Pub Date : 2024-02-29DOI: 10.1183/23120541.00837-2023
Jeanne-Marie Perotin, Lisa Gauquelin, Nicolas Just, Gilles Devouassoux, Cécile Chenivesse, Arnaud Bourdin, Gilles Garcia, Christel Saint Raymond, Amel Boudjemaa, Philippe Bonniaud, Pascal Chanez, Cindy Barnig, Antoine Beurnier, Cyril Maurer, Nathalie Freymond, Toufik Didi, C. Tcherakian, M. Russier, Mélanie Drucbert, Sylvie Guillo, Candice Estellat, Camille Taillé
The French RAMSES study is an observational prospective multicentre real-life cohort including severe asthmatics. The objective of the study was to compare the characteristics of patients, in terms of phenotype and asthma care trajectories, between those managed by tertiary referral centres (TRC) or secondary care centres (SCC).Patients were prospectively recruited and enrolled for a 5-year follow-up. Patients’ characteristics were analysed at inclusion and compared between TRC and SCC.Fifty-two centres (24 TRC, 28 SCC) included 2046 patients: 1502 (73.4%) were included by a TRC and 544 (26.6%) by a SCC. Patients were mainly women (62%), 53±15 yr old, 67% with Asthma control test <20, 14% received at inclusion oral corticosteroids and 66% biologics. Compared with SCC, the TRC group had more frequent comorbidities, and lower blood eosinophil count (262/mm3versus340/mm3, p=0.0036). OCS and biologics use did not differ between groups but patients in the TRC group benefited more frequently from an educational program (26%versus18%, p=0.0008), and received more frequently ≥2 sequential lines of biologics (33%versus24%, p=0.0105). In-depth investigations were more frequently performed in the TRC group (allergy tests: 74%versus62%, p<0.0001; FeNO: 56%versus21%, p<0.0001; induced sputum: 6%versus3%, p=0.0390).Phenotypes and care trajectories differed in the RAMSES cohort between SCC and TRC, probably related to different levels of asthma severity and differences in medical resources and practices among centres. This highlights the need for standardisation of severe asthma care.
法国 RAMSES 研究是一项观察性前瞻性多中心现实生活队列研究，研究对象包括重症哮喘患者。该研究的目的是比较由三级转诊中心（TRC）或二级医疗中心（SCC）管理的患者在表型和哮喘治疗轨迹方面的特征。52个中心（24个三级转诊中心，28个二级转诊中心）共纳入了2046名患者：52个中心（24个TRC和28个SCC）共纳入了2046名患者：其中1502名（73.4%）由TRC纳入，544名（26.6%）由SCC纳入。患者以女性为主（62%），年龄为 53±15 岁，67% 的患者哮喘控制测试结果小于 20，14% 的患者在纳入时接受了口服皮质类固醇治疗，66% 的患者接受了生物制剂治疗。与 SCC 相比，TRC 组合并症更多，血液中嗜酸性粒细胞计数更低（262/mm3 对 340/mm3，P=0.0036）。OCS和生物制剂的使用在组间无差异，但TRC组患者更常受益于教育计划（26%对18%，P=0.0008），更常连续使用≥2种生物制剂（33%对24%，P=0.0105）。TRC组进行深入检查的频率更高（过敏试验：74%对62%，P=0.0105）：在 RAMSES 队列中，SCC 和 TRC 的表型和护理轨迹有所不同，这可能与哮喘严重程度不同以及各中心的医疗资源和实践不同有关。这凸显了重症哮喘护理标准化的必要性。
{"title":"Severe asthma care trajectories: the French RAMSES cohort","authors":"Jeanne-Marie Perotin, Lisa Gauquelin, Nicolas Just, Gilles Devouassoux, Cécile Chenivesse, Arnaud Bourdin, Gilles Garcia, Christel Saint Raymond, Amel Boudjemaa, Philippe Bonniaud, Pascal Chanez, Cindy Barnig, Antoine Beurnier, Cyril Maurer, Nathalie Freymond, Toufik Didi, C. Tcherakian, M. Russier, Mélanie Drucbert, Sylvie Guillo, Candice Estellat, Camille Taillé","doi":"10.1183/23120541.00837-2023","DOIUrl":"https://doi.org/10.1183/23120541.00837-2023","url":null,"abstract":"The French RAMSES study is an observational prospective multicentre real-life cohort including severe asthmatics. The objective