He Liu, Tianyi Xia, Song Xiang, Zhenzhou Chen, Yang Pan, Xiaolong Liang, Zhengqiang Wei
Background
Tumor progression and recurrence are major contributors to the poor prognosis of colorectal cancer (CRC), with angiogenesis playing a critical role in these processes. Although tumor-derived exosomes are hypothesized to significantly promote angiogenesis, the underlying mechanisms in CRC remain poorly understood.
Methods
Serum exosomal samples from five paired CRC and non-CRC patients were sequenced to identify differentially expressed miRNAs. The biological function of miR-146a and its downstream targets in angiogenesis were investigated using in vitro and in vivo models.
Results
Our findings demonstrate that miR-146a is highly enriched in CRC-derived exosomes, and its expression in serum exosomes is significantly elevated in CRC patients compared to healthy controls. MiR-146a can be transferred from CRC cells to human umbilical vein endothelial cells (HUVECs) via exosomes, enhancing their proliferation, migration, and tube formation. Mechanistically, exosomal miR-146a promotes these proangiogenic effects by downregulating the tissue inhibitor of metalloproteinase 3 (TIMP3) in HUVECs. Furthermore, in vivo experiments confirmed that exosomal miR-146a from CRC cells drives tumor growth and angiogenesis.
Conclusions
This study highlights exosomal miR-146a as a key driver of angiogenesis in CRC, suggesting its potential as a therapeutic target for antiangiogenic strategies in CRC treatment.
{"title":"Cancer-Derived Exosomal miR-146a Promotes Angiogenesis by Suppressing TIMP3 in Colorectal Cancer","authors":"He Liu, Tianyi Xia, Song Xiang, Zhenzhou Chen, Yang Pan, Xiaolong Liang, Zhengqiang Wei","doi":"10.1155/ecc/8427059","DOIUrl":"https://doi.org/10.1155/ecc/8427059","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tumor progression and recurrence are major contributors to the poor prognosis of colorectal cancer (CRC), with angiogenesis playing a critical role in these processes. Although tumor-derived exosomes are hypothesized to significantly promote angiogenesis, the underlying mechanisms in CRC remain poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Serum exosomal samples from five paired CRC and non-CRC patients were sequenced to identify differentially expressed miRNAs. The biological function of miR-146a and its downstream targets in angiogenesis were investigated using in vitro and in vivo models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings demonstrate that miR-146a is highly enriched in CRC-derived exosomes, and its expression in serum exosomes is significantly elevated in CRC patients compared to healthy controls. MiR-146a can be transferred from CRC cells to human umbilical vein endothelial cells (HUVECs) via exosomes, enhancing their proliferation, migration, and tube formation. Mechanistically, exosomal miR-146a promotes these proangiogenic effects by downregulating the tissue inhibitor of metalloproteinase 3 (TIMP3) in HUVECs. Furthermore, in vivo experiments confirmed that exosomal miR-146a from CRC cells drives tumor growth and angiogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights exosomal miR-146a as a key driver of angiogenesis in CRC, suggesting its potential as a therapeutic target for antiangiogenic strategies in CRC treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/8427059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hosna Ghorbani, Akram Ghahramanian, Arefeh Davoodi, Tonia C. Onyeka, Leila Valizadeh, Farzaneh Bagheriyeh, Sana Mojtahedy
Background
This study aimed to identify the information needs of mothers of children diagnosed with leukemia and to examine the relationship between these needs and the care burden.
Methods
This longitudinal descriptive study, conducted in 2022, involved 110 mothers of children and adolescents aged 6 to 18 with leukemia. Data were collected at two points: upon admission and before discharge. The study utilized a 13-item information needs scale and a 22-item Caregiver Burden Scale (CBS) to gather data. The multivariable linear regression analyses were employed to identify predictors of caregiver burden, including variables that were significant in the bivariate analyses (p values < 0.05) as independent variables in the multivariate model.
Results
In the first week, the mean score for the overall information needs scale was 2.19 ± 0.54, which significantly increased to 2.99 ± 0.34 by the fourth week. The mean score for the overall CBS was 2.97 ± 0.41 (out of 4) in the first week, rising significantly to 3.34 ± 0.34 by the fourth week (p < 0.001). There was a significant inverse correlation between overall information needs and overall CBS both in the first week (r = −0.415, p < 0.01) and in the fourth week (r = −0.224, p < 0.05).
