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ƩexcessA1C index, the sum of yearly excess HbA1c values during the total period of diabetes, may have the potential to predict retinopathy by a linear regression setting regardless of duration in type 1 diabetes: a subgroup analysis of DCCT/EDIC data. ƩexcessA1C指数,即糖尿病总期间每年过量HbA1c值的总和,可能有可能通过线性回归设置预测1型糖尿病的视网膜病变,无论持续时间如何:DCCT/EDIC数据的亚组分析。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-08-10 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00654-w
Akira Hirose, Yasutaka Maeda, Atsushi Goto, Masae Minami, Shigehiko Kitano, Yasuko Uchigata

Aims: To find an index of glycemic exposure that predicts retinopathy by a simple regression setting regardless of duration in type 1 diabetes which might be useful for the care of diabetes.

Materials and methods: To exclude the possible disturbing effect of metabolic memory, we examined a subgroup of patients with glycohemoglobin A1c (A1C) data for the total period of type 1 diabetes selected from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications data. Three indices-(1) mean value of yearly A1C (mA1C), (2) sum of yearly A1C values (ƩA1C), and (3) sum of yearly A1C values above 6.5% (ƩexcessA1C)-were assessed as potential candidates. Development of retinopathy was defined by ≥ 3-steps' progression of retinopathy from baseline.

Results: The areas under the receiver operating characteristics curves of the indices for development of retinopathy at years 5, 9, and 13 after the onset of diabetes were the same: 0.8481, 0.8762, and 0.8213, respectively, indicating that each index was substantially capable of predicting development of retinopathy at each timepoint. Linear regression analyses showed that each index had significant and substantial linear relations to retinopathy at each timepoint: all P < 0.0001 for slopes; contribution rate R2 = 0.21 (year 5), 0.46 (year 9), and 0.48 (year 13) for each index. But only ƩexcessA1C index appeared to have similar linear relations to retinopathy at all three timepoints (interactions by timepoint: for slopes: P = 0.1393; for intercepts: P = 0.9366).

Conclusion: ƩexcessA1C may have the potential to predict retinopathy by just one linear regression setting regardless of duration in type 1 diabetes.

目的:找到一个血糖暴露指数,通过简单的回归设置预测1型糖尿病视网膜病变,而不考虑持续时间,这可能对糖尿病的治疗有用。材料和方法:为了排除代谢记忆可能的干扰作用,我们检查了一组1型糖尿病患者的糖化血红蛋白A1c(A1c)数据,这些数据选自糖尿病控制和并发症试验/糖尿病干预和并发症流行病学数据。三个指标——(1)年A1C平均值(mA1C),(2)年A1C值之和(ƩA1C),和(3)年A1C值之和超过6.5%(425 excessA1C)——被评估为潜在候选指标。视网膜病变的发展定义为 ≥ 视网膜病变从基线开始的3步进展。结果:糖尿病发病后第5年、第9年和第13年视网膜病变发展指标的受试者操作特征曲线下面积相同:分别为0.8481、0.8762和0.8213,表明每个指标基本上能够预测每个时间点的视网膜病变发展。线性回归分析表明,各指标在各时间点与视网膜病变呈显著的线性关系:P R2 = 每个指数分别为0.21(第5年)、0.46(第9年)和0.48(第13年)。但只有ƩexcessA1C指数在所有三个时间点似乎与视网膜病变具有相似的线性关系(按时间点的相互作用:斜率:P = 0.1393;对于拦截:P = 0.9366)。结论:ƩexcessA1C可能具有通过一个线性回归设置预测1型糖尿病视网膜病变的潜力,而不考虑持续时间。
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引用次数: 0
Lifestyle behaviors that reduce food and fat intake in patients with type 2 diabetes within 3 months of diagnosis lead to a reduction in the HbA1c level after 12 months. 2型糖尿病患者在确诊后3个月内减少食物和脂肪摄入的生活方式行为会导致12个月后HbA1c水平下降。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-08-10 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00650-0
Yuri Tokunaga-Nakawatase, Maki Aomori, Setsuko Watabe

