Pub Date : 2020-10-24DOI: 10.1007/s40674-020-00155-w
Ayida Al Khalili, J. Dutz
{"title":"Janus Kinase Inhibition and SLE: Is this a Plausible Treatment Option for SLE?","authors":"Ayida Al Khalili, J. Dutz","doi":"10.1007/s40674-020-00155-w","DOIUrl":"https://doi.org/10.1007/s40674-020-00155-w","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"1 1","pages":"406 - 417"},"PeriodicalIF":0.0,"publicationDate":"2020-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74165193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-13DOI: 10.1007/s40674-020-00163-w
Aprajita Jagpal, J. Singh
{"title":"Treatment Guidelines in Rheumatoid Arthritis—Optimizing the Best of Both Worlds","authors":"Aprajita Jagpal, J. Singh","doi":"10.1007/s40674-020-00163-w","DOIUrl":"https://doi.org/10.1007/s40674-020-00163-w","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"40 1","pages":"354 - 369"},"PeriodicalIF":0.0,"publicationDate":"2020-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86272564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-12DOI: 10.1007/s40674-020-00161-y
M. Prendecki, S. McAdoo, C. Pusey
{"title":"Is There a Role for Plasma Exchange in ANCA-Associated Vasculitis?","authors":"M. Prendecki, S. McAdoo, C. Pusey","doi":"10.1007/s40674-020-00161-y","DOIUrl":"https://doi.org/10.1007/s40674-020-00161-y","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"1 1","pages":"313 - 324"},"PeriodicalIF":0.0,"publicationDate":"2020-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91182925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01Epub Date: 2020-05-06DOI: 10.1007/s40674-020-00146-x
Alia M Obeidat, Anita Donner, Rachel E Miller
Purpose of review: a)Osteoarthritis (OA) is the most common form of arthritis, and pain is the primary symptom of the disease, yet analgesic options for treating OA pain remain limited. In this review, we aimed to give an update on the current clinical and preclinical studies targeting two pathways that are being investigated for treating OA pain: the nerve growth factor (NGF) pathway and the transient receptor potential vanilloid-1 (TRPV1) pathway.
Recent findings: b)Antibodies against NGF, small molecule inhibitors of TrkA, TRPV1 agonists, and TRPV1 antagonists are all in different stages of clinical and pre-clinical testing for the treatment of OA pain. NGF antibodies have shown efficacy in the primary endpoints tested compared to placebo, however, rapidly progressive OA has been consistently observed in a subset of patients and the cause remains unclear. TRPV1 agonists have also demonstrated reduced pain with no serious adverse events - the most common adverse events include a burning or warming sensation upon administration.
Summary: c)Targeting the NGF and TRPV1 pathways appear effective for reducing OA pain, but further work is needed to better understand which patients may benefit most from these treatments. The anti-NGF antibody tanezumab and the TRPV1 agonist CNTX-4975 have both received fast-track designation from the FDA for the treatment of OA pain.
{"title":"An update on targets for treating osteoarthritis pain: NGF and TRPV1.","authors":"Alia M Obeidat, Anita Donner, Rachel E Miller","doi":"10.1007/s40674-020-00146-x","DOIUrl":"https://doi.org/10.1007/s40674-020-00146-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>a)Osteoarthritis (OA) is the most common form of arthritis, and pain is the primary symptom of the disease, yet analgesic options for treating OA pain remain limited. In this review, we aimed to give an update on the current clinical and preclinical studies targeting two pathways that are being investigated for treating OA pain: the nerve growth factor (NGF) pathway and the transient receptor potential vanilloid-1 (TRPV1) pathway.</p><p><strong>Recent findings: </strong>b)Antibodies against NGF, small molecule inhibitors of TrkA, TRPV1 agonists, and TRPV1 antagonists are all in different stages of clinical and pre-clinical testing for the treatment of OA pain. NGF antibodies have shown efficacy in the primary endpoints tested compared to placebo, however, rapidly progressive OA has been consistently observed in a subset of patients and the cause remains unclear. TRPV1 agonists have also demonstrated reduced pain with no serious adverse events - the most common adverse events include a burning or warming sensation upon administration.</p><p><strong>Summary: </strong>c)Targeting the NGF and TRPV1 pathways appear effective for reducing OA pain, but further work is needed to better understand which patients may benefit most from these treatments. The anti-NGF antibody tanezumab and the TRPV1 agonist CNTX-4975 have both received fast-track designation from the FDA for the treatment of OA pain.</p>","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"6 3","pages":"129-145"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40674-020-00146-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39112963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-07DOI: 10.1007/s40674-020-00153-y
F. Baldo, G. Beretta, J. Tibaldi, R. Caorsi, F. Minoia
{"title":"Macrophage Activation Syndrome in Childhood Inflammatory Disorders: Diagnosis, Genetics, Pathophysiology, and Treatment","authors":"F. Baldo, G. Beretta, J. Tibaldi, R. Caorsi, F. Minoia","doi":"10.1007/s40674-020-00153-y","DOIUrl":"https://doi.org/10.1007/s40674-020-00153-y","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"93 1","pages":"245 - 259"},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76506963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-05DOI: 10.1007/s40674-020-00158-7
R. Kraus, R. Laxer
{"title":"Publisher Correction: Characteristics, Treatment Options, and Outcomes of Chronic Non-Bacterial Osteomyelitis in Children","authors":"R. Kraus, R. Laxer","doi":"10.1007/s40674-020-00158-7","DOIUrl":"https://doi.org/10.1007/s40674-020-00158-7","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"46 1","pages":"223 - 227"},"PeriodicalIF":0.0,"publicationDate":"2020-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83942242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-29DOI: 10.1007/s40674-020-00156-9
C. Boichat, A. Llewellyn, S. Grieve, C. McCabe
{"title":"The Role of Nonmedical Therapeutic Approaches in the Rehabilitation of Complex Regional Pain Syndrome","authors":"C. Boichat, A. Llewellyn, S. Grieve, C. McCabe","doi":"10.1007/s40674-020-00156-9","DOIUrl":"https://doi.org/10.1007/s40674-020-00156-9","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"16 1","pages":"299-311"},"PeriodicalIF":0.0,"publicationDate":"2020-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83328059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-23DOI: 10.1007/s40674-020-00157-8
C. Primeau, Ishita Joshi, B. Zomar, L. Somerville, H. Philpott, David D. McHugh, B. Lanting, E. Vasarhelyi, Jacquelyn D. Marsh
{"title":"Cost-Effectiveness of Arthroplasty Management in Hip and Knee Osteoarthritis: a Quality Review of the Literature","authors":"C. Primeau, Ishita Joshi, B. Zomar, L. Somerville, H. Philpott, David D. McHugh, B. Lanting, E. Vasarhelyi, Jacquelyn D. Marsh","doi":"10.1007/s40674-020-00157-8","DOIUrl":"https://doi.org/10.1007/s40674-020-00157-8","url":null,"abstract":"","PeriodicalId":11096,"journal":{"name":"Current Treatment Options in Rheumatology","volume":"33 1","pages":"160 - 190"},"PeriodicalIF":0.0,"publicationDate":"2020-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90269697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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