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Ionic Liquid-Based Electrolyte with Multiple Hydrogen Bonding Network Enabling High-Voltage Stable Proton Batteries Across Wide Temperature Range.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202416931
Xiaoyu Dong, Zhiwei Li, Hai Xu, Zhiyuan Wu, Fanhao Meng, Shuzhi Liu, Hui Dou, Xiaogang Zhang

Proton batteries are strong contender for next-generation energy storage due to their high safety and rapid response. However, the narrow electrochemical window of acidic aqueous electrolytes limits their energy density and stability. Here, an ionic liquid (IL)-based electrolyte (EMImOTf-H3PO4) containing H3PO4 in polar IL solvent 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (EMImOTf) is developed for stable high-voltage energy storage. H3PO4 serving as a proton source interacts with both EMIm+ and OTf-, forming an intricate hydrogen bonding network that effectively prevents electrolyte decomposition at high voltage. The half-cell in EMImOTf-H3PO4 electrolyte and pre-protonated vanadium hexacyanoferrate (H-VHCF) cathode demonstrates a 126% improvement in Coulombic efficiency over aqueous electrolytes at a current density of 1 A g-1. The fabricated PTCDA/MXene//EMImOTf-H3PO4//H-VHCF full battery achieves an operating voltage of 2 V at room temperature, surpassing currently reported values for proton batteries. After 30 000 cycles at 5 A g-1, the battery retains 86.1% of its initial capacity. It delivers an energy density of 87.5 Wh kg-1 and a power density of 30.6 kW kg-1 at room temperature, and can maintain stable operation across a temperature range of 110 °C (-60 ∼ 50 °C). These findings present new possibilities for proton batteries in all-weather grid-scale energy storage applications.

{"title":"Ionic Liquid-Based Electrolyte with Multiple Hydrogen Bonding Network Enabling High-Voltage Stable Proton Batteries Across Wide Temperature Range.","authors":"Xiaoyu Dong, Zhiwei Li, Hai Xu, Zhiyuan Wu, Fanhao Meng, Shuzhi Liu, Hui Dou, Xiaogang Zhang","doi":"10.1002/advs.202416931","DOIUrl":"https://doi.org/10.1002/advs.202416931","url":null,"abstract":"<p><p>Proton batteries are strong contender for next-generation energy storage due to their high safety and rapid response. However, the narrow electrochemical window of acidic aqueous electrolytes limits their energy density and stability. Here, an ionic liquid (IL)-based electrolyte (EMImOTf-H<sub>3</sub>PO<sub>4</sub>) containing H<sub>3</sub>PO<sub>4</sub> in polar IL solvent 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (EMImOTf) is developed for stable high-voltage energy storage. H<sub>3</sub>PO<sub>4</sub> serving as a proton source interacts with both EMIm<sup>+</sup> and OTf<sup>-</sup>, forming an intricate hydrogen bonding network that effectively prevents electrolyte decomposition at high voltage. The half-cell in EMImOTf-H<sub>3</sub>PO<sub>4</sub> electrolyte and pre-protonated vanadium hexacyanoferrate (H-VHCF) cathode demonstrates a 126% improvement in Coulombic efficiency over aqueous electrolytes at a current density of 1 A g<sup>-1</sup>. The fabricated PTCDA/MXene//EMImOTf-H<sub>3</sub>PO<sub>4</sub>//H-VHCF full battery achieves an operating voltage of 2 V at room temperature, surpassing currently reported values for proton batteries. After 30 000 cycles at 5 A g<sup>-1</sup>, the battery retains 86.1% of its initial capacity. It delivers an energy density of 87.5 Wh kg<sup>-1</sup> and a power density of 30.6 kW kg<sup>-1</sup> at room temperature, and can maintain stable operation across a temperature range of 110 °C (-60 ∼ 50 °C). These findings present new possibilities for proton batteries in all-weather grid-scale energy storage applications.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2416931"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti-Tumor Efficiency Based on a Functional Iridium(III) Complex.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202413879
Yu Pei, Yinzhen Pan, Zhijun Zhang, Jun Zhu, Yan Sun, Qian Zhang, Dongxia Zhu, Guangzhe Li, Martin R Bryce, Dong Wang, Ben Zhong Tang

