{"title":"Immunotherapy for Cancer: Strategies of Immunomodulation Therapy in Combination with Conventional Approaches","authors":"Tanvi Gupta","doi":"10.14744/ejmo.2022.51601","DOIUrl":"https://doi.org/10.14744/ejmo.2022.51601","url":null,"abstract":"DOI: 10.14744/ejmo.2022.51601 EJMO 2022;6(1):1–11 Eurasian Journal of Medicine and Oncology","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78189722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.19797
Y. Mori
Objectives: Treatment of multiple brain metastases more than 10 is challenging. Whole brain radiotherapy (WBRT) is generally believed to be the first treatment choice. In order to escape from mental deterioration after WBRT, we have performed Gamma Knife stereotactic radiosurgery (GKS) for numerous small brain metastases. Methods: Twelve cases of numerous (more than 30) brain metastases were treated by GKS. Mean total session number was 5.42 times, ranging 2 to 17. Each tumor was treated with the margin dose between 14 to 20 Gy. The tumor number treated in whole sessions was ranged from 31 to 144 (mean, 70.8). Results: Almost all the irradiated tumors either disappeared or shrank at the patient’s death or at the last follow-up, though new metastatic tumors were subsequently developed in some cases which required an additional treatment with GKS. At the last follow-up (3 to 51 months after GKS), nine cases were alive and well and three were dead. As adverse effects, two cases demonstrated seizures by radiation brain injury and another showed a gait disturbance. No apparent mental deterioration was observed during follow-up. Conclusion: Radiosurgery for numerous small brain metastases may be preferable rather than WBRT.
{"title":"Multi-Session Radiosurgery for Numerous Small Brain Metastases","authors":"Y. Mori","doi":"10.14744/ejmo.2022.19797","DOIUrl":"https://doi.org/10.14744/ejmo.2022.19797","url":null,"abstract":"Objectives: Treatment of multiple brain metastases more than 10 is challenging. Whole brain radiotherapy (WBRT) is generally believed to be the first treatment choice. In order to escape from mental deterioration after WBRT, we have performed Gamma Knife stereotactic radiosurgery (GKS) for numerous small brain metastases. Methods: Twelve cases of numerous (more than 30) brain metastases were treated by GKS. Mean total session number was 5.42 times, ranging 2 to 17. Each tumor was treated with the margin dose between 14 to 20 Gy. The tumor number treated in whole sessions was ranged from 31 to 144 (mean, 70.8). Results: Almost all the irradiated tumors either disappeared or shrank at the patient’s death or at the last follow-up, though new metastatic tumors were subsequently developed in some cases which required an additional treatment with GKS. At the last follow-up (3 to 51 months after GKS), nine cases were alive and well and three were dead. As adverse effects, two cases demonstrated seizures by radiation brain injury and another showed a gait disturbance. No apparent mental deterioration was observed during follow-up. Conclusion: Radiosurgery for numerous small brain metastases may be preferable rather than WBRT.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76691176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.57872
J. Spiliotis
,
，
{"title":"Role of Early Bedside HIPEC as Adjuvant Treatment in Colorectal Peritoneal Metastasis","authors":"J. Spiliotis","doi":"10.14744/ejmo.2022.57872","DOIUrl":"https://doi.org/10.14744/ejmo.2022.57872","url":null,"abstract":",","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77652572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2021.47478
I. Parra
{"title":"Sarcomatoid Transformation of Cromophobe Renal Cell Carcinoma: An Unusual Pathology. Our Experience, Definition of Therapeutic Guidelines and Review of Literature","authors":"I. Parra","doi":"10.14744/ejmo.2021.47478","DOIUrl":"https://doi.org/10.14744/ejmo.2021.47478","url":null,"abstract":"","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75482584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adhesive Glue vs Subcuticular Sutures for Cesarean Section Skin Closure: A Double Blind Randomized Controlled Trial","authors":"H. Rahman","doi":"10.14744/ejmo.2021.12232","DOIUrl":"https://doi.org/10.14744/ejmo.2021.12232","url":null,"abstract":"DOI: 10.14744/ejmo.2021.12232 EJMO 2021;5(4):332–340","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"212 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78782496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atypical Chronic Myeloid Leukemia: Case Report and Review of Literature","authors":"B. Miles","doi":"10.14744/ejmo.2021.24484","DOIUrl":"https://doi.org/10.14744/ejmo.2021.24484","url":null,"abstract":"DOI: 10.14744/ejmo.2021.24484 EJMO 2021;5(4):358–360","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90872044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.47068
