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Transplantation for the General Surgeon: Care of the Transplant Patient 普通外科医生的移植:移植病人的护理
Pub Date : 2018-11-26 DOI: 10.2310/surg.2321
S. Nazarian, Meera Gupta
In this chapter, we review the important clinical aspects of abdominal transplantation relevant to the general surgeon. Whereas only a fraction of readers will go on to specialize in transplantation, most will care for these patients during training. Operative techniques, post-transplantation management, outcomes, and transplantation complications are covered in this chapter. All providers will encounter patients with end-stage organ disease in the course of their careers, and therefore, they must understand the indications for transplantation and considerations for caring for these patients. Likewise, transplant recipients require general surgery procedures, and thus, an appreciation for the unique aspects of caring for this population is essential.This review contains 11 figures, 1 table, and 57 references. Key Words: dialysis, end-organ disease, graft survival, immunosuppression, intestine transplantation, kidney transplantation, liver transplantation, pancreas transplantation, patient survival, United Network of Organ Sharing /Organ Procurement and Transplantation Network
在本章中,我们回顾了与普通外科医生相关的腹部移植的重要临床方面。虽然只有一小部分读者会继续专攻移植,但大多数人会在训练期间照顾这些病人。本章涵盖手术技术、移植后处理、结果和移植并发症。所有提供者在其职业生涯中都会遇到终末期器官疾病患者,因此,他们必须了解移植的适应症和照顾这些患者的注意事项。同样,移植受者需要一般的外科手术,因此,对照顾这一人群的独特方面的欣赏是必不可少的。本综述包含11张图,1张表,57篇参考文献。关键词:透析,终末器官疾病,移植物存活,免疫抑制,肠移植,肾移植,肝移植,胰腺移植,患者存活,器官共享/器官获取与移植联合网络
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引用次数: 0
Endoscopic Techniques for Obtaining Enteral Access 获得肠内通路的内镜技术
Pub Date : 2018-11-25 DOI: 10.2310/surg.9055
M. Ryou, S. Salgado
In the absence of contraindications, enteral feeding is recommended for patients who are expected to be intolerant of oral feedings beyond 7 days. Enteral access can be accomplished by a variety of means, including surgical, endoscopic, or radiographic methods. This review focuses on endoscopy-guided options for enteral access. These methods include gastric feeding, which can be accomplished by orogastric, nasogastric, or percutaneous endoscopic gastrostomy tube placement, and postpyloric feeding, accessed through oral or nasal jejunal tubes, percutaneous gastrostomy with a jejunal extension, or direct percutaneous jejunostomy. The indications, techniques, complications, and comparative data of these placement options are outlined, and special clinical considerations (including establishing access in patients with dementia or cirrhosis and those on anticoagulation) are discussed.This review contains 5 figures, 1 table, and 33 references.Key words: direct percutaneous jejunostomy, endoscopy, enteral access in cirrhosis, enteral access in dementia, enteral feeding, enteric access, nasogastric feeding tubes, percutaneous endoscopic gastrojejunostomy tubes, percutaneous endoscopic gastrostomy tubes
在无禁忌症的情况下,对于预计不耐受口服喂养超过7天的患者,建议肠内喂养。肠内通路可以通过多种方式完成,包括手术、内窥镜或放射学方法。本综述的重点是内窥镜引导下的肠内通路选择。这些方法包括胃喂养,可以通过口胃、鼻胃或经皮内镜胃造瘘管置入,以及幽门后喂养,通过口腔或鼻空肠管,经皮胃造瘘伴空肠延伸,或直接经皮空肠造瘘。概述了这些安置方案的适应症、技术、并发症和比较数据,并讨论了特殊的临床考虑(包括在痴呆或肝硬化患者和抗凝患者中建立通道)。本综述包含5张图,1张表,33篇参考文献。关键词:直接经皮空肠造口术,内镜,肝硬化肠内通路,痴呆肠内通路,肠内喂养,肠内通路,鼻胃喂养管,经皮内镜胃空肠造口管,经皮内镜胃造口管