The tumor microenvironment (TME) severely limits the efficacy of clinical applications of photodynamic therapy (PDT). The development of a functional agent allowing full use of the TME to boost synergistic PDT and ferroptosis anti-tumor efficiency is an appealing yet significantly challenging task. Herein, to overcome the adverse influence on PDT of hypoxia and high level of glutathione (GSH) in the TME, an imine bond is introduced into an Ir(III)-ferrocene complex to construct a small molecule drug, named Ir-Fc, for tumors' imaging and therapy. The cleavage of the imine bond in the lysosome effectively disrupts the photoinduced electron transfer (PET) process, realizing the decomposition of Ir-Fc into Fc-CHO and Ir-NH2. Fc-CHO produces •OH by Fenton reactions under dark conditions and induces ferroptosis in tumor cells, and Ir-NH2 shows prominent performance for type-I and type-II reactive oxygen species (ROS) production. Meanwhile, the ferroptosis pathway simultaneously consumes large amounts of GSH and produces O2 for effectively relieving hypoxia. These distinctive outputs make Ir-Fc an exceptional molecule for effective tumor synergistic therapy. This study thus brings a new and revolutionary PDT protocol for practical cancer treatment.

{"title":"Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti-Tumor Efficiency Based on a Functional Iridium(III) Complex.","authors":"Yu Pei, Yinzhen Pan, Zhijun Zhang, Jun Zhu, Yan Sun, Qian Zhang, Dongxia Zhu, Guangzhe Li, Martin R Bryce, Dong Wang, Ben Zhong Tang","doi":"10.1002/advs.202413879","DOIUrl":"https://doi.org/10.1002/advs.202413879","url":null,"abstract":"<p><p>The tumor microenvironment (TME) severely limits the efficacy of clinical applications of photodynamic therapy (PDT). The development of a functional agent allowing full use of the TME to boost synergistic PDT and ferroptosis anti-tumor efficiency is an appealing yet significantly challenging task. Herein, to overcome the adverse influence on PDT of hypoxia and high level of glutathione (GSH) in the TME, an imine bond is introduced into an Ir(III)-ferrocene complex to construct a small molecule drug, named Ir-Fc, for tumors' imaging and therapy. The cleavage of the imine bond in the lysosome effectively disrupts the photoinduced electron transfer (PET) process, realizing the decomposition of Ir-Fc into Fc-CHO and Ir-NH<sub>2</sub>. Fc-CHO produces •OH by Fenton reactions under dark conditions and induces ferroptosis in tumor cells, and Ir-NH<sub>2</sub> shows prominent performance for type-I and type-II reactive oxygen species (ROS) production. Meanwhile, the ferroptosis pathway simultaneously consumes large amounts of GSH and produces O<sub>2</sub> for effectively relieving hypoxia. These distinctive outputs make Ir-Fc an exceptional molecule for effective tumor synergistic therapy. This study thus brings a new and revolutionary PDT protocol for practical cancer treatment.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413879"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifunctional Boron-based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202412626
Changyi Xu, Ming Liu, Xinran Xie, Zhixin Li, Yuefei Zhu, Yang Ye, Mengya Du, Suhua Hu, Tianrun Liu, Yubiao Guo, Weiping Wen, Huanliang Liu, Zhaoxu Tu