M. Barone
Faced with the complexity of emergency surgery and the aging of the population, it is increasingly common to have to deal with critically ill patients who require intensive care postoperatively. Surgical stress amplifies senescence mechanisms where the organism is called to face the establishment of both early and late pathophysiological mechanisms disrupting homeostasis. In this scenario, sarcopenia represents a prognostic factor with a multifactorial etiology that can lead to fearful complications in the early postoperative period. As an octogenarian adaptation, its multifactorial genesis allows to act and counterbalance the action of concomitant modifiable factors through post-operative optimization strategies. Abstract Article: Frontera R, Barone M, Ippoliti M. When Appearances Can be Deceiving: Sarcopenia and Obesity Paradox. Unsolved Issues in Critically Ill Surgical Patients. 2022;6(3):
面对急诊手术的复杂性和人口老龄化，需要在术后进行重症监护的危重患者越来越普遍。手术应激放大了衰老机制，生物体需要面对破坏体内平衡的早期和晚期病理生理机制的建立。在这种情况下，肌肉减少症是一个多因素的预后因素，可导致术后早期可怕的并发症。作为一种八十多岁的适应性，其多因素的发生允许通过术后优化策略来作用和抵消伴随的可改变因素的作用。文章摘要:Frontera R, Barone M, Ippoliti M.当表象可以欺骗:肌肉减少和肥胖悖论。外科危重患者未解决的问题[j] . 2022;6(3):
{"title":"When Appearances Can be Deceiving: Sarcopenia and Obesity Paradox. Unsolved Issues in Critically Ill Surgical Patients","authors":"M. Barone","doi":"10.14744/ejmo.2022.47068","DOIUrl":"https://doi.org/10.14744/ejmo.2022.47068","url":null,"abstract":"Faced with the complexity of emergency surgery and the aging of the population, it is increasingly common to have to deal with critically ill patients who require intensive care postoperatively. Surgical stress amplifies senescence mechanisms where the organism is called to face the establishment of both early and late pathophysiological mechanisms disrupting homeostasis. In this scenario, sarcopenia represents a prognostic factor with a multifactorial etiology that can lead to fearful complications in the early postoperative period. As an octogenarian adaptation, its multifactorial genesis allows to act and counterbalance the action of concomitant modifiable factors through post-operative optimization strategies. Abstract Article: Frontera R, Barone M, Ippoliti M. When Appearances Can be Deceiving: Sarcopenia and Obesity Paradox. Unsolved Issues in Critically Ill Surgical Patients. 2022;6(3):","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90251531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Angiotensin-Converting Enzyme Inhibitor ‘Enalapril’ Increases the Anti-Proliferative Activity of 5-Fluorouracil in Colorectal Cancer Cells","authors":"Asma Mostafapour","doi":"10.14744/ejmo.2021.60832","DOIUrl":"https://doi.org/10.14744/ejmo.2021.60832","url":null,"abstract":"DOI: 10.14744/ejmo.2021.60832 EJMO 2021;5(4):318–326","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90531996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2021.16863
Xian-yin Xu
{"title":"MiR-19a Mediates Epithelial Mesenchymal Transition of Breast Cancer by Inhibiting KRAS","authors":"Xian-yin Xu","doi":"10.14744/ejmo.2021.16863","DOIUrl":"https://doi.org/10.14744/ejmo.2021.16863","url":null,"abstract":"","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82298481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.12505
C. Oner
Objectives: Triple negative breast cancer cells are estrogen, progesterone
目的:三阴性乳腺癌细胞为雌激素、黄体酮
{"title":"PIWI Interacting RNA-823: Epigenetic Regulator of The Triple Negative Breast Cancer Cells Proliferation","authors":"C. Oner","doi":"10.14744/ejmo.2022.12505","DOIUrl":"https://doi.org/10.14744/ejmo.2022.12505","url":null,"abstract":"Objectives: Triple negative breast cancer cells are estrogen, progesterone","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87138874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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