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引用次数: 0
Transplantation for the General Surgeon: History of Transplantation, End-organ Disease, Organ Donation and Allocation, and Transplantation Regulation and Ethics 普通外科医生的移植:移植史,终末器官疾病,器官捐赠和分配,移植法规和伦理
Pub Date : 2018-11-23 DOI: 10.2310/surg.2320
S. Nazarian, J-K Hwang, Meera Gupta, M. Goldshore
This chapter provides a glimpse of the complex regulatory, financial, ethical, and procedural aspects of transplantation. The general surgeon should appreciate the evolution of the field as seen through a brief review of its history as well as its evolving self-governance as manifested through national policies. Knowledge of the process of organ donation is important for any practitioner as is an understanding of the burden of end-organ disease.This review contains 2 figures, 1 table and references.Key Words: brain death, donation after cardiac death, epidemiology and costs of end-organ disease, history of immunosuppression, history of transplantation, living donation, organ allocation, organ donation, transplantation ethics, transplantation regulation
本章提供了移植复杂的监管、财务、伦理和程序方面的一瞥。普通外科医生应该通过对其历史的简要回顾以及其通过国家政策体现的不断发展的自治来欣赏该领域的演变。器官捐献过程的知识对于任何医生来说都是很重要的,就像了解终末器官疾病的负担一样。本综述包含2张图,1张表和参考文献。关键词:脑死亡,心脏死亡后器官捐献,终末器官疾病的流行病学和费用,免疫抑制史,移植史,活体捐献,器官分配,器官捐献,移植伦理,移植法规
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引用次数: 0
Biomaterials 生物材料
Pub Date : 2018-11-13 DOI: 10.2310/ps.10009
P. G, S. Scherer
With the critical advances in material science and bioengineering, the clinical availability of biomaterials is rapidly expanding. Biomaterials are used to restore or correct function of tissues that have been modified by injury, malformation, pathology, or aging. Materials used in contact with living tissues should meet the criteria of biocompatibility, which are (1) biosafety, (2) biofunctionality, and (3) biointegration. Depending on the function they are asked to perform and the target tissue, the choice is among nonresorbable or resorbable biomaterials, metallic or polymeric, and natural or synthetic. Although some materials such as titanium are able to osteointegrate inducing minimal scarring at the interface with living tissues, it seems that a common limitation across all biomaterials is to induce some extent of foreign body reaction and scar encapsulation, which affects negatively the function of the device. Novel surface technologies at the micro- or nano-scale and advanced biomaterials will improve the biointegration of medical devices and allow for permanent implantation of functional biomaterials. This review contains 9 figures, 9 tables and 63 referencesKey Words: biocompatibility, biofilm, biofunctionality, biointegration, biomaterials, encapsulation, foreign body reaction, wound healing
随着材料科学和生物工程的重大进展,生物材料的临床可用性正在迅速扩大。生物材料用于恢复或纠正因损伤、畸形、病理或老化而改变的组织的功能。与活组织接触的材料应符合生物相容性标准,即(1)生物安全性,(2)生物功能性,(3)生物整合性。根据他们被要求执行的功能和目标组织,选择不可吸收或可吸收的生物材料,金属或聚合物,天然或合成。虽然一些材料,如钛,能够在与活组织的界面处诱导最小的疤痕,但似乎所有生物材料的共同限制是诱导一定程度的异物反应和疤痕封装,这对设备的功能产生负面影响。微型或纳米级的新型表面技术和先进的生物材料将改善医疗器械的生物整合,并允许功能生物材料的永久植入。关键词:生物相容性,生物膜,生物功能,生物整合,生物材料,包埋,异物反应,伤口愈合
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引用次数: 0
