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Prevalence of hepatitis B among pregnant women in Libreville, Gabon 加蓬利伯维尔孕妇乙型肝炎患病率
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-10 DOI: 10.1186/s43066-024-00360-5
Rick-Leonid Ngoua Meye Misso, Joseph Privat Ondo, Cédric Sima Obiang, Xavier Nze Makanga, Ndong Atome Guy Roger, Louis-Clément Obame Engonga
Hepatitis B virus (HBV) infection is one of the major public health problems worldwide. In pregnant women, there is a risk of mother-to-child transmission (vertical transmission) of the infection. The contaminated newborn will most often remain a chronic carrier. Gabon is part of the highly endemic area for hepatitis B. This study aims to determine the prevalence of hepatitis B in pregnant women at the Estuaire Regional Hospital of Melen, Libreville, Gabon. The study was carried out at the Laboratory of the Center Hospitalier Régionale Estuaire Melen (CHREM), over a period of 5 years, from January 2018 to December 2022. It was a retrospective and prospective study ranging from January 2018 to December 2022. For the prospective study, the data was collected in the CHREM Laboratory library, by using registers and filing cabinets. For the prospective study, blood samples were taken and analyzed using Abbott Determine® HBsAg kits and the BioMérieux mini Vidas system. The variables studied were age, HBs status, profession, level of study, and residence. The data collected was entered into an Excel file (Microsoft Office 2016) and analyzed using XLSTAT 2016.4.01 and Epi Info™ 7.2.5 software and expressed as means and percentages. A total of 1615 pregnant women seen in the CHREM laboratory department were included in the study. Of which, 315 were diagnosed as HBsAg carriers, representing a prevalence of 8.36%. Depending on the year, the highest prevalence was observed in 2019 with 20 positive cases out of 267 women screened, i.e., 9.38%. Depending on the districts, the highest prevalence was found in the Essassa and Plein Ciel districts with 16.43% and 18.18%, respectively. According to the age groups, the highest prevalence was observed in the age group 26–30 with 10.16% (p = 0.075) out of 492 patients screened. Depending on the profession, the prevalence was higher among female students with 21.97% (p = 0.020). According to marital status, unmarried had the highest prevalence with 8.8% (p = 0.064). And according to nationality, women of Gabonese nationality had a higher prevalence with 9.52%. Antenatal transmission of HBV is high in Libreville. The inaccessibility of antiviral therapy for viral hepatitis B makes the immunization of mothers and children a priority in Gabon.
乙型肝炎病毒(HBV)感染是全球主要的公共卫生问题之一。在孕妇中,存在母婴传播(垂直传播)感染的风险。受感染的新生儿通常会成为慢性携带者。加蓬是乙型肝炎高度流行区的一部分。本研究旨在确定加蓬利伯维尔梅伦 Estuaire 地区医院的孕妇乙型肝炎患病率。研究在埃斯图瓦雷梅伦地区中心医院实验室进行,为期5年,从2018年1月至2022年12月。这是一项回顾性和前瞻性研究,研究时间为2018年1月至2022年12月。在前瞻性研究中,数据是在 CHREM 实验室图书馆通过登记簿和档案柜收集的。在前瞻性研究中,使用雅培 Determine® HBsAg 试剂盒和生物梅里埃 mini Vidas 系统采集并分析血液样本。研究变量包括年龄、HBs 状态、职业、学习水平和居住地。收集到的数据被输入 Excel 文件(Microsoft Office 2016),并使用 XLSTAT 2016.4.01 和 Epi Info™ 7.2.5 软件进行分析,以均值和百分比表示。研究共纳入了 1615 名在 CHREM 实验室就诊的孕妇。其中 315 人被确诊为 HBsAg 携带者,患病率为 8.36%。根据年份的不同,2019 年的感染率最高,在 267 名接受筛查的妇女中有 20 例阳性病例,即 9.38%。根据地区划分,埃萨萨区和 Plein Ciel 区的患病率最高,分别为 16.43% 和 18.18%。根据年龄组划分,在 492 名接受筛查的患者中,26-30 岁年龄组的患病率最高,为 10.16%(p = 0.075)。根据职业划分,女学生的患病率较高,为 21.97%(p = 0.020)。根据婚姻状况,未婚女性的患病率最高,为 8.8%(p = 0.064)。根据国籍,加蓬籍女性的感染率较高,为 9.52%。在利伯维尔,产前传播 HBV 的比例很高。由于无法获得乙型病毒性肝炎的抗病毒治疗,因此在加蓬,为母亲和儿童进行免疫接种成为当务之急。
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引用次数: 0
A rare case of hepatic hydatid cyst in Somalia: a case report 索马里一例罕见的肝包虫囊肿:病例报告
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-09 DOI: 10.1186/s43066-024-00363-2
Mohamed Adam Mohamud, Abdirahman Ahmed Omar, Mohamed Hussein Adam, Arwa Elaagip, Ismail Gedi İbrahim
