Abdelmoughite Ouakil, Soumaya El ismaili, O. El Mahdi, A. Maurady, B. El Bali, M. Lachkar
{"title":"Quantitative Analysis of Total Phenolic and Flavonoid Contents from Stachys mouretii Leaf Extracts","authors":"Abdelmoughite Ouakil, Soumaya El ismaili, O. El Mahdi, A. Maurady, B. El Bali, M. Lachkar","doi":"10.3390/ecsoc-25-11802","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11802","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83054865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Odília M. P. F. Luís, Nuna L. P. Ramos, S. Costa, M. Raposo
{"title":"Synthesis, Characterization, and Preliminary Chemosensory Ability of a Novel 2,4,5-Tri(Hetero)Arylimidazole Based on an 8-Hydroxy-Quinoline Group","authors":"Odília M. P. F. Luís, Nuna L. P. Ramos, S. Costa, M. Raposo","doi":"10.3390/ecsoc-25-11748","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11748","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77918226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Ghafuri, B. Abbasi, Nastaran Ghanbari, Yegane Rostami, Zeinab Tajik, Mahdi Akhgari
{"title":"Benzene-1,3,5-tricarboxylic Acid-Functionalized Cherry Gum as a Novel and Recoverable Nanocatalyst for Efficient Synthesis of 1,4-polyhydroquinoline Derivatives","authors":"H. Ghafuri, B. Abbasi, Nastaran Ghanbari, Yegane Rostami, Zeinab Tajik, Mahdi Akhgari","doi":"10.3390/ecsoc-25-11717","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11717","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72923487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: In recent years, push–pull dicyanovinyl derivatives have been reported for several optical applications, including as fluorescent probes for cyanide ion detection. In the presence of cyanide ions, this type of compound exhibits an ICT mechanism associated with the addition of the cyanide ion to the β position of the dicyanovinyl group, due to the strong electron-withdrawing effect of the cyano groups. These structural changes caused by the addition reaction are accompanied by changes in the probe’s absorption and emission. In this work, we report a thiophene-based dicyanovinyl derivative and its prospective application as an anion chemosensor. The photophysical characterization was carried out in acetonitrile and aqueous acetonitrile solutions. Preliminary sensing assays in the presence of various anions of biological, medicinal, and environmental relevance were conducted, and the interaction with CN − was further explored through spectrophotometric titrations.
{"title":"A Thiophene-Based Dicyanovinyl as an Anion Chemosensor","authors":"J. P. Castro, M. Raposo, S. Costa","doi":"10.3390/ecsoc-25-11769","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11769","url":null,"abstract":": In recent years, push–pull dicyanovinyl derivatives have been reported for several optical applications, including as fluorescent probes for cyanide ion detection. In the presence of cyanide ions, this type of compound exhibits an ICT mechanism associated with the addition of the cyanide ion to the β position of the dicyanovinyl group, due to the strong electron-withdrawing effect of the cyano groups. These structural changes caused by the addition reaction are accompanied by changes in the probe’s absorption and emission. In this work, we report a thiophene-based dicyanovinyl derivative and its prospective application as an anion chemosensor. The photophysical characterization was carried out in acetonitrile and aqueous acetonitrile solutions. Preliminary sensing assays in the presence of various anions of biological, medicinal, and environmental relevance were conducted, and the interaction with CN − was further explored through spectrophotometric titrations.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84235627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Purpurogallin or (6 E ,8 Z )-2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one is a benzotropo-lone possessing a dienic system and is known to inhibit TLR1/TLR2 activation pathway. We have recently described the easy green synthesis of purpurogallin from pyrogallol catalyzed by a copper complex or by vegetable oxidases. The purpurogalline was acetylated and the tetraacetate derivative thus obtained was engaged in a Diels Alder reaction with various dienophiles (benzoquinone, maleic anhydride, ethylmaleimide, phenylmaleimide, etc.). The results obtained will be presented and discussed.
