Pub Date : 2024-05-01Epub Date: 2024-05-15DOI: 10.1097/eus.0000000000000055
Vishali Moond, Priyadarshini Loganathan, Bhargav Koyani, Shahab R Khan, Lena L Kassab, Saurabh Chandan, Babu P Mohan, Arkady Broder, Douglas G Adler
EUS-guided hepaticogastrostomy (EUS-HGS) is one of the preferred methods in biliary drainage where ERCP fails or is contraindicated. The clinical outcomes of EUS-HGS are not well studied because of variability in procedure technique. We conducted a search of multiple electronic databases and conference proceedings from inception through January 2023. The clinical outcomes studied were pooled technical success, clinical success, and adverse events. Standard meta-analysis methods were used using the random-effects model, and heterogeneity was studied by I2 statistics. We analyzed 44 studies, which included 19 prospective and 25 retrospective studies. The pooled technical success rate of EUS-HGS was 94.4% (confidence interval [CI], 92.4%-95.9%; I2 = 0%), and the pooled clinical success rate was 88.6% (CI, 83.7%-92.2%; I2 = 0%). The pooled adverse outcomes with EUS-HGS were 23.8% (CI, 19.6%-28.5%; I2 = 0%). The mild adverse event rate associated with HGS was 5.8% (4.2%-8.1%; I2 = 0%), moderate adverse event rate was 12.1% (9.1%-15.8%; I2 = 16%), and severe adverse event rate was 4.2% (3.0%-5.7%; I2 = 61%), whereas fatal adverse event rate was 3.2% (1.9%-5.4%; I2 = 62%). On subgroup analysis, the pooled rate of adverse events of EUS-guided hepaticogastrostomy with antegrade stenting was 13.3% (95% CI, 8.2%-21.0%). The pooled technical success with EUS-guided hepaticogastrostomy with antegrade stenting was 89.7% (95% CI, 82.6%-94.2%), and clinical success was 92.5% (95% CI, 77.9%-97.7%). On the basis of our analysis of EUS-HGS, the overall technical success was 94.4%, and the clinical success rate was 88.6%, and the overall adverse events were reported to be 23.8%. These data can also help improve the clinical benefits of EUS-HGS in the selected patients in whom it is performed.
{"title":"Efficacy and safety of EUS-guided hepatogastrostomy: A systematic review and meta-analysis.","authors":"Vishali Moond, Priyadarshini Loganathan, Bhargav Koyani, Shahab R Khan, Lena L Kassab, Saurabh Chandan, Babu P Mohan, Arkady Broder, Douglas G Adler","doi":"10.1097/eus.0000000000000055","DOIUrl":"https://doi.org/10.1097/eus.0000000000000055","url":null,"abstract":"<p><p>EUS-guided hepaticogastrostomy (EUS-HGS) is one of the preferred methods in biliary drainage where ERCP fails or is contraindicated. The clinical outcomes of EUS-HGS are not well studied because of variability in procedure technique. We conducted a search of multiple electronic databases and conference proceedings from inception through January 2023. The clinical outcomes studied were pooled technical success, clinical success, and adverse events. Standard meta-analysis methods were used using the random-effects model, and heterogeneity was studied by <i>I</i> <sup>2</sup> statistics. We analyzed 44 studies, which included 19 prospective and 25 retrospective studies. The pooled technical success rate of EUS-HGS was 94.4% (confidence interval [CI], 92.4%-95.9%; <i>I</i> <sup>2</sup> = 0%), and the pooled clinical success rate was 88.6% (CI, 83.7%-92.2%; <i>I</i> <sup>2</sup> = 0%). The pooled adverse outcomes with EUS-HGS were 23.8% (CI, 19.6%-28.5%; <i>I</i> <sup>2</sup> = 0%). The mild adverse event rate associated with HGS was 5.8% (4.2%-8.1%; <i>I</i> <sup>2</sup> = 0%), moderate adverse event rate was 12.1% (9.1%-15.8%; <i>I</i> <sup>2</sup> = 16%), and severe adverse event rate was 4.2% (3.0%-5.7%; <i>I</i> <sup>2</sup> = 61%), whereas fatal adverse event rate was 3.2% (1.9%-5.4%; <i>I</i> <sup>2</sup> = 62%). On subgroup analysis, the pooled rate of adverse events of EUS-guided hepaticogastrostomy with antegrade stenting was 13.3% (95% CI, 8.2%-21.0%). The pooled technical success with EUS-guided hepaticogastrostomy with antegrade stenting was 89.7% (95% CI, 82.6%-94.2%), and clinical success was 92.5% (95% CI, 77.9%-97.7%). On the basis of our analysis of EUS-HGS, the overall technical success was 94.4%, and the clinical success rate was 88.6%, and the overall adverse events were reported to be 23.8%. These data can also help improve the clinical benefits of EUS-HGS in the selected patients in whom it is performed.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"13 3","pages":"171-182"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EUS-guided abscess drainage in an elderly patient with an abscess in the right liver lobe (with video).","authors":"Yuki Ikeda, Daichi Watanabe, Ginji Oomori, Shota Yamada, Toshinori Okuda, Shinya Minami","doi":"10.1097/eus.0000000000000059","DOIUrl":"https://doi.org/10.1097/eus.0000000000000059","url":null,"abstract":"","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"13 3","pages":"198-200"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01Epub Date: 2024-06-21DOI: 10.1097/eus.0000000000000062
Vishali Moond, Babu P Mohan, David Diehl, Douglas G Adler
{"title":"EUS-guided through-the-needle microforceps biopsy for pancreatic cysts: Why no widespread adoption?","authors":"Vishali Moond, Babu P Mohan, David Diehl, Douglas G Adler","doi":"10.1097/eus.0000000000000062","DOIUrl":"https://doi.org/10.1097/eus.0000000000000062","url":null,"abstract":"","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"13 3","pages":"127-128"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1097/eus.0000000000000056
Kathleen Möller, Axel Löwe, Christian Jenssen, Manoop S. Bhutani, Wei On, Simon M. Everett, Barbara Braden, Michael Hocke, Andrew Healey, Yi Dong, Michael Gerber, Siegbert Faiss, Mihai Rimbas, Nan Ge, Siyu Sun, Heike Taut, David Srivastava, Eike Burmester, Christoph F. Dietrich
Rare malignant pancreatic lesions are systematically reported in this review. The focus is on the imaging appearance of the rare epithelial pancreatic tumors such as the solid pseudopapillary neoplasm, acinar cell carcinoma, rare subtypes of adenocarcinoma, and pancreatoblastoma as seen on ultrasound, EUS, and contrast-enhanced ultrasound or EUS. The present overview summarizes the data and shows that not every pancreatic tumor is likely to be the most common entities of ductal adenocarcinoma or neuroendocrine tumor.
