discriminate the different approach in the choice of cardiovascular drugs by gender. Then further more structured and bigger trials should be performed to target these issues, and to better clarify the underlining involved mechanisms.
{"title":"Gender Differences in Response to Therapy for Cardiovascular Diseases","authors":"Corbi Graziamaria, Ambrosino Immacolata, Komici Klara, Cellurale Michele, Lombardi Anna, F. Nicola","doi":"10.2174/1875692115666170508153322","DOIUrl":"https://doi.org/10.2174/1875692115666170508153322","url":null,"abstract":"DOI: 10.2174/1875692115666170508153322 Abstract: In the last decades, aging of population is becoming even more prevalent, with consequent increasing requirement in health assistance and services. Physical and social environments can affect health directly, or through barriers or incentives conditioning opportunities, decisions and behavior. Moreover, the relationship with environment varies according to several personal characteristics including family background, sex and ethnicity. The impact of these factors is often skewed by these characteristics, leading to inequalities in health. In almost all countries, the older population is predominantly female. The prevalence and incidence of Cardiovascular Diseases (CVD) are reported to be lower in women than in men, increasing with age in both genders, but at advanced ages women outnumber men. Gender-differences in the contribution of various pathophysiological processes, combined with suboptimal recognition of female specificities, may explain sexdifferences in presentation and outcomes of CVD and also partially explain the differences in cardiovascular drug therapy related to gender, where other behavioral and cultural factors can be involved. Starting by the conflicting data in literature, the aim of this article is to summarize the gender differences available on the use of the main cardiovascular drugs, and the possible explanation for these disparities. Till date, data on gender differences in cardiovascular therapy are still controversial, and overall no established factors have been identified to discriminate the different approach in the choice of cardiovascular drugs by gender. Then further more structured and bigger trials should be performed to target these issues, and to better clarify the underlining involved mechanisms.","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"18 1","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75027763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-31DOI: 10.2174/1875692115666170503105402
Marine Pingeon, B. Charlier, F. D. Lise, Francesca Mensitieri, F. Piaz, V. Izzo
{"title":"Novel Drug Targets for the Treatment of Cardiac Diseases","authors":"Marine Pingeon, B. Charlier, F. D. Lise, Francesca Mensitieri, F. Piaz, V. Izzo","doi":"10.2174/1875692115666170503105402","DOIUrl":"https://doi.org/10.2174/1875692115666170503105402","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"106 1","pages":"32-44"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82539610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.2174/1875692115666170214152152
M. Isidoro-García, Almudena Sánchez-Martín, B. García‐Berrocal
{"title":"Impact of New Technologies on Pharmacogenomics","authors":"M. Isidoro-García, Almudena Sánchez-Martín, B. García‐Berrocal","doi":"10.2174/1875692115666170214152152","DOIUrl":"https://doi.org/10.2174/1875692115666170214152152","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"31 1","pages":"74-85"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89922438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.2174/187569211402170424205258
A. Llerena, V. Ozdemir
{"title":"Editorial: CPPM Onward and Upward: Global Personalized Medicine Guided by Responsible Innovation","authors":"A. Llerena, V. Ozdemir","doi":"10.2174/187569211402170424205258","DOIUrl":"https://doi.org/10.2174/187569211402170424205258","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"1 1","pages":"66-67"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80889644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.2174/1875692115666170224094023
G. Castelli, E. Pelosi, U. Testa
{"title":"New Developments of Differentiation Therapy of Acute Myeloid Leukemia","authors":"G. Castelli, E. Pelosi, U. Testa","doi":"10.2174/1875692115666170224094023","DOIUrl":"https://doi.org/10.2174/1875692115666170224094023","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"59 1","pages":"86-105"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89081844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.2174/1875692115666170208121925
K. Pramod
{"title":"DNA-drug Conjugates for Site-specific Delivery in Anti-cancer Therapy","authors":"K. Pramod","doi":"10.2174/1875692115666170208121925","DOIUrl":"https://doi.org/10.2174/1875692115666170208121925","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"11 1","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76233166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.2174/1875692115666170403101207
Upinder Kaur, S. Chakrabarti, I. Gambhir
{"title":"Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs","authors":"Upinder Kaur, S. Chakrabarti, I. Gambhir","doi":"10.2174/1875692115666170403101207","DOIUrl":"https://doi.org/10.2174/1875692115666170403101207","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"51 2 1","pages":"106-123"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87699046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.2174/1875692115666170126152349
A. Semaan, K. Delfino, A. Wilber, Thomas K. Mathews, Kathy Robinson, L. Brard, S. Alanee
{"title":"Exome Sequencing of Ovarian Cancer Patients to Identify Variants Predictive of Sensitivity to Platinum-based Chemotherapy","authors":"A. Semaan, K. Delfino, A. Wilber, Thomas K. Mathews, Kathy Robinson, L. Brard, S. Alanee","doi":"10.2174/1875692115666170126152349","DOIUrl":"https://doi.org/10.2174/1875692115666170126152349","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"73 1","pages":"124-133"},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79488181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-16DOI: 10.2174/1875692114666160801151257
F. F. Vasilyev, D. A. Danilova, V. Kaimonov, Y. Chertovskih, N. Maksimova
{"title":"Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population","authors":"F. F. Vasilyev, D. A. Danilova, V. Kaimonov, Y. Chertovskih, N. Maksimova","doi":"10.2174/1875692114666160801151257","DOIUrl":"https://doi.org/10.2174/1875692114666160801151257","url":null,"abstract":"","PeriodicalId":11056,"journal":{"name":"Current Pharmacogenomics and Personalized Medicine","volume":"25 1","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2017-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76649678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：