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[Role of apoptosis in autoimmune thyroid disorders]. 凋亡在自身免疫性甲状腺疾病中的作用
Artur Bossowski, Anna Moniuszko, Joanna Bouzyk, Mirosława Urban

Apoptosis, programmed cell death, is a physiological phenomenon, necessary for normal function of every organism. This is an active process, per-current with a participation of the cellular metabolism embracing the activation of genes and the synthesis of proteins. The signal to apoptosis can be started practically in every cell of our organism. Disturbances of the apoptosis regulation determine the essential link of the pathogenesis of many diseases, including autoimmune thyroid disorders. Such molecules as FasL, TNF (tumor necrosis factor), TRAIL (the ligand inducing apoptosis), inducing different apoptotic pathway can play the key-role in the pathogenesis of Graves' disease or Hashimoto's thyroiditis. Besides in the destructive thyroiditis an important role is also played by proteins from the bcl-2 family and the proinflammatory cytokines. The aim of this publication is to present the influence of different factors on the apoptosis and the role of programmed cells death in autoimmune thyroid diseases.

细胞凋亡,即细胞程序性死亡,是一种生理现象,是机体正常功能所必需的。这是一个活跃的过程,目前参与了细胞代谢,包括基因的激活和蛋白质的合成。凋亡的信号几乎可以在我们生物体的每一个细胞中开始。细胞凋亡调控的紊乱决定了包括自身免疫性甲状腺疾病在内的许多疾病发病机制的重要环节。FasL、TNF(肿瘤坏死因子)、TRAIL(诱导凋亡的配体)等分子,诱导不同的凋亡通路,在Graves病或桥本甲状腺炎的发病机制中发挥关键作用。此外,在破坏性甲状腺炎中,bcl-2家族蛋白和促炎细胞因子也起着重要作用。本文的目的是介绍不同因素对自身免疫性甲状腺疾病中细胞凋亡的影响和程序性细胞死亡的作用。
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引用次数: 0
[Prognostic factors of celiac disease occurrence in type 1 diabetes mellitus children]. [1型糖尿病患儿乳糜泻发生的预后因素]
Małgorzata Myśliwiec, Anna Balcerska, Jan Stepiński, Alicja Bakowska, Anna Jedrzejczyk, Joanna Bautembach-Minkowska, Beata Sztangierska, Piotr Banach, Piotr Wiśniewski

Introduction: Discussion on the frequency of coexistent celiac disease and type 1 diabetes mellitus (DM1) as well as an attempt to standardize diagnostic methods of celiac disease detection among DM1 children have been performed.

Objectives: To assess the incidence of celiac disease among DM1 children in the Pomeranian region of Poland followed by analysis of the putative prognostic factors for celiac disease development in this particular group of children.

Materials and methods: 70 children aged 9.47+/-4.59 (group 1) de novo diagnosed with DM1 and 223 children aged 10.20+/-3.87 with long-standing diabetes mellitus type 1 (4.47+/-3.16 years from the diagnosis) were enrolled in the study. All the patients had C-peptide, HbA1c, CRP, TSH, fT4, fT3, urinary albumin secretion rate, IgA, level of antigliadin antibodies (AGA), anti-tissue transglutaminase (TGA) IgA and IgG antibodies (ELISA), anti-endomysium (EmA) IgA and IgG antibodies (immunofluorescence) and anti-tyreoglobulin antibodies (TG), anti-thyroid peroxidase (TPO) antibodies (ELISA) evaluated. All the patients had jejunal biopsy and thyroid ultrasound examination.

Results: 5.7% of group 1 patients were diagnosed with celiac disease based on the positive jejunal biopsy in comparison with 9.4% in the group 2. TGA antibodies were present in 9.52% of group 2, AGA in 7.62%, EmA in 6.19%. 10% of group 1 children had autoimmune thyroiditis versus 24.2% of group 2 children. The group of children with coincident long-lasting DM1 and celiac disease (group A) was characterized by significantly earlier age at diagnosis (p=0.003), higher HbA(1)c (p=<0.001), CRP (p<0.001) and elevated urine albumin secretion in relation to children without celiac disease and autoimmune thyroiditis (group B). Serologic test detecting TGA antibodies was found to be the most sensitive (95.2%) for the detection of celiac disease among DM1 children, while the lowest sensitivity was obtained in the case of the EmA antibody test (61.9%).