It is important to provide "Diabetes Self-Management Education and Support," the ongoing process of facilitating the knowledge, skills, and ability necessary for diabetes self-care, immediately after diagnosis. In this 12-month (12 M) longitudinal observational study, outpatients within 3 months of their first diagnosis of type 2 diabetes mellitus (T2DM) were surveyed at baseline (BL) and 12 M using a self-administered questionnaire used in the "Lifestyle Intervention Support Software for Diabetes Prevention" and medical record survey. To explore factors associated with the change extent in HbA1c level during the 12 M post-diagnosis, hierarchical multiple regression analysis was performed with sex, age, HbA1c level at BL, medication in the first 12 M post-diagnosis, and lifestyle behaviors related to diet and exercise therapy as independent variables. The HbA1c level of the 89 participants was 8.4% ± 2.2% at BL and 6.7% ± 1.0% at 12 M. "ND06 I add milk to coffee or tea (reverse item)" (β = -0.110, p = 0.015), "RD15 I eat vegetable dishes such as a vegetable side dish and/or a vinegar or pickle dish" (β = 0.151, p = 0.003), "ND02 I eat until I feel full (reverse item)" (β = -0.115, p = 0.024), and "RD14 I select udon or soba instead of Chinese noodles in soups" (β = -0.113, p = 0.007) were associated with the change extent in the HbA1c level during the 12 M post-diagnosis. Overall, it may be useful to support patients with T2DM early post-diagnosis to improve lifestyle behaviors associated with the extent of change in HbA1c level during the 12 M post-diagnosis.

重要的是提供“糖尿病自我管理教育和支持”,这是一个在诊断后立即促进糖尿病自我护理所需知识、技能和能力的持续过程。在这项为期12个月(12个月)的纵向观察性研究中,首次诊断为2型糖尿病(T2DM)后3个月内的门诊患者在基线(BL)和12个月内使用“糖尿病预防生活方式干预支持软件”中使用的自填问卷和病历调查进行了调查。为了探讨与诊断后12个月HbA1c水平变化程度相关的因素,以性别、年龄、BL时的HbA1c含量、诊断后前12个月的药物以及与饮食和运动治疗相关的生活方式行为为自变量进行了分层多元回归分析。89名参与者的HbA1c水平为8.4% ± 界区2.2%和6.7% ± 在12 M时为1.0%。“ND06我在咖啡或茶中添加牛奶(反向项目)”(β = -0.110,p = 0.015),“RD15我吃蔬菜配菜和/或醋或泡菜”(β = 0.151,p = 0.003),“ND02我吃到饱为止(反向项)”(β = -0.115,p = 0.024),以及“RD14我在汤中选择乌冬面或荞麦面而不是中国面条”(β = -0.113,p = 0.007)与诊断后12个月HbA1c水平的变化程度有关。总的来说,支持T2DM患者在诊断后早期改善与诊断后12个月HbA1c水平变化程度相关的生活方式行为可能是有用的。
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引用次数: 0
Glucose control in the early phase of hospitalization is associated with severe prognosis in coronavirus disease 2019 (COVID-19) patients with diabetes in Japan. 日本2019冠状病毒病(新冠肺炎)糖尿病患者住院早期血糖控制与严重预后相关。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-08-07 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00656-8
Yukiyoshi Okauchi, Ryuki Sakamoto, Tomoko Kaketaka, Eri Yamabayashi, Motohiro Kubori, Shinya Inada, Osamu Morimura, Yasushi Otani, Kinya Abe, Tsutomu Nishida, Hiromi Iwahashi

We investigated the association of glycemic control in the early phase of hospitalization with the prognosis of COVID-19 in patients with diabetes. We analyzed the relationship between various clinical indices, including preprandial blood glucose levels measured by self-monitoring devices in the early phase after admission, and severe prognosis in 189 patients with complicated diabetes who were admitted to our hospital between February 22, 2020 and June 20, 2021. Enrolled patients had a median age of 72 years, median body mass index of 24.7, median HbA1c of 7.1%, and median mean preprandial capillary glucose (PPCG) of 179.1 mg/dL. Sixty-six patients progressed to severe disease, and the mean PPCG in severe cases was significantly higher than that in non-severe cases, 195.2 vs 167.8 mg/dL (p = 0.005). Analysis of the receiver operating characteristic curve showed that 179 mg/dL was the cut-off value, and the risk of severity was significantly higher in patients with a mean PPCG of 180 mg/dL or higher (odds ratio (OR) 3.210, p = 0.017) in multiple regression analysis. In this study, we found that the risk of severe COVID-19 increased in patients with a high mean PPCG in the early phase of hospitalization, suggesting that good glucose control in the early phase of COVID-19 with diabetes may be effective in preventing disease severity.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00656-8.