Conclusions
This study highlights the evolving information needs and increasing caregiver burden among mothers of children and adolescents with leukemia during their initial round of chemotherapy. Although increasing information helps alleviate the caregiver burden, the upward trend in perceived caregiver burden from the first suggests the need for additional supportive interventions.
本研究旨在了解白血病患儿母亲的信息需求，并探讨这些需求与护理负担之间的关系。这项纵向描述性研究于2022年进行，涉及110名6至18岁白血病儿童和青少年的母亲。数据收集于两点：入院时和出院前。本研究采用13项信息需求量表和22项照顾者负担量表（CBS）收集数据。采用多变量线性回归分析来确定照顾者负担的预测因子，包括在双变量分析中显著的变量（p值<； 0.05）作为多变量模型中的自变量。结果第1周患者总体信息需求量表平均得分为2.19±0.54分，第4周显著提高至2.99±0.34分。第一周CBS总分平均为2.97±0.41分（总分4分），第四周显著上升至3.34±0.34分（p < 0.001）。总体信息需求与总体CBS在第一周（r = - 0.415, p < 0.01）和第四周（r = - 0.224, p < 0.05）呈显著负相关。结论：本研究突出了白血病儿童和青少年的母亲在第一轮化疗期间不断变化的信息需求和不断增加的照顾者负担。虽然越来越多的信息有助于减轻照顾者的负担，但从一开始感知到的照顾者负担的上升趋势表明需要额外的支持性干预。
{"title":"Examining Caregiving Burden in Mothers of Children With Newly Diagnosed Leukemia: The Role of Information Needs","authors":"Hosna Ghorbani, Akram Ghahramanian, Arefeh Davoodi, Tonia C. Onyeka, Leila Valizadeh, Farzaneh Bagheriyeh, Sana Mojtahedy","doi":"10.1155/ecc/5535983","DOIUrl":"https://doi.org/10.1155/ecc/5535983","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to identify the information needs of mothers of children diagnosed with leukemia and to examine the relationship between these needs and the care burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This longitudinal descriptive study, conducted in 2022, involved 110 mothers of children and adolescents aged 6 to 18 with leukemia. Data were collected at two points: upon admission and before discharge. The study utilized a 13-item information needs scale and a 22-item Caregiver Burden Scale (CBS) to gather data. The multivariable linear regression analyses were employed to identify predictors of caregiver burden, including variables that were significant in the bivariate analyses (<i>p</i> values < 0.05) as independent variables in the multivariate model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the first week, the mean score for the overall information needs scale was 2.19 ± 0.54, which significantly increased to 2.99 ± 0.34 by the fourth week. The mean score for the overall CBS was 2.97 ± 0.41 (out of 4) in the first week, rising significantly to 3.34 ± 0.34 by the fourth week (<i>p</i> < 0.001). There was a significant inverse correlation between overall information needs and overall CBS both in the first week (<i>r</i> = −0.415, <i>p</i> < 0.01) and in the fourth week (<i>r</i> = −0.224, <i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the evolving information needs and increasing caregiver burden among mothers of children and adolescents with leukemia during their initial round of chemotherapy. Although increasing information helps alleviate the caregiver burden, the upward trend in perceived caregiver burden from the first suggests the need for additional supportive interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5535983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manon Gouez, Mayeul Tabutin, Jean Dubrez, Coralie D’Inca, Charlotte Bruneau, Lidia Delrieu, Houssein El Hajj, Baptiste Fournier, Béatrice Fervers, Olivia Pérol
Purpose
Despite its demonstrated benefits, prehabilitation before lung cancer surgery remains poorly implemented. This study investigated the preferences, interests, and barriers to exercise-based prehabilitation among patients eligible for thoracic surgery.
Method
This cross-sectional study conducted from January 2022 to July 2023 used self-administered questionnaires to collect data on preferences and barriers to exercise-based prehabilitation in cancer patients scheduled for lung resection at a French comprehensive cancer center.
Results
Most of the 23 participants (n = 20, 90.9%) were unaware of prehabilitation but expressed a strong interest in participating in an exercise program prior to lung surgery (n = 16, 72.7%). Walking (n = 16, 80.0%) and home-based exercise (n = 14, 70.0%) were the most preferred activities. Programs of short to moderate duration (1–4 weeks) and located within 30 min travel from home were preferred. Participants preferred exercising alone or with family members and showed limited interest in the group or facility-based sessions. While 81.8% (n = 18) felt capable of engaging in an exercise-based prehabilitation program, common barriers included distance from the care center, breathlessness, and fatigue. Physical and medical limitations were more frequently reported than psychological ones.