Conclusions: The celiac disease morbidity confirmed by jejunal biopsy is high among DM1 children (9.4%). The assessment of the serum TGA appears to be the most sensitive screening marker for the celiac disease detection in DM1 children.

前言:讨论了乳糜泻与1型糖尿病(DM1)共存的频率,并试图规范DM1患儿乳糜泻的诊断方法。目的:评估波兰波美拉尼亚地区DM1儿童乳糜泻的发病率,并分析这一特殊儿童群体中乳糜泻发展的推定预后因素。材料与方法:将70名年龄为9.47+/-4.59(第一组)的新发DM1患儿和223名年龄为10.20+/-3.87(诊断后4.47+/-3.16年)的长期1型糖尿病患儿纳入研究。检测c肽、HbA1c、CRP、TSH、fT4、fT3、尿白蛋白分泌率、IgA、抗麸质蛋白抗体(AGA)、抗组织转谷氨酰胺酶(TGA) IgA和IgG抗体(ELISA)、抗肌内膜(EmA) IgA和IgG抗体(免疫荧光)和抗酪蛋白抗体(TG)、抗甲状腺过氧化物酶(TPO)抗体(ELISA)水平。所有患者均行空肠活检和甲状腺超声检查。结果:基于空肠活检阳性,第1组患者中有5.7%被诊断为乳糜泻,而第2组为9.4%。2组TGA抗体阳性率为9.52%,AGA抗体阳性率为7.62%,EmA抗体阳性率为6.19%。10%的1组儿童有自身免疫性甲状腺炎,而24.2%的2组儿童有。长期DM1与乳糜泻同时存在的儿童组(A组)的特点是诊断年龄明显早(p=0.003), HbA(1)c较高(p=结论:DM1患儿空肠活检证实乳糜泻发病率高(9.4%)。血清TGA的评估似乎是DM1儿童乳糜泻检测最敏感的筛查标志物。
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引用次数: 0
[Familial precocious puberty -- a variant of norm or pathology?]. [家族性性早熟——是常态还是病理的变体?]。
Katarzyna Ziora, Joanna Oświecimska, Gabriela Geisler, Katarzyna Broll-Waśka, Mieczysław Szalecki, Antoni Dyduch

Since 1937, when familial precocious puberty (FPP) was described for the first time, only few reports on FPP have been published. The majority of them is concerned with the most investigated form of FPP, occurring only in male --testotoxicosis (male-limited precocious puberty -- MLPP). Recently another form of FPP -- familial hyperestrogenism (aromatase excess syndrome -- AES) has been described. The authors aimed to review the literature data concerning different forms of FPP emphasizing the diagnostic criteria, etiology, mode of inheritance and treatment.

自1937年首次报道家族性性早熟(familial preco性puberty, FPP)以来,有关FPP的报道很少。其中大多数与研究最多的FPP形式有关,仅发生在男性-睾酮症(男性限制性性性早熟- MLPP)。最近,另一种形式的FPP -家族性高雌激素(芳香酶过量综合征- AES)被描述。本文就不同形式FPP的诊断标准、病因、遗传方式及治疗进行综述。
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引用次数: 0
[Precocious puberty caused by McCune-Albright syndrome in a girl aged 6 years and 9 months]. [6岁9个月女童mcune - albright综合征致性早熟]。
Beata Wikiera, Józef Wawro, Anna Noczyńska

The McCune-Albright syndrome is characterised by polyostotic fibrous dysplasia, "cafe-au-lait" spots and autonomous hyperfunction of various endocrine organs. The authors present the case of a girl at the age of 6 years 9 months with precocious puberty (thelarche III, menarche). High estradiol level (204 pg/ml) and low gonadoptopins concentration as well as their level after GnRH administration suggested ovarian autonomy. Ovarian cysts were found on pelvic ultrasound. Other endocrine abnormalities were excluded. Single "cafe-au-lait" spot was found on the patient skin. Scintigraphy, radiography and computed tomography scans showed fibrous dysplastic bones in the right tibia and in maxillary and sphenoid sinuses.

