Dermato-Endocrinology最新文献

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Investigating the Early Events after Skin-Barrier Disruption Using Microdialysis—A Human Ex Vivo Skin Model 利用微透析研究皮肤屏障破坏后的早期事件——人离体皮肤模型

Dermato-Endocrinology

Pub Date : 2021-11-30 DOI: 10.3390/dermato1020008

K. Baumann, N. P. Knudsen, A. O. Gadsbøll, A. Woetmann, P. Skov

Skin-barrier restoration following abrasive trauma is facilitated by mediator release from skin-resident cells, a process that has been investigated primarily in mice or simplified human systems with previous studies focusing on a limited number of biomarkers. Here, we demonstrate how early events caused by skin-barrier disruption can be studied in a human ex vivo skin model. Ten relevant biomarkers were recovered from the interstitial fluid by skin microdialysis with subsequent sample analysis using a multiplex platform. As a control, the biomarker profiles obtained from microdialysis sampling were compared to profiles of skin biopsy homogenates. We found that nine (GM-CSF, CXCL1/GROα, CXCL8/IL-8 CXCL10/IP-10, IL-1α, IL-6, MIF, TNF-α, and VEGF) of the 10 biomarkers were significantly upregulated in response to abrasive trauma. Only dialysate levels of CCL27/CTACK were unaffected by skin abrasion. Biomarker levels in the homogenates corresponded to dialysate levels for CCL27/CTACK, CXCL1/GROα, CXCL8/IL-8, and IL-6. However, IL-1α showed an inverse trend in response to trauma, and biopsy levels of MIF were unchanged. GM-CSF, CXCL10/IP-10, TNF-α, and VEGF were not detected in the biopsy homogenates. Our results suggest that the human ex vivo skin model is a reliable approach to study early events after disruption of the skin barrier.

磨料损伤后的皮肤屏障修复是由皮肤驻留细胞释放介质促进的，这一过程主要在小鼠或简化的人体系统中进行了研究，之前的研究主要集中在有限数量的生物标志物上。在这里，我们展示了如何在人类离体皮肤模型中研究由皮肤屏障破坏引起的早期事件。通过皮肤微透析从间质液中回收10个相关生物标志物，随后使用多重平台进行样本分析。作为对照，将从微透析取样获得的生物标志物谱与皮肤活检匀浆谱进行比较。我们发现，10种生物标志物中的9种(GM-CSF、CXCL1/GROα、CXCL8/IL-8、CXCL10/IP-10、IL-1α、IL-6、MIF、TNF-α和VEGF)在磨料损伤后显著上调。只有透析液的CCL27/CTACK水平不受皮肤磨损的影响。匀浆中的生物标志物水平与透析液中CCL27/CTACK、CXCL1/GROα、CXCL8/IL-8和IL-6的水平一致。然而，IL-1α对创伤的反应呈相反趋势，MIF的活检水平没有变化。活检匀浆中未检测到GM-CSF、CXCL10/IP-10、TNF-α和VEGF。我们的研究结果表明，人类离体皮肤模型是研究皮肤屏障破坏后早期事件的可靠方法。

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引用次数: 0

A Case of Atypical Klippel-Trenaunay Syndrome 非典型Klippel-Trenaunay综合征1例

Dermato-Endocrinology

Pub Date : 2021-11-04 DOI: 10.3390/dermato1020007

Yujin Han, Se-Hoon Lee, M. Cho, S. Cho, Jeong-Deuk Lee, Yukari Woo, Hei Sung Kim

Klippel-Trenaunay syndrome (KTS) is a rare complex vascular syndrome with limb hypertrophy. KTS is diagnosed if at least two of the three features of capillary malformation, venous malformation, and soft tissue and/or bone overgrowth are present. Of these, capillary malformation (i.e., port-wine stain) is the most commonly observed feature but may be absent in atypical KTS. We herein report a case of atypical KTS with venous malformation and unilateral soft tissue hypertrophy.