Effective management of serious respiratory diseases, such as asthma and recalcitrant rhinitis, remains a global challenge. Here, it is shown that induced sputum supernatants (ISS) from patients with asthma contain higher levels of cell-free DNA (cfDNA) compared to that of healthy volunteers. Although cfDNA scavenging strategies have been developed for inflammation modulation in previous studies, this fall short in clinical settings due to the excessive neutrophil extracellular trap (NET) formation, reactive oxygen and nitrogen species (RONS) and bacterial infections in injured airway tissues. Based on this, a multifunctional boron-based 2D nanoplatform B-PM is designed by coating boron nanosheets (B-NS) with polyamidoamine generation 1 (PG1) dendrimer, which can simultaneously target cfDNA, NETs, RONS, and bacteria. The effects of B-PM in promoting mucosal repair, reducing airway inflammation, and mucus production have been demonstrated in model mice, and the therapeutic effect is superior to dexamethasone. Furthermore, flow cytometry with clustering analysis and transcriptome analysis with RNA-sequencing are adopted to comprehensively evaluate the in vivo anti-inflammation therapeutic effects. These findings emphasize the significance of a multi-targeting strategy to modulate dysregulated inflammation and highlight multifunctional boron-based 2D nanoplatforms for the amelioration of respiratory inflammatory diseases.

{"title":"Multifunctional Boron-based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators.","authors":"Changyi Xu, Ming Liu, Xinran Xie, Zhixin Li, Yuefei Zhu, Yang Ye, Mengya Du, Suhua Hu, Tianrun Liu, Yubiao Guo, Weiping Wen, Huanliang Liu, Zhaoxu Tu","doi":"10.1002/advs.202412626","DOIUrl":"https://doi.org/10.1002/advs.202412626","url":null,"abstract":"<p><p>Effective management of serious respiratory diseases, such as asthma and recalcitrant rhinitis, remains a global challenge. Here, it is shown that induced sputum supernatants (ISS) from patients with asthma contain higher levels of cell-free DNA (cfDNA) compared to that of healthy volunteers. Although cfDNA scavenging strategies have been developed for inflammation modulation in previous studies, this fall short in clinical settings due to the excessive neutrophil extracellular trap (NET) formation, reactive oxygen and nitrogen species (RONS) and bacterial infections in injured airway tissues. Based on this, a multifunctional boron-based 2D nanoplatform B-P<sub>M</sub> is designed by coating boron nanosheets (B-NS) with polyamidoamine generation 1 (PG1) dendrimer, which can simultaneously target cfDNA, NETs, RONS, and bacteria. The effects of B-P<sub>M</sub> in promoting mucosal repair, reducing airway inflammation, and mucus production have been demonstrated in model mice, and the therapeutic effect is superior to dexamethasone. Furthermore, flow cytometry with clustering analysis and transcriptome analysis with RNA-sequencing are adopted to comprehensively evaluate the in vivo anti-inflammation therapeutic effects. These findings emphasize the significance of a multi-targeting strategy to modulate dysregulated inflammation and highlight multifunctional boron-based 2D nanoplatforms for the amelioration of respiratory inflammatory diseases.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2412626"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-Tough Copper-Copper Bonding by Nano-Oxide-Dispersed Copper Nanomembranes.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202408302
Yun Teng, Wenqing Zhu, Qing Wang, Zhibo Zhang, Hang Wang, Baisong Guo, Ziyin Yang, Hao Gong, Chuan He, Boxi Qu, Shien-Ping Feng, Yong Yang

Metal-metal bonding has played a pivotal role in advancing human technologies across various industrial sectors. As devices continue to miniaturize, there is an increasing need for efficient bonding techniques capable of achieving metal-metal bonds at smaller length scales. In this study, a facile but effective bonding technique is developed that enables the bonding of randomly oriented copper with copper nanomembranes under low temperatures and pressures. The fabricated copper nanomembranes, with a thickness of ≈50 nm and a width of 1 cm or above, exhibit a unique heterogeneous nanostructure, comprising copper nanocrystals along with nano-copper-oxide dispersions. Consequently, these copper nanomembranes display exceptional mechanical properties, including an ultra-low elastic modulus of ≈35 GPa, a remarkable yield strength of ≈1 GPa, and excellent ductility of ≈40%, overcoming the conventional strength-ductility trade-off observed in various copper alloys. Most importantly, these ultra-soft copper nanomembranes serve as metallic "glues", promoting grain growth across the bonding interface between randomly oriented copper surfaces. This process leads to an average interfacial shear strength of up to 73 MPa at room temperature, representing an approximate 35 times increase in bonding strength compared to direct copper-copper bonding achieved under identical temperature and pressure conditions.