我们研究了糖尿病患者住院早期血糖控制与新冠肺炎预后的关系。我们分析了各种临床指标之间的关系,包括入院后早期通过自我监测设备测量的餐前血糖水平,以及2020年2月22日至2021年6月20日期间入住我院的189名复杂糖尿病患者的严重预后。入选患者的中位年龄为72岁,中位体重指数为24.7,中位HbA1c为7.1%,中位餐前毛细血管葡萄糖(PPCG)为179.1 mg/dL。66名患者进展为重症,重症患者的平均PPCG显著高于非重症患者,分别为195.2和167.8 mg/dL(p = 0.005)。受试者操作特征曲线的分析表明,179 mg/dL是临界值,平均PPCG为180 mg/dL或更高的患者严重程度的风险显著更高(比值比(or)3.210,p = 0.017)。在这项研究中,我们发现住院早期平均PPCG较高的患者患严重新冠肺炎的风险增加,这表明新冠肺炎糖尿病早期良好的血糖控制可能有效预防疾病的严重性。补充信息:在线版本包含补充材料,可访问10.1007/s13340-023-00656-8。
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引用次数: 0
A fact-finding survey on pre-ulcerative lesions of foot in patients with diabetes: analysis using the Diabetes Study from the Center of Tokyo Women's Medical University 2018 (DIACET 2018). 糖尿病患者足部溃疡前病变的实况调查:使用东京女子医科大学中心2018年糖尿病研究的分析(DIACET 2018)。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-08-02 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00649-7
Haruna Azuma, Kazuki Ikura, Junnosuke Miura, Tetsuya Babazono

Aims/introduction: We aimed to identify the frequency and risk factors of pre-ulcerative lesions of foot in Japanese individuals with diabetes.

Materials and methods: This was a single-center cross-sectional observational study. We conducted a questionnaire survey of 5029 individuals with diabetes (mean age 63 years; 2185 women; 1015 individuals with type 1 diabetes and 4014 individuals with type 2 diabetes) who (a) participated in the Diabetes Study from the Center of Tokyo Women's Medical University: DIACET 2018, and (b) responded to the presence of pre-ulcerative lesions of foot. A pre-ulcerative lesions of foot was defined as a calluses, ingrown nails, or symptoms of fungal infection. The associations between pre-ulcerative lesions of foot and commonly available clinical information were examined using the logistic regression analysis.

Results: 412 of 1015 (40.6%) individuals with type 1 diabetes and 1585 of 4014 (39.5%) individuals with type 2 diabetes reported having any type of pre-ulcerative lesions of foot. The frequency of calluses, ingrown nails, and symptoms of fungal infection, respectively, were 16.8%, 15.8%, and 21.9% in type 1 diabetes and 10.5%, 18.5%, and 24.7% in type 2 diabetes. In the separate analysis by type of diabetes, common risk factors found to be significantly correlated with pre-ulcerative lesions of foot were female gender, numbness in the feet and foot deformation.

Conclusion: Proactive foot screening by health care professionals was considered important, especially in individuals with type 1 and type 2 diabetes with advanced complications and foot deformation.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00649-7.