McCune-Albright综合征的特征是多骨纤维发育不良,“咖啡-au-lait”斑点和各种内分泌器官的自主功能亢进。作者提出的情况下,女孩在6岁9个月与性早熟(初潮III期)。高雌二醇水平(204 pg/ml)和低促性腺激素浓度以及给药后促性腺激素水平提示卵巢自主。盆腔超声检查发现卵巢囊肿。排除其他内分泌异常。在病人的皮肤上发现了一个单一的“咖啡精”斑点。显像、x线摄影和计算机断层扫描显示右胫骨、上颌窦和蝶窦纤维性骨发育不良。
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引用次数: 0
[Pituitary response to GnRH analogue testing in girls with a polycystic ovary syndrome]. [多囊卵巢综合征女孩对GnRH类似物检测的垂体反应]。
Beata Wikiera, Renata Wasikowa

Unlabelled: THE AIM of our study was to estimate the gonadotropin level after GnRH analogue injection in girls with PCOS after suppression with dexamethasone.

Material and methods: 57 girls with hirsutism, mean age 15.9 years, were involved in the study. The research was performed in the early and middle follicular stage. Menstrual disorders were observed in 78% of them. The patients were divided into 3 groups: I -- with clinical and laboratory symptoms of PCOS (menstruation disorders, testosterone >65 ng/ml and/or LH/FSH >2; n=29), II -- with menstruation disorders and without elevated androgen level (n=15), III -- without menstruation disorders and without elevated androgen level (n=13). Basal blood samples were drawn at 8 a.m. GnRH analogue (Relefact LH-RH) 100 microg was then given subcutaneously and blood samples were drawn every 4 hours for 24 hours.

Results: Basal level of LH was the highest in group I (6,18+/-4,10 IU/l) in comparison with II (5.53+/-3.40 IU/l) and III (3.82+/-2.79 IU/l). After GnRH analogue administration mean LH concentration increased in all groups and peaked after 2 hours. Stimulated LH level was the highest in group I and differed statistically significantly from group III during the whole period of the test. The most significant difference occurred at 12 a.m. (p=0.003) and 10 a.m. (p=0.004). The FSH secretion in all tested groups was similar. It peaked, like LH, after 2 hours after GnRH analogue injection and decreased slightly during next 2 hours. A marked decrease was observed in the following period of time.

Conclusions: 1. High and fast LH secretion responding to GnRH analogue indicates masculinization of the hypothalamo-pituitary axis in PCOS girls. 2. The hirsute girls without menstrual disturbances and hormonal abnormalities probably also have subtle masculinization of the pituitary response to stimulation by GnRH analogue.

未标记:我们研究的目的是估计GnRH类似物注射后的促性腺激素水平在女孩多囊卵巢综合征抑制地塞米松。材料与方法:研究对象为57例多毛症女生,平均年龄15.9岁。研究是在卵泡早期和中期进行的。其中78%的患者出现月经紊乱。患者分为3组:I -有PCOS临床和实验室症状(月经紊乱,睾酮>65 ng/ml和/或LH/FSH >2);n=29), II -有月经障碍但没有雄激素水平升高(n=15), III -没有月经障碍但没有雄激素水平升高(n=13)。上午8点抽取基础血液样本。然后皮下给予GnRH类似物(relfact LH-RH) 100微克,每4小时抽取血样,持续24小时。结果:ⅰ组LH基础水平(6、18+/-4、10 IU/l)高于ⅱ组(5.53+/-3.40 IU/l)和ⅲ组(3.82+/-2.79 IU/l)。给予GnRH类似物后,各组平均LH浓度均升高,并在2小时后达到峰值。在整个测试期间,刺激LH水平以I组最高,与III组差异有统计学意义。上午12点(p=0.003)和上午10点(p=0.004)差异最大。各组FSH分泌量相近。与LH一样,在GnRH类似物注射后2小时达到峰值,随后2小时略有下降。在接下来的一段时间里,观察到明显的下降。结论:1。高和快速的黄体生成素分泌对GnRH类似物的反应表明PCOS女孩的下丘脑-垂体轴男性化。2. 没有月经紊乱和激素异常的多毛女孩也可能对GnRH类似物的刺激有轻微的垂体男性化反应。
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引用次数: 0
[Sense of self-contact experienced by an obese child]. [肥胖儿童的自我接触感]。
Joanna Radoszewska