of the study was to compare the characteristics of patients, in terms of phenotype and asthma care trajectories, between those managed by tertiary referral centres (TRC) or secondary care centres (SCC).Patients were prospectively recruited and enrolled for a 5-year follow-up. Patients’ characteristics were analysed at inclusion and compared between TRC and SCC.Fifty-two centres (24 TRC, 28 SCC) included 2046 patients: 1502 (73.4%) were included by a TRC and 544 (26.6%) by a SCC. Patients were mainly women (62%), 53±15 yr old, 67% with Asthma control test <20, 14% received at inclusion oral corticosteroids and 66% biologics. Compared with SCC, the TRC group had more frequent comorbidities, and lower blood eosinophil count (262/mm3versus340/mm3, p=0.0036). OCS and biologics use did not differ between groups but patients in the TRC group benefited more frequently from an educational program (26%versus18%, p=0.0008), and received more frequently ≥2 sequential lines of biologics (33%versus24%, p=0.0105). In-depth investigations were more frequently performed in the TRC group (allergy tests: 74%versus62%, p<0.0001; FeNO: 56%versus21%, p<0.0001; induced sputum: 6%versus3%, p=0.0390).Phenotypes and care trajectories differed in the RAMSES cohort between SCC and TRC, probably related to different levels of asthma severity and differences in medical resources and practices among centres. This highlights the need for standardisation of severe asthma care.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.1183/23120541.00806-2023
Laurent Guilleminault, V. Li, E. Fonseca, Ashley Martin, Jonathan Schelfhout, Helen Ding, Gaëlle Le Moine
Chronic cough is a common condition that is associated with lower health-related quality of life and greater health care resource use. There are limited data on the prevalence, population characteristics, and burden of chronic cough in France.This was a cross-sectional study based on responses from French adult residents to the 2020 National Health and Wellness Survey. Respondents with chronic cough were compared to 1:3 propensity score-matched controls without chronic cough.The weighted lifetime and 12-month prevalence of chronic cough were estimated as 7.5% and 4.8%, respectively. Respondents with chronic cough reported significantly worse perceived health than did matched controls, with lower mean (sd) scores of 46.68 (9.28)versus50.42 (8.26) on the physical health component and 40.32 (9.87)versus44.32 (9.69) on the mental health component of the SF-12v2 survey (p<0.001 for both comparisons). Respondents with chronic cough also had higher rates of moderate-to-severe forms of anxiety (24.4%versus12.4%) and depression (36.4%versus20.2%); higher rates of multiple forms of sleep disturbance; greater impairment of work productivity (38.2%versus25.5%) and other activities (41.8%versus28.2%;p<0.001 for all comparisons). Respondents with chronic cough also had higher rates of all-cause health care resource use including ER visits, hospitalisation, overall and specialist health care provider visits compared to controls (p<0.001 for all comparisons).Chronic cough is a common condition in France that is associated with lower health-related quality of life and greater health care resource utilisation.
