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Study on Evaluation of Laparoscopic Retroperitoneal Approach for Management of Various Renal Calculi 腹腔镜腹膜后入路治疗各种肾结石的评价研究
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/3179f
.. Rudramani, V. Singh, Shesh Kumar, Anil Kumar, Shailendra Kumar, M. Singh
Background: Laparoscopic surgery as an alternate to open surgery has been grown in recent years as a result of the increasing use of laparoscopy in urology together with inherent limitations of Percutaneous nephrolithotomy (PCNL). Evaluation of Laparoscopic retroperitoneal approach for management of various renal calculi must be done to get the efficacy of the procedure according to the calculus and renal morphology. Aims: The aim of present study was to evaluate laparoscopic retroperitoneal approach for management of various renal calculi. Methods: Laparoscopic retroperitoneal pyelolithotomy/nephrolithotomy was performed on 58 patients with various renal calculi patterns viz. solitary pelvic calculus, staghorn calculus, staghorn calculus with calyceal and isolated calyceal calculi. Extended pyelolithotomy, Gilvernet’s technique were used as per the need. Results: Out of the 58 cases with renal calculi, solitary renal pelvic stones (n=23; 39.7%) were most common followed by staghorn (n=11; 19% Mean size 4.40±1.17 cm) and isolated caliceal stones (n=9; 15.5% with Mean size2.21±0.25 cm) respectively. There were 15 (25.9%) cases with mixed stones (11 cases solitary renal pelvic and isolated caliceal stones and 4 cases had staghorn and isolated caliceal stones). Stone clearance was 93.3 to 100%. Conclusions: laparoscopic retroperitoneal approach is a useful modality for clearance of renal calculi of different types with minimum complications and a high success rate. However, the technique seems to have a limited role for isolated caliceal stones where direct or C-arm guided nephrolithotomy can be performed for better clearance of stones.
背景:近年来,由于腹腔镜在泌尿外科的应用越来越多,以及经皮肾镜取石术(PCNL)固有的局限性,腹腔镜手术作为开放手术的替代方法越来越多。评估腹腔镜腹膜后入路治疗各种肾结石的疗效,必须根据结石和肾脏形态进行评估。目的:本研究的目的是评估腹腔镜腹膜后入路治疗各种肾结石。方法:对58例单纯性肾盂结石、鹿角结石、鹿角结石伴肾盏结石、孤立肾盏结石进行腹腔镜肾盂取石/肾镜取石术治疗。根据需要采用扩展肾盂取石术和Gilvernet技术。结果:58例肾结石中,孤立性肾盂结石23例;39.7%)最常见,其次是鹿角(n=11;19%平均大小(4.40±1.17 cm)和孤立肾盏结石(n=9;15.5%,平均尺寸分别为2.21±0.25 cm。混合性肾结石15例(25.9%),其中孤立性肾盂肾结石11例,鹿角性肾结石4例。结石清除率为93.3 ~ 100%。结论:腹腔镜腹膜后入路是治疗不同类型肾结石的有效方式,并发症少,成功率高。然而,该技术似乎对孤立肾盏结石的作用有限,直接或c臂引导的肾镜取石术可以更好地清除结石。
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引用次数: 0
Maxillofacial Non-Hodgkin’s Lymphoma 颌面部非霍奇金淋巴瘤
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/12289d
Santan Reddy Muthyam, P. Surekha, Charan Paul Motupalli
Morbidity and mortality are the devastating outcomes of noncommunicable diseases like cancer. Incidence of cancer has been growing globally due to consumption of tobacco, alcohol, radiation, chemicals, viral infections, obesity and immunosupression. Non-Hodgkin’s Lymphoma is one of the many cancers that humans suffer with. With the increasing number of health conditions that eventually lead to immunosupression and exposure to potential risk factors, the incidence of Non-Hodgkin’s Lymphoma has increased. It’s multivariate and misleading presentation in the head and neck region is a diagnostic nightmare. Early diagnosis is possible with critical evaluation of the presenting symptoms even in disseminated cases. Fine needle aspiration cytology should be unhesitently performed that may lead the physician in opting for more confirmative histological and radiological investigations. Standard therapeutic regimens seem to work well with patients diagnosed early, however risk of relapse looms over the future. The contents of this chapter focus on the maxillofacial and head and neck manifestations of Non-Hodgkin’s Lymphoma which are not frequently encountered.