Background: Sense of self-contact experienced by a child is a mental availability of the contents of self-experience. It is a possibility of identifying and expressing the contents of own feelings, experiences and conditions. Sense of self-contact is an element of a sense of identity. The sense of identity involves the contents of mental self-experiencing, sense of differentiation and sense of continuity.

Objectives: The aim of this article is an attempt to answer what is a sense of self-contact experienced by an obese child.

Material and methods: 142 children have been examined (71 obese and 71 slim) at the age from 5 to 10 years. Children Apperception Test, the version with animal figures (CAT-A) has been used to children examination. The CAT-A consists of 10 black-white pictures presenting animals in different situations, significant in view of the child's development and functioning.

Results: The specific difficulties in an experience of self-contact by an obese child were pointed out.

Conclusion: Psychotherapy should be aimed at finding internal, mental points for self-description, thus also the sense of mental self-contact and self experience in personal dimension.

背景:儿童的自我接触感是对自我体验内容的心理可得性。它是一种识别和表达自己的感受、经历和条件的可能性。自我接触感是认同感的一个组成部分。认同感包括心理自我体验感、分化感和连续性感的内容。目的:这篇文章的目的是试图回答什么是一个肥胖的孩子所经历的自我接触感。材料与方法:对5 ~ 10岁儿童142例(肥胖71例,瘦弱71例)进行了调查。儿童统觉测验,动物形象版本(CAT-A)已被用于儿童考试。CAT-A由10张黑白图片组成,展示了不同情况下的动物,对儿童的发育和功能有重要意义。结果:指出了肥胖儿童自我接触体验中的具体困难。结论:心理治疗应以寻找自我描述的内在心理点为目标,从而在个人维度上寻找心理上的自我接触感和自我体验。
{"title":"[Sense of self-contact experienced by an obese child].","authors":"Joanna Radoszewska","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Sense of self-contact experienced by a child is a mental availability of the contents of self-experience. It is a possibility of identifying and expressing the contents of own feelings, experiences and conditions. Sense of self-contact is an element of a sense of identity. The sense of identity involves the contents of mental self-experiencing, sense of differentiation and sense of continuity.</p><p><strong>Objectives: </strong>The aim of this article is an attempt to answer what is a sense of self-contact experienced by an obese child.</p><p><strong>Material and methods: </strong>142 children have been examined (71 obese and 71 slim) at the age from 5 to 10 years. Children Apperception Test, the version with animal figures (CAT-A) has been used to children examination. The CAT-A consists of 10 black-white pictures presenting animals in different situations, significant in view of the child's development and functioning.</p><p><strong>Results: </strong>The specific difficulties in an experience of self-contact by an obese child were pointed out.</p><p><strong>Conclusion: </strong>Psychotherapy should be aimed at finding internal, mental points for self-description, thus also the sense of mental self-contact and self experience in personal dimension.</p>","PeriodicalId":11550,"journal":{"name":"Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26122767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The influence of polymorphism the Gly972Arg variant insulin receptor substrate-1 (IRS-1) gene, and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity]. [Gly972Arg变异胰岛素受体底物-1 (IRS-1)基因和G-308A tnf - α基因多态性对肥胖儿童肥胖和胰岛素抵抗的影响]。
Beata Pyrzak, Alicja Wiśniewska, Barbara Rymkiewicz-Kluczyńska

Unlabelled: Genetic factors play a role in the pathogenesis of insulin resistance in obese subjects. The insulin receptor substrate-1 (IRS-1) and IRS-2 are the most important elements of the insulin-signaling pathways, and mutations in this gene have been reported to play a role in determining insulin resistance, particulary in presence of obesity. The polymorpism of the TNF-a-308 gene is also involved in the development of obesity-related insulin resistance, therefore, we investigated whether the IRS-1 and TNF-a polymorphism can predict conversion to insulin resistance and obesity parameters in children with obesity.