klipppel - trenaunay综合征(KTS)是一种罕见的伴有肢体肥大的复杂血管综合征。如果出现毛细血管畸形、静脉畸形、软组织和/或骨骼过度生长这三种特征中的至少两种，就可以诊断为KTS。其中，毛细血管畸形(即葡萄酒色斑)是最常见的特征，但在非典型KTS中可能不存在。我们在此报告一例不典型KTS伴静脉畸形及单侧软组织肥大。

引用次数: 1

Dermal Melanocytic Disorders 皮肤黑色素细胞疾病

Dermato-Endocrinology

Pub Date : 2021-10-01 DOI: 10.3390/dermato1020006

Yujin Han, Se-Hoon Lee, M. Cho, S. Cho, Jeong-Deuk Lee, Y. Woo, Hei Sung Kim

Dermal melanocytic disorders present as bluish pigmentation on the skin. Several entities including Mongolian spot, aberrant Mongolian spot, nevus of Ota, and nevus of Ito have been reported. It is often difficult to distinguish between the different entities from their overlapping features. Although they share similar etiologies and histologic findings, their co-morbidities and prognosis differ. In this paper, we report four cases of dermal melanocytic disorders of which we were not able to make a clear-cut diagnosis. Also, we briefly review the dermal melanocytic disorders.

皮肤黑色素细胞疾病表现为皮肤上的淡蓝色色素沉着。蒙古斑、异常蒙古斑、太田痣、伊藤痣等几种痣已被报道。通常很难从重叠的特征中区分不同的实体。虽然他们有相似的病因和组织学发现，但他们的合并症和预后不同。在本文中，我们报告四例皮肤黑色素细胞疾病，我们不能作出明确的诊断。同时，我们也简要回顾了皮肤黑色素细胞疾病。

引用次数: 1

Friction-Induced Biphasic Cutaneous Amyloidosis 摩擦诱导的双期皮肤淀粉样变性

Dermato-Endocrinology

Pub Date : 2021-08-19 DOI: 10.3390/dermato1010005

T. Gambichler, L. Susok, M. H. Segert

Primary cutaneous amyloidoses (PCA) are a group of conditions characterized by deposition of amyloid in previously normal skin, without association with other skin or systemic diseases. We describe a Kazakhstani female with a 30-year history of increasingly spreading hyperpigmented macular as well papular skin lesions on her upper trunk accompanied by pruritus. Moreover, her medical history included intensely rubbing her skin with a cotton towel following bathing and showering. On the basis of the clinical and histopathological findings, the diagnosis of biphasic cutaneous amyloidosis was made. The present unusual case of biphasic cutaneous amyloidosis can be subsumed under mechanically-induced forms of cutaneous amyloidosis. In conclusion, the present case underscores the necessity to explore carefully the patient’s history in order to discover the cause of PCA.

原发性皮肤淀粉样病变(PCA)是一组以淀粉样蛋白沉积在先前正常皮肤为特征的疾病，与其他皮肤或全身性疾病无关。我们描述了一个哈萨克斯坦女性与30年的历史日益蔓延的色素沉着黄斑以及丘疹皮肤病变在她的上躯干伴随瘙痒。此外，她的病史包括在沐浴和淋浴后用棉巾强烈摩擦皮肤。根据临床和组织病理学结果，诊断为双期性皮肤淀粉样变性。本不寻常的双期皮肤淀粉样变病例可归入机械诱导的皮肤淀粉样变。总之，本病例强调了仔细探讨患者病史以发现PCA病因的必要性。

引用次数: 1

A Case of Unilateral Hyperpigmentation 单侧色素沉着症1例

Dermato-Endocrinology

Pub Date : 2021-07-01 DOI: 10.3390/DERMATO1010004

Yujin Han, Se-Hoon Lee, M. Cho, S. Cho, Jeong-Deuk Lee, Yukari Woo, Hei Sung Kim

Phytophotodermatitis is a cutaneous phototoxic reaction resulting from contact with plant compounds such as furocoumarin in citrus fruits, followed by exposure to ultraviolet light. Erythema and vesicles appear on the contact area, followed by hyperpigmented lesions. Hyperpigmentation may exist for weeks to months before fading but can remain up to several years. Diagnosis is often challenging due to the variety of clinical presentations, and it is not always easy to identify trigger exposures. A detailed history is key to diagnosis. We herein report a case of lime-induced phytophotodermatitis which was initially mistaken for unilateral lentiginosis. The patient underwent Q-switched Nd:YAG laser and intense pulsed light (IPL) treatment with immediate improvement.