{"title":"Ultra-Tough Copper-Copper Bonding by Nano-Oxide-Dispersed Copper Nanomembranes.","authors":"Yun Teng, Wenqing Zhu, Qing Wang, Zhibo Zhang, Hang Wang, Baisong Guo, Ziyin Yang, Hao Gong, Chuan He, Boxi Qu, Shien-Ping Feng, Yong Yang","doi":"10.1002/advs.202408302","DOIUrl":"https://doi.org/10.1002/advs.202408302","url":null,"abstract":"<p><p>Metal-metal bonding has played a pivotal role in advancing human technologies across various industrial sectors. As devices continue to miniaturize, there is an increasing need for efficient bonding techniques capable of achieving metal-metal bonds at smaller length scales. In this study, a facile but effective bonding technique is developed that enables the bonding of randomly oriented copper with copper nanomembranes under low temperatures and pressures. The fabricated copper nanomembranes, with a thickness of ≈50 nm and a width of 1 cm or above, exhibit a unique heterogeneous nanostructure, comprising copper nanocrystals along with nano-copper-oxide dispersions. Consequently, these copper nanomembranes display exceptional mechanical properties, including an ultra-low elastic modulus of ≈35 GPa, a remarkable yield strength of ≈1 GPa, and excellent ductility of ≈40%, overcoming the conventional strength-ductility trade-off observed in various copper alloys. Most importantly, these ultra-soft copper nanomembranes serve as metallic \"glues\", promoting grain growth across the bonding interface between randomly oriented copper surfaces. This process leads to an average interfacial shear strength of up to 73 MPa at room temperature, representing an approximate 35 times increase in bonding strength compared to direct copper-copper bonding achieved under identical temperature and pressure conditions.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2408302"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenal High-Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202413299
Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang

Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects. This study found that PDE increased histone 3 lysine 27 acetylation (H3K27ac) levels in the promoter region of cholesterol 27 hydroxylase (CYP27A1) and its expression, as well as total bile acids (TBA) concentrations and enhanced endoplasmic reticulum stress (ERS) and inhibit steroid synthesis in adult male offspring rat adrenal glands. However, it is reversed in females. Tracing back to the prenatal stage and in combination with cellular experiments, it is further revealed that dexamethasone can regulate glucocorticoid receptor (GR)/SET binding protein 1 (SETBP1)/CYP27A1 signal pathway, consequently cause intracellular increase of bile acids. Finally, administration of nilvadipine (CYP27A1 inhibitor) to male offspring for 4 weeks after birth resulted in the reversal of PDE-induced adrenal morphological and functional damage. In conclusion, PDE induces fetal adrenal corticosteroid dysfunction in adult male offspring by upregulating CYP27A1 promoter region H3K27ac levels and expression in the adrenal gland through the GR/SETBP1 signaling pathway. This effect persists beyond birth, leading to bile acids local increase and subsequent enhancement of ERS, ultimately inducing cellular dysfunction in adult adrenal glands.

