Pub Date : 2016-03-01DOI: 10.1177/014556131609500303
A. Batıoğlu-Karaaltın, Ozlem Saatci, M. Akpinar, M. Celik, O. Develioglu, O. Yigit, M. Külekçi, A. Akarsubaşı
The aim of this study was to investigate the presence of Helicobacter pylori in human lacrimal and nasal secretions. Eighty patients with complaints of dyspepsia who had undergone endoscopies and gastric antrum biopsies were included in the study. A total of five specimens, including 2 lacrimal secretion samples, 2 nasal mucosal swab samples, and 1 gastric antrum biopsy, were collected from each patient and investigated with polymerase chain reaction (PCR) methods consisting of the urease enzyme coding gene GlmM (UreC) and the H pylori-specific 16S rRNA coding gene. The Reflux Symptom Index and ophthalmologic complaints of the patients were recorded. The detected positivity rates of the H pylori 16S rRNA coding gene in gastric biopsies and nasal mucous and lacrimal secretions were 55, 11.2, and 20%, respectively. The patients were grouped as gastric-antrum-biopsy–negative (Group I [n = 36]) and –positive (Group II [n = 44). In Group II, H pylori positivity in the lacrimal and nasal mucous secretions was 36.3 and 18%, respectively. A comparison between the groups in terms of H pylori presence in nasal mucous and lacrimal secretions yielded statistically significant differences (p = 0.0001, p = 0.003). The simultaneous presence of H pylori in nasal mucous and lacrimal secretions was 13.6% in Group II. H pylori positivity in nasal mucous and lacrimal secretions had a positive moderate correlation (r = 0.40; p = 0.0003). The present study is the first report on the presence of H pylori in lacrimal secretions through nested PCR, which suggested the presence of a number of mechanisms for H pylori transmission to lacrimal secretions.
{"title":"Helicobacter pylori in lacrimal secretions","authors":"A. Batıoğlu-Karaaltın, Ozlem Saatci, M. Akpinar, M. Celik, O. Develioglu, O. Yigit, M. Külekçi, A. Akarsubaşı","doi":"10.1177/014556131609500303","DOIUrl":"https://doi.org/10.1177/014556131609500303","url":null,"abstract":"The aim of this study was to investigate the presence of Helicobacter pylori in human lacrimal and nasal secretions. Eighty patients with complaints of dyspepsia who had undergone endoscopies and gastric antrum biopsies were included in the study. A total of five specimens, including 2 lacrimal secretion samples, 2 nasal mucosal swab samples, and 1 gastric antrum biopsy, were collected from each patient and investigated with polymerase chain reaction (PCR) methods consisting of the urease enzyme coding gene GlmM (UreC) and the H pylori-specific 16S rRNA coding gene. The Reflux Symptom Index and ophthalmologic complaints of the patients were recorded. The detected positivity rates of the H pylori 16S rRNA coding gene in gastric biopsies and nasal mucous and lacrimal secretions were 55, 11.2, and 20%, respectively. The patients were grouped as gastric-antrum-biopsy–negative (Group I [n = 36]) and –positive (Group II [n = 44). In Group II, H pylori positivity in the lacrimal and nasal mucous secretions was 36.3 and 18%, respectively. A comparison between the groups in terms of H pylori presence in nasal mucous and lacrimal secretions yielded statistically significant differences (p = 0.0001, p = 0.003). The simultaneous presence of H pylori in nasal mucous and lacrimal secretions was 13.6% in Group II. H pylori positivity in nasal mucous and lacrimal secretions had a positive moderate correlation (r = 0.40; p = 0.0003). The present study is the first report on the presence of H pylori in lacrimal secretions through nested PCR, which suggested the presence of a number of mechanisms for H pylori transmission to lacrimal secretions.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"32 1","pages":"E8 - E9"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78412066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/014556131609500302
Lester D. R. Thompson
Rhinosporidium seeberi is the etiologic agent of a chronic, and usually painless, localized granulomatous infection of the mucous membranes of the sinonasal tract, conjunctiva, and urethra. Endemic in India and Sri Lanka, the disease is becoming more significant as a result of migration. R seeberi has not been definitively cultured but is thought to be a blue-green algae, with the infectious agent being a thick-walled sporangium containing endospores. It is passed to humans from animals (cats, free-grazing horses) or possibly fomites, identified in water or soil contaminated by waste. Common symptoms are nonspecific and include nasal obstruction, epistaxis, and rhinorrhea. Nasal and urethral infections have a male predominance, while