Conclusion
Despite limited awareness, lung cancer patients show a strong interest in exercise-based prehabilitation. Home-based and flexible programs aligned with patient preferences may help overcome participation barriers. These findings support the development of personalized, accessible prehabilitation strategies to enhance engagement before lung surgery.
{"title":"Preferences, Interests, and Barriers to Physical Activity–Based Prehabilitation Prior to Lung Resection: A Survey Study","authors":"Manon Gouez, Mayeul Tabutin, Jean Dubrez, Coralie D’Inca, Charlotte Bruneau, Lidia Delrieu, Houssein El Hajj, Baptiste Fournier, Béatrice Fervers, Olivia Pérol","doi":"10.1155/ecc/5723896","DOIUrl":"https://doi.org/10.1155/ecc/5723896","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Despite its demonstrated benefits, prehabilitation before lung cancer surgery remains poorly implemented. This study investigated the preferences, interests, and barriers to exercise-based prehabilitation among patients eligible for thoracic surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This cross-sectional study conducted from January 2022 to July 2023 used self-administered questionnaires to collect data on preferences and barriers to exercise-based prehabilitation in cancer patients scheduled for lung resection at a French comprehensive cancer center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most of the 23 participants (<i>n</i> = 20, 90.9%) were unaware of prehabilitation but expressed a strong interest in participating in an exercise program prior to lung surgery (<i>n</i> = 16, 72.7%). Walking (<i>n</i> = 16, 80.0%) and home-based exercise (<i>n</i> = 14, 70.0%) were the most preferred activities. Programs of short to moderate duration (1–4 weeks) and located within 30 min travel from home were preferred. Participants preferred exercising alone or with family members and showed limited interest in the group or facility-based sessions. While 81.8% (<i>n</i> = 18) felt capable of engaging in an exercise-based prehabilitation program, common barriers included distance from the care center, breathlessness, and fatigue. Physical and medical limitations were more frequently reported than psychological ones.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite limited awareness, lung cancer patients show a strong interest in exercise-based prehabilitation. Home-based and flexible programs aligned with patient preferences may help overcome participation barriers. These findings support the development of personalized, accessible prehabilitation strategies to enhance engagement before lung surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5723896","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145626437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadio Righes, Pauline Waroquier, Marie Caillier, Oriane Verkaeren, Paulus Kristanto, Isabelle Merckaert
Background
Cancer-related fatigue (CRF) is one of the most frequently reported symptoms among breast cancer survivors. Recommendations regarding nonpharmacological treatments for CRF include physical activity, psychosocial, and mind–body interventions. Despite the close association of CRF with psychological symptoms, to our knowledge, no study has assessed the impact of a psychosocial intervention on CRF among patients meeting criteria for clinical levels of psychological symptoms.
Aim
This study presents findings on changes in CRF, sleep disturbances, energy levels, and physical activity from a randomized controlled trial (RCT) evaluating the efficacy of an eight-session emotion and self-regulation group intervention ecologically boosted through daily app-based prompts. The intervention, specifically designed for breast cancer survivors in the early survivorship period who exhibited clinical levels of psychological symptoms, showed its efficacy in targeting some psychological symptoms (i.e., worry, intrusive thoughts, and negative emotions).
Method
At the end of radiation therapy treatment, breast cancer survivors were screened for clinical levels of psychological symptoms and randomly assigned to either an immediate (n = 61) or a delayed intervention group (n = 59, intervention delayed by 5 months). CRF, sleep disturbances, energy levels, and physical activity were assessed using self-reported questionnaires, visual analog scales, and ecological momentary assessments. Assessments were performed at baseline (T1), 5 months (T2), and 10 months (T3). Mixed models were conducted to evaluate the intervention’s efficacy in treating CRF.
Results
Treated patients reported less general fatigue (p = 0.028), reduced motivation (p = 0.005), and mental fatigue (p = 0.024), as well as lower levels of habitual physical fatigue (p = 0.043) and momentary fatigue in daily life (p = 0.009).
