Pub Date : 2026-02-23DOI: 10.1186/s13098-026-02130-2
Yuan-Liang Wen, Yu-Chieh Huang, Chun-Cheng Liao, Senyeong Kao, Ke-Ting Pan, Hui-Wen Yang, Sheng-Yin To, Chin-Bin Yeh, Li-Ting Kao
{"title":"Agomelatine and the potential inverse risk of metabolic disorders: a nationwide cohort study with an active comparator design in Taiwan.","authors":"Yuan-Liang Wen, Yu-Chieh Huang, Chun-Cheng Liao, Senyeong Kao, Ke-Ting Pan, Hui-Wen Yang, Sheng-Yin To, Chin-Bin Yeh, Li-Ting Kao","doi":"10.1186/s13098-026-02130-2","DOIUrl":"https://doi.org/10.1186/s13098-026-02130-2","url":null,"abstract":"","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of high intensity interval training on body composition, metabolic, inflammatory and oxidative stress markers in adolescents with obesity.","authors":"Gulten Atabay Arslan, Ozgur Kasimay, Ilknur Bingul, Asuman Gedikbasi, Ani Agopyan, Meral Kucuk Yetgin","doi":"10.1186/s13098-026-02110-6","DOIUrl":"https://doi.org/10.1186/s13098-026-02110-6","url":null,"abstract":"","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Chewing gum could play a role in managing hyperglycemia in individuals with diabetes. The study evaluated the effects of chewing gum on blood sugar management in women diagnosed with Gestational Diabetes Mellitus (GDM).
Methods: This open-label, single-center randomized controlled clinical trial enrolled 100 women recently diagnosed with GDM. Participants received either standard care or an additional chewing gum intervention. Self-monitored blood glucose (SMBG) levels were recorded over a period of five days.
Results: The gum-chewing group consistently exhibited notably lower mean postprandial blood glucose (PPG) and fasting blood glucose levels compared to the control group. The estimated mean differences (intervention vs. control group) were: -7.86 mg/dl, p = 0.053 (fasting blood glucose); -13.2 mg/dl, p = 0.022 (breakfast); -8.92 mg/dl, p = 0.014 (lunch); -12.96 mg/dl, p = 0.006 (dinner).
Conclusions: To summarize, notable variations in blood glucose levels were identified between the groups, indicating that chewing gum serves as an effective alternative approach to reducing high blood sugar in women with GDM.
目的：口香糖可能在糖尿病患者控制高血糖中发挥作用。该研究评估了口香糖对诊断为妊娠期糖尿病（GDM）的女性血糖管理的影响。方法：这项开放标签、单中心随机对照临床试验招募了100名新近诊断为GDM的女性。参与者要么接受标准治疗，要么接受额外的口香糖干预。自我监测血糖（SMBG）水平在五天内被记录下来。结果：与对照组相比，嚼口香糖组的平均餐后血糖（PPG）和空腹血糖水平持续显著降低。估计平均差异（干预组与对照组）为：-7.86 mg/dl, p = 0.053（空腹血糖）；-13.2 mg/dl, p = 0.022（早餐）；-8.92 mg/dl, p = 0.014（午餐）；-12.96 mg/dl, p = 0.006（晚餐）。结论：总而言之，两组之间血糖水平存在显著差异，表明口香糖是降低GDM女性高血糖的有效替代方法。
{"title":"Effectiveness of chewing gum on blood glucose level among pregnant women with gestational diabetes: a randomized controlled clinical trial.","authors":"Perimah Pasha Zanussi, Shayan Abedi Samakoosh, Farideh Mohsenzadeh-Ledari, Romina Fili, Shabnam Omidvar, Soheila Abbaszadeh, Hemmatollah Gholinia, Neda Meftah","doi":"10.1186/s13098-026-02111-5","DOIUrl":"https://doi.org/10.1186/s13098-026-02111-5","url":null,"abstract":"<p><strong>Aims: </strong>Chewing gum could play a role in managing hyperglycemia in individuals with diabetes. The study evaluated the effects of chewing gum on blood sugar management in women diagnosed with Gestational Diabetes Mellitus (GDM).</p><p><strong>Methods: </strong>This open-label, single-center randomized controlled clinical trial enrolled 100 women recently diagnosed with GDM. Participants received either standard care or an additional chewing gum intervention. Self-monitored blood glucose (SMBG) levels were recorded over a period of five days.</p><p><strong>Results: </strong>The gum-chewing group consistently exhibited notably lower mean postprandial blood glucose (PPG) and fasting blood glucose levels compared to the control group. The estimated mean differences (intervention vs. control group) were: -7.86 mg/dl, p = 0.053 (fasting blood glucose); -13.2 mg/dl, p = 0.022 (breakfast); -8.92 mg/dl, p = 0.014 (lunch); -12.96 mg/dl, p = 0.006 (dinner).</p><p><strong>Conclusions: </strong>To summarize, notable variations in blood glucose levels were identified between the groups, indicating that chewing gum serves as an effective alternative approach to reducing high blood sugar in women with GDM.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146775948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-19DOI: 10.1186/s13098-026-02126-y