{"title":"Adrenal High-Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure.","authors":"Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang","doi":"10.1002/advs.202413299","DOIUrl":"https://doi.org/10.1002/advs.202413299","url":null,"abstract":"<p><p>Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects. This study found that PDE increased histone 3 lysine 27 acetylation (H3K27ac) levels in the promoter region of cholesterol 27 hydroxylase (CYP27A1) and its expression, as well as total bile acids (TBA) concentrations and enhanced endoplasmic reticulum stress (ERS) and inhibit steroid synthesis in adult male offspring rat adrenal glands. However, it is reversed in females. Tracing back to the prenatal stage and in combination with cellular experiments, it is further revealed that dexamethasone can regulate glucocorticoid receptor (GR)/SET binding protein 1 (SETBP1)/CYP27A1 signal pathway, consequently cause intracellular increase of bile acids. Finally, administration of nilvadipine (CYP27A1 inhibitor) to male offspring for 4 weeks after birth resulted in the reversal of PDE-induced adrenal morphological and functional damage. In conclusion, PDE induces fetal adrenal corticosteroid dysfunction in adult male offspring by upregulating CYP27A1 promoter region H3K27ac levels and expression in the adrenal gland through the GR/SETBP1 signaling pathway. This effect persists beyond birth, leading to bile acids local increase and subsequent enhancement of ERS, ultimately inducing cellular dysfunction in adult adrenal glands.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413299"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202416905
Haiqiao Huang, Yingnan Wu, Xin He, Yahang Liu, Jing-Hui Zhu, Mingrui Gu, Danhong Zhou, Saran Long, Yahui Chen, Lei Wang, Mingle Li, Xiaoqiang Chen, Xiaojun Peng

Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging-guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high-contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self-assembly of two cyanines, C5TNa (anionic) and Cy-Et (cationic). The Coulombic interactions between C5TNa and Cy-Et facilitate the formation of a complementary cyanine pair (C5T-ET) and the creation of supramolecular CT-J-type aggregates in water. This complementary cyanine pair (C5T-ET) results in completely quenched fluorescence and significantly enhances nonradiative deactivation (≈22 ps), leading to a 3.3-fold increase in photothermal conversion efficiency and a 7.1-fold enhancement in photoacoustic response compared to indocyanine green (ICG). As a result, the J-type aggregate cyanine pair (C5T-ET) demonstrates high photoacoustic imaging capability and remarkable antitumor phototheranostic efficacy in vivo, highlighting its potential for clinical applications. This work provides strong experimental evidence for the superior performance of the complementary cyanine pair (C5T-ET) in enhancing photosensitization and photoacoustic response. It is believed that this strategy will propel the advancement of controllable dye J-aggregates and contribute to the practical implementation of photoacoustic imaging and phototherapy in vivo.

{"title":"Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.","authors":"Haiqiao Huang, Yingnan Wu, Xin He, Yahang Liu, Jing-Hui Zhu, Mingrui Gu, Danhong Zhou, Saran Long, Yahui Chen, Lei Wang, Mingle Li, Xiaoqiang Chen, Xiaojun Peng","doi":"10.1002/advs.202416905","DOIUrl":"https://doi.org/10.1002/advs.202416905","url":null,"abstract":"<p><p>Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging-guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high-contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self-assembly of two cyanines, C5TNa (anionic) and Cy-Et (cationic). The Coulombic interactions between C5TNa and Cy-Et facilitate the formation of a complementary cyanine pair (C5T-ET) and the creation of supramolecular CT-J-type aggregates in water. This complementary cyanine pair (C5T-ET) results in completely quenched fluorescence and significantly enhances nonradiative deactivation (≈22 ps), leading to a 3.3-fold increase in photothermal conversion efficiency and a 7.1-fold enhancement in photoacoustic response compared to indocyanine green (ICG). As a result, the J-type aggregate cyanine pair (C5T-ET) demonstrates high photoacoustic imaging capability and remarkable antitumor phototheranostic efficacy in vivo, highlighting its potential for clinical applications. This work provides strong experimental evidence for the superior performance of the complementary cyanine pair (C5T-ET) in enhancing photosensitization and photoacoustic response. It is believed that this strategy will propel the advancement of controllable dye J-aggregates and contribute to the practical implementation of photoacoustic imaging and phototherapy in vivo.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2416905"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogen-Associated Filling-Controlled Mottronics Within Thermodynamically Metastable Vanadium Dioxide.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202414991
Xuanchi Zhou, Yongjie Jiao, Wentian Lu, Jinjian Guo, Xiaohui Yao, Jiahui Ji, Guowei Zhou, Huihui Ji, Zhe Yuan, Xiaohong Xu