本综述系统地报道了罕见的胰腺恶性病变。重点是罕见胰腺上皮性肿瘤(如实性假乳头状瘤、尖细胞癌、罕见亚型腺癌和胰母细胞瘤)在超声、EUS 和对比增强超声或 EUS 上的影像学表现。本综述总结了相关数据,并表明并非每种胰腺肿瘤都可能是最常见的导管腺癌或神经内分泌肿瘤实体。
{"title":"Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine contrast-enhanced ultrasound guidelines. Rare pancreatic tumors, imaging features on transabdominal ultrasound and EUS with contrast enhancement: Rare epithelial pancreatic tumors: solid pseudopapillary neoplasm, acinar cell carcinoma, mixed neuroendocrine-non-neuroendocrine neoplasms, some rare subtypes of pancreatic adenocarcinoma and pancreatoblastoma","authors":"Kathleen Möller, Axel Löwe, Christian Jenssen, Manoop S. Bhutani, Wei On, Simon M. Everett, Barbara Braden, Michael Hocke, Andrew Healey, Yi Dong, Michael Gerber, Siegbert Faiss, Mihai Rimbas, Nan Ge, Siyu Sun, Heike Taut, David Srivastava, Eike Burmester, Christoph F. Dietrich","doi":"10.1097/eus.0000000000000056","DOIUrl":"https://doi.org/10.1097/eus.0000000000000056","url":null,"abstract":"<p>Rare malignant pancreatic lesions are systematically reported in this review. The focus is on the imaging appearance of the rare epithelial pancreatic tumors such as the solid pseudopapillary neoplasm, acinar cell carcinoma, rare subtypes of adenocarcinoma, and pancreatoblastoma as seen on ultrasound, EUS, and contrast-enhanced ultrasound or EUS. The present overview summarizes the data and shows that not every pancreatic tumor is likely to be the most common entities of ductal adenocarcinoma or neuroendocrine tumor.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"64 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141745022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.1097/eus.0000000000000054
Kathleen Möller, Sotirios Ntovas, Michael Hocke, Wei On, Simon M. Everett, Barbara Braden, Christian Jenssen, Benjamin Misselwitz, Nan Ge, Siyu Sun, Michael Gerber, Siegbert Faiss, Christoph F. Dietrich
Rare malignant mesenchymal pancreatic tumors are systematized and reported in this review. The focus is on the appearance on imaging. The present overview summarizes the data and shows that not every pancreatic tumor corresponds to the most common entities of ductal adenocarcinoma or neuroendocrine tumor.
{"title":"Comments and illustrations of the European Federation of Societies for Ultrasound in Medicine guidelines: Rare pancreatic tumors, ultrasound and contrast-enhanced ultrasound features—Malignant mesenchymal tumors","authors":"Kathleen Möller, Sotirios Ntovas, Michael Hocke, Wei On, Simon M. Everett, Barbara Braden, Christian Jenssen, Benjamin Misselwitz, Nan Ge, Siyu Sun, Michael Gerber, Siegbert Faiss, Christoph F. Dietrich","doi":"10.1097/eus.0000000000000054","DOIUrl":"https://doi.org/10.1097/eus.0000000000000054","url":null,"abstract":"<p>Rare malignant mesenchymal pancreatic tumors are systematized and reported in this review. The focus is on the appearance on imaging. The present overview summarizes the data and shows that not every pancreatic tumor corresponds to the most common entities of ductal adenocarcinoma or neuroendocrine tumor.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"31 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140799090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Artificial intelligence (AI) is an epoch-making technology, among which the 2 most advanced parts are machine learning and deep learning algorithms that have been further developed by machine learning, and it has been partially applied to assist EUS diagnosis. AI-assisted EUS diagnosis has been reported to have great value in the diagnosis of pancreatic tumors and chronic pancreatitis, gastrointestinal stromal tumors, esophageal early cancer, biliary tract, and liver lesions. The application of AI in EUS diagnosis still has some urgent problems to be solved. First, the development of sensitive AI diagnostic tools requires a large amount of high-quality training data. Second, there is overfitting and bias in the current AI algorithms, leading to poor diagnostic reliability. Third, the value of AI still needs to be determined in prospective studies. Fourth, the ethical risks of AI need to be considered and avoided.