conjunctival infections have a female predominance. All ages are affected, although there is a peak in the third and fourth decades. Surgical treatment is the mainstay of therapy for rhinosporidiosis, but there is a 10% recurrence rate. While dapsone may be helpful, antibiotics for the most part are ineffective. The lesions clinically form single or multiple polypoid, friable, red-to-pink masses, frequently mistaken clinically for neoplasia. Rhinosporidiosis is characterized histologically by a well-developed acute and chronic inflammation that surrounds round, thickwalled sporangia (up to 300 μm) (figure 1) filled with hundreds of small (2 to 9-μm endospores/algae) (figure 2). There may be overlying surface hyperplasia (pseudoepitheliomatous hyperplasia). The cyst walls are thick and birefringent, stained with hematoxylin and eosin (deeply magenta), Grocott Gomori methenamine silver stain (GMS), digested periodic acid– Schiff, and Mayer mucicarmine. The sporangia are below the surface, not within the epithelium. The clinical and pathology differential diagnosis includes squamous papilloma, oncocytic type; Coccidioidomycosis immitis; and other infectious agents.
{"title":"Rhinosporidiosis","authors":"Lester D. R. Thompson","doi":"10.1177/014556131609500302","DOIUrl":"https://doi.org/10.1177/014556131609500302","url":null,"abstract":"Rhinosporidium seeberi is the etiologic agent of a chronic, and usually painless, localized granulomatous infection of the mucous membranes of the sinonasal tract, conjunctiva, and urethra. Endemic in India and Sri Lanka, the disease is becoming more significant as a result of migration. R seeberi has not been definitively cultured but is thought to be a blue-green algae, with the infectious agent being a thick-walled sporangium containing endospores. It is passed to humans from animals (cats, free-grazing horses) or possibly fomites, identified in water or soil contaminated by waste. Common symptoms are nonspecific and include nasal obstruction, epistaxis, and rhinorrhea. Nasal and urethral infections have a male predominance, while conjunctival infections have a female predominance. All ages are affected, although there is a peak in the third and fourth decades. Surgical treatment is the mainstay of therapy for rhinosporidiosis, but there is a 10% recurrence rate. While dapsone may be helpful, antibiotics for the most part are ineffective. The lesions clinically form single or multiple polypoid, friable, red-to-pink masses, frequently mistaken clinically for neoplasia. Rhinosporidiosis is characterized histologically by a well-developed acute and chronic inflammation that surrounds round, thickwalled sporangia (up to 300 μm) (figure 1) filled with hundreds of small (2 to 9-μm endospores/algae) (figure 2). There may be overlying surface hyperplasia (pseudoepitheliomatous hyperplasia). The cyst walls are thick and birefringent, stained with hematoxylin and eosin (deeply magenta), Grocott Gomori methenamine silver stain (GMS), digested periodic acid– Schiff, and Mayer mucicarmine. The sporangia are below the surface, not within the epithelium. The clinical and pathology differential diagnosis includes squamous papilloma, oncocytic type; Coccidioidomycosis immitis; and other infectious agents.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"57 1","pages":"101 - 101"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84029441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/014556131609500304
J. Numminen, A. Bizaki, Jarno Kujansivu, S. Huovinen, M. Rautiainen
Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade, malignant, soft-tissue tumor that typically affects the distal extremities of middle-aged patients. In most cases, it presents as a painless, slowly growing mass within the subcutaneous tissue. It is associated with a low rate of metastasis but a high rate of local recurrence. In addition to the distal extremities, MIFS has been reported in the thigh, arm, forearm, groin, upper back, neck, and temporal area. As far as we know, no case has been previously reported in the nasal area. We report for the first time a case of MIFS presenting on the dorsum of the nose. The painless, 3.0-cm tumor was initially mistaken for reticular erythematous mucinosis, a benign skin condition that occurs when fibroblasts produce abnormally large amounts of mucopolysaccharides. The tumor was surgically removed in its entirety with surgical margins of 3 to 5 mm. During 4 years of follow-up, no clinical or radiologic evidence of a recurrence or metastasis was seen. We discuss the imaging and histologic features of MIFS, as well as its clinical management and follow-up, and we review related reports in the literature.