The discovery of hydrogen-associated topotactic phase modulations in correlated oxide system has emerged as a promising paradigm to explore exotic electronic states and physical functionality. Here hydrogen-induced Mott phase transitions are demonstrated for metastable VO2 (B) toward new electron-itinerant hydrogenated phases via introducing non-equilibrium condition, delicately delivering a rich spectrum of hydrogen-associated electronic states. Of particular interest, the highly robust but reversible hydrogenated phase achievable in metastable VO2 (B) significantly benefits protonic device applications, which is in contrast with well-known VO2 (M1), where the metallic hydrogenated phase readily turns into insulating state with extensive hydrogen doping. Establishing correlated VO2 at metastable status fundamentally surpasses the thermodynamic restrictions to expand the adjustability in their electronic structure, giving rise to new electronic states and a superior resistive switching of 102-105 to the counterparts in widely-reported VO2 (M1). Utilizing the theoretical calculations and synchrotron radiation analysis, the hydrogen-associated phase modulation in metastable VO2 (B) is dominantly driven by band-filling-controlled orbital reconfiguration, while the concurrent structural evolution unveils a strong ion-electron-lattice coupling. The present work provides fundamentally new tuning knob for adjusting the energy landscape of electron-correlated system, advancing the rational design of unachievable electronic states in hydrogen-related equilibrium phase diagram.

{"title":"Hydrogen-Associated Filling-Controlled Mottronics Within Thermodynamically Metastable Vanadium Dioxide.","authors":"Xuanchi Zhou, Yongjie Jiao, Wentian Lu, Jinjian Guo, Xiaohui Yao, Jiahui Ji, Guowei Zhou, Huihui Ji, Zhe Yuan, Xiaohong Xu","doi":"10.1002/advs.202414991","DOIUrl":"https://doi.org/10.1002/advs.202414991","url":null,"abstract":"<p><p>The discovery of hydrogen-associated topotactic phase modulations in correlated oxide system has emerged as a promising paradigm to explore exotic electronic states and physical functionality. Here hydrogen-induced Mott phase transitions are demonstrated for metastable VO<sub>2</sub> (B) toward new electron-itinerant hydrogenated phases via introducing non-equilibrium condition, delicately delivering a rich spectrum of hydrogen-associated electronic states. Of particular interest, the highly robust but reversible hydrogenated phase achievable in metastable VO<sub>2</sub> (B) significantly benefits protonic device applications, which is in contrast with well-known VO<sub>2</sub> (M1), where the metallic hydrogenated phase readily turns into insulating state with extensive hydrogen doping. Establishing correlated VO<sub>2</sub> at metastable status fundamentally surpasses the thermodynamic restrictions to expand the adjustability in their electronic structure, giving rise to new electronic states and a superior resistive switching of 10<sup>2</sup>-10<sup>5</sup> to the counterparts in widely-reported VO<sub>2</sub> (M1). Utilizing the theoretical calculations and synchrotron radiation analysis, the hydrogen-associated phase modulation in metastable VO<sub>2</sub> (B) is dominantly driven by band-filling-controlled orbital reconfiguration, while the concurrent structural evolution unveils a strong ion-electron-lattice coupling. The present work provides fundamentally new tuning knob for adjusting the energy landscape of electron-correlated system, advancing the rational design of unachievable electronic states in hydrogen-related equilibrium phase diagram.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2414991"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanodot-Inspired Precise Bacterial Gene Suppression in a Smart Hydrogel Bandage for Underwater Wound Healing.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202415169
Qingsong Zhang, Menghan Lu, Richang Ou, Hong Lin, Guanhua Xuan, Xiudan Wang, Xiaofeng Xu, Weiwei Zhang, Guoqing Wang