{"title":"Prevalence and Burden of Chronic Cough in France","authors":"Laurent Guilleminault, V. Li, E. Fonseca, Ashley Martin, Jonathan Schelfhout, Helen Ding, Gaëlle Le Moine","doi":"10.1183/23120541.00806-2023","DOIUrl":"https://doi.org/10.1183/23120541.00806-2023","url":null,"abstract":"Chronic cough is a common condition that is associated with lower health-related quality of life and greater health care resource use. There are limited data on the prevalence, population characteristics, and burden of chronic cough in France.This was a cross-sectional study based on responses from French adult residents to the 2020 National Health and Wellness Survey. Respondents with chronic cough were compared to 1:3 propensity score-matched controls without chronic cough.The weighted lifetime and 12-month prevalence of chronic cough were estimated as 7.5% and 4.8%, respectively. Respondents with chronic cough reported significantly worse perceived health than did matched controls, with lower mean (sd) scores of 46.68 (9.28)versus50.42 (8.26) on the physical health component and 40.32 (9.87)versus44.32 (9.69) on the mental health component of the SF-12v2 survey (p<0.001 for both comparisons). Respondents with chronic cough also had higher rates of moderate-to-severe forms of anxiety (24.4%versus12.4%) and depression (36.4%versus20.2%); higher rates of multiple forms of sleep disturbance; greater impairment of work productivity (38.2%versus25.5%) and other activities (41.8%versus28.2%;p<0.001 for all comparisons). Respondents with chronic cough also had higher rates of all-cause health care resource use including ER visits, hospitalisation, overall and specialist health care provider visits compared to controls (p<0.001 for all comparisons).Chronic cough is a common condition in France that is associated with lower health-related quality of life and greater health care resource utilisation.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.1183/23120541.00513-2023
Pierre Halitim, Jean Pastré, Tristan Mirault, Guillaume Canaud, Dominique Israël-Biet
{"title":"A cystic and bullous lung disease associated with a PIK3CA related overgrowth syndrome","authors":"Pierre Halitim, Jean Pastré, Tristan Mirault, Guillaume Canaud, Dominique Israël-Biet","doi":"10.1183/23120541.00513-2023","DOIUrl":"https://doi.org/10.1183/23120541.00513-2023","url":null,"abstract":"","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.1183/23120541.00134-2024
Laura Delgado-Ortiz, Selin Çakmakcı Karakaya, P. Williams, Emilie Pacheco Da Silva, Beatrice Cornu Hewitt, O. Dumas, H. Meteran
In this article, early career members of the Epidemiology and Environment Assembly of the European Respiratory Society (ERS) summarise a selection of four poster and oral sessions from the Society's 2023 hybrid congress. The topics covered the following areas: micro – and macro-environments and respiratory health, occupational upper and lower airway diseases, selected tobacco and nicotine research, and multimorbidity in people with lung diseases. The topics and studies covered in this review illustrate the broad range of the multifaceted research taking place within Assembly 6, from the identification of indoor and outdoor environmental risk factors for the development and worsening of respiratory diseases to the concerningly increasing use of nicotine products and their health consequences beyond respiratory health and comorbidity in respiratory diseases.
{"title":"ERS International Congress, 2023: highlights from the Epidemiology and Environment Assembly","authors":"Laura Delgado-Ortiz, Selin Çakmakcı Karakaya, P. Williams, Emilie Pacheco Da Silva, Beatrice Cornu Hewitt, O. Dumas, H. Meteran","doi":"10.1183/23120541.00134-2024","DOIUrl":"https://doi.org/10.1183/23120541.00134-2024","url":null,"abstract":"In this article, early career members of the Epidemiology and Environment Assembly of the European Respiratory Society (ERS) summarise a selection of four poster and oral sessions from the Society's 2023 hybrid congress. The topics covered the following areas: micro – and macro-environments and respiratory health, occupational upper and lower airway diseases, selected tobacco and nicotine research, and multimorbidity in people with lung diseases. The topics and studies covered in this review illustrate the broad range of the multifaceted research taking place within Assembly 6, from the identification of indoor and outdoor environmental risk factors for the development and worsening of respiratory diseases to the concerningly increasing use of nicotine products and their health consequences beyond respiratory health and comorbidity in respiratory diseases.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.1183/23120541.00945-2023
J. Saccomanno, T. Sgarbossa, E. Pappe, Lara Kilic, Shaida Biglari, N. Shargill, Sri Radhakrishnan, Martin Witzenrath, Ralf-Harto Hübner
{"title":"VT20 Method for Chartis® Assessment of Collateral Ventilation with Flexible Bronchoscopy Under Procedural Sedation","authors":"J. Saccomanno, T. Sgarbossa, E. Pappe, Lara Kilic, Shaida Biglari, N. Shargill, Sri Radhakrishnan, Martin Witzenrath, Ralf-Harto Hübner","doi":"10.1183/23120541.00945-2023","DOIUrl":"https://doi.org/10.1183/23120541.00945-2023","url":null,"abstract":"","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.1183/23120541.00993-2023
Bryan C. Husta, Anu Menon, Reza Bergemann, I-Hsin Lin, Jaclyn Schmitz, Rastko Rakočević, Tejaswi R. Nadig, P. Adusumilli, J. Beattie, Robert P. Lee, Bernard J. Park, G. Rocco, Matthew J. Bott, M. Chawla, O. Kalchiem-Dekel
{"title":"The Incremental Contribution of Mobile Cone-Beam CT to Tool-Lesion Relationship during Shape Sensing Robotic-Assisted Bronchoscopy","authors":"Bryan C. Husta, Anu Menon, Reza Bergemann, I-Hsin Lin, Jaclyn Schmitz, Rastko Rakočević, Tejaswi R. Nadig, P. Adusumilli, J. Beattie, Robert P. Lee, Bernard J. Park, G. Rocco, Matthew J. Bott, M. Chawla, O. Kalchiem-Dekel","doi":"10.1183/23120541.00993-2023","DOIUrl":"https://doi.org/10.1183/23120541.00993-2023","url":null,"abstract":"","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-26eCollection Date: 2024-01-01DOI: 10.1183/23120541.01036-2023
Richard J Russell
A systematic review highlights limitations and variability in outcome measures for trials in asthma attack treatment. Now is the time to adopt a consistent approach to ensure best patient care in a precision medicine future. https://bit.ly/3O4zDHY.