发病率和死亡率是癌症等非传染性疾病的破坏性后果。由于烟草、酒精、辐射、化学品、病毒感染、肥胖和免疫抑制的消费,全球癌症发病率一直在上升。非霍奇金淋巴瘤是人类所患的多种癌症之一。随着越来越多的健康状况最终导致免疫抑制和暴露于潜在危险因素,非霍奇金淋巴瘤的发病率也在增加。它在头颈部的多变量和误导性表现是诊断的噩梦。早期诊断是可能的,即使在播散性病例中,也可以对出现的症状进行严格的评估。应毫不犹豫地进行细针穿刺细胞学检查,这可能导致医生选择更确认的组织学和放射学检查。标准的治疗方案似乎对早期诊断的患者很有效,然而复发的风险在未来隐约可见。本章的内容主要集中在不常见的非霍奇金淋巴瘤的颌面部和头颈部表现。
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引用次数: 0
Determination Coagulase-nagative Staphylococcus and Antibiotic Susceptibility Patterns in Cases of Sepsis in the Neonatal Intensive Care Unit of Amiens-Picardie University Hospital (France) 法国亚胺-皮卡第大学医院新生儿重症监护病房脓毒症患者凝固酶阴性葡萄球菌及抗生素药敏型的测定
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/11838d
A. Léké, Géraldine Amar, Bertin Elion Dzon, G. Kongolo, M. Biendo
Neonatal sepsis is the most serious disease encountered in the neonatal Intensive Care Unit, and is associated with high morbidity and mortality rates. Here, we evaluated coagulase-negative Staphylococcus strains and the corresponding antibiotic susceptibility profiles in clinically suspected cases of neonatal sepsis. The objectives of the study were to determine the significance of coagulase-negative Staphylococcus strains isolated from cases of neonatal sepsis, another isolation site for coagulase-negative Staphylococcus other than blood culture and their susceptibility pattern. In a prospective study of newborns admitted to our neonatal Intensive Care Unit between January 20th, 2017, and January 20th, 2019, we analyzed all cases of sepsis with a positive blood culture, and available stool, central venous catheter, tracheobronchial, and nasopharyngeal fluid. Strains were identified using Matrix-Assisted-Laser Desorption Ionization Time of Flight Mass Spectrometry. Antimicrobial susceptibility patterns were recorded and analyzed. Of 157 premature newborns enrolled in the study, 28 (17.8%) had a coagulase-negative Staphyloccus-positive blood culture. Eighteen (64.2%) presented with early onset sepsis and 10 (35.8%) presented with late onset sepsis. Based on the gestational age at birth, there were 10 (35%) extremely preterm newborns, 12 (42.8%) very preterm newborns, and 6 (21.5%) moderately preterm newborns. The birth weight was extremely low in 13 (46.4%), very low in 9 (32.2%), low in 4 (14.2%), and normal 2 (7.2%). All coagulase-negative Staphylococcus isolates showed high levels of resistance to cefoxitin (100% of the strains), aminoglycosides (100%), fusidic acid and, ofloxacin (100%). The isolates were highly susceptible to pristinamycin (100% of the strains), vancomycin (100%) and trimethoprim-sulfamethoxazole (100%). Coagulase-negative Staphylococcus isolates constituted the most frequent cause of neonatal sepsis. The abundance of these strains may contribute to the emergence of multi-drug resistance.
新生儿败血症是新生儿重症监护病房最严重的疾病,其发病率和死亡率都很高。在这里,我们评估凝固酶阴性葡萄球菌菌株和相应的抗生素敏感性谱在临床疑似新生儿败血症病例。本研究的目的是确定从新生儿脓毒症病例中分离的凝固酶阴性葡萄球菌菌株的意义,血培养之外的凝固酶阴性葡萄球菌的另一个分离点及其药敏模式。在一项前瞻性研究中,我们对2017年1月20日至2019年1月20日入住我们新生儿重症监护病房的新生儿进行了研究,分析了所有血培养阳性的脓毒症病例,以及可用的粪便、中心静脉导管、气管支气管和鼻咽液体。采用基质辅助激光解吸电离飞行时间质谱法对菌株进行鉴定。记录并分析药敏模式。157名早产儿中,28名(17.8%)的凝固酶阴性葡萄球菌血培养呈阳性。早发性败血症18例(64.2%),晚发性败血症10例(35.8%)。根据出生胎龄,极早产儿10例(35%),极早产儿12例(42.8%),中度早产儿6例(21.5%)。出生体重极低13例(46.4%),极低9例(32.2%),低4例(14.2%),正常2例(7.2%)。所有凝固酶阴性葡萄球菌分离株均对头孢西丁(100%)、氨基糖苷类(100%)、福西地酸和氧氟沙星(100%)具有高水平耐药性。该菌株对普司他霉素(100%)、万古霉素(100%)和甲氧苄啶-磺胺甲恶唑(100%)高度敏感。凝固酶阴性葡萄球菌是导致新生儿败血症的最常见原因。这些菌株的丰富可能导致多药耐药的出现。
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引用次数: 0
Latent Class Analysis of Exposure to Childhood Trauma and Health Risks among Justice-Involved Youth: An Approach towards Gender Differences 参与司法的青少年暴露于童年创伤和健康风险的潜在阶级分析:一种性别差异的方法
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/12366d
R. Dembo, Julie M. Krupa, Jennifer Wareham, Jessica Wolff, R. DiClemente, J. Schmeidler
Research indicates juvenile justice-involved youth experience increased risk of exposure to childhood trauma and health risks. Little is known about the heterogeneity in trauma and health risk experiences among delinquent youth, especially across gender. The current study uses latent class analysis to examine typologies of self-reported exposure to trauma and health risks among a sample of 435 female and 1,198 male juvenile offenders. The study objectives were to identify any subgroups of justice-involved youths with varying patterns of trauma and health risk behaviors across gender, examine the size of these trauma-health risk subgroups, and examine socio-demographic differences in the trauma-health risk latent classes. Findings suggest the presence of three groups of trauma and health risk behaviors within the gender groups. For females, the three subgroups demonstrated linear trends in increasing prevalence of trauma and health risks. For males, the three subgroups reflected a generally low-risk group, a group with high rates of marijuana use and risky sexual behaviors, and a group with high rates of depression, family problems, sexual assault victimization, and bullying. The analyses for the covariates revealed racial differences in trauma and health risks. The findings suggest gendered intervention strategies should be considered for justice-involved youth.