Echinococcosis, or hydatid disease, is caused by the larval forms of taeniid cestodes belonging to the genus Echinococcus. Echinococcus granulosus and E. multilocularis are the primary species responsible for human echinococcosis, and mostly they affect the liver. The disease course is typically slow, and the patients tend to remain asymptomatic for many years. A case of 19-year-old male Somali from Medina, Saudi Arabia, was presented to the Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research Hospital with the complaint of right upper quadrant abdominal pain and dysuria for 1 month. A thorough physical examination, laboratory examination, and imaging investigations, including abdominal sonography and computed tomography (CT), were conducted. Both ultrasound and CT scans revealed a cystic lesion in the right lobe of the liver, confirming the diagnosis of a hydatid cyst. Consequently, the patient underwent exploratory laparotomy. It was successfully managed surgically, and the definitive diagnosis was provided by the pathologist, confirming degenerated echinococcal cysts that contain abundant debris. Additionally, the patient received oral albendazole both before and after the surgery and after 7 months and is currently symptom-free. Hydatid disease in the liver may persist without symptoms and often goes undiagnosed due to the slow growth of the cysts. The diagnosis needs careful history reporting, physical examination, and appropriate imaging investigations.
棘球蚴病又称包虫病,是由棘球蚴属奚尼绦虫的幼虫引起的。颗粒棘球蚴和多角棘球蚴是导致人类棘球蚴病的主要种类,它们主要影响肝脏。病程通常比较缓慢,患者往往多年无症状。摩加迪沙索马里土耳其雷杰普-塔伊普-埃尔多安培训与研究医院收治了一例来自沙特阿拉伯麦地那的 19 岁索马里男性患者,主诉右上腹疼痛和排尿困难 1 个月。医院对患者进行了全面的体格检查、实验室检查和影像学检查,包括腹部超声波和计算机断层扫描(CT)。超声波和 CT 扫描均显示肝脏右叶有囊性病变,确诊为包虫囊肿。因此,患者接受了剖腹探查术。手术取得了成功,病理学家给出了明确诊断,确诊为含有大量碎屑的变性棘球蚴囊肿。此外,患者在手术前后和 7 个月后都口服了阿苯达唑,目前已无症状。肝包虫病可能持续存在而无症状,而且由于囊肿生长缓慢,往往无法确诊。诊断时需要仔细询问病史、进行体格检查和适当的影像学检查。
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引用次数: 0
Hepatic cholera: a case report with literature review 肝性霍乱:病例报告与文献综述
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-09 DOI: 10.1186/s43066-024-00365-0
Gaurav Khatana, Lal Krishna Unnikrishnan, Sandesh Kolassery, Saji Sebastian, Sindhu Radha Sadasivan Nair, Ramu Muraleedharanpillai
Vasoactive intestinal peptide-secreting tumors (VIPomas), also known as WDHA syndrome (or “pancreatic cholera”), are rare neuroendocrine tumors (NETs) with an incidence of 0.05 to 2%. It secretes excessive amounts of VIP, leading to watery diarrhea, hypokalemia, and hypochlorhydria. In adults, they occur most commonly between the ages of 30 and 50 years and are mostly intrapancreatic, occurring in the tail of the pancreas, and rarely located in other segments of the gastrointestinal tract, such as the adrenal glands (35%), paraspinal retroperitoneal ganglia (30–35%), posterior mediastinum (20%), head and neck (1–5%), pelvis (2–3%), and rarely (1%) thymus, lung, kidney, anterior mediastinum, and liver. Our patient, a 22-year-old man, was admitted with recurrent episodes of large-volume chronic watery diarrhea, generalized muscle weakness, and significant weight loss. After a complete workup, a solitary primary hepatic VIPoma was diagnosed. The patient underwent surgical resection of the liver lesion. Following surgery, there was immediate regression of diarrhea and electrolyte abnormalities, with no recurrence at the 1-year follow-up. Neuroendocrine tumors, particularly VIPomas, are rare and mostly intrapancreatic. Solitary primary hepatic VIPoma is extremely rare, and to the best of our knowledge, only four cases without any evidence of a pancreatic lesion have been reported. Diagnosis remains challenging, as it is often not detected on conventional imaging. The prognosis mostly depends on tumor grade, stage, and surgical resectability.