Parotidectomy 腮腺切除术
Pub Date : 2018-11-13 DOI: 10.2310/surg.2030
J. A. Ridge, Francis Si Wai Zih
When a patient presents with a mass at the angle of the mandible, a neoplasm within the parotid gland is a strong consideration. The parotid is the largest of the salivary glands. Terminal branches of the facial nerve are found within the gland. Their functional preservation is an important goal of parotid surgery. Risks of facial nerve injury rise in reoperative procedures and resection of cancers. Surgical principles apply in parotidectomy. In addition to facial nerve injury, a numb earlobe, contour deficit, salivary fistula, and gustatory sweating should be discussed with the patient before an operation. Most lesions can be removed after identification of the main trunk of the facial nerve, but a retrograde approach after finding a peripheral branch may be required. No randomized trials support a benefit from nerve monitoring. An intact facial nerve will usually begin to function, but months of recovery time may be needed. Permanent paralysis is rare. Salivary fistulae are usually self-limited. Many methods to ameliorate the cosmetic changes after parotidectomy have been described. None has gained ascendency.This review contains 6 figures and 61 references.Key words: facial nerve, facial paralysis, Frey syndrome, gustatory sweating, nerve monitoring, parotid gland, parotid neoplasm, parotidectomy, salivary fistula 
当患者在下颌骨的角度出现肿块时,腮腺内的肿瘤是一个强有力的考虑。腮腺是最大的唾液腺。面神经的末梢分支在腺内。保留腮腺的功能是腮腺手术的重要目标。面神经损伤的风险在再手术和肿瘤切除中增加。手术原则适用于腮腺切除术。除面神经损伤外,耳垂麻木、轮廓缺损、唾液瘘、味觉出汗等应在手术前与患者讨论。大多数病变可以在识别面神经主干后切除,但在发现周围分支后可能需要逆行入路。没有随机试验支持神经监测的益处。完整的面神经通常会开始发挥功能,但可能需要数月的恢复时间。永久性瘫痪是罕见的。唾液瘘管通常是自限性的。许多改善腮腺切除术后美容变化的方法已被描述。没有人获得优势。本综述包含6个图和61篇参考文献。关键词:面神经,面瘫,Frey综合征,味觉出汗,神经监测,腮腺,腮腺肿瘤,腮腺切除术,唾液瘘
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引用次数: 0
Benign and Malignant Thyroid Diseases 良性和恶性甲状腺疾病
Pub Date : 2018-10-29 DOI: 10.2310/surg.2409
L. Kuo, Matthew A. Nehs
The thyroid is key to numerous metabolic and homeostatic processes, including thermomodulation, protein synthesis, carbohydrate and lipid metabolism, and adrenergic regulation. A normal thyroid gland weighs 15 to 25 g and is firm, mobile, and smooth to palpation. There are two distinct physiologically active cell types: follicular cells, which synthesize thyroid hormone, and parafollicular or C cells, which produce calcitonin. Surgery is indicated for three broad categories of thyroid disease: (1) a hyperfunctioning gland, (2) an enlarged gland (goiter) causing compressive symptoms, and (3) diagnosing or treating malignancy. These indications may overlap in a patient presenting for surgical consultation. Regardless of the indication, a thorough discussion with the patient about the thyroid disease and other diagnostic or therapeutic options (if any) should be conducted.This reviews contains 3 figures, 13 tables, and 56 references.Key Words: anaplastic thyroid cancer, antithyroid medications, Bethesda classification, follicular thyroid cancer, Graves disease, medullary thyroid cancer, nontoxic multinodular goiter, papillary thyroid cancer, radioactive iodine, toxic nodular goiter