植物性皮炎是一种皮肤光毒性反应，是由于接触植物化合物，如柑橘类水果中的呋喃香豆素，然后暴露在紫外线下引起的。接触部位出现红斑和小泡，随后出现色素沉着。色素沉着可能会持续几周到几个月，然后逐渐消失，但可能持续数年。由于临床表现的多样性，诊断往往具有挑战性，并且并不总是容易识别触发暴露。详细的病史是诊断的关键。我们在此报告一例石灰引起的植物性皮炎，最初被误认为单侧小透镜病。患者接受调q Nd:YAG激光和强脉冲光(IPL)治疗后立即好转。

引用次数: 0

Rare TERT Promoter Mutations Present in Benign and Malignant Cutaneous Vascular Tumors 良恶性皮肤血管肿瘤中罕见的TERT启动子突变

Dermato-Endocrinology

Pub Date : 2021-06-25 DOI: 10.3390/dermato1010003

P. Jansen, G. Lodde, A. Zaremba, C. M. Thielmann, Johanna Matull, H. Müller, Inga Möller, A. Sucker, S. Esser, J. Schaller, D. Schadendorf, T. Mentzel, E. Hadaschik, K. Griewank

Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene have been described as the most common hot-spot mutations in different solid tumors. High frequencies of TERT promoter mutations have been reported to occur in tumors arising in tissues with low rates of self-renewal. For cutaneous vascular tumors, the prevalence of TERT promoter mutations has not yet been investigated in larger mixed cohorts. With targeted next-generation sequencing (NGS), we screened for different known recurrent TERT promoter mutations in various cutaneous vascular proliferations. In our cohort of 104 representative cutaneous vascular proliferations, we identified 7 TERT promoter mutations. We could show that 4 of 64 (6.3%) hemangiomas and vascular malformations harbored TERT promoter mutations (1 Chr.5:1295228 C > T mutations, 1 Chr.5:1295228_9 CC > TT mutation, and 2 Chr.5:1295250 C > T mutations), 1 of 19 (5.3%) angiosarcomas harbored a Chr.5:1295250 C > T TERT promoter mutation, and 2 of 21 (9.5%) Kaposi’s sarcomas harbored TERT promoter mutations (2 Chr.5:1295250 C > T mutations). To our knowledge, this is the first general description of the distribution of TERT promoter mutations in a mixed cohort of cutaneous vascular tumors, revealing that TERT promoter mutations seem to occur with low prevalence in both benign and malignant cutaneous vascular proliferations.

端粒酶逆转录酶(TERT)基因启动子的突变已被描述为不同实体肿瘤中最常见的热点突变。据报道，TERT启动子突变的高频率发生在自我更新率低的组织中产生的肿瘤中。对于皮肤血管肿瘤，TERT启动子突变的患病率尚未在更大的混合队列中进行研究。通过靶向下一代测序(NGS)，我们筛选了各种皮肤血管增生中不同已知的复发性TERT启动子突变。在我们的104例具有代表性的皮肤血管增生队列中，我们确定了7个TERT启动子突变。我们发现64例血管瘤和血管畸形中有4例(6.3%)存在TERT启动子突变(1例chr5:1295228 C > T突变，1例chr5:1295228_9 CC > TT突变，2例chr5: 1295250c > T突变)，19例血管肉瘤中有1例(5.3%)存在TERT启动子突变(2例chr5: 1295250c > T突变)，21例卡波西氏肉瘤中有2例(9.5%)存在TERT启动子突变(2例chr5: 1295250c > T突变)。据我们所知，这是首次对TERT启动子突变在皮肤血管肿瘤混合队列中的分布进行一般性描述，揭示了TERT启动子突变在良性和恶性皮肤血管增生中的发生率似乎都很低。