{"title":"Study of Diels–Alder Reactions of Purpurogallin Tetraacetate with Various Dienophiles","authors":"Salima Dib, B. Mostefa-Kara, D. Villemin, N. Bar","doi":"10.3390/ecsoc-25-11707","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11707","url":null,"abstract":": Purpurogallin or (6 E ,8 Z )-2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one is a benzotropo-lone possessing a dienic system and is known to inhibit TLR1/TLR2 activation pathway. We have recently described the easy green synthesis of purpurogallin from pyrogallol catalyzed by a copper complex or by vegetable oxidases. The purpurogalline was acetylated and the tetraacetate derivative thus obtained was engaged in a Diels Alder reaction with various dienophiles (benzoquinone, maleic anhydride, ethylmaleimide, phenylmaleimide, etc.). The results obtained will be presented and discussed.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75866780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Fernández-Fariña, Isabel Velo-Heleno, M. Martínez‐Calvo, Ana M. González-Noya, Rosa Pedrido
{"title":"Design, Synthesis and Structural Characterization of a Novel Asymmetric Hydrazone-Thiosemicarbazone Ligand with the Aim of Obtaining Interesting Metallosupramolecular Architectures","authors":"Sandra Fernández-Fariña, Isabel Velo-Heleno, M. Martínez‐Calvo, Ana M. González-Noya, Rosa Pedrido","doi":"10.3390/ecsoc-25-11738","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11738","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86536590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Teixeira, Nuno F S Pinto, David M. Pereira, R. Pereira, M. J. Fernandes, E. M. Castanheira, A. Fortes, M. S. Gonçalves
: Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β -amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results show that some structural modi-fications resulted in enhanced cytotoxic activity towards cancer cells. In addition, the activation of caspase-3 and hence apoptosis induced by these molecules, was also explored. Considering the ob-tained results, some structure/activity relationships can be drawn, which may guide future structural improvements for anticancer agents.
{"title":"Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives","authors":"C. Teixeira, Nuno F S Pinto, David M. Pereira, R. Pereira, M. J. Fernandes, E. M. Castanheira, A. Fortes, M. S. Gonçalves","doi":"10.3390/ecsoc-25-11689","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11689","url":null,"abstract":": Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β -amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results show that some structural modi-fications resulted in enhanced cytotoxic activity towards cancer cells. In addition, the activation of caspase-3 and hence apoptosis induced by these molecules, was also explored. Considering the ob-tained results, some structure/activity relationships can be drawn, which may guide future structural improvements for anticancer agents.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89738434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Pristinamycin IIB (PIIB) is a potent antibiotic with limited use, due to some structural problems and also due to the bacterial resistance exhibited toward the antibiotic. A thorough study led to the design of novel analogues of PIIB, based on the introduction of a difluorostatone moiety. Herein, we describe the initial in silico studies toward these novel analogues using ADMET modeling of predictive models in order to compute the physicochemistry and estimate the pharmacokinetics, drug-likeness and medicinal chemistry friendliness of these newly designed analogues.
{"title":"In-Silico Studies toward the Improvement of the Antibacterial Activity of Pristinamycin IIB","authors":"Assia Chebieb, C. Ziani-Chérif, Khadidja Bellifa","doi":"10.3390/ecsoc-25-11703","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11703","url":null,"abstract":": Pristinamycin IIB (PIIB) is a potent antibiotic with limited use, due to some structural problems and also due to the bacterial resistance exhibited toward the antibiotic. A thorough study led to the design of novel analogues of PIIB, based on the introduction of a difluorostatone moiety. Herein, we describe the initial in silico studies toward these novel analogues using ADMET modeling of predictive models in order to compute the physicochemistry and estimate the pharmacokinetics, drug-likeness and medicinal chemistry friendliness of these newly designed analogues.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89745922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
César Ray, Carolina Díaz-Norambuena, C. Schad, Florencio Moreno, A. R. Agarrabeitia, M. Ortiz, T. Arbeloa, J. Bañuelos, B. L. Maroto, S. D. L. Moya
: A new helicoBODIPY (bisBODIPY with helical chirality) with nitro groups at the chiral bridge has been synthesized as a model to study the influence of the at-bridge substitution on the photophysics and chiroptics of the helicoBODIPY. This preliminary study reveals that at-bridge substitution can be a strategy for the development of chiroptical sensors based on helicoBODIPYs.
{"title":"Influence of At-Bridge Nitro Groups on the Photophysics and Chiroptics of helicoBODIPYs: A Step Forward towards the Development of New Chiroptical Sensors","authors":"César Ray, Carolina Díaz-Norambuena, C. Schad, Florencio Moreno, A. R. Agarrabeitia, M. Ortiz, T. Arbeloa, J. Bañuelos, B. L. Maroto, S. D. L. Moya","doi":"10.3390/ecsoc-25-11701","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11701","url":null,"abstract":": A new helicoBODIPY (bisBODIPY with helical chirality) with nitro groups at the chiral bridge has been synthesized as a model to study the influence of the at-bridge substitution on the photophysics and chiroptics of the helicoBODIPY. This preliminary study reveals that at-bridge substitution can be a strategy for the development of chiroptical sensors based on helicoBODIPYs.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85628804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Patil, P. Bhatt, H. Suryawanshi, J. Patil, Rajesh Chaudhari
{"title":"Synthesis and Biological Evaluation of Some Substituted Benzimidazole Derivatives","authors":"S. Patil, P. Bhatt, H. Suryawanshi, J. Patil, Rajesh Chaudhari","doi":"10.3390/ecsoc-25-11764","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11764","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84368566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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