Conclusions
Our study highlights the usefulness of targeting emotion and self-regulation in a brief group intervention to treat CRF among patients with clinical levels of psychological symptoms. Further research is needed to clarify the mechanisms driving the efficacy of the intervention.
{"title":"Efficacy of a Brief Ecologically Boosted Emotion Regulation Group Intervention on Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial","authors":"Sadio Righes, Pauline Waroquier, Marie Caillier, Oriane Verkaeren, Paulus Kristanto, Isabelle Merckaert","doi":"10.1155/ecc/6659905","DOIUrl":"https://doi.org/10.1155/ecc/6659905","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cancer-related fatigue (CRF) is one of the most frequently reported symptoms among breast cancer survivors. Recommendations regarding nonpharmacological treatments for CRF include physical activity, psychosocial, and mind–body interventions. Despite the close association of CRF with psychological symptoms, to our knowledge, no study has assessed the impact of a psychosocial intervention on CRF among patients meeting criteria for clinical levels of psychological symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study presents findings on changes in CRF, sleep disturbances, energy levels, and physical activity from a randomized controlled trial (RCT) evaluating the efficacy of an eight-session emotion and self-regulation group intervention ecologically boosted through daily app-based prompts. The intervention, specifically designed for breast cancer survivors in the early survivorship period who exhibited clinical levels of psychological symptoms, showed its efficacy in targeting some psychological symptoms (i.e., worry, intrusive thoughts, and negative emotions).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>At the end of radiation therapy treatment, breast cancer survivors were screened for clinical levels of psychological symptoms and randomly assigned to either an immediate (<i>n</i> = 61) or a delayed intervention group (<i>n</i> = 59, intervention delayed by 5 months). CRF, sleep disturbances, energy levels, and physical activity were assessed using self-reported questionnaires, visual analog scales, and ecological momentary assessments. Assessments were performed at baseline (T1), 5 months (T2), and 10 months (T3). Mixed models were conducted to evaluate the intervention’s efficacy in treating CRF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Treated patients reported less general fatigue (<i>p</i> = 0.028), reduced motivation (<i>p</i> = 0.005), and mental fatigue (<i>p</i> = 0.024), as well as lower levels of habitual physical fatigue (<i>p</i> = 0.043) and momentary fatigue in daily life (<i>p</i> = 0.009).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study highlights the usefulness of targeting emotion and self-regulation in a brief group intervention to treat CRF among patients with clinical levels of psychological symptoms. Further research is needed to clarify the mechanisms driving the efficacy of the intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/6659905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Living with prostate cancer presents considerable psychological challenges. Previous research has identified masculinity, intolerance of uncertainty, coping, and psychological flexibility as predictors of psychological adjustment, suggesting an integrative framework. However, the interplay between these factors remains underexplored. This study aims to address this gap by examining how these psychological factors collectively influence distress and well-being in prostate cancer, with a specific focus on the moderated mediation models involving coping and psychological flexibility. Findings will inform the development of tailored interventions and supportive care for men with prostate cancer.
Methods
A cross-sectional, correlational survey design was employed. A total of 162 men diagnosed with prostate cancer completed an online survey containing a battery of validated measures and demographic questions. Bivariate correlation, hierarchical regression, and conditional process analyses were conducted to test the proposed relationships.
Results
Psychological flexibility, masculine identity, masculine self-esteem, intolerance of uncertainty, and coping collectively explained 61.9% of the variance in distress and 52.7% in mental well-being. Masculine self-esteem emerged as the strongest predictor of both outcomes. Psychological flexibility explained significant additional variance beyond other psychological predictors and prostate cancer symptoms. Moreover, psychological flexibility moderated the indirect relationship between masculine self-esteem and distress through avoidant coping, as well as the direct effect of intolerance of uncertainty on distress.
Conclusions
Screening for difficulties related to masculine self-esteem and intolerance of uncertainty may help identify men at higher risk of poorer psychological adjustment following prostate cancer diagnosis. Interventions such as Acceptance and Commitment Therapy or mindfulness-based approaches may enhance psychological flexibility, improve tolerance of uncertainty, and foster adaptive engagement with masculine identity. Targeted interventions addressing the framing and enactment of masculinity may also prove beneficial.