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引用次数: 0

The Impact of Titanium Dioxide Type Combined with Coffee Oil Obtained from Coffee Industry Waste on Sunscreen Product Performance 从咖啡工业废料中提取的二氧化钛型复合咖啡油对防晒产品性能的影响

Dermato-Endocrinology

Pub Date : 2021-06-21 DOI: 10.3390/dermato1010002

B. G. Chiari-Andréo, J. Marto, A. Ascenso, C. Carneiro, L. Rodríguez, Antonio José Guillot, T. Garrigues, H. Ribeiro, A. Melero, V. Isaac

(1) Background: Titanium dioxide (TiO2) consists of three polymorphs, including anatase, rutile and brookite. This work aimed to elucidate the influence of rutile and anatase forms in the performance of sunscreens formulated with green coffee oil (GCO) from coffee beans discarded in the agri-food industry. (2) Methods: TiO2 particles were characterized in terms of size and wettability. The sunscreens formulated with GCO were characterized regarding the droplet size, rheology, texture profile analysis (TPA), in vitro Sun Protection Factor and Water Resistance Retention. Topical delivery and permeation studies were performed to confirm caffeine release and skin penetration. (3) Results: Particle size distributions of rutile and anatase TiO2 particles were similar, however, smaller droplets as well as decreased viscosity and increased thixotropy were obtained for anatase TiO2 and GCO formulation compared to rutile form formulations. Notwithstanding, all formulations exhibited linear viscoelastic behavior. Regarding the TPA, a wide range of mechanical properties improved mainly by GCO rather than TiO2 form has been demonstrated. The influence of TiO2 form on UV protection was better evidenced in absence of GCO. The sunscreen formulations containing GCO presented a favorable topical delivery as confirmed by caffeine release and permeation. (4) Conclusions: Both TiO2 forms combined with GCO provided suitable properties including an effective ultraviolet (UV)-light protection.

(1)背景:二氧化钛(TiO2)由锐钛矿、金红石和板红石三种多晶岩组成。本工作旨在阐明金红石和锐钛矿形式对用农业食品工业中丢弃的咖啡豆中的绿咖啡油(GCO)配制的防晒霜性能的影响。(2)方法:从粒径和润湿性两方面对TiO2颗粒进行表征。对GCO配制的防晒霜进行了粒径、流变性、质构分析(TPA)、体外防晒系数和抗水保持性等方面的表征。局部给药和渗透研究证实了咖啡因的释放和皮肤渗透。(3)结果:金红石型和锐钛矿型TiO2颗粒的粒径分布相似，但与金红石型相比，锐钛矿型和GCO型的TiO2颗粒粒径更小，粘度降低，触变性增加。尽管如此，所有配方都表现出线性粘弹性行为。对于TPA，主要通过GCO而不是TiO2形式改善了广泛的机械性能。在没有GCO的情况下，TiO2形态对紫外线防护的影响得到了更好的证明。含有GCO的防晒霜配方表现出良好的局部递送，证实了咖啡因的释放和渗透。(4)结论:与GCO结合的两种TiO2形态均具有良好的性能，包括有效的紫外线防护。

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引用次数: 1

Editorial Retraction. 编辑收缩。

Dermato-Endocrinology

Pub Date : 2018-11-02 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1512251

[This retracts the article Dermatoendocrinol. 2014 Oct 31;8(1):e983685.]

[本文撤回文章Dermatoendocrinol. 2014 Oct 31;8(1):e983685]

引用次数: 0

Relation between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes. 1 型糖尿病儿童患者皮肤和皮肤外并发症之间的关系。

Dermato-Endocrinology

Pub Date : 2018-08-17 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1467717

