Pub Date : 2019-12-30DOI: 10.38109/2225-1685-2019-4-108-121
S. Gratsianskaya, T. Martynyuk
Objective: to conduct a comprehensive analysis of the clinical, functional, hemodynamic profile of patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) according to the Russian Registry.Materials and methods: The study involved 30 patients with Eisenmenger syndrome, 25 patients with PAH associated with prevalent systemic-to-pulmonary shunts and 26 patients with PAH after defect correction. All patients had been entered in the Russian registry (NCT03707561). A comparative analysis of clinical, functional, hemodynamic parameters was held. The diagnosis was established by the algorithm proposed in the Russian guidelines for the diagnosis and treatment of PH (2016).Results: The patients of three subgroups of PAH-CHD were comparable in age and sex. The time from the onset of symptoms to the final diagnosis in the first and second PAH-CHD subgroups was significantly longer: on average, it took three years to establish the diagnosis, whereas in patients with PAH after defect correction, on average, after 9 months the correct diagnosis was made (p=0,0006). Patients with Eisenmenger syndrome were characterized by significantly high values of mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) according to right heart catheterization (mPAP (81,0 [72,0;92,0] mm Hg against 52,0 [41,0;75,0] mm Hg, p=0,001 and PVR 2329,0 [1333,0;2778,0] dyn*sec*cm-5 vs. 954,5 [591,0;1439,0] dyn*sec*cm-5, p=0,02) compared with the second subgroup of PAH-CHD, and significant decrease in arterial blood oxygen saturation (SpO2) (90,0 [85,0;93,0]% vs. 94,5 [92,5;96,0]% and 96,0 [92,0;98;0]%) compared with patients of the other subgroups (p=0,002).Conclusions: Patients with PAH-CHD are a heterogeneous population, the division of which is presented in the clinical classification, and therefore have a different course of the disease. Analyzing the data of patients with PAH-CHD, we found various clinical, functional, physical and hemodynamic features of these patients. With comparable 6MWT and FC (WHO), patients with Eisenmenger syndrome have the highest values of PAP and PVR, as well as lower values of arterial blood oxygen saturation compared to other subgroups of PAH-CHD. In the group of patients with PAH associated with prevalent systemic-to-pulmonary PVR was significantly less compared to other groups of PAH-CHD. In patients with PAH after defect closure, the correlation between 6MWT and FC (WHO) and the area of the right atrium was detected. The obtained data can be useful in the choice of management of these patients
{"title":"COMPARATIVE CLINICAL CHARACTERISTICS OF PATIENTS WITH VARIOUS FORMS OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASE, ACCORDING TO THE CLINICAL CLASSIFICATION","authors":"S. Gratsianskaya, T. Martynyuk","doi":"10.38109/2225-1685-2019-4-108-121","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-4-108-121","url":null,"abstract":"Objective: to conduct a comprehensive analysis of the clinical, functional, hemodynamic profile of patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) according to the Russian Registry.Materials and methods: The study involved 30 patients with Eisenmenger syndrome, 25 patients with PAH associated with prevalent systemic-to-pulmonary shunts and 26 patients with PAH after defect correction. All patients had been entered in the Russian registry (NCT03707561). A comparative analysis of clinical, functional, hemodynamic parameters was held. The diagnosis was established by the algorithm proposed in the Russian guidelines for the diagnosis and treatment of PH (2016).Results: The patients of three subgroups of PAH-CHD were comparable in age and sex. The time from the onset of symptoms to the final diagnosis in the first and second PAH-CHD subgroups was significantly longer: on average, it took three years to establish the diagnosis, whereas in patients with PAH after defect correction, on average, after 9 months the correct diagnosis was made (p=0,0006). Patients with Eisenmenger syndrome were characterized by significantly high values of mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) according to right heart catheterization (mPAP (81,0 [72,0;92,0] mm Hg against 52,0 [41,0;75,0] mm Hg, p=0,001 and PVR 2329,0 [1333,0;2778,0] dyn*sec*cm-5 vs. 954,5 [591,0;1439,0] dyn*sec*cm-5, p=0,02) compared with the second subgroup of PAH-CHD, and significant decrease in arterial blood oxygen saturation (SpO2) (90,0 [85,0;93,0]% vs. 94,5 [92,5;96,0]% and 96,0 [92,0;98;0]%) compared with patients of the other subgroups (p=0,002).Conclusions: Patients with PAH-CHD are a heterogeneous population, the division of which is presented in the clinical