{"title":"Psychological Flexibility Buffers the Effects of Intolerance of Uncertainty and Diminished Masculine Self-Esteem on Distress in Prostate Cancer","authors":"Yingna Li, Anne Finucane, David Gillanders","doi":"10.1155/ecc/7770664","DOIUrl":"https://doi.org/10.1155/ecc/7770664","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Living with prostate cancer presents considerable psychological challenges. Previous research has identified masculinity, intolerance of uncertainty, coping, and psychological flexibility as predictors of psychological adjustment, suggesting an integrative framework. However, the interplay between these factors remains underexplored. This study aims to address this gap by examining how these psychological factors collectively influence distress and well-being in prostate cancer, with a specific focus on the moderated mediation models involving coping and psychological flexibility. Findings will inform the development of tailored interventions and supportive care for men with prostate cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional, correlational survey design was employed. A total of 162 men diagnosed with prostate cancer completed an online survey containing a battery of validated measures and demographic questions. Bivariate correlation, hierarchical regression, and conditional process analyses were conducted to test the proposed relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Psychological flexibility, masculine identity, masculine self-esteem, intolerance of uncertainty, and coping collectively explained 61.9% of the variance in distress and 52.7% in mental well-being. Masculine self-esteem emerged as the strongest predictor of both outcomes. Psychological flexibility explained significant additional variance beyond other psychological predictors and prostate cancer symptoms. Moreover, psychological flexibility moderated the indirect relationship between masculine self-esteem and distress through avoidant coping, as well as the direct effect of intolerance of uncertainty on distress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Screening for difficulties related to masculine self-esteem and intolerance of uncertainty may help identify men at higher risk of poorer psychological adjustment following prostate cancer diagnosis. Interventions such as Acceptance and Commitment Therapy or mindfulness-based approaches may enhance psychological flexibility, improve tolerance of uncertainty, and foster adaptive engagement with masculine identity. Targeted interventions addressing the framing and enactment of masculinity may also prove beneficial.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/7770664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elsa Vitale, Roberto Lupo, Giorgio De Nunzio, Stefano Botti, Serena Maci, Ilaria Baldini, Valentina Rizzo, Maicol Carvello, Raffaella Massafra, Gianandrea Pasquinelli, Valeria Cremonini, Ivan Rubbi, Luana Conte
Introduction
Nursing advocacy represents an important factor in professional nursing ethics, as a combined element of the nurse’s achievements to enhance and assure both the well-being and interests of patients, ensuring their rights and accessibility to information to achieve a more informed decision. As burnout was associated to the working condition, we also hypothesized that years of work experience could worsen advocacy, too. Thus, the present study aimed to assess any differences that existed in oncology nursing advocacy according to work experience and burnout subdimensions, as emotional exhaustion, depersonalization, and personal accomplishment.
Methods
An observational, cross-sectional, national study was conducted from December 2023 to August 2024. Nursing advocacy attitudes and burnout levels were collected with also sociodemographic characteristics.
Results
A total of 183 Italian oncology nurses were enrolled. Data reported that there were no significant differences recorded among recruited nurses and their work experience associated to cognitive and behavioral attitudes in advocacy. Considering advocacy subdimensions related to burnout ones, significant differences were recorded between E.E. and behavior aspect of advocacy attitude (p = 0.038). Additionally, nurses, who recorded lower P.A. levels, registered higher values in behavioral attitudes in advocacy, too (p = 0.042).
Conclusion
Advocacy would seem to be inherent in nursing practice. However, in oncology settings, advocacy seemed to be more difficult to implement, both because the patient would seem more reluctant to communicate and because the nurse is more prone to burnout.