甲状腺是许多代谢和体内平衡过程的关键,包括体温调节、蛋白质合成、碳水化合物和脂质代谢以及肾上腺素能调节。正常甲状腺重15 - 25g,结实、可动、触诊平滑。有两种不同的生理活性细胞类型:滤泡细胞,合成甲状腺激素,滤泡旁细胞或C细胞,产生降钙素。手术适用于三大类甲状腺疾病:(1)甲状腺功能亢进,(2)甲状腺肿大(甲状腺肿)引起压迫症状,(3)诊断或治疗恶性肿瘤。这些适应症可能重叠的病人提出外科会诊。无论何种适应症,都应与患者就甲状腺疾病和其他诊断或治疗方案(如果有的话)进行彻底的讨论。本综述包含3个图,13个表,56篇参考文献。关键词:间变性甲状腺癌,抗甲状腺药物,Bethesda分类,滤泡性甲状腺癌,Graves病,甲状腺髓样癌,无毒多结节性甲状腺肿,甲状腺乳头状癌,放射性碘,中毒性结节性甲状腺肿
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引用次数: 0
Thyroidectomy: Technique, Tips, and Troubleshooting 甲状腺切除术:技术、技巧和故障排除
Pub Date : 2018-10-26 DOI: 10.2310/surg.2408
L. Kuo, Matthew A. Nehs
Historically, thyroidectomy was associated with a high mortality rate, now understood to likely be secondary to postoperative hypocalcemia. In the modern age, perioperative morbidity and mortality rates are extremely low, although some complications, such as recurrent laryngeal nerve injury, can have significant consequences. Understanding the safe approach to total thyroidectomy and thyroid lobectomy is key to minimizing operative morbidity. In particular, the capsular dissection technique facilitates identification and preservation of the recurrent laryngeal nerve and parathyroid glands. The postoperative care of the patient, including diagnosis and management of the more common complications such as hematoma or hypocalcemia, is crucial to optimize patient outcomes. Although novel thyroidectomy techniques have been developed to avoid or minimize the traditional neck incision, these approaches have not become widely used.This review contains 9 figures, 1 table, and 29 references. Key Words: capsular dissection, external branch of the superior laryngeal nerve, intraoperative nerve monitoring, minimally invasive thyroidectomy, postoperative hematoma, postoperative hoarseness, postoperative hypocalcemia, recurrent laryngeal nerve, remote access thyroidectomy
从历史上看,甲状腺切除术与高死亡率相关,现在认为可能继发于术后低钙血症。在现代,围手术期的发病率和死亡率极低,尽管一些并发症,如喉返神经损伤,可造成严重后果。了解全甲状腺切除术和甲状腺小叶切除术的安全入路是降低手术发病率的关键。特别是,囊膜剥离技术有助于识别和保存喉返神经和甲状旁腺。患者的术后护理,包括血肿或低钙血症等常见并发症的诊断和处理,对于优化患者预后至关重要。虽然新的甲状腺切除术技术已经发展到避免或减少传统的颈部切口,但这些方法尚未得到广泛应用。本综述包含9个图,1个表,29篇参考文献。关键词:囊膜剥离,喉上神经外支,术中神经监测,微创甲状腺切除术,术后血肿,术后声音嘶哑,术后低钙,喉返神经,远程入路甲状腺切除术
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引用次数: 0
Health Economics: Select Concepts of the Health Production Function, Risk, and Insurance 卫生经济学:选择卫生生产函数、风险和保险的概念
Pub Date : 2018-10-17 DOI: 10.2310/surg.2405
B. Hall
The production of health as an output of various inputs is a key concept of health care economics and a key influence on health care policy. Similarly, the notion of risk—that an outcome might not turn out as expected or hoped—underpins the entire theory of insurance. Insurance, and the benefits it can provide, cannot be understood without understanding risk, or without understanding how the features of an insurance contract transform risk for the individual, the payer, or society. The health economist, policy maker, leader, expert operator, financier, insurer, clinician of any stripe, patient or family or advocate, or other interested stakeholder must always consider the structural, clinical, and economic anatomy of health care in the context of the underlying physiology of these economic concepts.This review contains 2 figures, 1 table, and 14 references.Key Words: health economics, health policy, health production, marginal return (diminishing), utility, inputs, QALY, risk (aversion or tolerance), insurance (contract features)