目的/简介:我们旨在确定日本糖尿病患者足部溃疡前病变的频率和危险因素。材料和方法:这是一项单中心横断面观察性研究。我们对5029名糖尿病患者(平均年龄63岁;2185名女性;1015名1型糖尿病患者和4014名2型糖尿病患者)进行了问卷调查,他们(a)参加了东京女子医科大学中心的糖尿病研究:DIACET 2018,以及(b)对足溃疡前病变的存在做出了反应。足部溃疡前病变被定义为老茧、指甲向内生长或真菌感染症状。采用logistic回归分析检验足部溃疡前病变与常见临床信息之间的相关性。结果:1015名1型糖尿病患者中有412人(40.6%)和4014名2型糖尿病患者的1585人(39.5%)报告有任何类型的足部溃疡前病变。1型糖尿病患者出现老茧、指甲向内生长和真菌感染症状的频率分别为16.8%、15.8%和21.9%,2型糖尿病患者分别为10.5%、18.5%和24.7%。在按糖尿病类型进行的单独分析中,发现与足部溃疡前病变显著相关的常见风险因素是女性、足部麻木和足部变形。结论:由卫生保健专业人员进行积极的足部筛查被认为是重要的,尤其是对于患有1型和2型糖尿病并伴有晚期并发症和足部变形的患者。补充信息:在线版本包含补充材料,网址为10.1007/s13340-023-00649-7。
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引用次数: 0
Anti-GAD antibody-positive fulminant type 1 diabetes developed following SARS-CoV-2 vaccination. 接种严重急性呼吸系统综合征冠状病毒2型疫苗后出现抗GAD抗体阳性的暴发型1型糖尿病。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-07-31 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00648-8
Tomohito Izumi, Hironobu Takahashi, Hironori Takahashi

Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been used worldwide since the 2020 coronavirus pandemic. However, several negative side-effects of these vaccines have been reported. Herein, we present a case of a patient with fulminant type 1 diabetes that developed shortly after administration of the SARS-CoV-2 vaccine. A 47-year-old man with no medical history presented with hyperglycemia-related symptoms shortly after receiving the third messenger ribonucleic acid SARS-CoV-2 vaccine. Based on hyperglycemia, diabetic ketoacidosis at onset, relatively low hemoglobin A1c levels, and complete depletion of endogenous insulin secretion, the patient was diagnosed with fulminant type 1 diabetes and insulin therapy was initiated. Through human leukocyte antigen genotyping, the disease-susceptible alleles for type 1 diabetes, DRB1*04:05 and DQB1*04:01, were identified. The patient tested positive for serum anti-glutamic acid decarboxylase antibodies, which are normally negative for fulminant type 1 diabetes, implying that immunomodulation triggered by SARS-CoV-2 vaccination influenced the onset of type 1 diabetes.

自2020年冠状病毒大流行以来,针对严重急性呼吸综合征冠状病毒2型(严重急性呼吸系统综合征冠状病毒)的疫苗已在全球范围内使用。然而,据报道,这些疫苗有几种负面副作用。在此,我们介绍了一例在接种严重急性呼吸系统综合征冠状病毒2型疫苗后不久出现的暴发性1型糖尿病患者。一名无病史的47岁男子在接种第三种信使核糖核酸严重急性呼吸系统综合征冠状病毒2型疫苗后不久出现高血糖相关症状。基于高血糖、糖尿病酮症酸中毒、血红蛋白A1c水平相对较低以及内源性胰岛素分泌完全耗尽,患者被诊断为暴发性1型糖尿病,并开始胰岛素治疗。通过人类白细胞抗原基因分型,确定了1型糖尿病的易感等位基因DRB1*04:05和DQB1*04:0.1。该患者的血清抗谷氨酸脱羧酶抗体检测呈阳性,通常对暴发性1型糖尿病呈阴性,这意味着严重急性呼吸系统综合征冠状病毒2型疫苗引发的免疫调节影响了1型糖尿病的发病。
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引用次数: 0
Effect of joint limitation and balance control on gait changes in diabetic peripheral neuropathy. 关节限制和平衡控制对糖尿病周围神经病变步态变化的影响。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-07-24 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00647-9
Hiroyuki Yamasaki, Yoshiro Abe, Shunsuke Mima, Mayu Bando, Shinji Nagasaka, Yutaro Yamashita, Kazuhide Mineda, Akio Kuroda, Munehide Matsuhisa, Masahiro Takaiwa, Ichiro Hashimoto

Aims: This study analyzed the gait patterns of diabetic peripheral neuropathy (DPN) patients and changes in the center of mass sway to prevent the formation and recurrence of foot ulcers.