{"title":"Oncology Nursing Advocacy According to Burnout Subdimensions and Work Experience: An Investigational Study","authors":"Elsa Vitale, Roberto Lupo, Giorgio De Nunzio, Stefano Botti, Serena Maci, Ilaria Baldini, Valentina Rizzo, Maicol Carvello, Raffaella Massafra, Gianandrea Pasquinelli, Valeria Cremonini, Ivan Rubbi, Luana Conte","doi":"10.1155/ecc/9811411","DOIUrl":"https://doi.org/10.1155/ecc/9811411","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Nursing advocacy represents an important factor in professional nursing ethics, as a combined element of the nurse’s achievements to enhance and assure both the well-being and interests of patients, ensuring their rights and accessibility to information to achieve a more informed decision. As burnout was associated to the working condition, we also hypothesized that years of work experience could worsen advocacy, too. Thus, the present study aimed to assess any differences that existed in oncology nursing advocacy according to work experience and burnout subdimensions, as emotional exhaustion, depersonalization, and personal accomplishment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An observational, cross-sectional, national study was conducted from December 2023 to August 2024. Nursing advocacy attitudes and burnout levels were collected with also sociodemographic characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 183 Italian oncology nurses were enrolled. Data reported that there were no significant differences recorded among recruited nurses and their work experience associated to cognitive and behavioral attitudes in advocacy. Considering advocacy subdimensions related to burnout ones, significant differences were recorded between E.E. and behavior aspect of advocacy attitude (<i>p</i> = 0.038). Additionally, nurses, who recorded lower P.A. levels, registered higher values in behavioral attitudes in advocacy, too (<i>p</i> = 0.042).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Advocacy would seem to be inherent in nursing practice. However, in oncology settings, advocacy seemed to be more difficult to implement, both because the patient would seem more reluctant to communicate and because the nurse is more prone to burnout.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9811411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elmira Aboutalebi Vand Beilankouhi, Yosra Vaez-Gharamaleki, Reza Zarezadeh, Peyman Hassani, Mohammad Rasoul Amini, Reza Safaralizadeh, Mohammad Valilo
The development of breast cancer (BC) is a multistep process in which different cells and genes are involved, and its prevention and treatment are challenging. If BC is detected in the early stages, it can be prevented and the survival rate is high, and vice versa. Growing studies show that in recent years, many advances have been made in the field of BC prevention and treatment. Tamoxifen (TAM) is one of the important drugs used in the treatment of BC. Research shows that stem cells and various genes have a key role in TAM drug resistance in BC. Therefore, in this study, we intend to clarify the genes that are involved in the resistance to TAM in BC and perhaps take a small step in the prevention and treatment of BC.
{"title":"Tamoxifen and the Risk of Breast Cancer in Women With Different Types of Mutation","authors":"Elmira Aboutalebi Vand Beilankouhi, Yosra Vaez-Gharamaleki, Reza Zarezadeh, Peyman Hassani, Mohammad Rasoul Amini, Reza Safaralizadeh, Mohammad Valilo","doi":"10.1155/ecc/6145261","DOIUrl":"https://doi.org/10.1155/ecc/6145261","url":null,"abstract":"<p>The development of breast cancer (BC) is a multistep process in which different cells and genes are involved, and its prevention and treatment are challenging. If BC is detected in the early stages, it can be prevented and the survival rate is high, and vice versa. Growing studies show that in recent years, many advances have been made in the field of BC prevention and treatment. Tamoxifen (TAM) is one of the important drugs used in the treatment of BC. Research shows that stem cells and various genes have a key role in TAM drug resistance in BC. Therefore, in this study, we intend to clarify the genes that are involved in the resistance to TAM in BC and perhaps take a small step in the prevention and treatment of BC.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/6145261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer patients often experience various unmet supportive care needs throughout their treatment journey. Identifying these needs is essential to enhancing care and quality of life. This study aimed to assess the unmet supportive care needs and associated factors among adult cancer patients at Jimma Medical Center, Oromia, Southwest Ethiopia, in 2024.
Methods
A cross-sectional study of 261 adult cancer patients was conducted at Jimma Medical Center between December 1 and January 1, 2024. Data were collected through face-to-face interviews using a validated supportive care needs survey. Descriptive statistics and logistic regression analyses identified factors associated with unmet supportive care needs, with results reported using crude and adjusted odds ratios at a 95% confidence interval. A p value of < 0.05 was considered statistically significant.
Results
Of the 261 cancer patients surveyed, 98.5% responded, with a mean age of 44 ± 13.14 years. Psychological needs were the most unmet need (87.1%), followed by physical (79.1%) and sexual needs (47.8%). Factors significantly associated with unmet needs included younger age, low education, lack of health insurance, financial difficulties, treatment side effects, and poor quality of life (p < 0.05).
Conclusion and Recommendation
The study revealed high levels of unmet supportive care needs among cancer patients, particularly in the psychological domain. Individualized, patient-centered care should be prioritized, especially for younger, less educated, uninsured patients, and those facing financial issues, treatment side effects, or poor quality of life.