{"title":"Myxoinflammatory Fibroblastic Sarcoma of the Nose: First Reported Case at an Unusual Location (Nasal Dorsum), with a Review of the Literature","authors":"J. Numminen, A. Bizaki, Jarno Kujansivu, S. Huovinen, M. Rautiainen","doi":"10.1177/014556131609500304","DOIUrl":"https://doi.org/10.1177/014556131609500304","url":null,"abstract":"Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade, malignant, soft-tissue tumor that typically affects the distal extremities of middle-aged patients. In most cases, it presents as a painless, slowly growing mass within the subcutaneous tissue. It is associated with a low rate of metastasis but a high rate of local recurrence. In addition to the distal extremities, MIFS has been reported in the thigh, arm, forearm, groin, upper back, neck, and temporal area. As far as we know, no case has been previously reported in the nasal area. We report for the first time a case of MIFS presenting on the dorsum of the nose. The painless, 3.0-cm tumor was initially mistaken for reticular erythematous mucinosis, a benign skin condition that occurs when fibroblasts produce abnormally large amounts of mucopolysaccharides. The tumor was surgically removed in its entirety with surgical margins of 3 to 5 mm. During 4 years of follow-up, no clinical or radiologic evidence of a recurrence or metastasis was seen. We discuss the imaging and histologic features of MIFS, as well as its clinical management and follow-up, and we review related reports in the literature.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"82 1","pages":"E32 - E35"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80892979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/014556131609500301
Kevin Shaigany, A. Vázquez, Kelvin M Kwong, J. Liu, R. Jyung
{"title":"Endolymphatic Sac Tumor in Association with Von Hippel-Lindau Syndrome","authors":"Kevin Shaigany, A. Vázquez, Kelvin M Kwong, J. Liu, R. Jyung","doi":"10.1177/014556131609500301","DOIUrl":"https://doi.org/10.1177/014556131609500301","url":null,"abstract":"","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"74 1","pages":"96 - 96"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86312297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/014556131609500203
S. Brady, Michele W Wesling, J. Donzelli, Scott M. Kaszuba
We conducted a prospective, descriptive study of 27 individuals with known or suspected dysphagia to investigate the relationship between swallowing frequency, accumulated oropharyngeal secretion levels, and gustatory stimulation. Assessment of the secretion level was quantified with the use of a previously published 5-point rating scale using endoscopy. Overall, we found a moderate relationship between the baseline swallowing frequency at rest and the accumulated oropharyngeal secretion level (Pearson correlation 0.470; p = 0.01). The study sample was divided into two groups based on their secretion level. Group 1 (n = 19; mean age 59.7 ± 21.5 years) included patients whose accumulated oropharyngeal secretion level was rated as 1 (normal) or 2 (mild). Group 2 (n = 8; mean age 69.78 ± 8.35 years) included patients whose accumulated oropharyngeal secretion level was rated as 4 (severe) or 5 (profound). For Group 1, swallowing frequency increased from a baseline of 1.05 to 5.26 swallows over 2 minutes, following gustatory stimulation; for Group 2 it increased from a baseline of 0.125 swallows to 3.5 swallows. These results indicate that individuals with a lower baseline swallowing frequency at rest demonstrated a higher accumulated oropharyngeal secretion level as viewed by nasal endoscopy and that, regardless of secretion level, gustatory stimulation was effective at increasing swallowing frequency. Increasing swallowing frequency may be a functional dysphagia treatment objective in efforts to improve the efficiency of the swallow and may offer better management of accumulated oropharyngeal secretions.