人工智能(AI)是一项划时代的技术,其中最先进的两部分是机器学习和深度学习算法,并通过机器学习得到进一步发展,目前已部分应用于辅助 EUS 诊断。据报道,人工智能辅助 EUS 诊断在胰腺肿瘤和慢性胰腺炎、胃肠道间质瘤、食管早癌、胆道和肝脏病变的诊断中具有重要价值。人工智能在 EUS 诊断中的应用仍有一些亟待解决的问题。首先,开发灵敏的人工智能诊断工具需要大量高质量的训练数据。第二,目前的人工智能算法存在过度拟合和偏差,导致诊断可靠性差。第三,人工智能的价值仍需要前瞻性研究来确定。第四,需要考虑和避免人工智能的伦理风险。
{"title":"The application of artificial intelligence in EUS.","authors":"Deyu Zhang, Chang Wu, Zhenghui Yang, Hua Yin, Yue Liu, Wanshun Li, Haojie Huang, Zhendong Jin","doi":"10.1097/eus.0000000000000053","DOIUrl":"10.1097/eus.0000000000000053","url":null,"abstract":"<p><p>Artificial intelligence (AI) is an epoch-making technology, among which the 2 most advanced parts are machine learning and deep learning algorithms that have been further developed by machine learning, and it has been partially applied to assist EUS diagnosis. AI-assisted EUS diagnosis has been reported to have great value in the diagnosis of pancreatic tumors and chronic pancreatitis, gastrointestinal stromal tumors, esophageal early cancer, biliary tract, and liver lesions. The application of AI in EUS diagnosis still has some urgent problems to be solved. First, the development of sensitive AI diagnostic tools requires a large amount of high-quality training data. Second, there is overfitting and bias in the current AI algorithms, leading to poor diagnostic reliability. Third, the value of AI still needs to be determined in prospective studies. Fourth, the ethical risks of AI need to be considered and avoided.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"13 2","pages":"65-75"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2023-07-14DOI: 10.1177/1742271X231183356
Mark Charnock, Matthew Kinsella, Annu Chopra
Introduction: Patients with posterior knee swellings are commonly encountered in clinical practice with the vast majority referred for an ultrasound scan to assess for a clinically suspected Baker's cyst.
Aims: Our aim was to determine the incidence of different pathologies in patients investigated for a posterior knee swelling of a clinically suspected Baker's cyst using ultrasound. We also wanted to investigate the incidence of significant pathologies in the popliteal fossa to assess whether the ultrasound scan findings influenced patient management.
Methodology: Retrospective analysis was performed on all patients who underwent an ultrasound scan for a suspected Baker's cyst or posterior knee swelling at our institution, between January 2017 and December 2018. Patient demographics, ultrasound findings, further imaging investigations and histopathology were recorded. Patient records were followed up for a minimum period of 3 years after ultrasound.
Results: A total of 680 patients had a posterior knee ultrasound scan. Of that, 51% (347/680) had a Baker's cyst and 40% (273/680) had a normal ultrasound scan. Sixty (9%) patients had other abnormalities identified within the popliteal fossa. Four patients had significant findings on ultrasound that required a change of management. No malignancies identified.
Conclusion: This study confirms the high incidence of Baker's cysts in patients presenting with a posterior knee swelling. In the absence of red flag symptoms, ultrasound of the posterior knee for a clinically suspected Baker's cyst is of limited clinical value.
{"title":"Ultrasound for suspected Baker's cyst: A test of limited clinical value?","authors":"Mark Charnock, Matthew Kinsella, Annu Chopra","doi":"10.1177/1742271X231183356","DOIUrl":"10.1177/1742271X231183356","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with posterior knee swellings are commonly encountered in clinical practice with the vast majority referred for an ultrasound scan to assess for a clinically suspected Baker's cyst.</p><p><strong>Aims: </strong>Our aim was to determine the incidence of different pathologies in patients investigated for a posterior knee swelling of a clinically suspected Baker's cyst using ultrasound. We also wanted to investigate the incidence of significant pathologies in the popliteal fossa to assess whether the ultrasound scan findings influenced patient management.</p><p><strong>Methodology: </strong>Retrospective analysis was performed on all patients who underwent an ultrasound scan for a suspected Baker's cyst or posterior knee swelling at our institution, between January 2017 and December 2018. Patient demographics, ultrasound findings, further imaging investigations and histopathology were recorded. Patient records were followed up for a minimum period of 3 years after ultrasound.