Material and methods: The 70 children with obesity simplex were included in this study (9-18 y.o). The antropometric investigations: weight, height, BMI, SDS for BMI, WHR, sum of 3, 10 skinfolds, and percent of body fat by Slaughter's equation was calculated. In each children after 12 hour overnight fast glucose, insulin, leptin and lipids: triglycerides (Tg), cholesterol total (Chol-T), cholesterol HDL (Chol-HDL), cholesterol LDL (Chol-LDL) were measured. The oral glucose tolerance test was performed and HOMA-IR was calculated.

Results: Two variants of genotypic IRS-1 were obtained: C/C(85.7 %), A/C(14.3%), and 3 variants of TNF-a G/G 68 % A/G 29% A/A 3%. Statistical analysis of anthropometric and biochemical variables in groups C/C, vs A/C and variables between IRS and TNF (G/G, A/G + A/A) groups was performed. We did not find any significant differences between these groups in the t-Student test. The girls heterozygous for the A allele--A/C (IRS) had higher body weight than girls who were homozygous C/C (chi(2) =3.87, Pr>chi(2)=0,048). In smaller children studies, both polymorphism--IRS and TNF seems not to be associated with the degree of obesity and insulin resistance.

未标记:遗传因素在肥胖患者胰岛素抵抗的发病机制中起作用。胰岛素受体底物-1 (IRS-1)和IRS-2是胰岛素信号通路中最重要的元件,据报道,该基因的突变在决定胰岛素抵抗中起作用,特别是在肥胖的情况下。TNF-a-308基因的多态性也参与了肥胖相关胰岛素抵抗的发展,因此,我们研究了IRS-1和TNF-a多态性是否可以预测肥胖儿童转化为胰岛素抵抗和肥胖参数。材料与方法:选取单纯性肥胖儿童70例(9 ~ 18岁)。通过Slaughter's方程计算体重、身高、BMI、BMI的SDS、臀重比、3、10个皮褶的总和和体脂百分比。各组患儿12小时后测空腹血糖、胰岛素、瘦素及血脂:甘油三酯(Tg)、总胆固醇(cholt)、胆固醇高密度脂蛋白(choll -HDL)、胆固醇低密度脂蛋白(choll -LDL)。进行口服糖耐量试验,计算HOMA-IR。结果:获得2个基因型IRS-1变异:C/C(85.7%)、A/C(14.3%)和3个基因型TNF-a G/G 68%、A/G 29%、A/A 3%。对C/C组、vs A/C组及IRS与TNF (G/G、A/G + A/A)组间的人体测量和生化变量进行统计分析。在t-Student检验中,我们没有发现这些组之间有任何显著差异。A等位基因-A/C (IRS)杂合子的女孩体重高于C/C纯合子的女孩(chi(2) =3.87, Pr>chi(2)= 0.048)。在规模较小的儿童研究中,IRS和TNF多态性似乎与肥胖程度和胰岛素抵抗无关。
{"title":"[The influence of polymorphism the Gly972Arg variant insulin receptor substrate-1 (IRS-1) gene, and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity].","authors":"Beata Pyrzak,&nbsp;Alicja Wiśniewska,&nbsp;Barbara Rymkiewicz-Kluczyńska","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>Genetic factors play a role in the pathogenesis of insulin resistance in obese subjects. The insulin receptor substrate-1 (IRS-1) and IRS-2 are the most important elements of the insulin-signaling pathways, and mutations in this gene have been reported to play a role in determining insulin resistance, particulary in presence of obesity. The polymorpism of the TNF-a-308 gene is also involved in the development of obesity-related insulin resistance, therefore, we investigated whether the IRS-1 and TNF-a polymorphism can predict conversion to insulin resistance and obesity parameters in children with obesity.</p><p><strong>Material and methods: </strong>The 70 children with obesity simplex were included in this study (9-18 y.o). The antropometric investigations: weight, height, BMI, SDS for BMI, WHR, sum of 3, 10 skinfolds, and percent of body fat by Slaughter's equation was calculated. In each children after 12 hour overnight fast glucose, insulin, leptin and lipids: triglycerides (Tg), cholesterol total (Chol-T), cholesterol HDL (Chol-HDL), cholesterol LDL (Chol-LDL) were measured. The oral glucose tolerance test was performed and HOMA-IR was calculated.</p><p><strong>Results: </strong>Two variants of genotypic IRS-1 were obtained: C/C(85.7 %), A/C(14.3%), and 3 variants of TNF-a G/G 68 % A/G 29% A/A 3%. Statistical analysis of anthropometric and biochemical variables in groups C/C, vs A/C and variables between IRS and TNF (G/G, A/G + A/A) groups was performed. We did not find any significant differences between these groups in the t-Student test. The girls heterozygous for the A allele--A/C (IRS) had higher body weight than girls who were homozygous C/C (chi(2) =3.87, Pr>chi(2)=0,048). In smaller children studies, both polymorphism--IRS and TNF seems not to be associated with the degree of obesity and insulin resistance.</p>","PeriodicalId":11550,"journal":{"name":"Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26291827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of final height in patients with pituitary growth hormone deficiency who were treated with growth hormone replacement]. [垂体生长激素缺乏症患者经生长激素替代治疗后最终身高的评价]。
Maria Korpal-Szczyrska, Bohdana Dorant, Halina Kamińska, Dorota Birkholz, Maciej Niedźwiecki