{"title":"Swallowing Frequency: Impact of Accumulated Oropharyngeal Secretion Levels and Gustatory Stimulation","authors":"S. Brady, Michele W Wesling, J. Donzelli, Scott M. Kaszuba","doi":"10.1177/014556131609500203","DOIUrl":"https://doi.org/10.1177/014556131609500203","url":null,"abstract":"We conducted a prospective, descriptive study of 27 individuals with known or suspected dysphagia to investigate the relationship between swallowing frequency, accumulated oropharyngeal secretion levels, and gustatory stimulation. Assessment of the secretion level was quantified with the use of a previously published 5-point rating scale using endoscopy. Overall, we found a moderate relationship between the baseline swallowing frequency at rest and the accumulated oropharyngeal secretion level (Pearson correlation 0.470; p = 0.01). The study sample was divided into two groups based on their secretion level. Group 1 (n = 19; mean age 59.7 ± 21.5 years) included patients whose accumulated oropharyngeal secretion level was rated as 1 (normal) or 2 (mild). Group 2 (n = 8; mean age 69.78 ± 8.35 years) included patients whose accumulated oropharyngeal secretion level was rated as 4 (severe) or 5 (profound). For Group 1, swallowing frequency increased from a baseline of 1.05 to 5.26 swallows over 2 minutes, following gustatory stimulation; for Group 2 it increased from a baseline of 0.125 swallows to 3.5 swallows. These results indicate that individuals with a lower baseline swallowing frequency at rest demonstrated a higher accumulated oropharyngeal secretion level as viewed by nasal endoscopy and that, regardless of secretion level, gustatory stimulation was effective at increasing swallowing frequency. Increasing swallowing frequency may be a functional dysphagia treatment objective in efforts to improve the efficiency of the swallow and may offer better management of accumulated oropharyngeal secretions.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"27 1","pages":"E7 - E9"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75451196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/014556131609500207
J. Bakshi, A. Mohammed, Saudamini J. Lele, R. Nada
Ganglioneuromas are benign tumors that arise from the Schwann cells of the autonomic nervous system. They are usually seen in the posterior mediastinum and the paraspinal retroperitoneum in relation to the sympathetic chain. In the head and neck, they are usually related to the cervical sympathetic ganglia or to the ganglion nodosum of the vagus nerve or the hypoglossal nerve. We describe what we believe is the first reported case of multiple ganglioneuromas of the parapharyngeal space in which two separate cranial nerves were involved. The patient was a 10-year-old girl who presented with a 2-year history of a painless and slowly progressive swelling on the left side of her neck and a 1-year history hoarseness. She had no history of relevant trauma or surgery. Intraoperatively, we found two tumors in the left parapharyngeal space—one that had arisen from the hypoglossal nerve and the other from the vagus nerve. Both ganglioneuromas were surgically removed, but the affected nerves had to be sacrificed. Postoperatively, the patient exhibited hypoglossal nerve and vocal fold palsy, but she was asymptomatic. In addition to the case description, we discuss the difficulties we faced during surgical excision.