{"title":"Determinants of Unmet Supportive Care Needs Among Adults Living With Cancer: A Cross-Sectional Study in Southwest Ethiopia","authors":"Frezer Kedir, Ebrahim Yimam, Sadik Abdulwehab, Yeshitila Belay, Admasu Belay","doi":"10.1155/ecc/9721552","DOIUrl":"https://doi.org/10.1155/ecc/9721552","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cancer patients often experience various unmet supportive care needs throughout their treatment journey. Identifying these needs is essential to enhancing care and quality of life. This study aimed to assess the unmet supportive care needs and associated factors among adult cancer patients at Jimma Medical Center, Oromia, Southwest Ethiopia, in 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study of 261 adult cancer patients was conducted at Jimma Medical Center between December 1 and January 1, 2024. Data were collected through face-to-face interviews using a validated supportive care needs survey. Descriptive statistics and logistic regression analyses identified factors associated with unmet supportive care needs, with results reported using crude and adjusted odds ratios at a 95% confidence interval. A <i>p</i> value of < 0.05 was considered statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 261 cancer patients surveyed, 98.5% responded, with a mean age of 44 ± 13.14 years. Psychological needs were the most unmet need (87.1%), followed by physical (79.1%) and sexual needs (47.8%). Factors significantly associated with unmet needs included younger age, low education, lack of health insurance, financial difficulties, treatment side effects, and poor quality of life (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Recommendation</h3>\u0000 \u0000 <p>The study revealed high levels of unmet supportive care needs among cancer patients, particularly in the psychological domain. Individualized, patient-centered care should be prioritized, especially for younger, less educated, uninsured patients, and those facing financial issues, treatment side effects, or poor quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/9721552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zsuzsanna Iyizoba-Ebozue, Robin Prestwich, Karen O’Reilly, Louise Murray, Florien Boele
Introduction
Cancer-related fatigue (CRF) is a pervasive and debilitating symptom in patients treated for oropharyngeal cancer (OPC). This study explores communication about CRF in routine care according to patients and clinicians.
Method
This work integrated qualitative data from a secondary analysis of a cross-sectional study evaluating long-term fatigue and neurocognitive impairment in OPC patients treated with radiotherapy ± chemotherapy and a complementary qualitative service evaluation focused on exploring how healthcare professionals (HCPs) discuss CRF. Semistructured interviews were conducted with disease-free OPC survivors and HCPs experienced in managing OPC. Reflexive thematic analysis was undertaken.
Result
Thirty-one interviews (21 patients, 10 HCPs) were conducted. Mean interview duration was 40 min. Four themes were identified: (1) limited awareness and knowledge, (2) approaches to discussing CRF: proactive versus reactive, (3) impact of available time and timing of CRF discussions and (4) solution-oriented mindset and identified solutions. Both patients and HCPs described a lack of comprehensive understanding of CRF, contributing to an overall sense of vagueness and uncertainty. This led to a reactive rather than proactive approach to discussions, especially in the long term. Time, often limited amidst competing priorities in consultations, was seen as insufficient to address the complexities of CRF. In addition, no single optimal time to discuss CRF was identified, instead it may require multiple discussions. HCPs prioritised tangible solutions to address patient concerns, but a lack of straightforward strategies to manage CRF challenged this approach. HCPs proposed potential approaches, showing a willingness to engage in addressing the existing gaps.
Conclusion
While patients treated for OPC often seek validation and support for CRF, discussions are hindered by limited knowledge, time and lack of clear accessible solutions. Improved dialogue is needed to address the existing gaps in communication and inform the development of patient-centred strategies for managing CRF.