血管活性肠肽分泌瘤(VIP瘤)又称WDHA综合征(或 "胰霍乱"),是一种罕见的神经内分泌肿瘤(NET),发病率为0.05%至2%。它分泌过量的 VIP,导致水样腹泻、低钾血症和低氯血症。在成人中,它们最常发生在 30 至 50 岁之间,大多位于胰腺内,发生在胰腺尾部,很少发生在胃肠道的其他部位、如肾上腺(35%)、脊柱旁腹膜后神经节(30%-35%)、后纵隔(20%)、头颈部(1%-5%)、骨盆(2%-3%),胸腺、肺、肾、前纵隔和肝很少发生(1%)。我们的患者是一名 22 岁的男性,因反复发作大量慢性水样腹泻、全身肌肉无力和体重明显减轻而入院。经过全面检查,确诊为单发原发性肝VIP瘤。患者接受了肝脏病变手术切除。手术后,腹泻和电解质异常立即得到缓解,随访 1 年未再复发。神经内分泌肿瘤,尤其是肝VIP瘤,非常罕见,而且大多发生在胰腺内。单发原发性肝VIP瘤极为罕见,据我们所知,目前仅有四例无胰腺病变证据的报道。诊断仍然具有挑战性,因为常规影像学检查往往无法发现该病。预后主要取决于肿瘤的分级、分期和手术切除能力。
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引用次数: 0
Correction: Exploring the prognostic significance of blood carnitine and acylcarnitines in hepatitis C virus‑induced hepatocellular carcinoma 更正:探讨丙型肝炎病毒诱导的肝细胞癌中血液肉碱和酰基肉碱的预后意义
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-06 DOI: 10.1186/s43066-024-00347-2
Ashraf Abbass Basuni, Azza El Sheashaey, Ashraf El Fert, Manar Obada, Eman Abdelsameea, Mohamed Abdel‑Samiee, Asmaa Ibrahim, Ashraf Khalil

Correction: Egypt Liver J 14, 19 (2024)

https://doi.org/10.1186/s43066-024-00322-x


Following publication of the original article [1], the following corrections have been made to this published article.

1. Corrections to the names of the first and fifth authors.

“Ashraf Abbass” has been corrected to “Ashraf Abbass Basuni”.

“Mohammed” of Mohamed Abdel‑Samiee has been corrected to “Mohamed”.

2. Rectification of the reference section (Incorrect placement of the publication year): The following reference entries have been amended to move the year of publication at the of authors’ names instead of appearing in the middle of the authors’ names.

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1186/s43066-024-00322-xArticle Google Scholar Download references作者和单位埃及 Shibin El Kom,Menoufia 大学国家肝脏研究所生物化学和分子诊断系Ashraf Abbass Basuni、Ashraf El Fert、Manar Obada &Ashraf KhalilDepartment of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shibin El Kom, EgyptEman Abdelsameea, Mohamed Abdel-Samiee &Asmaa IbrahimDepartment of Zoology, Faculty of Science, Menoufia University, Shibin El Kom、EgyptAzza El SheashaeyAuthorsAshraf Abbass BasuniView Author publications您也可以在PubMed Google Scholar中搜索该作者Azza El SheashaeyView Author publications您也可以在PubMed Google Scholar中搜索该作者Ashraf El FertView Author publications您也可以在PubMed Google Scholar中搜索该作者Manar ObadaView Author publications您也可以在PubMed Google Scholar中搜索该作者EmanAbdelsameeaView作者发表的作品您也可以在PubMed Google Scholar中搜索该作者Mohamed Abdel-SamieeView作者发表的作品您也可以在PubMed Google Scholar中搜索该作者Asmaa IbrahimView作者发表的作品您也可以在PubMed Google Scholar中搜索该作者Ashraf KhalilView作者发表的作品您也可以在PubMed Google Scholar中搜索该作者通信作者Ashraf Khalil.开放存取 本文采用知识共享署名 4.0 国际许可协议进行许可,该协议允许以任何媒介或格式使用、共享、改编、分发和复制本文,但须注明原作者和出处,提供知识共享许可协议链接,并说明是否进行了修改。本文中的图片或其他第三方材料均包含在文章的知识共享许可协议中,除非在材料的署名栏中另有说明。如果材料未包含在文章的知识共享许可协议中,且您打算使用的材料不符合法律规定或超出许可使用范围,您需要直接从版权所有者处获得许可。如需查看该许可的副本,请访问 http://creativecommons.org/licenses/by/4.0/.Reprints and permissionsCite this articleBasuni, A.A., Sheashaey, A.E., Fert, A.E. et al. Correction:探讨血液肉碱和酰基肉碱在丙型肝炎病毒诱导的肝细胞癌中的预后意义。Egypt Liver Journal 14, 52 (2024). https://doi.org/10.1186/s43066-024-00347-2Download citationPublished: 06 July 2024DOI: https://doi.org/10.1186/s43066-024-00347-2Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative
{"title":"Correction: Exploring the prognostic significance of blood carnitine and acylcarnitines in hepatitis C virus‑induced hepatocellular carcinoma","authors":"Ashraf Abbass Basuni, Azza El Sheashaey, Ashraf El Fert, Manar Obada, Eman Abdelsameea, Mohamed Abdel‑Samiee, Asmaa Ibrahim, Ashraf Khalil","doi":"10.1186/s43066-024-00347-2","DOIUrl":"https://doi.org/10.1186/s43066-024-00347-2","url":null,"abstract":"<p><b>Correction: Egypt Liver J 14, 19 (2024)</b></p><p><b>https://doi.org/10.1186/s43066-024-00322-x</b></p><br/><p>Following publication of the original article [1], the following corrections have been made to this published article.</p><p>1. Corrections to the names of the first and fifth authors.</p><p>“Ashraf Abbass” has been corrected to “Ashraf Abbass Basuni”.</p><p>“Mohammed” of Mohamed Abdel‑Samiee has been corrected to “Mohamed”.</p><p>2. Rectification of the reference section (Incorrect placement of the publication year): The following reference entries have been amended to move the year of publication at the of authors’ names instead of appearing in the middle of the authors’ names.</p><p>[7] Fitian AI, DR Nelson, C Liu, Y Xu, M Araratand R Cabrera (2014) Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int 34(9):1428–1444</p><p>[9] Koppenol WH, PL Boundsand, CV Dang (2011) Otto Warburg’s contributions to current concepts of cancer metabolism. Nat Rev Cancer 11(5):325–337</p><p>[10] Longo N, M Frigeniand M Pasquali (2016) Carnitine transport and fatty acid oxidation. Biochim Biophys Acta 1863(10):2422–2435</p><p>[11] Ganti S, Taylor SL, Kim K, Hoppel CL, Guo L, Yang J, RH Weiss (2012) Urinary acylcarnitines are altered in human kidney cancer. Int J Cancer 130(12):2791–800</p><p>[15] Violante S, L Ijlst, H Te Brinke, I Tavares de Almeida, RJ Wanders, FV Venturaand SM Houten (2013) Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines. FASEB J 27(5):2039–2044.</p><p>[17] Ni J, L Xu, W Li, C Zhengand L Wu (2019) Targeted metabolomics for serum amino acids and acylcarnitines in patients with lung cancer. Exp Ther Med 18(1):188–198</p><p>[18] Sun C, F Wang, Y Zhang, J Yuand X Wang (2020) Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer. Theranostics 10(16):7070–7082</p><p>[20] Pugh RN, IM Murray-Lyon, JL Dawson, MC Pietroniand R Williams (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60(8):646–649</p><p>[21] Smith A, K Baumgartnerand C Bositis (2019) Cirrhosis: diagnosis and management. Am Fam Physician 100(12):759–770</p><p>[23] de Freitas LBR, L Longo, D Santos, I Grivicichand MR Alvares-da-Silva (2019) Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona Clinic Liver Cancer in a Western population. World J Hepatol 11(9):678–688</p><p>[29] Miyaaki H, H Kobayashi, S Miuma, M Fukusima, R Sasaki, M Haraguchiand K Nakao (2020) Blood carnitine profiling on tandem mass spectrometry in liver cirrhotic patients. BMC Gastroenterol 20(1):41</p><p>[30] Shibahara J, S Ando, Y Sakamoto, N Kokudoand M Fukayama (2014) Hepatocellular carcinoma with steatohepatitic features: a clinicopathological study of Japanese patients. Histopathology 64(7):951–","PeriodicalId":11620,"journal":{"name":"Egyptian Liver Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141571683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the performance of two different chemiluminescence analyzers systems in screening donors’ samples for HCV infection 评估两种不同的化学发光分析仪系统在筛查捐献者样本是否感染 HCV 方面的性能
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-05 DOI: 10.1186/s43066-024-00359-y