卫生生产作为各种投入的产出是卫生保健经济学的一个关键概念,也是对卫生保健政策的一个关键影响。同样,风险的概念——结果可能与预期或希望的不一样——支撑着整个保险理论。如果不了解风险,或者不了解保险合同的特征如何为个人、付款人或社会转变风险,就无法理解保险及其所能提供的利益。卫生经济学家、政策制定者、领导者、专家运营商、金融家、保险公司、任何类型的临床医生、患者、家庭或倡导者,或其他感兴趣的利益相关者,必须始终在这些经济概念的潜在生理学背景下考虑卫生保健的结构、临床和经济解剖。本综述包含2张图,1张表,14篇参考文献。关键词:卫生经济学,卫生政策,卫生生产,边际收益(递减),效用,投入,质量aly,风险(规避或容忍),保险(契约特征)
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引用次数: 1
Health Economics: National Health Care Expenditures 卫生经济学:国家卫生保健支出
Pub Date : 2018-10-15 DOI: 10.2310/ps.2404
B. Hall
A picture of the overall structure of the US health care industry can be garnered by examining national health expenditures. In 2015, US national health expenditures grew to $3.2 trillion (US), outpacing growth in gross domestic product. Valuable insights are found by examining categories of spending, sources of funds, and target areas of spending, raising questions about the logic and performance of the US system. These perspectives can inform deeper consideration of healthcare policy and reform.This review contains 3 tables and 20 references.Key Words: health economics, health policy, Medicaid, Medicare, national health expenditures, opportunity cost, projections
通过检查国家卫生支出,可以了解美国卫生保健行业的整体结构。2015年,美国国家卫生支出增长到3.2万亿美元,超过了国内生产总值的增长。通过检查支出类别、资金来源和支出目标领域,发现了有价值的见解,对美国体系的逻辑和绩效提出了质疑。这些观点可以为更深入地考虑医疗政策和改革提供信息。本综述包含3个表格和20篇参考文献。关键词:卫生经济学,卫生政策,医疗补助,医疗保险,国家卫生支出,机会成本,预测
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引用次数: 0
Initial Management of Life-Threatening Trauma 危及生命的创伤的初步处理
Pub Date : 2018-10-12 DOI: 10.2310/surg.2129
Emily F. Cantrell, J. Doucet
Management of the critically injured patient is optimized by a coordinated team effort in an organized trauma system that allows for rapid assessment and initiation of life-preserving therapies. This initial assessment must proceed systematically and be prioritized according to physiologic necessity for survival. Beginning in the prehospital setting, coordination, preparation, and appropriate triage of the injured are crucial to facilitating rapid resuscitation of the trauma patient. Next, active efforts to support airway, breathing, circulation, and disability are performed with simultaneous intervention to treat life-threatening injuries and restore hemodynamic stability in the primary survey. With ongoing evaluation and continued resuscitation, a secondary survey provides a head-to-toe assessment of the patient allowing for further diagnosis of injuries and triage to more definitive care.This review contains 12 figures, 8 tables and 63 referencesKey Words: advanced trauma life support, definitive airway, FAST/eFAST, field triage, Glasgow coma scale, primary survey, 1:1:1 resuscitation, secondary survey
在有组织的创伤系统中,通过协调一致的团队努力,优化了重症患者的管理,从而可以快速评估和启动维持生命的治疗。这种初步评估必须系统地进行,并根据生存的生理需要进行优先排序。从院前开始,伤者的协调、准备和适当的分诊对促进创伤患者的快速复苏至关重要。接下来,在初步调查中,积极努力支持气道、呼吸、循环和残疾,同时进行干预,以治疗危及生命的损伤并恢复血流动力学稳定性。随着持续的评估和持续的复苏,二次调查提供了患者从头到脚的评估,允许进一步诊断损伤和分诊,以获得更明确的护理。关键词:晚期创伤生命支持,明确气道,FAST/eFAST,现场分诊,格拉斯哥昏迷量表,初次调查,1:1:1复苏,二次调查
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引用次数: 1
期刊
DeckerMed Plastic Surgery
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