Pub Date : 2023-05-13DOI: 10.21608/djs.2023.207827.1113
wessam ragab
Hepatitis C is caused by the hepatitis C virus. Various treatments for hepatitis C were ineffective before the use of direct-acting antivirals (DAAs). DAA has few (negative) adverse effects and high sustained virologic response rate (SVR12). The aim of this study was to investigate the efficacy and safety of (Velpatasvir-containing regimen) in adult chronic HCV patients unresponsive to Sofosbuvir plus Daclatasvir in Egypt. Patients were assessed clinically and laboratory at the baseline before beginning treatment regimen and monitored clinically and laboratory weekly in the follow up visits for 12 weeks, we report the adverse events t for the safety of the drug. At 12 weeks after treatment, RT-PCR was used to evaluate efficacy. A total of 102 patients. The average age was 55.64 ± 11.13 years old, with (87.3%) male and (12.7%) female. Most patients were treated with SOF+DAC for 3 months 72 (70.6%) while, 30 patients (29
{"title":"Efficacy and Safety of Generic (Velpatasvir containing regimen) among Adult Chronic HCV Patients Non-responders to Treatment by Sofosbuvir Plus Daclatasvir Regimen in Egypt","authors":"wessam ragab","doi":"10.21608/djs.2023.207827.1113","DOIUrl":"https://doi.org/10.21608/djs.2023.207827.1113","url":null,"abstract":"Hepatitis C is caused by the hepatitis C virus. Various treatments for hepatitis C were ineffective before the use of direct-acting antivirals (DAAs). DAA has few (negative) adverse effects and high sustained virologic response rate (SVR12). The aim of this study was to investigate the efficacy and safety of (Velpatasvir-containing regimen) in adult chronic HCV patients unresponsive to Sofosbuvir plus Daclatasvir in Egypt. Patients were assessed clinically and laboratory at the baseline before beginning treatment regimen and monitored clinically and laboratory weekly in the follow up visits for 12 weeks, we report the adverse events t for the safety of the drug. At 12 weeks after treatment, RT-PCR was used to evaluate efficacy. A total of 102 patients. The average age was 55.64 ± 11.13 years old, with (87.3%) male and (12.7%) female. Most patients were treated with SOF+DAC for 3 months 72 (70.6%) while, 30 patients (29","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80423578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-13DOI: 10.21608/djs.2023.180434.1059
Mohamed Hasabo, Mahmoud Soliman, H. E. Abdel Hafiez, Amr Thabet, S. Saraya
{"title":"Probability of Magnitude Detection for the Greater Cairo Seismological Network, Egypt.","authors":"Mohamed Hasabo, Mahmoud Soliman, H. E. Abdel Hafiez, Amr Thabet, S. Saraya","doi":"10.21608/djs.2023.180434.1059","DOIUrl":"https://doi.org/10.21608/djs.2023.180434.1059","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91188935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.21608/djs.2023.202505.1102
S. Hamdy, N. Fouad, O. Sayed
{"title":"Role of serum expression of long non-coding RNA growth arrest-specific 5 (GAS5) of Behçet's disease","authors":"S. Hamdy, N. Fouad, O. Sayed","doi":"10.21608/djs.2023.202505.1102","DOIUrl":"https://doi.org/10.21608/djs.2023.202505.1102","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88742792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.21608/djs.2023.200511.1096
hadeer abosamra, A. El-Shanshoury, T. El-Sakhawy
L-asparaginase is an enzyme included in the treatment of acute lymphoblastic leukemia (ALL). Its therapeutic mechanism is the hydrolyzes of L-asparagine, which is an essential amino acid for neoplastic cells while it can be synthesized by normal cells. The problem of L-asparaginase from microbial origin represented in its association with glutaminase activity. The search for new eukaryotic L-asparaginase-producers among microorganisms with low glutaminase affinity is important. This study investigated the biotechnological potential of filamentous fungi isolated from the cogongrass ( Imperata cylindrical ) rhizosphere soil. Fifteen