Methods: Forty-two subjects were divided into the diabetes mellitus (DM), DPN, and diabetic foot ulcer (DFU) groups. We measured the range of motion (ROM) of the lower limb joints in the resting position and the center of mass sway in the standing position. Joint angles, ROM during walking, and distance factors were evaluated.

Results: In the DFU group, ROM limitation during walking was detected at the knee joint, and functional and ROM limitations were found at the ankle joint. The step length ratio and step width in the DFU group were significantly lower and higher than those in the DM group, respectively. The sway distances in the DFU group were greater than those in the DM and DPN groups.

Conclusions: Functional joint limitations and gait changes due to the decreased ability to maintain the center of gravity were observed in the DFU group. As DPN progressed, the patients' gait became small, wide, and shuffled. Thus, supporting joint movement during walking may help reduce the incidence and recurrence of foot ulcers.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00647-9.

目的:本研究分析糖尿病周围神经病变(DPN)患者的步态模式和重心摆动的变化,以防止足部溃疡的形成和复发。方法:将42例受试者分为糖尿病(DM)组、糖尿病足溃疡(DFU)组。我们测量了静息姿势下下肢关节的运动范围(ROM)和站立姿势下重心的摆动。评估关节角度、行走过程中的ROM和距离因素。结果:在DFU组中,在膝关节处检测到行走过程中的ROM限制,在踝关节处发现功能和ROM限制。DFU组的步长比和步长分别显著低于DM组和DM组。DFU组的摆动距离大于DM和DPN组。结论:DFU组由于维持重心能力下降而出现功能性关节限制和步态变化。随着DPN的进展,患者的步态变得小、宽、乱。因此,在步行过程中支持关节运动可能有助于减少足部溃疡的发生率和复发率。补充信息:在线版本包含补充材料,可访问10.1007/s13340-023-00647-9。
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引用次数: 0
Effects of pemafibrate on left ventricular diastolic function in patients with type 2 diabetes mellitus: a pilot study. 培马贝特对2型糖尿病患者左心室舒张功能的影响:一项初步研究。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-07-19 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00645-x
Kaoru Yamamoto, Yasuharu Ohta, Akihiko Taguchi, Masaru Akiyama, Hiroko Nakabayashi, Yuko Nagao, Hatanaka Ryoko, Yasuaki Wada, Takeshi Yamamoto, Masafumi Yano, Yukio Tanizawa

Aims/introduction: Diabetic cardiomyopathy (DCM) is characterized predominantly by diastolic dysfunction. The multiple mechanisms underlying DCM include altered energy substrate utilization. Recent studies indicate that PPARα plays an important role in the pathogenesis of lipotoxic cardiomyopathy. Pemafibrate is known to be a selective PPARα modulator (SPPARMα). We thus investigated the effects of pemafibrate on cardiac diastolic function in patients with type 2 diabetes.

Materials and methods: Seventeen patients with type 2 diabetes (T2D) and hypertriglyceridemia were screened and treated with pemafibrate at a dose of 0.2 mg/day for 8-16 weeks. Fourteen patients were eligible for analysis. Echocardiography was used for assessment of diastolic function. Early diastolic filling velocity (E), late atrial filling velocity (A) and the E/A ratio were included in this study. Peak early diastolic annular velocities (e') were also assessed using color tissue Doppler images. The primary endpoints were changes in the ratio of E to A (E/A), e', and the ratio of E to e' (E/e') from baseline.

Results: Pemafibrate significantly increased average e' (7.24 ± 0.58 vs 7.94 ± 0.67, p = 0.019) and a significant reduction in E/e' (9.01 ± 0.94 vs 8.20 ± 0.91, p = 0.041). The increase in e' was significantly related to increases in fasting blood glucose (r = 0.607, p = 0.021) and non-esterified fatty acid (r = 0.592, p = 0.026).

Conclusion: Pemafibrate improved diastolic function in patients with T2D and hypertriglyceridemia, suggesting that PPARα activation by pemafibrate prevents the development of DCM at an early stage.