Dalia Diaa ElDine Salem, Heba-TAllah Nader ElSayed
The approved screening test for HCV infection among blood donors is the HCV antibody test. The diagnostic performances of the available immunoassays in the market that target different HCV antigens have not yet been thoroughly analyzed. Our study aimed to assess the diagnostic performances of two different chemiluminescence immunoassay (CLIA) assays. We analyzed 1909 samples using two assay systems (COBAS e601 ROCHE® & Vitros 3600 ORTHO®) and evaluated the agreement of each with the gold standard method ELISA, as well as studying their diagnostic performances. The Cohen’s Kappa statistics revealed excellent agreement between ELISA and both CLIA methods performed on Cobas e 601 ROCHE and Vitrous 3600 ORTHO (0.81 & 0.994 respectively). The sensitivities and positive predictive values were 95.05% and 73.85% for Cobas e 601 ROCHE, 100.00%, and 98.97% for Vitrous 3600 ORTHO, respectively. Excellent diagnostic performance was detected by both assays; however, Vitros 3600 ORTHO outperformed Cobas e 601 ROCHE in terms of sensitivity and specificity.
已获批准的献血者 HCV 感染筛查试验是 HCV 抗体检测。目前尚未对市场上针对不同 HCV 抗原的现有免疫测定的诊断性能进行全面分析。我们的研究旨在评估两种不同化学发光免疫测定(CLIA)的诊断性能。我们使用两种检测系统(COBAS e601 ROCHE® 和 Vitros 3600 ORTHO®)分析了 1909 份样本,评估了每种系统与黄金标准方法 ELISA 的一致性,并研究了它们的诊断性能。科恩卡帕(Cohen's Kappa)统计显示,ELISA 与在 Cobas e 601 ROCHE 和 Vitrous 3600 ORTHO 上进行的两种 CLIA 方法之间的一致性非常好(分别为 0.81 和 0.994)。Cobas e 601 ROCHE 的灵敏度和阳性预测值分别为 95.05% 和 73.85%,Vitrous 3600 ORTHO 的灵敏度和阳性预测值分别为 100.00% 和 98.97%。两种检测方法都具有出色的诊断性能;但就灵敏度和特异性而言,Vitros 3600 ORTHO 优于 Cobas e 601 ROCHE。
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引用次数: 0
Filarial chylous ascites with chylothorax: challenge of diagnosis and management case report 伴有乳糜胸的丝状糜烂性腹水:诊断和处理的挑战 病例报告
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-03 DOI: 10.1186/s43066-024-00354-3
Abdelmoneim Elhadidy, Mohamed Elrefaay, Hamdy Elsheshiny, Fathy Elnagdy
Chylous ascites (CA), an uncommon clinical condition, is defined as a milky-appearing, triglyceride-rich peritoneal fluid in the abdominal cavity. It may be due to malignancy or cirrhosis in developed countries or infections such as tuberculosis or filariasis in developing countries. This report presents a female patient with chylous ascites with chylothorax secondary to lymphatic filariasis after the exclusion of other etiologies. A 33-year-old female, from Damietta, Egypt, was referred to us complaining of abdominal distension and easy fatigability for 5 months. The patient was diagnosed to have elephantiasis of both lower limbs caused by filariasis and treated by ant-filarial therapy for 9 years. Aspirated ascitic fluid was milky in appearance and rich in triglyceride. All other causes of chylous ascites were excluded by ascetic fluid analysis (chemical, microbiological, and pathological). The patient was treated with diethylcarbamazine (DEC), albendazole, pheniramine, and hydrocortisone followed by a therapeutic pleural and ascitic tapping but ascites re-accumulate. With the addition of doxycycline and Somatostatin/ocreotide, the ascites gradually decreased. Three months later, the patient came back with a significant increase in ascites, and paracentesis was done. Despite rarity, filarial chylous ascites remains a challenge, and the only effective treatment is still repeated aspiration of the accumulated fluid. More work and discussion are needed.