classification, and therefore have a different course of the disease. Analyzing the data of patients with PAH-CHD, we found various clinical, functional, physical and hemodynamic features of these patients. With comparable 6MWT and FC (WHO), patients with Eisenmenger syndrome have the highest values of PAP and PVR, as well as lower values of arterial blood oxygen saturation compared to other subgroups of PAH-CHD. In the group of patients with PAH associated with prevalent systemic-to-pulmonary PVR was significantly less compared to other groups of PAH-CHD. In patients with PAH after defect closure, the correlation between 6MWT and FC (WHO) and the area of the right atrium was detected. The obtained data can be useful in the choice of management of these patients","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91303874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.38109/2225-1685-2019-4-134-143
O. Vasiltseva, K. Ivanov, E. A. Devetyarova, O. E. Yakovleva
Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Binding NO with sGC - enzyme catalyzes the synthesis of a signal molecule of cyclic guanosine monophosphate (cGMP), which plays an important role in the regulation of processes that affect vascular tone, proliferation, fibrosis and inflammation. Impaired bioavailability and/or responsiveness to endogenous NO has been implicated in the pathogenesis of cardiovascular and other diseases. Pulmonary arterial hypertension (PAH) is a well-known complication of systemic connective tissue diseases (CTD) and ranks second among the most common types of PAH after idiopathic PAH (IPAH). The usage of organic nitrates and other NO donors has limitations, including non-specific interactions of NO with various biomolecules, lack of response and the development of tolerance following prolonged administration. Compounds that activate sGC in NO-independent manner might therefore provide considerable therapeutic advantages. The purpose of this article is to provide contemporary data on the management and treatment of patients, as well as the role of specific therapy and the place of riociguat in the treatment of patients with CTD associated PAH
{"title":"THE ROLE OF RIOCIGUAT IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE","authors":"O. Vasiltseva, K. Ivanov, E. A. Devetyarova, O. E. Yakovleva","doi":"10.38109/2225-1685-2019-4-134-143","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-4-134-143","url":null,"abstract":"Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Binding NO with sGC - enzyme catalyzes the synthesis of a signal molecule of cyclic guanosine monophosphate (cGMP), which plays an important role in the regulation of processes that affect vascular tone, proliferation, fibrosis and inflammation. Impaired bioavailability and/or responsiveness to endogenous NO has been implicated in the pathogenesis of cardiovascular and other diseases. Pulmonary arterial hypertension (PAH) is a well-known complication of systemic connective tissue diseases (CTD) and ranks second among the most common types of PAH after idiopathic PAH (IPAH). The usage of organic nitrates and other NO donors has limitations, including non-specific interactions of NO with various biomolecules, lack of response and the development of tolerance following prolonged administration. Compounds that activate sGC in NO-independent manner might therefore provide considerable therapeutic advantages. The purpose of this article is to provide contemporary data on the management and treatment of patients, as well as the role of specific therapy and the place of riociguat in the treatment of patients with CTD associated PAH","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.38109/2225-1685-2019-3-50-64
M. L. Kazantseva, E. Oshchepkova, M. Saidova, A. Avalyan, I. Chazova
Oncological and cardiovascular diseases (CVD) hold a leading position among the causes of mortality in many countries of the world, including the Russian Federation [1]. In recent years, a decrease in mortality due to oncologic diseases (OD) is noted around the world thanks to early diagnostics, as well as to the development and implementation of new technologies and therapeutic treatment strategies (chemotherapy, targeted and radiation therapy). Among patients with OD who received chemotherapy and radiation therapy, CVD is one of the leading causes of poor prognosis, including lethal outcomes [2-5]. The long-term cardiotoxic effects of antitumor therapy (chemotherapy, radiation therapy) reduce the survival rate and quality of life of patients who suffer from cancer. Thus, early diagnostics and timely detection of the cardiotoxic effects that follow antitumor treatment is one of the main tasks of cardio-oncology.