M I Kamel, Y I Elhenawy, W M Saudi

Background: The relationship between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes is unclear. Objective: The objective of the current study is to investigate the relationship between skin disorders and diabetic microangiopathic changes in pediatric and adolescent patients with type 1 diabetes. Patients and methods: Eighty patients with type 1 diabetes and 50 healthy controls were enrolled in the study. All recruited patients were followed up monthly for a total period of 12 month. Monthly visit included thorough clinical examination with system review, as well as whole-body cutaneous examination. HbA1c was assessed every 3 month. Twenty-four hours urine was collected for measurement of urinary albumin. Results: Fifty percent of the screened diabetic cohort had diabetic nephropathy (DN). The overall prevalence of cutaneous lesion among the studied diabetic cohort was high (72.5%), with cutaneous infections (40%) and xerosis (30%) being the most prevalent. The frequency of cutaneous infections, xerosis and rubeosis faciei was higher in patients with nephropathy than in those without nephropathy. Conclusion: cutaneous affection in patients with diabetes may be a clue to the presence of associated microangioapthic complications. The significant association between diabetic nephropathy and cutaneous lesions support the concept that cutaneous lesion in diabetes is a reflection of diabetic angiopathy, highlighting the importance of identifying patients at risk of other microvascular complications.

背景：1 型糖尿病儿童患者的皮肤和皮肤外并发症之间的关系尚不清楚。研究目的本研究旨在探讨 1 型糖尿病儿童和青少年患者的皮肤疾病与糖尿病微血管病变之间的关系。患者和方法：研究共招募了 80 名 1 型糖尿病患者和 50 名健康对照者。所有入组患者每月接受一次为期 12 个月的随访。每月随访包括全面的临床检查和系统复查，以及全身皮肤检查。每三个月评估一次 HbA1c。收集 24 小时尿液以测量尿白蛋白。结果：接受筛查的糖尿病患者中有 50% 患有糖尿病肾病 (DN)。所研究的糖尿病人群中，皮肤病变的总体发病率较高（72.5%），其中以皮肤感染（40%）和皮肤干燥症（30%）最为普遍。肾病患者出现皮肤感染、角化病和红斑狼疮的频率高于无肾病患者。结论：糖尿病患者的皮肤病可能是相关微血管并发症的线索。糖尿病肾病与皮肤病变之间的明显关联支持了糖尿病皮肤病变是糖尿病血管病变反映的概念，突出了识别有其他微血管并发症风险的患者的重要性。

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引用次数: 0

The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women. 年轻成年女性脂联素水平和ADIPOQ基因变异与BMI的关系。

Dermato-Endocrinology

Pub Date : 2018-06-18 eCollection Date: 2018-01-01 DOI: 10.1080/19381980.2018.1477902

Omar F Khabour, Mahmoud A Alomari, Asmaa A Abu Obaid

The current study examined the effect of single nucleotide (SNPs) polymorphisms in the ADIPOQ gene (I146T and G276T) on body mass index (BMI) of young adult women. The women were divided into underweight, normal, overweight and obese according to BMI. The circulating levels of adiponectin were measured using commercially available ELISA kits. Genetic polymorphisms were genotyped using the PCR-RFLP method. G276T and I164T SNPs are common in the examined population as the frequency of G allele of 276 SNP was 54.8% and for the T allele of 164 SNP it was 41.7%. Circulating adiponectin levels were related to BMI and were lowest in the obese versus overweight, normal weight and underweight groups (p<0.01). However, ADIPOQ gene SNPs (I146T and G276T) showed no association with BMI groups. In conclusion, the results may suggest that adiponectin level, but not ADIPOQ gene SNPs, is a good indicator to BMI in young adult women.

目前的研究检测了ADIPOQ基因(I146T和G276T)单核苷酸多态性对年轻成年女性体重指数(BMI)的影响。根据体重指数，这些女性被分为体重过轻、正常、超重和肥胖。脂联素循环水平用市售ELISA试剂盒测定。采用PCR-RFLP方法对遗传多态性进行基因分型。G276T和I164T SNP在研究人群中很常见，276 SNP的G等位基因频率为54.8%，164 SNP的T等位基因频率为41.7%。循环脂联素水平与BMI相关，并且在肥胖组与超重组、正常体重组和体重不足组中最低(pADIPOQ基因snp (I146T和G276T)与BMI组无关)。综上所述，这些结果可能表明，脂联素水平，而不是ADIPOQ基因snp，是年轻成年女性BMI的一个很好的指标。

引用次数: 15

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