{"title":"Outcome measures in asthma attack trials: can't see the good for the wheeze.","authors":"Richard J Russell","doi":"10.1183/23120541.01036-2023","DOIUrl":"10.1183/23120541.01036-2023","url":null,"abstract":"<p><p><b>A systematic review highlights limitations and variability in outcome measures for trials in asthma attack treatment. Now is the time to adopt a consistent approach to ensure best patient care in a precision medicine future.</b> https://bit.ly/3O4zDHY.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-26eCollection Date: 2024-01-01DOI: 10.1183/23120541.00051-2024
Woo-Jung Song, Esther Barreiro
The key achievements and highlights of ERJ Open Research from 2023 are discussed, along with the introduction of new programmes and future directions for 2024 https://bit.ly/41UktKX.
{"title":"<i>ERJ Open Research</i> 2024: achievements, vision and gratitude.","authors":"Woo-Jung Song, Esther Barreiro","doi":"10.1183/23120541.00051-2024","DOIUrl":"10.1183/23120541.00051-2024","url":null,"abstract":"<p><p><b>The key achievements and highlights of <i>ERJ Open Research</i> from 2023 are discussed, along with the introduction of new programmes and future directions for 2024</b> https://bit.ly/41UktKX.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-26eCollection Date: 2024-01-01DOI: 10.1183/23120541.01012-2023
Rainer Gloeckl, Fabio Pitta, Andre Nyberg
Upper-limb interval training may be a promising new modality in pulmonary rehabilitation https://bit.ly/41KSLAs.
上肢间歇训练可能是一种很有前途的肺康复新模式 https://bit.ly/41KSLAs。
{"title":"Optimising upper-limb exercise in patients with COPD: another step towards personalised pulmonary rehabilitation?","authors":"Rainer Gloeckl, Fabio Pitta, Andre Nyberg","doi":"10.1183/23120541.01012-2023","DOIUrl":"10.1183/23120541.01012-2023","url":null,"abstract":"<p><p><b>Upper-limb interval training may be a promising new modality in pulmonary rehabilitation</b> https://bit.ly/41KSLAs.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Articular manifestations should be screened before and during anti-IL-5/5R biologic treatment in severe asthma. Rigorous multidisciplinary team discussion should be carried out to assess the risk-benefit balance of withholding effective treatment. https://bit.ly/3vfPn4k.
{"title":"Articular manifestations related to anti-interleukin-5 therapies in severe asthma: a case series.","authors":"Clairelyne Dupin, Solène Valéry, Laurent Guilleminault, Gilles Devouassoux, Marine Merveilleau, Maud Russier, Gisèle Mourin, Johana Pradelli, Philippe Bonniaud, Mathilde Le Brun, Esther Ebstein, Pierre-Antoine Juge, Agnès Lillo-Lelouet, Camille Taillé","doi":"10.1183/23120541.00935-2023","DOIUrl":"10.1183/23120541.00935-2023","url":null,"abstract":"<p><p><b>Articular manifestations should be screened before and during anti-IL-5/5R biologic treatment in severe asthma. Rigorous multidisciplinary team discussion should be carried out to assess the risk-benefit balance of withholding effective treatment.</b> https://bit.ly/3vfPn4k.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：