{"title":"LONG-TERM CARDIOVASCULAR COMPLICATIONS IN ONCOLOGIC PATIENTS AFTER ANTITUMOR THERAPY (>1 YEAR)","authors":"M. L. Kazantseva, E. Oshchepkova, M. Saidova, A. Avalyan, I. Chazova","doi":"10.38109/2225-1685-2019-3-50-64","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-3-50-64","url":null,"abstract":"Oncological and cardiovascular diseases (CVD) hold a leading position among the causes of mortality in many countries of the world, including the Russian Federation [1]. In recent years, a decrease in mortality due to oncologic diseases (OD) is noted around the world thanks to early diagnostics, as well as to the development and implementation of new technologies and therapeutic treatment strategies (chemotherapy, targeted and radiation therapy). Among patients with OD who received chemotherapy and radiation therapy, CVD is one of the leading causes of poor prognosis, including lethal outcomes [2-5]. The long-term cardiotoxic effects of antitumor therapy (chemotherapy, radiation therapy) reduce the survival rate and quality of life of patients who suffer from cancer. Thus, early diagnostics and timely detection of the cardiotoxic effects that follow antitumor treatment is one of the main tasks of cardio-oncology.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75048987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.38109/2225-1685-2019-3-4-33
S. Tereshchenko, I. Zhirov, V. P. Masenko, O. Narusov, S. Nasonova, A. Samko, O. V. Stukalova, M. Shariya
.
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{"title":"DIAGNOSIS AND TREATMENT OF MYOCARDITIDES","authors":"S. Tereshchenko, I. Zhirov, V. P. Masenko, O. Narusov, S. Nasonova, A. Samko, O. V. Stukalova, M. Shariya","doi":"10.38109/2225-1685-2019-3-4-33","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-3-4-33","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84161031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.38109/2225-1685-2019-3-42-48
V. Baev, T. F. Vagapov
Study of the effect of the degree of arterial hypertension (AH) on the severity of the clinical manifestations of chronic venous disease (CVD) of the lower extremities in men of working age.Material and methods. A comparative analysis of the clinical severity and severity of CVD (diagnosed by CEAP) was performed using the VCSS scale of two groups of male patients with hypertension aged 3055 years. Group 1 - 40 patients with 1 degree of hypertension (SBP 143 (140-147) mmHg, DBP 92 (90-95) mmHg) and group 2 - 34 patients with 2 and 3 degrees of hypertension (SBP 164 (156-179) mmHg, DBP 107 (101-109) mmHg). Comparison of shares is performed using the contingency table using the X2 criterion.Results. Symptoms of chronic venous diseases such as pain, varicose veins, edema and hyperpigmentation, have been reported in the observed patients. Signs with greater severity were not noted. Leg pain (p = 0.047) and edema (p = 0.002) were more often diagnosed in patients with grade 2 and 3 hypertension than in patients with grade 1 hypertension.Conclusion. The severity of hypertension worsens the clinic of chronic venous diseases in men 30-55 years old.
{"title":"THE SEVERITY OF THE CLINICAL MANIFESTATIONS OF CHRONIC VENOUS DISEASES IN MEN, DEPENDING ON THE DEGREE OF ARTERIAL HYPERTENSION","authors":"V. Baev, T. F. Vagapov","doi":"10.38109/2225-1685-2019-3-42-48","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-3-42-48","url":null,"abstract":"Study of the effect of the degree of arterial hypertension (AH) on the severity of the clinical manifestations of chronic venous disease (CVD) of the lower extremities in men of working age.Material and methods. A comparative analysis of the clinical severity and severity of CVD (diagnosed by CEAP) was performed using the VCSS scale of two groups of male patients with hypertension aged 3055 years. Group 1 - 40 patients with 1 degree of hypertension (SBP 143 (140-147) mmHg, DBP 92 (90-95) mmHg) and group 2 - 34 patients with 2 and 3 degrees of hypertension (SBP 164 (156-179) mmHg, DBP 107 (101-109) mmHg). Comparison of shares is performed using the contingency table using the X2 criterion.Results. Symptoms of chronic venous diseases such as pain, varicose veins, edema and hyperpigmentation, have been reported in the observed patients. Signs with greater severity were not noted. Leg pain (p = 0.047) and edema (p = 0.002) were more often diagnosed in patients with grade 2 and 3 hypertension than in patients with grade 1 hypertension.Conclusion. The severity of hypertension worsens the clinic of chronic venous diseases in men 30-55 years old.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91469572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.38109/2225-1685-2019-3-34-41