l -天冬酰胺酶是一种用于治疗急性淋巴细胞白血病(ALL)的酶。其治疗机制是l -天冬酰胺的水解作用，而l -天冬酰胺是肿瘤细胞必需的氨基酸，正常细胞可以合成。l -天冬酰胺酶与谷氨酰胺酶活性的关系是微生物来源的问题。在谷氨酰胺酶亲和力较低的微生物中寻找新的真核l -天冬酰胺酶产生物是很重要的。本文研究了从铜草根际土壤中分离得到的丝状真菌的生物技术潜力。15
{"title":"Optimizing the Production of Glutaminase-Free L-Asparaginase by Halotolerant Penicillium sp. Isolated from Halophyte Cogongrass Rhizosphere","authors":"hadeer abosamra, A. El-Shanshoury, T. El-Sakhawy","doi":"10.21608/djs.2023.200511.1096","DOIUrl":"https://doi.org/10.21608/djs.2023.200511.1096","url":null,"abstract":"L-asparaginase is an enzyme included in the treatment of acute lymphoblastic leukemia (ALL). Its therapeutic mechanism is the hydrolyzes of L-asparagine, which is an essential amino acid for neoplastic cells while it can be synthesized by normal cells. The problem of L-asparaginase from microbial origin represented in its association with glutaminase activity. The search for new eukaryotic L-asparaginase-producers among microorganisms with low glutaminase affinity is important. This study investigated the biotechnological potential of filamentous fungi isolated from the cogongrass ( Imperata cylindrical ) rhizosphere soil. Fifteen","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74074029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.21608/djs.2023.202501.1101
S. Hamdy, N. Fouad
{"title":"Biochemical study on expression of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in Behçet's disease","authors":"S. Hamdy, N. Fouad","doi":"10.21608/djs.2023.202501.1101","DOIUrl":"https://doi.org/10.21608/djs.2023.202501.1101","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89537379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.21608/djs.2023.177585.1048
Y. Abdou, A. Mosbah, Fathy ELhoseny, Nomany Nomany, E. Salim
{"title":"The effect of Cetuximab and Egg Serum Albumin on Caco-2 cells after 48h incubation with Caco-2 cells","authors":"Y. Abdou, A. Mosbah, Fathy ELhoseny, Nomany Nomany, E. Salim","doi":"10.21608/djs.2023.177585.1048","DOIUrl":"https://doi.org/10.21608/djs.2023.177585.1048","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72707887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.21608/djs.2023.200516.1098
Sobhy E. Elsilk, Mohammed Eid
{"title":"Carbohydrates and Plant Extracts as Natural Alternatives for Preventing Staphylococcus aureus Biofilm Formation","authors":"Sobhy E. Elsilk, Mohammed Eid","doi":"10.21608/djs.2023.200516.1098","DOIUrl":"https://doi.org/10.21608/djs.2023.200516.1098","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"13 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76292283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.21608/djs.2023.208583.1114
Othman Othman, Reham Sayed, A. Mohammed
{"title":"Serum Adiponectin and Leptin hormone with H. Pylori infection in Obese Patients","authors":"Othman Othman, Reham Sayed, A. Mohammed","doi":"10.21608/djs.2023.208583.1114","DOIUrl":"https://doi.org/10.21608/djs.2023.208583.1114","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78438193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.21608/djs.2023.294171
{"title":"Petrophysical Modeling of Lower Rudeis Sandstone in Shukheir Bay Field, Gulf of Suez, Egypt","authors":"","doi":"10.21608/djs.2023.294171","DOIUrl":"https://doi.org/10.21608/djs.2023.294171","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80056587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.21608/djs.2023.197952.1083
A. Khalifa, R. Diab, M. Hamouda, Adel Elshanshoury, R. Gaafar
{"title":"Genetic Diversity Assessment of Egyptian Soybean Varieties Based on SDS-PAGE and ISSR Fingerprinting","authors":"A. Khalifa, R. Diab, M. Hamouda, Adel Elshanshoury, R. Gaafar","doi":"10.21608/djs.2023.197952.1083","DOIUrl":"https://doi.org/10.21608/djs.2023.197952.1083","url":null,"abstract":"","PeriodicalId":11368,"journal":{"name":"Delta Journal of Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88295023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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