Background: Growth hormone (GH) therapy has been used for children with pituitary GH deficiency. It resulted in improving their height velocity and achieving an adult height in the normal range for the general population.

Objectives: To evaluate the final height in childhood-onset growth hormone deficiency patients who had already completed treatment and were still GH deficient in adult life.

Material and methods: 21 children (12 boys and 9 girls) diagnosed as GH deficiency and treated with growth hormone to final height at doses of 0.17 mg/kg/week (0.5 IU/kg/week) subcutaneously for 7 days. There were 7 patients with isolated GHD and 14 with multiple pituitary hormone deficiencies.

Results: At the diagnosis peak serum GH concentrations were 2.8+/-2.8 mU/l in insulin tolerance test and 3.3+/-2.2 mU/l in clonidine test. Reconfirmation of the GH deficiency diagnosis after growth hormone treatment revealed a peak serum GH 1.77+/-1.2 mU/l in insulin tolerance test. Mean chronological age of the patients at the beginning of treatment was 10.29+/-3.57 years and was significantly higher in boys. Patients had completed a course of treatment in the chronological age of 17.85+/-1.97 years. Children began treatment with mean bone age 7.24+/-3.57 years and ended with 15+/-0.97 years. After the treatment a significant improvement in height was shown. Height SDS at the beginning of the treatment was -4.03+/-0.91 and -0.69+/-1.01 after the treatment. There was no difference between final height and target height (-0.54+/-0.93 SDS) in our patients.

Conclusions: Children with pituitary growth hormone deficiency who were treated with growth hormone replacement achieve a final height in the normal range for the general population and their target height.