R. Alieva, S. Hoshimov, S. S. Ahmedova, F. Bekmetova, A. Shek, R. Kurbanov
Objective: to study the severity of carotid artery atherosclerosis in patients with heterozygous familial hypercholesterolemia in the Uzbek population, depending on the level of PCSK-9 and the genetic polymorphism E670G of the PCSK-9 gene.Material and methods. The study included 57 patients with chronic stable coronary artery disease (SCAD) and familial heterozygous hypercholesterolemia (HeFH, group I). The comparison group consisted of 144 patients with SCAD without HeFH divided into two subgroups: A - statin free before the research (n=63) and B (n=81) who took it as outpatients; control group consisted of 17 healthy people. The level of proprotein convertase subtilisin-kexin type 9 (PCSK-9) was measured with Human Proprotein Convertase 9/PCSK9 ELISA Kit (MULTI SCIENCE, China). The genetic typing of PCSK9 E670G (rs505151) polymorphism was performed by means of the PCR-RFLP method.Results. A comparison of the results of duplex scanning of carotid arteries in patients with HeFH showed that the carotid intima-media thickness (CIMT) on the left (1.14±0.18 mm, P<0.01) and on the right (1.15±0.16 mm, P<0.01) was higher, than in the comparison group: 1.05±0.17 mm and 1.04±0.18 mm, respectively. The studies revealed a positive correlation between the incidence of Myocardial infarction (MI) in the history in patients with HeFH and the (r=0.38, P<0.05). The CIMT also correlated with an increase in the concentration of PCSK9 (r = 0.31, P <0.05) in the blood and the carriage of the G allele of polymorphism E670G (r = 0.39, P <0.05) of the PCSK9 gene.Conclusion. Inpatientswithheterozygousfamilialhypercholesterolemia in the Uzbek population a direct correlation was established between Myocardial infarction in the history, the carotid intima-media thickness, an increase in the concentration of PCSK-9 in the blood and the carriage of the G allele of E670G polymorphism of the PCSK9 gene, that allows them to be used as prognostic markers for the risk of development of cardiovascular complications.
目的:研究乌兹别克斯坦人群杂合子家族性高胆固醇血症患者颈动脉粥样硬化的严重程度与PCSK-9水平及PCSK-9基因遗传多态性E670G的关系。材料和方法。本研究纳入57例慢性稳定型冠状动脉疾病(SCAD)合并家族性杂合型高胆固醇血症(HeFH, I组)患者，对照组144例无HeFH的SCAD患者分为两组:A组研究前未使用他汀类药物(n=63)， B组作为门诊患者使用他汀类药物(n=81);对照组由17名健康人组成。采用Human proprotein convertase 9/PCSK9 ELISA Kit (MULTI SCIENCE, China)检测蛋白转化酶枯草素-激酶9 (PCSK-9)水平。采用PCR-RFLP方法对PCSK9 E670G (rs505151)多态性进行遗传分型。对比HeFH患者颈动脉双相扫描结果显示，左侧颈动脉内膜-中膜厚度(CIMT)(1.14±0.18 mm, P<0.01)和右侧颈动脉内膜-中膜厚度(CIMT)(1.15±0.16 mm, P<0.01)高于对照组(1.05±0.17 mm和1.04±0.18 mm)。研究发现，HeFH患者史上心肌梗死(MI)的发生率与心绞痛的发生率呈正相关(r=0.38, P<0.05)。CIMT与PCSK9血中浓度升高(r = 0.31, P <0.05)和PCSK9基因E670G多态性等位基因携带(r = 0.39, P <0.05)相关。在乌兹别克斯坦人群中患有杂合子家族性高胆固醇血症的住院患者中，心肌梗死史、颈动脉内膜-中膜厚度、血液中PCSK-9浓度的增加和PCSK9基因E670G多态性的G等位基因的携带之间建立了直接相关性，这使得它们可以用作心血管并发症发生风险的预后标志物。
{"title":"ASSOTIATION OF THE GENETIC POLYMORPHISM E670G OF THE PCSK-9 AND THE SEVERITY OF THE CAROTID ATHEROSCLEROSIS IN PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA IN UZBEK POPULATION","authors":"R. Alieva, S. Hoshimov, S. S. Ahmedova, F. Bekmetova, A. Shek, R. Kurbanov","doi":"10.38109/2225-1685-2019-3-34-41","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-3-34-41","url":null,"abstract":"Objective: to study the severity of carotid artery atherosclerosis in patients with heterozygous familial hypercholesterolemia in the Uzbek population, depending on the level of PCSK-9 and the genetic polymorphism E670G of the PCSK-9 gene.Material and methods. The study included 57 patients with chronic stable coronary artery disease (SCAD) and familial heterozygous hypercholesterolemia (HeFH, group I). The comparison group consisted of 144 patients with SCAD without HeFH divided into two subgroups: A - statin free before the research (n=63) and B (n=81) who took it as outpatients; control group consisted of 17 healthy people. The level of proprotein convertase subtilisin-kexin type 9 (PCSK-9) was measured with Human Proprotein Convertase 9/PCSK9 ELISA Kit (MULTI SCIENCE, China). The genetic typing of PCSK9 E670G (rs505151) polymorphism was performed by means of the PCR-RFLP method.Results. A comparison of the results of duplex