乳糜腹水(CA)是一种不常见的临床症状,是指腹腔内出现乳白色、富含甘油三酯的腹腔积液。在发达国家,其原因可能是恶性肿瘤或肝硬化,在发展中国家则可能是感染,如结核病或丝虫病。本报告介绍的是一名女性患者,在排除其他病因后,继发于淋巴丝虫病的乳糜腹水和乳糜胸。一名来自埃及达米埃塔的 33 岁女性患者因腹胀和易疲劳 5 个月而转诊至我院。患者被诊断为丝虫病引起的双下肢象皮病,接受了长达 9 年的抗丝虫治疗。抽出的腹水呈乳白色,富含甘油三酯。通过腹水分析(化学、微生物和病理),排除了导致乳糜腹水的所有其他原因。患者接受了二乙基卡马嗪(DEC)、阿苯达唑、苯海拉明和氢化可的松治疗,随后进行了治疗性胸膜和腹水穿刺,但腹水再次积聚。在加用强力霉素和促生长素/奥曲肽后,腹水逐渐减少。三个月后,患者再次复发,腹水明显增多,于是做了腹腔穿刺术。丝虫性乳糜腹水尽管罕见,但仍是一个难题,唯一有效的治疗方法仍是反复抽吸积液。还需要更多的工作和讨论。
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引用次数: 0
Prognostic scores for predicting clinical outcomes in upper gastrointestinal bleeding 预测上消化道出血临床结果的预后评分
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-03 DOI: 10.1186/s43066-024-00357-0
Gaurav Khatana, Sunil Kumar K, Sandesh Kolassery, Saji Sebastian, Deni Joseph, Ramu Muraleedharanpillai, Tony Joseph, Nithya V, Lal Krishna Unnikrishnan, Gino Rony
This study aimed to determine the performance of AIMS65, Rockall score, and Glasgow-Blatchford score (GBS) in patients presenting with upper gastrointestinal bleeding (UGIB) and to compare results between patients with nonvariceal UGIB (NVUGIB) and variceal UGIB (VUGIB). We conducted a single-center prospective cohort study between December 2021 and December 2022. A total of 400 patients who met the inclusion criteria were included in the study, out of which 232 patients (58%) had NVUGIB and 168 patients (42%) had VUGIB. Receiver operating characteristic curve analysis was performed for all outcomes for comparison. Of the total of 400 patients with UGIB, 232 patients (58%) had NVUGIB, and 168 patients (42%) had VUGIB. The present study showed that GBS (AUROC 0.729, 95% CI: 0.598–0.859, p = 0.001) and RS (AUROC 0.693, 95% CI: 0.579–0.807, p = 0.005) but not AIMS65 (AUROC, 0.545, 95% CI: 0.412–0.679, p = 0.500) predicted in-hospital and overall 6-week mortality in patients with UGIB. All the three scores predicted need for blood transfusion and poor composite outcomes (p < 0.05). The need for endoscopic intervention was predicted by all the three scores in overall UGIB (OUGIB) patients (p < 0.05), only GBS and RS in NVUGIB patients (p < 0.05). Rebleeding was best predicated by RS in both OUGIB and NVUGIB patients (p < 0.05). None of the scores predicted the need for endoscopic intervention, rebleeding, need for surgical and radiological intervention, and composite outcomes in VUGIB patients (p > 0.05). GBS and RS were superior to AIMS65 in predicted in-hospital and overall 6-week mortality in all the three categories: OUGIB, NVUGIB, and VUGIB patients.