Sara Samie, Mahbobeh Sajadi, Rahmatollah Moradzadeh, Somaye Sayahi
{"title":"Self-care needs and obstacles of adolescents with type 1 diabetes: a narrative review.","authors":"Sara Samie, Mahbobeh Sajadi, Rahmatollah Moradzadeh, Somaye Sayahi","doi":"10.1186/s13098-026-02126-y","DOIUrl":"https://doi.org/10.1186/s13098-026-02126-y","url":null,"abstract":"","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-14DOI: 10.1186/s13098-026-02114-2
Iva Vukelić, Art Sefedini, Dijana Detel, Sunčica Buljević, Branislav Šuša, Tine Tesovnik, Francesco Giorgino, Tadej Battelino, Dario Rahelić, Sanja Klobučar
Type 2 diabetes is a chronic and progressive metabolic disease, with a steadily increasing global incidence and prevalence, representing a major public health concern due to its substantial impact on morbidity and mortality. Type 2 diabetes is characterized by defective insulin secretion and peripheral insulin resistance, resulting in dysregulated glucose homeostasis. Optimal disease management is critical due to its association with multiple systemic complications, including diabetic retinopathy, nephropathy, neuropathy, foot ulcers, cardiomyopathy, and diabetes-related cognitive impairment. The involvement of exosomes in the initiation and progression of type 2 diabetes has recently gained considerable attention. These nanosized vesicles, secreted by virtually all cell types, play a pivotal role in mediating intercellular communication. This review highlights the potential of exosomes and their molecular cargo, particularly microRNAs, as endogenous biomarkers for the detection and monitoring of type 2 diabetes and its associated complications, while also exploring their emerging therapeutic applications.
{"title":"Exosomal MicroRNAs as theranostic tools in type 2 diabetes and its complications: mechanistic insights and clinical implications.","authors":"Iva Vukelić, Art Sefedini, Dijana Detel, Sunčica Buljević, Branislav Šuša, Tine Tesovnik, Francesco Giorgino, Tadej Battelino, Dario Rahelić, Sanja Klobučar","doi":"10.1186/s13098-026-02114-2","DOIUrl":"10.1186/s13098-026-02114-2","url":null,"abstract":"<p><p>Type 2 diabetes is a chronic and progressive metabolic disease, with a steadily increasing global incidence and prevalence, representing a major public health concern due to its substantial impact on morbidity and mortality. Type 2 diabetes is characterized by defective insulin secretion and peripheral insulin resistance, resulting in dysregulated glucose homeostasis. Optimal disease management is critical due to its association with multiple systemic complications, including diabetic retinopathy, nephropathy, neuropathy, foot ulcers, cardiomyopathy, and diabetes-related cognitive impairment. The involvement of exosomes in the initiation and progression of type 2 diabetes has recently gained considerable attention. These nanosized vesicles, secreted by virtually all cell types, play a pivotal role in mediating intercellular communication. This review highlights the potential of exosomes and their molecular cargo, particularly microRNAs, as endogenous biomarkers for the detection and monitoring of type 2 diabetes and its associated complications, while also exploring their emerging therapeutic applications.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-13DOI: 10.1186/s13098-026-02104-4
Yuerong Chai, Jie Tang, Aimin Liu, Qin Zhou
{"title":"Correction: THBS1 regulates the function and insulin sensitivity of HTR8/SVneo cells treated with high glucose through the RhoA/ROCK1 signaling pathway.","authors":"Yuerong Chai, Jie Tang, Aimin Liu, Qin Zhou","doi":"10.1186/s13098-026-02104-4","DOIUrl":"10.1186/s13098-026-02104-4","url":null,"abstract":"","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"18 1","pages":"60"},"PeriodicalIF":3.9,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obstructive sleep apnea a synergistic health risk in type 2 diabetes mellitus: a cross-sectional analytical study using STOP-BANG questionnaire in a tertiary care teaching hospital of Eastern Odisha.","authors":"Prateek Goyal, Manika Bose, Srimannarayan Mishra, Tapaswini Mishra, Debasish Misra, Swayamsidha Mangaraj","doi":"10.1186/s13098-026-02117-z","DOIUrl":"10.1186/s13098-026-02117-z","url":null,"abstract":"","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号