目的/简介:糖尿病性心肌病(DCM)主要以舒张功能障碍为特征。DCM的多种机制包括能量底物利用率的改变。最近的研究表明PPARα在脂中毒性心肌病的发病机制中起着重要作用。已知培马贝特是一种选择性PPARα调节剂(SPPARMα)。因此,我们研究了培马贝特对2型糖尿病患者心脏舒张功能的影响。材料和方法:对17例2型糖尿病(T2D)和高甘油三酯血症患者进行筛查,并用0.2mg/天的培马贝特治疗8-16周。14名患者符合分析条件。超声心动图用于评估舒张功能。本研究包括舒张早期充盈速度(E)、心房晚期充盈速度(A)和E/A比值。还使用彩色组织多普勒图像评估舒张早期环速度峰值(e’)。主要终点是与基线相比E与A(E/A)、E’和E与E’(E/E’)的比率的变化。结果:培马贝特显著提高平均e'(7.24 ± 0.58对7.94 ± 0.67,p = 0.019)和E/E'显著降低(9.01 ± 0.94对8.20 ± 0.91,p = 0.041)。e’的增加与空腹血糖的增加显著相关(r = 0.607,p = 0.021)和非酯化脂肪酸(r = 0.592,p = 0.026)。结论:培马贝特改善了T2D和高甘油三酯血症患者的舒张功能,表明培马贝特激活PPARα可在早期预防DCM的发展。
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引用次数: 0
Patients with gestational diabetes mellitus may be treated in both early and late pregnancy, especially in patients with pre-pregnancy overweight: A cross-sectional study in Japan. 妊娠期糖尿病患者可在妊娠早期和晚期接受治疗,尤其是妊娠前超重患者:日本的一项横断面研究。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-07-16 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00646-w
Ayaka Takemoto, Yoshio Nagai, Shin Kawanabe, Tomoko Nakagawa, Kaho Matsumoto, Jyunichi Hasegawa, Nao Suzuki, Yasushi Tanaka, Masakatsu Sone

The significance of diagnosing gestational diabetes mellitus (GDM) in early pregnancy is controversial. We used the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria to investigate whether clinical background and neonatal outcomes differ depending on when GDM is diagnosed in early or late pregnancy. This was a single-center, observational study conducted between November 2012 and March 2020 at St. Marianna University Hospital (Kawasaki, Japan). We compared the background and perinatal outcomes of patients with GDM depending on the time of diagnosis (at < 24 gestational weeks or ≥ 24 weeks). Insulin sensitivity index, homeostasis model assessment of insulin resistance, and β-cell function were calculated from a 75-g oral glucose tolerance test. Stratified analysis was performed by pre-pregnancy BMI in patients with early GDM. As a result, in the 507 patients, 89.9% gave birth at our hospital. The pre-pregnancy BMI was significantly higher in patients with early GDM than in those with late GDM (the median [interquartile range], 22.7 [20.3, 26.3] and 21.5 [19.3, 23.8] kg/m2, respectively; p = 0.001). Perinatal outcomes were not different between the two groups. However, in the subgroup analysis of patients with early GDM, the prevalence of large-for-gestational-age infants was significantly higher in the group with overweight (15.4% vs 2.1%, respectively; p = 0.008). In conclusion, patients with GDM using the IADPSG criteria in early pregnancy may be treated, especially in patients with pre-pregnancy overweight.

妊娠早期诊断妊娠期糖尿病(GDM)的意义一直存在争议。我们使用国际糖尿病与妊娠研究小组协会(IADPSG)的标准来调查临床背景和新生儿结局是否因妊娠早期或晚期诊断为GDM而不同。这是一项单中心观察性研究,于2012年11月至2020年3月在圣玛利亚那大学医院(日本川崎)进行。我们根据诊断时间比较了GDM患者的背景和围产期结果( 2;p = 0.001)。两组之间的围产期结果没有差异。然而,在早期GDM患者的亚组分析中,超重组中妊娠期大婴儿的患病率显著较高(分别为15.4%和2.1%;p = 0.008)。总之,在妊娠早期使用IADPSG标准的GDM患者可以得到治疗,尤其是在妊娠前超重的患者中。
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引用次数: 0
Correction: A consensus statement from the Japan Diabetes Society (JDS): a proposed algorithm for pharmacotherapy in people with type 2 diabetes. 更正:日本糖尿病学会(JDS)的一份共识声明:一种针对2型糖尿病患者的药物治疗算法。
IF 2.2 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-07-14 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00644-y
Ryotaro Bouchi, Tatsuya Kondo, Yasuharu Ohta, Atsushi Goto, Daisuke Tanaka, Hiroaki Satoh, Daisuke Yabe, Rimei Nishimura, Norio Harada, Hideki Kamiya, Ryo Suzuki, Toshimasa Yamauchi

[This corrects the article DOI: 10.1007/s13340-022-00605-x.].