scanning of carotid arteries in patients with HeFH showed that the carotid intima-media thickness (CIMT) on the left (1.14±0.18 mm, P<0.01) and on the right (1.15±0.16 mm, P<0.01) was higher, than in the comparison group: 1.05±0.17 mm and 1.04±0.18 mm, respectively. The studies revealed a positive correlation between the incidence of Myocardial infarction (MI) in the history in patients with HeFH and the (r=0.38, P<0.05). The CIMT also correlated with an increase in the concentration of PCSK9 (r = 0.31, P <0.05) in the blood and the carriage of the G allele of polymorphism E670G (r = 0.39, P <0.05) of the PCSK9 gene.Conclusion. Inpatientswithheterozygousfamilialhypercholesterolemia in the Uzbek population a direct correlation was established between Myocardial infarction in the history, the carotid intima-media thickness, an increase in the concentration of PCSK-9 in the blood and the carriage of the G allele of E670G polymorphism of the PCSK9 gene, that allows them to be used as prognostic markers for the risk of development of cardiovascular complications.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88832210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.38109/2225-1685-2019-2-76-83
O. M. Korolkova, T. Chernykh
The purpose of the study: to study the effectiveness of the use of the drug iloprost in patients with PH III - IV FC according to the register of the Voronezh region. The material was the base register data. The effectiveness of the drug «iloprost» evaluated in patients with PH III - IV FC according to the register. The safety of therapy «iloprost» shown on the basis of a complex of clinical and hemodynamic parameters.Glinical example presented.
该研究的目的:根据沃罗涅日地区的登记，研究药物伊洛前列素在PH III - IV FC患者中使用的有效性。材料是基本寄存器数据。根据注册表，评估了药物“伊洛前列素”在PH III - IV型FC患者中的有效性。治疗«伊洛前列素»的安全性显示在复杂的临床和血流动力学参数的基础上。提出临床实例。
{"title":"EFFECTIVENESS OF ILOPROST IN PATIENTS WITH PULMONARY HYPERTENSION FC III - IV BASED ON VORONEZH REGION REGISTRY DATA","authors":"O. M. Korolkova, T. Chernykh","doi":"10.38109/2225-1685-2019-2-76-83","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-2-76-83","url":null,"abstract":"The purpose of the study: to study the effectiveness of the use of the drug iloprost in patients with PH III - IV FC according to the register of the Voronezh region. The material was the base register data. The effectiveness of the drug «iloprost» evaluated in patients with PH III - IV FC according to the register. The safety of therapy «iloprost» shown on the basis of a complex of clinical and hemodynamic parameters.Glinical example presented.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84414574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.38109/2225-1685-2019-2-64-75
N. Babayeva
The aim of this study was to investigate the heart and common carotid arteries (CCA) morphological and functional condition and the lipid spectrum in patients with arterial hypertension (AH) and type 2 diabetes mellitus (DM-2).Material and methods. The study included 144 patients with varying degrees of AH, 103 had AH without DM-2 (AH subgroup) and 41 patients with AH and DM-2 (AH+DM-2 subgroup). In all investigated patients the blood plasma lipid profile, echocardiographic examination of the heart and ultrasound Doppler examination of the CCA were carried out. The results. Significant differences between the AH and AH+DM-2 subgroups were discovered, which confirmed the significant effect of DM-2 on various parameters of the cardiovascular system. The lipid profile in the above mentioned subgroups has not significant differences, but some separated indices (TG, VLDL) in the AH+DM-2 subgroup were comparatively higher and HDL level lower comparing to AH subgroup. Marked changes in echocardiographic parameters, such as lowering of left ventricle (LV) ejection fraction (EF), significant increase of interventricular septum and LV posterior wall thickness, high frequency of LV hypertrophy detection, diastolic dysfunction, diffuse hypokinesis and dilatation of the heart cavities in the AH+DM-2 subgroup were confirmed. A significant rise of CCA intima-media thickness also was found in the AH+DM-2 in comparison with AH subgroup, which proved the essential role of comorbidity of AH and DM-2 in the heart and vessels remodeling. The conclusion. The results of the study confirm the role and significance of comorbidity of AH with DM-2 in the development of the cardiovascular system pathological changes.