背景:生长激素治疗已被用于儿童垂体生长激素缺乏症。结果提高了他们的身高速度,达到了一般人群正常范围内的成人身高。目的:评价儿童期生长激素缺乏症患者的最终身高,这些患者已经完成治疗,成年后仍然缺乏生长激素。材料和方法:诊断为生长激素缺乏症的儿童21例(男12例,女9例),给予生长激素治疗至最终身高,剂量为0.17 mg/kg/周(0.5 IU/kg/周),皮下注射7天。单纯GHD 7例,多发性垂体激素缺乏14例。结果:诊断时胰岛素耐量试验血清GH浓度为2.8+/-2.8 mU/l,可乐定试验血清GH浓度为3.3+/-2.2 mU/l。生长激素治疗后再次确认GH缺乏诊断,胰岛素耐量试验显示血清GH峰值为1.77+/-1.2 mU/l。治疗开始时患者的平均实足年龄为10.29+/-3.57岁,其中男孩明显高于男孩。患者完成一个疗程的实足年龄为17.85±1.97岁。儿童开始治疗时平均骨龄为7.24±3.57岁,结束时平均骨龄为15±0.97岁。治疗后,身高明显改善。治疗开始时的高度SDS为-4.03+/-0.91,治疗后的高度SDS为-0.69+/-1.01。在我们的患者中,最终身高和目标身高(-0.54+/-0.93 SDS)没有差异。结论:垂体生长激素缺乏症患儿经生长激素替代治疗后,最终身高在正常人群及目标身高范围内。
{"title":"[Evaluation of final height in patients with pituitary growth hormone deficiency who were treated with growth hormone replacement].","authors":"Maria Korpal-Szczyrska,&nbsp;Bohdana Dorant,&nbsp;Halina Kamińska,&nbsp;Dorota Birkholz,&nbsp;Maciej Niedźwiecki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Growth hormone (GH) therapy has been used for children with pituitary GH deficiency. It resulted in improving their height velocity and achieving an adult height in the normal range for the general population.</p><p><strong>Objectives: </strong>To evaluate the final height in childhood-onset growth hormone deficiency patients who had already completed treatment and were still GH deficient in adult life.</p><p><strong>Material and methods: </strong>21 children (12 boys and 9 girls) diagnosed as GH deficiency and treated with growth hormone to final height at doses of 0.17 mg/kg/week (0.5 IU/kg/week) subcutaneously for 7 days. There were 7 patients with isolated GHD and 14 with multiple pituitary hormone deficiencies.</p><p><strong>Results: </strong>At the diagnosis peak serum GH concentrations were 2.8+/-2.8 mU/l in insulin tolerance test and 3.3+/-2.2 mU/l in clonidine test. Reconfirmation of the GH deficiency diagnosis after growth hormone treatment revealed a peak serum GH 1.77+/-1.2 mU/l in insulin tolerance test. Mean chronological age of the patients at the beginning of treatment was 10.29+/-3.57 years and was significantly higher in boys. Patients had completed a course of treatment in the chronological age of 17.85+/-1.97 years. Children began treatment with mean bone age 7.24+/-3.57 years and ended with 15+/-0.97 years. After the treatment a significant improvement in height was shown. Height SDS at the beginning of the treatment was -4.03+/-0.91 and -0.69+/-1.01 after the treatment. There was no difference between final height and target height (-0.54+/-0.93 SDS) in our patients.</p><p><strong>Conclusions: </strong>Children with pituitary growth hormone deficiency who were treated with growth hormone replacement achieve a final height in the normal range for the general population and their target height.</p>","PeriodicalId":11550,"journal":{"name":"Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26028531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of growth hormone therapy in a 14-years-old boy with Crohn's disease and growth hormone deficiency]. [生长激素治疗对14岁克罗恩病合并生长激素缺乏症的影响]。
Mieczysław Szalecki, Alicja Mierzejewska-Rudnicka, Jolanta Nawrotek

We present a case of a 14-year-old boy in whom, at age of nine a dramatic decrease of growth velocity was observed. At the age of 14 the growth hormone therapy was introduced after the diagnosis of partial growth hormone deficiency and Crohn's disease. During the two years period of follow up increased growth velocity and improvement in the general condition was observed. We present the case because of many controversial opinions about growth hormone treatment in Crohn's disease.

我们提出一个14岁男孩的病例,在他9岁时,生长速度急剧下降。14岁时,在诊断出部分生长激素缺乏症和克罗恩病后,开始了生长激素治疗。在两年的随访期间,观察到生长速度加快,一般情况有所改善。我们提出的情况下,因为许多有争议的意见生长激素治疗克罗恩病。
{"title":"[Effect of growth hormone therapy in a 14-years-old boy with Crohn's disease and growth hormone deficiency].","authors":"Mieczysław Szalecki,&nbsp;Alicja Mierzejewska-Rudnicka,&nbsp;Jolanta Nawrotek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a case of a 14-year-old boy in whom, at age of nine a dramatic decrease of growth velocity was observed. At the age of 14 the growth hormone therapy was introduced after the diagnosis of partial growth hormone deficiency and Crohn's disease. During the two years period of follow up increased growth velocity and improvement in the general condition was observed. We present the case because of many controversial opinions about growth hormone treatment in Crohn's disease.</p>","PeriodicalId":11550,"journal":{"name":"Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26122724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fetal dystrophy--one of the feature of Turner syndrome]. [胎儿营养不良——特纳综合征的特征之一]。
Andrzej Wiśniewski, Katarzyna Milde, Romuald Stupnicki