研究表明,参与少年司法的青少年遭受童年创伤和健康风险的风险增加。人们对不良青少年的创伤和健康风险经历的异质性知之甚少,尤其是跨性别的。目前的研究使用潜在类别分析来检查435名女性和1198名男性少年犯的自我报告暴露于创伤和健康风险的类型。本研究的目的是找出不同性别有不同创伤和健康风险行为模式的涉事青少年亚组,检查这些创伤健康风险亚组的规模,并检查创伤健康风险潜在类别的社会人口统计学差异。研究结果表明,在性别群体中存在三组创伤和健康风险行为。对于女性,这三个亚组在创伤患病率和健康风险增加方面表现出线性趋势。对于男性来说,这三个亚组反映了一个总体上低风险的群体,一个大麻使用率和危险性行为高的群体,以及一个抑郁、家庭问题、性侵犯受害者和欺凌发生率高的群体。对协变量的分析揭示了创伤和健康风险的种族差异。研究结果表明,应考虑对涉事青少年采取性别干预策略。
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引用次数: 0
New-Competitive- Principal of Tumor Control by Low Dose Radiation 低剂量辐射控制肿瘤的新竞争原理
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/12422d
A. N. Shoutko, L. Yurkova, K. S. Borodulya, L. P. Ekimova
In order to verify the principle of indirect control a tumor on the base of morphogenic cells distraction from it, the 114 patients with advanced ovarian carcinoma (stage III-56, stage IY-21, relapse 37), were treated with subtotal half-body (low part) irradiation at low doses (0,1 Gy x 10 for 3 weeks or 3Gy x 3 daily), and obtained data were compared with that for 190 patients (stage III-66, stage IY-25, relapse-99) received conventional local irradiation of the tumor (2 Gy x 23 daily). The surgery and chemotherapy components were equalized in both groups. The 34% and 11% of 5-years survival was obtained at low dose half body irradiation for primary and relapsed patients in comparison with conventional local radiotherapy (7% and 0%). It is concluded, that reparation /regeneration processes being provoked artificially in normal tissues of cancer host are capable to compete remotely with tumor for the morphogenic/feeding cells originated from bone marrow and circulating with the blood.
为了验证间接控制肿瘤的原则的基础上地貌成因的细胞分散,114年晚期卵巢癌患者癌(IY-21 III-56阶段,阶段,复发37),服用小计一半身体(低部分)在低剂量辐照(0,1 Gy x 10 3周或3 Gy x 3日报),和获得的数据相比,190名患者(阶段3 - 66、舞台IY-25、复发- 99)接受传统的局部照射肿瘤(2 Gy x 23日报)。两组的手术和化疗成分相等。与常规局部放疗(7%和0%)相比,低剂量半体照射对原发和复发患者的5年生存率分别为34%和11%。由此可见,在肿瘤宿主的正常组织中,人工激活的修复/再生过程能够与肿瘤进行远程竞争,争夺来自骨髓并随血液循环的形态形成/喂养细胞。
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引用次数: 0
COVID Epitope is Magic COVID表位是神奇的
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/12683d
G. Pieczenik
We have identified the amino acid sequences that are almost identical between the COVID 19 amino acid sequence and the Platelet Factor 4 amino acid sequence by using proprietary modifications of the NIH Blast amino acid comparison algorithm. Using molecular mimicry one can then deduce which of the many possible epitopes on the surface of the Spike protein is the true epitope which actually induces the antibody response to the COVID 19 virus and, thereby, cross reacting with the platelets. Molecular mimicry with vaccines is a known phenomenon. However, it has never been used before to identify the actual binding sequence induced by a vaccine.