{"title":"CLINICAL AND INSTRUMENTAL ASSESSMENT OF MORPHO-FUNCTIONAL CONDITION OF THE HEART AND VASCULATURE IN COMORBIDITY OF ARTERIAL HYPERTENSION AND DIABETES MELLITUS TYPE 2","authors":"N. Babayeva","doi":"10.38109/2225-1685-2019-2-64-75","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-2-64-75","url":null,"abstract":"The aim of this study was to investigate the heart and common carotid arteries (CCA) morphological and functional condition and the lipid spectrum in patients with arterial hypertension (AH) and type 2 diabetes mellitus (DM-2).Material and methods. The study included 144 patients with varying degrees of AH, 103 had AH without DM-2 (AH subgroup) and 41 patients with AH and DM-2 (AH+DM-2 subgroup). In all investigated patients the blood plasma lipid profile, echocardiographic examination of the heart and ultrasound Doppler examination of the CCA were carried out. The results. Significant differences between the AH and AH+DM-2 subgroups were discovered, which confirmed the significant effect of DM-2 on various parameters of the cardiovascular system. The lipid profile in the above mentioned subgroups has not significant differences, but some separated indices (TG, VLDL) in the AH+DM-2 subgroup were comparatively higher and HDL level lower comparing to AH subgroup. Marked changes in echocardiographic parameters, such as lowering of left ventricle (LV) ejection fraction (EF), significant increase of interventricular septum and LV posterior wall thickness, high frequency of LV hypertrophy detection, diastolic dysfunction, diffuse hypokinesis and dilatation of the heart cavities in the AH+DM-2 subgroup were confirmed. A significant rise of CCA intima-media thickness also was found in the AH+DM-2 in comparison with AH subgroup, which proved the essential role of comorbidity of AH and DM-2 in the heart and vessels remodeling. The conclusion. The results of the study confirm the role and significance of comorbidity of AH with DM-2 in the development of the cardiovascular system pathological changes.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87244564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-30DOI: 10.38109/2225-1685-2019-2-54-63
R. Kurbanov, R. Trigulova, D. D. Akhmedov, R. K. Bazarov, N. F. Tashkenbaeva
The application of the medical standard HL7 CDA for the tasks of creating clinical documents and digital signature means suitable for use in a single information space is described. A new specification (FHIR standard) is presented, based on the latest approaches in the field of e-health, but taking into account all the accumulated experience (real needs, successful solutions and typical difficulties). The structure of the electronic medical map (EMC), the conceptual, logical and physical model of the database for the needs of the cardiological service, which is the core of the unified information space of the RSSPMCC, is developed.
{"title":"THE MAIN DIRECTIONS OF STANDARDIZATION IN MEDICAL INFORMATICS","authors":"R. Kurbanov, R. Trigulova, D. D. Akhmedov, R. K. Bazarov, N. F. Tashkenbaeva","doi":"10.38109/2225-1685-2019-2-54-63","DOIUrl":"https://doi.org/10.38109/2225-1685-2019-2-54-63","url":null,"abstract":"The application of the medical standard HL7 CDA for the tasks of creating clinical documents and digital signature means suitable for use in a single information space is described. A new specification (FHIR standard) is presented, based on the latest approaches in the field of e-health, but taking into account all the accumulated experience (real needs, successful solutions and typical difficulties). The structure of the electronic medical map (EMC), the conceptual, logical and physical model of the database for the needs of the cardiological service, which is the core of the unified information space of the RSSPMCC, is developed.","PeriodicalId":11859,"journal":{"name":"Eurasian heart journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79385713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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