Background: Turner's syndrome is one of the most frequent diseases with accompanying growth deficiency, the developmental disorders being observed as early as in the fetal period.

Objectives: To determine the body mass of Turner's syndrome newborns delivered at term.

Material and methods: A total of 474 female newborns with Turner's syndrome were studied, the pregnancies, mostly second ones, lasting 40 weeks on average but not less than 38 weeks. Turner's syndrome was confirmed by chromosome analysis. Body mass at birth (BM) was related to the norms for gestational age (GA) designed by Usher and McLean. Newborns, whose BM was lower than -2 SD for GA, were considered as small for gestational age (SGA).

Results: Mean body mass (+/-SD) at birth was 2963 +/- g and in 87% of newborns was below the normal value for gestational age. Mean body mass deficiency amounted to 611 g, but in 20% of newborns exceeded 1000 g.

Conclusion: In 19% of newborns body mass was below -2 SD for gestational age which classified intrauterine dystrophy as one of the most frequent features of the Turner's syndrome. It might, furthermore, imply that intrauterine dystrophy could be associated with impaired gene expression, presumably on the X-chromosome.

背景:特纳氏综合征是最常见的伴有生长缺陷的疾病之一,这种发育障碍早在胎儿时期就被观察到。目的:了解特纳氏综合征足月新生儿的体质量。材料与方法:对474例特纳氏综合征女性新生儿进行研究,平均妊娠期40周但不少于38周,以二次妊娠居多。染色体分析证实了特纳氏综合征。出生时体重(BM)与Usher和McLean设计的胎龄标准(GA)有关。新生儿BM低于-2 SD的GA被认为是小胎龄(SGA)。结果:出生时平均体重(+/- sd)为2963 +/- g, 87%的新生儿低于胎龄正常值。平均体重不足611克,但20%的新生儿超过1000克。结论:19%的新生儿体重低于胎龄-2 SD,子宫内营养不良是Turner综合征最常见的特征之一。此外,这可能意味着子宫内营养不良可能与基因表达受损有关,可能是在x染色体上。
{"title":"[Fetal dystrophy--one of the feature of Turner syndrome].","authors":"Andrzej Wiśniewski,&nbsp;Katarzyna Milde,&nbsp;Romuald Stupnicki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Turner's syndrome is one of the most frequent diseases with accompanying growth deficiency, the developmental disorders being observed as early as in the fetal period.</p><p><strong>Objectives: </strong>To determine the body mass of Turner's syndrome newborns delivered at term.</p><p><strong>Material and methods: </strong>A total of 474 female newborns with Turner's syndrome were studied, the pregnancies, mostly second ones, lasting 40 weeks on average but not less than 38 weeks. Turner's syndrome was confirmed by chromosome analysis. Body mass at birth (BM) was related to the norms for gestational age (GA) designed by Usher and McLean. Newborns, whose BM was lower than -2 SD for GA, were considered as small for gestational age (SGA).</p><p><strong>Results: </strong>Mean body mass (+/-SD) at birth was 2963 +/- g and in 87% of newborns was below the normal value for gestational age. Mean body mass deficiency amounted to 611 g, but in 20% of newborns exceeded 1000 g.</p><p><strong>Conclusion: </strong>In 19% of newborns body mass was below -2 SD for gestational age which classified intrauterine dystrophy as one of the most frequent features of the Turner's syndrome. It might, furthermore, imply that intrauterine dystrophy could be associated with impaired gene expression, presumably on the X-chromosome.</p>","PeriodicalId":11550,"journal":{"name":"Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25642251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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