本研究旨在确定 AIMS65、Rockall 评分和格拉斯哥-布拉奇福德评分(GBS)在上消化道出血(UGIB)患者中的表现,并比较非静脉曲张性 UGIB(NVUGIB)和静脉曲张性 UGIB(VUGIB)患者的结果。我们在 2021 年 12 月至 2022 年 12 月期间开展了一项单中心前瞻性队列研究。研究共纳入了 400 名符合纳入标准的患者,其中 232 名患者(58%)患有 NVUGIB,168 名患者(42%)患有 VUGIB。对所有结果进行了接收者操作特征曲线分析,以进行比较。在总共 400 名 UGIB 患者中,232 名患者(58%)为 NVUGIB,168 名患者(42%)为 VUGIB。本研究显示,GBS(AUROC 0.729,95% CI:0.598-0.859,p = 0.001)和 RS(AUROC 0.693,95% CI:0.579-0.807,p = 0.005)而非 AIMS65(AUROC,0.545,95% CI:0.412-0.679,p = 0.500)可预测 UGIB 患者的院内死亡率和 6 周总死亡率。所有三个评分都能预测输血需求和不良的综合结果(P 0.05)。在预测所有三个类别患者的院内死亡率和 6 周总死亡率方面,GBS 和 RS 均优于 AIMS65:OUGIB、NVUGIB 和 VUGIB 患者。
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引用次数: 0
A case of gallbladder hemangioma detected in a patient with jaundice and suspected Klatskin tumor: case report and review of the literature 一例胆囊血管瘤病例:病例报告和文献综述
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-26 DOI: 10.1186/s43066-024-00356-1
F. Karahan, A. Atay, N. Ekinci, O. N. Dilek
The diagnosis and treatment of benign tumors of the gallbladder and bile ducts are difficult due to their anatomical relationships with neighboring vital organs. Hemangiomas are non-epithelial benign tumors of the gallbladder. The gallbladder is an extremely rare localization for cavernous hemangiomas. To date, 7 cases of cavernous gallbladder hemangioma have been reported in the literature. Although it is seen very rarely, the main problem is that it mimics malignant lesions. Pre-operative diagnosis of gallbladder hemangiomas is difficult. Ultrasound (US), computed tomography (CT) magnetic resonance imaging(MRI), endoscopic ultrasound (EUS), and angiography are helpful in differential diagnosis. Here, we aimed to present our case, which is the first case of cavernous gallbladder hemangioma and obstructive jaundice in the literature. A 49-year-old female patient was admitted with the complaint of pain in the right upper quadrant of her abdomen. Bilirubin levels were high due to obstructive jaundice. Abdominal CT and MRI showed an appearance in favor of hemangioma in the gallbladder. There was an increase in bile duct wall thickness on MRCP, and it was evaluated as suspicious for malignant neoplasia. The patient was operated on, and extrahepatic bile duct resection + Roux-en-Y hepaticojejunostomy procedure was performed. As a result of histopathology, hemangioma was detected in the gallbladder. There was no malignancy in the bile ducts. It should be kept in mind that the mass detected in the gallbladder in a patient with jaundice who is suspected of having a bile duct tumor may also be a hemangioma.
由于胆囊和胆管与邻近重要器官的解剖关系,胆囊和胆管良性肿瘤的诊断和治疗非常困难。血管瘤是胆囊的非上皮性良性肿瘤。胆囊是海绵状血管瘤极为罕见的发病部位。迄今为止,文献中已报道了 7 例胆囊海绵状血管瘤。虽然胆囊海绵状血管瘤很少见,但主要问题是它会模仿恶性病变。胆囊血管瘤的术前诊断非常困难。超声(US)、计算机断层扫描(CT)、磁共振成像(MRI)、内窥镜超声(EUS)和血管造影有助于鉴别诊断。我们的病例是文献中首例胆囊海绵状血管瘤合并梗阻性黄疸的病例。一名 49 岁的女性患者因右上腹疼痛入院。由于阻塞性黄疸,胆红素水平较高。腹部 CT 和 MRI 显示胆囊内有血管瘤。MRCP 检查显示胆管壁厚度增加,被评估为可疑恶性肿瘤。患者接受了手术,进行了肝外胆管切除+Roux-en-Y肝空肠吻合术。组织病理学结果显示,胆囊内发现了血管瘤。胆管内没有恶性肿瘤。需要注意的是,黄疸患者胆囊中发现的肿块如果怀疑是胆管肿瘤,也可能是血管瘤。
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引用次数: 0
Predicting acute complications in endoscopic retrograde cholangiopancreatography based on the severity and onset of post-procedural pain 根据术后疼痛的严重程度和起始时间预测内镜逆行胰胆管造影术的急性并发症
IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-24 DOI: 10.1186/s43066-024-00355-2
Fardad Ejtehadi, Iraj Shahramian, Mojtaba Khademi Befrouei, Gholam Reza Sivandzadeh, Seyed Alireza Taghavi, Ramin Niknam, Masoud Tahani