{"title":"Ganglioneuromas Involving the Hypoglossal Nerve and the Vagus Nerve in a Child: Surgical Difficulties","authors":"J. Bakshi, A. Mohammed, Saudamini J. Lele, R. Nada","doi":"10.1177/014556131609500207","DOIUrl":"https://doi.org/10.1177/014556131609500207","url":null,"abstract":"Ganglioneuromas are benign tumors that arise from the Schwann cells of the autonomic nervous system. They are usually seen in the posterior mediastinum and the paraspinal retroperitoneum in relation to the sympathetic chain. In the head and neck, they are usually related to the cervical sympathetic ganglia or to the ganglion nodosum of the vagus nerve or the hypoglossal nerve. We describe what we believe is the first reported case of multiple ganglioneuromas of the parapharyngeal space in which two separate cranial nerves were involved. The patient was a 10-year-old girl who presented with a 2-year history of a painless and slowly progressive swelling on the left side of her neck and a 1-year history hoarseness. She had no history of relevant trauma or surgery. Intraoperatively, we found two tumors in the left parapharyngeal space—one that had arisen from the hypoglossal nerve and the other from the vagus nerve. Both ganglioneuromas were surgically removed, but the affected nerves had to be sacrificed. Postoperatively, the patient exhibited hypoglossal nerve and vocal fold palsy, but she was asymptomatic. In addition to the case description, we discuss the difficulties we faced during surgical excision.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"28 1","pages":"E22 - E24"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78161836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/014556131609500208
Judy Pan, T. Harris
External auditory canal stenosis, although uncommon, is a condition that is sometimes encountered by otolaryngologists. This condition has been shown to result from inflammatory changes that may be incited by many different causes. Various methods of stenting the canal open postoperatively have been described. We describe a readily accessible and inexpensive method of stenting the canal open postoperatively. The technique presented has been used effectively in all age groups at our institution, in cases ranging from trauma to postmastoidectomy procedures.
{"title":"External Auditory Canal Stenting with Nonlatex Glove and Gelfoam","authors":"Judy Pan, T. Harris","doi":"10.1177/014556131609500208","DOIUrl":"https://doi.org/10.1177/014556131609500208","url":null,"abstract":"External auditory canal stenosis, although uncommon, is a condition that is sometimes encountered by otolaryngologists. This condition has been shown to result from inflammatory changes that may be incited by many different causes. Various methods of stenting the canal open postoperatively have been described. We describe a readily accessible and inexpensive method of stenting the canal open postoperatively. The technique presented has been used effectively in all age groups at our institution, in cases ranging from trauma to postmastoidectomy procedures.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"53 1","pages":"E25 - E26"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88731264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/014556131609500209
J. Parry, H. Stupak, Calvin M. Johnson
Silicone has been used successfully postoperatively in the prevention of hypertrophic and other types of adverse scars. The Silicone Suture Plate (SSP) is a new, minimally invasive, sterile wound closure device that is applied intraoperatively to prevent adverse scarring. The SSP device permits immediate application of silicone while concurrently allowing for wound-edge tension redistribution. In this prospective, controlled, single-blinded clinical study, 8 consecutive patients undergoing deep-plane rhytidectomy were selected. SSP devices were placed on the patients’ posterior rhytidectomy hairline incision; the mirror-image controlsite underwent standard suturing techniques. Three blinded, independent raters assessed the treatment and control sides at 6-week and 4-month follow-up visits, using the Objective Scar Assessment Scale (OSAS), a validated scar assessment tool. The 6-week OSAS scores revealed an 18.4% improvement on the side with the SSP device (13.3) when compared to the control side (16.3). The 4-month OSAS scores showed a 27.3% improvement on the treatment side from 12.7 (control) to 9.2 (SSP). These OSAS results were found to be statistically significant when taken as an aggregate of the observers’ scores, but not when observers’ scores were measured individually (p < 0.05). In our series of patients, we showed promising results with the use of the SSP device. Early silicone application and tissue tension distribution contributed to an overall more aesthetically pleasing scar compared to those seen with standard suturing techniques, although more testing is required.