我们使用NIH Blast氨基酸比较算法的专有修改,鉴定出COVID - 19氨基酸序列与血小板因子4氨基酸序列之间几乎相同的氨基酸序列。利用分子模拟,人们可以推断出Spike蛋白表面许多可能的表位中哪一个是真正的表位,它实际上诱导了对COVID - 19病毒的抗体反应,从而与血小板发生交叉反应。疫苗的分子模仿是一种已知现象。然而,以前从未用它来鉴定由疫苗诱导的实际结合序列。
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引用次数: 0
A Case Report on Persistent Mullerian Duct Syndrome 持续性苗勒管综合征1例报告
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/4099f
Shabnam Izhar, Purnima Singh, K. Gupta
Persistent Mullerian duct syndrome (PMDS) is usually an accidental finding either during orchidopexy or during routine inguinal hernia repair in male patients presenting with undescended testes. It is a rare form of internal male pseudohermaphroditism caused by defect in synthesis or action of Mullerian inhibiting factor due to which Mullerian derivatives such as uterus, fallopian tube and upper vagina are normally present in 46XY males. PMDS has an autosomal recessive inheritance. Screening of the siblings is necessary. Familiarity of operating surgeon with this disease condition would increase the chances of correctly diagnosing the case. Distinguishing PMDS from other intersex disorder is critical. A karyotyping and assessment of testicular response to chorionic gonadotropin stimulation are essential to verify both genetic sex and existence of functional testicular tissue. Here we report a 7 year old male presenting with bilateral undescended testes.
持续性苗勒管综合征(PMDS)通常是在睾丸切除术或常规腹股沟疝修补术中偶然发现的男性隐睾患者。这是一种罕见的男性内部假两性畸形,是由缪勒管抑制因子的合成或作用缺陷引起的,因此在46XY男性中通常存在子宫、输卵管和上阴道等缪勒管衍生物。经前综合征为常染色体隐性遗传。兄弟姐妹的筛查是必要的。熟悉手术医生对这种疾病的情况将增加正确诊断的机会。将经前综合症与其他双性人障碍区分开来是至关重要的。睾丸对绒毛膜促性腺激素刺激反应的核型和评估是验证遗传性别和功能性睾丸组织存在的必要条件。在这里我们报告一个7岁的男性表现为双侧隐睾。
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引用次数: 0
Two Dimensional Ultrasonographic Analysis of Placental Maturity and Its Correlation to Gestational Age and Maternal Parameters 二维超声分析胎盘成熟度及其与胎龄及母体参数的关系
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/11915d
M. N. Mishra
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引用次数: 0
Study on Psychiatric Disorders and Their Medical-Social Consequences in Patients with Amyotrophic Lateral Sclerosis and Members of Their Families 肌萎缩性侧索硬化症患者及其家庭成员精神障碍及其医疗社会后果的研究
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/4030f
G. Levitsky, A. S. Levitsky, Vadim M. Gilod
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引用次数: 0
Surrogate Motherhood-An Act of Violation or Protection of Human Rights 代孕母亲——侵犯人权还是保护人权的行为
Pub Date : 2021-08-27 DOI: 10.9734/bpi/nfmmr/v12/4045f
P. Mol, Shweta D. Gowda
Introduction: Surrogacy is providing joy of parenthood to the intended couple but the irony is that to protect one woman from being called childless, surrogate takes over the responsibility of carrying her child to be stigmatized by the society. Though many issues of exploitation have received attention some like surrogacy have been overlooked. The global crisis of population and resources limitation is turning the attention of the world of reproduction towards adoption. Deep down everyone who opts for surrogacy wants to have their own DNA but how does genetic linkage tend to be more than humanity. Objectives: The objective of this commentary is to give an insight into the exploitation of surrogacy market. Another objective is to discuss how adoption is an alternative option to surrogacy.
导读:代孕为夫妇提供了为人父母的乐趣,但具有讽刺意味的是,为了保护一个女人不被称为无子女,代孕者承担了怀孕的责任,被社会污名化。尽管许多剥削问题受到了关注,但像代孕这样的问题却被忽视了。人口和资源限制的全球危机正把生育世界的注意力转向收养。在内心深处,每个选择代孕的人都希望拥有自己的DNA,但基因联系往往比人性更重要。目的:这篇评论的目的是为了深入了解代孕市场的开发。另一个目的是讨论收养如何成为代孕的另一种选择。
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引用次数: 0
期刊
New Frontiers in Medicine and Medical Research Vol. 12
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