</p><p><strong>Results: </strong>A total of 680 patients had a posterior knee ultrasound scan. Of that, 51% (347/680) had a Baker's cyst and 40% (273/680) had a normal ultrasound scan. Sixty (9%) patients had other abnormalities identified within the popliteal fossa. Four patients had significant findings on ultrasound that required a change of management. No malignancies identified.</p><p><strong>Conclusion: </strong>This study confirms the high incidence of Baker's cysts in patients presenting with a posterior knee swelling. In the absence of red flag symptoms, ultrasound of the posterior knee for a clinically suspected Baker's cyst is of limited clinical value.</p>","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":"1 1","pages":"36-42"},"PeriodicalIF":4.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85390403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-29DOI: 10.1097/eus.0000000000000039
Ning Xu, Longsong Li, Song Su, Danqi Zhao, J. Xiang, Pengju Wang, Yaxuan Cheng, E. Linghu, N. Chai
Previous studies showed that lumen-apposing metal stent (LAMS) provides a feasible route to perform direct endoscopic necrosectomy. However, the high risk of bleeding and migration induced by the placement of LAMS attracted attention. The aim of this study was to evaluate the safety and effectiveness of a novel LAMS. In this retrospective study, we enrolled patients with symptomatic pancreatic fluid collections (PFCs) to perform EUS–guided drainage with a LAMS in our hospital. Evaluation variables included technical success rate, clinical success rate, and adverse events. Thirty-two patients with a mean age of 41.38 ± 10.72 years (53.1% males) were included in our study, and the mean size of PFC was 10.06 ± 3.03 cm. Technical success rate and clinical success rate reached 96.9% and 93.8%, respectively. Stent migration occurred in 1 patient (3.1%), and no stent-induced bleeding occurred. The outcomes of using LAMS in 10 patients with pancreatic pseudocyst and 22 patients with walled-off necrosis were comparable. Compared with pancreatic pseudocyst, walled-off necrosis needed more direct endoscopic necrosectomy times to achieve resolution (P = 0.024). Our study showed that the novel LAMS is effective and safe for endoscopic drainage of PFCs with a relatively low rate of adverse events. Further large-scale multicenter studies are needed to confirm the present findings.
{"title":"A novel lumen-apposing metal stent for endoscopic drainage of symptomatic pancreatic fluid collections: a retrospective study","authors":"Ning Xu, Longsong Li, Song Su, Danqi Zhao, J. Xiang, Pengju Wang, Yaxuan Cheng, E. Linghu, N. Chai","doi":"10.1097/eus.0000000000000039","DOIUrl":"https://doi.org/10.1097/eus.0000000000000039","url":null,"abstract":"Previous studies showed that lumen-apposing metal stent (LAMS) provides a feasible route to perform direct endoscopic necrosectomy. However, the high risk of bleeding and migration induced by the placement of LAMS attracted attention. The aim of this study was to evaluate the safety and effectiveness of a novel LAMS. In this retrospective study, we enrolled patients with symptomatic pancreatic fluid collections (PFCs) to perform EUS–guided drainage with a LAMS in our hospital. Evaluation variables included technical success rate, clinical success rate, and adverse events. Thirty-two patients with a mean age of 41.38 ± 10.72 years (53.1% males) were included in our study, and the mean size of PFC was 10.06 ± 3.03 cm. Technical success rate and clinical success rate reached 96.9% and 93.8%, respectively. Stent migration occurred in 1 patient (3.1%), and no stent-induced bleeding occurred. The outcomes of using LAMS in 10 patients with pancreatic pseudocyst and 22 patients with walled-off necrosis were comparable. Compared with pancreatic pseudocyst, walled-off necrosis needed more direct endoscopic necrosectomy times to achieve resolution (P = 0.024). Our study showed that the novel LAMS is effective and safe for endoscopic drainage of PFCs with a relatively low rate of adverse events. Further large-scale multicenter studies are needed to confirm the present findings.","PeriodicalId":11577,"journal":{"name":"Endoscopic Ultrasound","volume":" 82","pages":""},"PeriodicalIF":4.5,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139144816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}