{"title":"The Immediate Use of a Silicone Sheet Wound Closure Device in Scar Reduction and Prevention","authors":"J. Parry, H. Stupak, Calvin M. Johnson","doi":"10.1177/014556131609500209","DOIUrl":"https://doi.org/10.1177/014556131609500209","url":null,"abstract":"Silicone has been used successfully postoperatively in the prevention of hypertrophic and other types of adverse scars. The Silicone Suture Plate (SSP) is a new, minimally invasive, sterile wound closure device that is applied intraoperatively to prevent adverse scarring. The SSP device permits immediate application of silicone while concurrently allowing for wound-edge tension redistribution. In this prospective, controlled, single-blinded clinical study, 8 consecutive patients undergoing deep-plane rhytidectomy were selected. SSP devices were placed on the patients’ posterior rhytidectomy hairline incision; the mirror-image controlsite underwent standard suturing techniques. Three blinded, independent raters assessed the treatment and control sides at 6-week and 4-month follow-up visits, using the Objective Scar Assessment Scale (OSAS), a validated scar assessment tool. The 6-week OSAS scores revealed an 18.4% improvement on the side with the SSP device (13.3) when compared to the control side (16.3). The 4-month OSAS scores showed a 27.3% improvement on the treatment side from 12.7 (control) to 9.2 (SSP). These OSAS results were found to be statistically significant when taken as an aggregate of the observers’ scores, but not when observers’ scores were measured individually (p < 0.05). In our series of patients, we showed promising results with the use of the SSP device. Early silicone application and tissue tension distribution contributed to an overall more aesthetically pleasing scar compared to those seen with standard suturing techniques, although more testing is required.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"1 1","pages":"E27 - E33"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89759600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/014556131609500201
J. P. Mirante, D. Christmas, E. Yanagisawa
{"title":"Endoscopic View of a Unilateral Nasal Soft-Tissue Obstruction","authors":"J. P. Mirante, D. Christmas, E. Yanagisawa","doi":"10.1177/014556131609500201","DOIUrl":"https://doi.org/10.1177/014556131609500201","url":null,"abstract":"","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"46 1","pages":"56 - 56"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79459582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-01DOI: 10.1177/014556131609500210
D. Ahn, Jin Ho Sohn, Jae Hyug Kim, Jeong Eun Lee, Shin Hyung Park, Jae Chul Kim
A combination of 5-fluorouracil and cisplatin (FP regimen) is widely used as a standard treatment for head and neck cancer. Recently, capecitabine has received increased attention. We conducted a retrospective study to compare the efficacy and safety of the FP regimen with that of the “XP regimen,” which entails concurrent chemoradiotherapy (CCRT) with capecitabine and cisplatin, in patients with resectable laryngohypopharyngeal squamous cell carcinoma (SCC). We retrospectively reviewed the records of 71 patients—67 men and 4 women, mean age 63.1 years—who had undergone CCRT from August 2004 through March 2010 as a primary treatment for resectable laryngohypopharyngeal SCC. There were 19 patients in the FP group and 52 in the XP group. With regard to chemotherapy morbidity, the XP group had less need for healthcare resources and fewer delays in treatment due to toxicity. After CCRT, a higher (but not statistically significant) rate of complete response was observed in the XP group than in the FP group (71.2 vs. 57.9%; p = 0.291); the XP group also had a better, although not significant, response among patients with neck metastases (67.7 vs. 30%; p = 0.063). During follow-up (mean: 34.8 ± 30.6 mo), recurrence rates were 25.6% in the XP group and 21.4% in the FP group—again, not a statistically significant difference (p = 0.745). At the time of the fnal follow-up, 20 of the 71 patients (28.2%) had died of disease. Compared with the FP group, the XP group had a significantly lower incidence of disease-specific death (21.2 vs. 47.4% respectively; p = 0.030). However, the Kaplan-Meier method identified no significant difference between the two groups in the 3-year survival rate (69.6 vs. 63.2%; p = 0.263). Overall toxicities and grade 3 or 4 toxicities (with the exception of hand-foot syndrome) were generally far less common in the XP group, with statistical significance identified for patients who experienced anemia, nausea, and vomiting. On the basis of our experience, we conclude that the results of the XP regimen were comparable to those of the FP regimen for CCRT in patients with resectable laryngohypopharyngeal SCC in terms of treatment efficacy, toxicity, and patient convenience.