The complex and dynamic nature of aquatic ecosystems, particularly in marine environments, makes managing wound infections a significant challenge for individuals engaged in underwater activities and for aquatic organisms. Although antibiotics have played a critical role in safeguarding humans and aquatic health, their risk of drug resistance and environmental impact present substantial obstacles to long-term sustainability. Using fin rot disease in turbot (Scophthalmus maximus) caused by infection of Vibrio anguillarum (V. anguillarum) as a model, a new strategy is presented that employs a carbon dot (CD)-based antisense oligonucleotide (ASO) delivery system, combined with an adhesive hydrogel, to achieve targeted gene silencing of V. anguillarum for underwater healing. The CDs that cause enhanced cytoplasmic membrane permeability, efficiently deliver ASOs into V. anguillarum without requiring additional equipment or chemical facilitators. The specific design of the ASO sequence enables targeted silencing of empA, achieving efficiency as high as 71.2%. An adhesive hydrogel is applied to boost the local concentration of ASO/CDs at wound sites in seawater, effectively sealing the infected area and preventing fin rot disease in turbot. This study pioneer targeted bacterial gene regulation using CD-based delivery integrated with a hydrogel bandage, offering practical solutions for managing underwater bacterial diseases.

{"title":"Nanodot-Inspired Precise Bacterial Gene Suppression in a Smart Hydrogel Bandage for Underwater Wound Healing.","authors":"Qingsong Zhang, Menghan Lu, Richang Ou, Hong Lin, Guanhua Xuan, Xiudan Wang, Xiaofeng Xu, Weiwei Zhang, Guoqing Wang","doi":"10.1002/advs.202415169","DOIUrl":"https://doi.org/10.1002/advs.202415169","url":null,"abstract":"<p><p>The complex and dynamic nature of aquatic ecosystems, particularly in marine environments, makes managing wound infections a significant challenge for individuals engaged in underwater activities and for aquatic organisms. Although antibiotics have played a critical role in safeguarding humans and aquatic health, their risk of drug resistance and environmental impact present substantial obstacles to long-term sustainability. Using fin rot disease in turbot (Scophthalmus maximus) caused by infection of Vibrio anguillarum (V. anguillarum) as a model, a new strategy is presented that employs a carbon dot (CD)-based antisense oligonucleotide (ASO) delivery system, combined with an adhesive hydrogel, to achieve targeted gene silencing of V. anguillarum for underwater healing. The CDs that cause enhanced cytoplasmic membrane permeability, efficiently deliver ASOs into V. anguillarum without requiring additional equipment or chemical facilitators. The specific design of the ASO sequence enables targeted silencing of empA, achieving efficiency as high as 71.2%. An adhesive hydrogel is applied to boost the local concentration of ASO/CDs at wound sites in seawater, effectively sealing the infected area and preventing fin rot disease in turbot. This study pioneer targeted bacterial gene regulation using CD-based delivery integrated with a hydrogel bandage, offering practical solutions for managing underwater bacterial diseases.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2415169"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202413925
Dan Wang, Shuya Wang, Jinjin Liu, Xiaojing Shi, Tingli Xiong, Ruishi Li, Wei Wei, Liandong Ji, Qiong Huang, Xuejun Gong, Kelong Ai