[这更正了文章DOI:10.1007/s1330-022-00605-x.]。
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引用次数: 0
Association between dietary carbohydrate intake and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies. 饮食碳水化合物摄入与2型糖尿病风险之间的关系:队列研究的系统综述和荟萃分析。
IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-07-04 eCollection Date: 2023-10-01 DOI: 10.1007/s13340-023-00642-0
Akinori Yaegashi, Satoshi Sunohara, Takashi Kimura, Wen Hao, Takato Moriguchi, Akiko Tamakoshi

Background: Previous meta-analyses have assessed the relationship between carbohydrate intake and type 2 diabetes (T2D) risk; however, they included few studies of Asian populations who have a higher carbohydrate intake and lower insulin secretory capacity than non-Asians. Since the publication of the previous meta-analyses, three further studies of Asian populations have been conducted. Based on this background, the present study aimed to perform an updated systematically examine observational studies concerning the link between dietary carbohydrate intake and T2D risk.

Methods: We conducted a systematic search for cohort studies that investigated the target association. For each analyzed study, parameter-adjusted risk ratios were used to compare the lowest and highest carbohydrate-intake groups in terms of their risk of incident T2D. The risk ratios were calculated using a random-effects model.

Results: Ten publications were analyzed. Overall, carbohydrate intake was found not to be associated with increased risk ratios of incident T2D (risk ratio [RR] = 1.07; 95% confidence interval [95% CI] = 0.94, 1.21; P < 0.01, I2 = 61.9%). However, studies of Asian populations reported that high carbohydrate intake is significantly associated with this risk (RR = 1.29; 95% CI 1.15, 1.45; P = 0.59, I2 = 0.0%).

Conclusions: This updated meta-analysis showed that, overall, carbohydrate intake is not associated with the risk of T2D; nevertheless, a significant association exists among Asian populations. To confirm the association between dietary carbohydrate intake and T2D risk observed in this study, further evidence from long-term observational studies of Asian populations is required.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-023-00642-0.

背景:先前的荟萃分析评估了碳水化合物摄入与2型糖尿病(T2D)风险之间的关系;然而,他们很少对碳水化合物摄入量高于非亚洲人、胰岛素分泌能力低于非亚洲人的亚洲人进行研究。自之前的荟萃分析发表以来,已经对亚洲人群进行了三项进一步的研究。基于这一背景,本研究旨在对饮食碳水化合物摄入与T2D风险之间的联系进行最新的系统性观察研究。方法:我们对研究目标关联的队列研究进行了系统搜索。对于每项分析的研究,使用参数调整后的风险比来比较碳水化合物摄入量最低和最高的组发生T2D的风险。使用随机效应模型计算风险比率。结果:对10篇出版物进行了分析。总体而言,碳水化合物摄入与T2D发病风险比的增加无关(风险比[RR] = 1.07;95%置信区间[95%CI] = 0.94.121;P 2. = 61.9%)。然而,对亚洲人群的研究报告称,高碳水化合物摄入与这种风险显著相关(RR = 1.29;95%置信区间1.15、1.45;P = 0.59,I2 = 0.0%)。结论:这项最新的荟萃分析显示,总体而言,碳水化合物摄入与T2D的风险无关;然而,亚洲人口之间存在着显著的关联。为了证实本研究中观察到的饮食碳水化合物摄入与T2D风险之间的相关性,需要来自亚洲人群的长期观察性研究的进一步证据。补充信息:在线版本包含补充材料,可访问10.1007/s13340-023-00642-0。
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Diabetology International
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