5-氟尿嘧啶联合顺铂(FP方案)被广泛用于头颈癌的标准治疗。最近，卡培他滨受到越来越多的关注。我们进行了一项回顾性研究，比较FP方案与“XP方案”的有效性和安全性，XP方案需要卡培他滨和顺铂同步放化疗(CCRT)，用于可切除的喉下咽鳞状细胞癌(SCC)患者。我们回顾性回顾了71例患者的记录，其中67名男性和4名女性，平均年龄63.1岁，从2004年8月到2010年3月接受了CCRT作为可切除喉下咽鳞状细胞癌的主要治疗。FP组19例，XP组52例。在化疗发病率方面，XP组对医疗资源的需求较少，因毒性导致的治疗延误也较少。CCRT后，XP组的完全缓解率高于FP组(71.2 vs 57.9%;P = 0.291);在颈部转移患者中，XP组也有更好的反应，尽管不显著(67.7 vs 30%;P = 0.063)。随访期间(平均34.8±30.6个月)，XP组复发率为25.6%，FP组复发率为21.4%，差异无统计学意义(p = 0.745)。在最后随访时，71例患者中有20例(28.2%)死于疾病。与FP组相比，XP组疾病特异性死亡发生率显著降低(分别为21.2 vs 47.4%;P = 0.030)。然而，Kaplan-Meier方法发现两组的3年生存率无显著差异(69.6 vs. 63.2%;P = 0.263)。总的毒性和3级或4级毒性(手足综合征除外)在XP组中普遍较少见，出现贫血、恶心和呕吐的患者具有统计学意义。根据我们的经验，我们得出结论，在可切除喉下咽鳞状细胞癌患者的治疗效果、毒性和患者便利性方面，XP方案的结果与FP方案的CCRT结果相当。
{"title":"Concurrent Chemoradiotherapy with Capecitabine/Cisplatin versus 5-Fluorouracil/Cisplatin in Resectable Laryngohypopharyngeal Squamous Cell Carcinoma","authors":"D. Ahn, Jin Ho Sohn, Jae Hyug Kim, Jeong Eun Lee, Shin Hyung Park, Jae Chul Kim","doi":"10.1177/014556131609500210","DOIUrl":"https://doi.org/10.1177/014556131609500210","url":null,"abstract":"A combination of 5-fluorouracil and cisplatin (FP regimen) is widely used as a standard treatment for head and neck cancer. Recently, capecitabine has received increased attention. We conducted a retrospective study to compare the efficacy and safety of the FP regimen with that of the “XP regimen,” which entails concurrent chemoradiotherapy (CCRT) with capecitabine and cisplatin, in patients with resectable laryngohypopharyngeal squamous cell carcinoma (SCC). We retrospectively reviewed the records of 71 patients—67 men and 4 women, mean age 63.1 years—who had undergone CCRT from August 2004 through March 2010 as a primary treatment for resectable laryngohypopharyngeal SCC. There were 19 patients in the FP group and 52 in the XP group. With regard to chemotherapy morbidity, the XP group had less need for healthcare resources and fewer delays in treatment due to toxicity. After CCRT, a higher (but not statistically significant) rate of complete response was observed in the XP group than in the FP group (71.2 vs. 57.9%; p = 0.291); the XP group also had a better, although not significant, response among patients with neck metastases (67.7 vs. 30%; p = 0.063). During follow-up (mean: 34.8 ± 30.6 mo), recurrence rates were 25.6% in the XP group and 21.4% in the FP group—again, not a statistically significant difference (p = 0.745). At the time of the fnal follow-up, 20 of the 71 patients (28.2%) had died of disease. Compared with the FP group, the XP group had a significantly lower incidence of disease-specific death (21.2 vs. 47.4% respectively; p = 0.030). However, the Kaplan-Meier method identified no significant difference between the two groups in the 3-year survival rate (69.6 vs. 63.2%; p = 0.263). Overall toxicities and grade 3 or 4 toxicities (with the exception of hand-foot syndrome) were generally far less common in the XP group, with statistical significance identified for patients who experienced anemia, nausea, and vomiting. On the basis of our experience, we conclude that the results of the XP regimen were comparable to those of the FP regimen for CCRT in patients with resectable laryngohypopharyngeal SCC in terms of treatment efficacy, toxicity, and patient convenience.","PeriodicalId":11842,"journal":{"name":"ENT Journal","volume":"162 1","pages":"E34 - E42"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80218946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：