Acute pancreatitis (AP) is a primary contributor to hospitalization and in-hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail to overcome the physiological barriers of the pancreas to effectively reach PACs mitochondria due to the trade-off between conventional positively charged mitochondrial-targeting groups and their inability to penetrate the blood-pancreas barrier (BPB). Here, a tungsten-based heteropolyacid nano-antioxidant (mTWNDs) is introduced, co-modified with tannic acid (TA) and melanin, enabling site-specific clearance of mtROS in PACs, offering a highly effective treatment for AP. TA exhibits a strong affinity for proline-rich type III collagen and the mitochondrial outer membrane protein TOM20. This unique property allows mTWNDs to traverse the damaged BPB-exposing type III collagen to reach PACs and subsequently penetrate mitochondria for targeted mtROS elimination. In cerulein-induced AP mice, mTWNDs reversed AP at 1/50th the dose of N-acetylcysteine, suppressing PACs apoptosis and inflammation by blocking the stimulator of the interferon genes pathway activation in macrophage. This study establishes a mitochondrial-targeting antioxidant nanomedicine strategy for AP treatment.

{"title":"Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.","authors":"Dan Wang, Shuya Wang, Jinjin Liu, Xiaojing Shi, Tingli Xiong, Ruishi Li, Wei Wei, Liandong Ji, Qiong Huang, Xuejun Gong, Kelong Ai","doi":"10.1002/advs.202413925","DOIUrl":"https://doi.org/10.1002/advs.202413925","url":null,"abstract":"<p><p>Acute pancreatitis (AP) is a primary contributor to hospitalization and in-hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail to overcome the physiological barriers of the pancreas to effectively reach PACs mitochondria due to the trade-off between conventional positively charged mitochondrial-targeting groups and their inability to penetrate the blood-pancreas barrier (BPB). Here, a tungsten-based heteropolyacid nano-antioxidant (mTWNDs) is introduced, co-modified with tannic acid (TA) and melanin, enabling site-specific clearance of mtROS in PACs, offering a highly effective treatment for AP. TA exhibits a strong affinity for proline-rich type III collagen and the mitochondrial outer membrane protein TOM20. This unique property allows mTWNDs to traverse the damaged BPB-exposing type III collagen to reach PACs and subsequently penetrate mitochondria for targeted mtROS elimination. In cerulein-induced AP mice, mTWNDs reversed AP at 1/50th the dose of N-acetylcysteine, suppressing PACs apoptosis and inflammation by blocking the stimulator of the interferon genes pathway activation in macrophage. This study establishes a mitochondrial-targeting antioxidant nanomedicine strategy for AP treatment.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2413925"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.
IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-02-14 DOI: 10.1002/advs.202500061
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua

Electroactive platforms have gained significant attention for their ability to convert various types of energy into electrical signals, offering promising applications in diverse biomedical fields. In cardiovascular care, these platforms are increasingly valued for their innovative solutions in managing cardiac functions and disorders. By regulating electrical activity in the heart, electroactive platforms offer novel methods for managing abnormal heart rhythms. This review explores the latest advancements in electroactive systems, categorizing them based on their energy sources and mechanisms, such as self-powered and conductive systems. It also highlights their applications in arrhythmia management, including monitoring, intervention, pacing, and repairing. Finally, the challenges, limitations, and future opportunities for clinical translation of these technologies are discussed.

{"title":"Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.","authors":"Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua","doi":"10.1002/advs.202500061","DOIUrl":"https://doi.org/10.1002/advs.202500061","url":null,"abstract":"<p><p>Electroactive platforms have gained significant attention for their ability to convert various types of energy into electrical signals, offering promising applications in diverse biomedical fields. In cardiovascular care, these platforms are increasingly valued for their innovative solutions in managing cardiac functions and disorders. By regulating electrical activity in the heart, electroactive platforms offer novel methods for managing abnormal heart rhythms. This review explores the latest advancements in electroactive systems, categorizing them based on their energy sources and mechanisms, such as self-powered and conductive systems. It also highlights their applications in arrhythmia management, including monitoring, intervention, pacing, and repairing. Finally, the challenges, limitations, and future opportunities for clinical translation of these technologies are discussed.</p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":" ","pages":"e2500061"},"PeriodicalIF":14.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Advanced Science
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