Endoscopic retrograde cholangiopancreatography (ERCP), a standard procedure used for diagnosing and treating pancreaticobiliary disorders, has the highest rate of complications among endoscopic procedures. We aimed to evaluate the association of post-ERCP pain onset and its severity with the development of acute complications. This cross-sectional study included 172 candidates for ERCP who were referred to Namazi Hospital, Shiraz, from January 21, 2021, to January 21, 2022. Demographic features of the participants, including age and gender, were recorded. ERCP indications, complications during and after ERCP, and narcotic requirements were also noted. Post-ERCP pain severity was evaluated using a 10-point visual analogue scale (VAS), with 0 indicating no pain and 10 indicating the worst pain. Pain severity was evaluated twice: once by the physician and once by the patient. The interval between the procedure and the onset of pain was also recorded. Out of the 172 participants of this study with a mean age of 53.77 ± 20.20 years, 98 (57%) were male. The most typical indication of ERCP was common bile duct stone (36%). Complications during and after ERCP occurred in 2.3% and 2.9%, respectively, with retroperitoneal/sphincterotomy perforation (1.2%) being the most common post-ERCP complication. Post-ERCP pain score (both by patient and physician) was significantly higher in patients with complications compared to those without complications (P < 0.001). The interval between the ERCP procedure and the onset of pain was significantly shorter in patients with post-ERCP complications (P = 0.003). Also, a significantly higher percentage of patients with complications required narcotics (40% vs 1.2%, P = 0.004). Although the presence of post-ERCP pain may not necessarily be indicative of complications, post-ERCP pain severity and onset, as well as narcotic requirement, appear to be associated with the development of post-ERCP complications.
内镜逆行胰胆管造影术(ERCP)是用于诊断和治疗胰胆管疾病的标准手术,是并发症发生率最高的内镜手术。我们的目的是评估ERCP术后疼痛发作及其严重程度与急性并发症发生的关系。这项横断面研究纳入了 2021 年 1 月 21 日至 2022 年 1 月 21 日期间转诊至设拉子市纳马齐医院的 172 名 ERCP 患者。研究记录了参与者的人口统计学特征,包括年龄和性别。此外,还记录了ERCP适应症、ERCP期间和之后的并发症以及麻醉剂需求。ERCP术后疼痛严重程度采用10分视觉模拟量表(VAS)进行评估,0分表示无痛,10分表示疼痛最严重。疼痛严重程度评估两次:一次由医生评估,一次由患者评估。此外,还记录了手术与疼痛发生之间的间隔时间。这项研究的 172 名参与者平均年龄为(53.77±20.20)岁,其中 98 人(57%)为男性。ERCP最典型的适应症是胆总管结石(36%)。ERCP术中和术后并发症的发生率分别为2.3%和2.9%,其中腹膜后/括约肌切开穿孔(1.2%)是ERCP术后最常见的并发症。与无并发症的患者相比,有并发症的患者ERCP术后疼痛评分(患者和医生评分)明显更高(P < 0.001)。有ERCP术后并发症的患者从ERCP手术到出现疼痛的间隔时间明显较短(P = 0.003)。此外,有并发症的患者需要使用麻醉剂的比例明显更高(40% vs 1.2%,P = 0.004)。虽然ERCP术后疼痛的出现不一定是并发症的征兆,但ERCP术后疼痛的严重程度和开始时间以及麻醉剂需求似乎与ERCP术后并发症的发生有关。
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引用次数: 0
Bile level of cytokeratin 7 as a diagnostic marker for cholangiocarcinoma: a case-control study in Egyptian patients 胆汁中细胞角蛋白 7 的含量作为胆管癌的诊断指标:一项针对埃及患者的病例对照研究
IF 0.8 Q4 Medicine Pub Date : 2024-06-15 DOI: 10.1186/s43066-024-00353-4
Ali Nada, Alzhraa Alkhatib, Fady Abdelmalik, Mona El-Abd, N. Elabd, Hossam El-Din Abdel-Latif
{"title":"Bile level of cytokeratin 7 as a diagnostic marker for cholangiocarcinoma: a case-control study in Egyptian patients","authors":"Ali Nada, Alzhraa Alkhatib, Fady Abdelmalik, Mona El-Abd, N. Elabd, Hossam El-Din Abdel-Latif","doi":"10.1186/s43066-024-00353-4","DOIUrl":"https://doi.org/10.1186/s43066-024-00353-4","url":null,"abstract":"","PeriodicalId":11620,"journal":{"name":"Egyptian Liver Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Egyptian Liver Journal
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