{"title":"“It’s Just Being Honest, Isn’t It?” The Communication Gap on Cancer-Related Fatigue in Oropharyngeal Cancer Survivors: A Qualitative Study","authors":"Zsuzsanna Iyizoba-Ebozue, Robin Prestwich, Karen O’Reilly, Louise Murray, Florien Boele","doi":"10.1155/ecc/3052808","DOIUrl":"https://doi.org/10.1155/ecc/3052808","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cancer-related fatigue (CRF) is a pervasive and debilitating symptom in patients treated for oropharyngeal cancer (OPC). This study explores communication about CRF in routine care according to patients and clinicians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This work integrated qualitative data from a secondary analysis of a cross-sectional study evaluating long-term fatigue and neurocognitive impairment in OPC patients treated with radiotherapy ± chemotherapy and a complementary qualitative service evaluation focused on exploring how healthcare professionals (HCPs) discuss CRF. Semistructured interviews were conducted with disease-free OPC survivors and HCPs experienced in managing OPC. Reflexive thematic analysis was undertaken.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Thirty-one interviews (21 patients, 10 HCPs) were conducted. Mean interview duration was 40 min. Four themes were identified: (1) limited awareness and knowledge, (2) approaches to discussing CRF: proactive versus reactive, (3) impact of available time and timing of CRF discussions and (4) solution-oriented mindset and identified solutions. Both patients and HCPs described a lack of comprehensive understanding of CRF, contributing to an overall sense of vagueness and uncertainty. This led to a reactive rather than proactive approach to discussions, especially in the long term. Time, often limited amidst competing priorities in consultations, was seen as insufficient to address the complexities of CRF. In addition, no single optimal time to discuss CRF was identified, instead it may require multiple discussions. HCPs prioritised tangible solutions to address patient concerns, but a lack of straightforward strategies to manage CRF challenged this approach. HCPs proposed potential approaches, showing a willingness to engage in addressing the existing gaps.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While patients treated for OPC often seek validation and support for CRF, discussions are hindered by limited knowledge, time and lack of clear accessible solutions. Improved dialogue is needed to address the existing gaps in communication and inform the development of patient-centred strategies for managing CRF.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3052808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qun-Hong Liu, Li-Fang Yuan, Li-Ling Zhou, Li-Hao Ye, Xia Yang
Background
It has been shown that physical activity (PA) improves health outcomes in patients with colorectal cancer. Some studies have explored a few correlates of PA separately. However, the specific factors underlying cognitive appraisals and their pathways remain unclear.
Objective
To investigate the relationship between benefit finding and PA among patients with colorectal cancer and examine the mediating role of cancer-related fatigue in this relationship.
Methods
A cross-sectional study was performed at the colorectal departments of a hospital in Guangzhou, China between November 2023 and May 2024. A total of 355 patients with colorectal cancer were included in the analysis. Data were collected using the International Physical Activity Questionnaire-Long Form, Benefit Finding Scale, and Cancer Fatigue Scale. Spearman’s correlation and a structural equation model were used to analyze the data.
Results
Benefit finding directly (β = 0.20, p < 0.001, 95% confidence interval = 0.09–0.31) and indirectly (β = 0.04, p = 0.030, 95% confidence interval = 0.01–0.09) influenced PA through cancer-related fatigue. Moreover, cancer-related fatigue partially mediated the effect of benefit finding on PA.
Conclusions
Benefit finding and cancer-related fatigue directly and indirectly influenced PA among patients with colorectal cancer. Future health education and effective interventions should focus on helping patients actively cope with disease to concurrently increase benefit finding and reduce cancer-related fatigue.
Implications for Nursing
The findings provide new insights into PA in patients with colorectal cancer and suggest that developing positive strategies to increase benefit finding and reduce cancer-related fatigue can thereby improve PA.
研究表明，身体活动（PA）可以改善结直肠癌患者的健康状况。一些研究分别探讨了PA的一些相关因素。然而，认知评价的具体因素及其途径尚不清楚。目的探讨结直肠癌患者获益感与前列腺癌相关性的关系，并探讨癌症相关性疲劳在其中的中介作用。方法于2023年11月至2024年5月在广州某医院结直肠科进行横断面研究。共有355名结直肠癌患者被纳入分析。数据收集使用国际体育活动问卷-长表格，效益发现量表和癌症疲劳量表。采用Spearman相关和结构方程模型对数据进行分析。结果获益发现直接（β = 0.20, p < 0.001, 95%可信区间= 0.09-0.31）和间接（β = 0.04, p = 0.030, 95%可信区间= 0.01-0.09）通过癌症相关疲劳影响PA。此外，癌症相关疲劳在一定程度上介导了有益发现对PA的影响。结论获益和癌症相关疲劳直接或间接影响结直肠癌患者的PA。未来的健康教育和有效干预应侧重于帮助患者积极应对疾病，同时增加获益，减少癌症相关疲劳。该研究结果为结肠直肠癌患者的PA提供了新的见解，并建议制定积极的策略来增加获益，减少癌症相关的疲劳，从而改善PA。
{"title":"The Cognitive Appraisal Path of Physical Activity, Benefit Finding, and Cancer-Related Fatigue Among Patients With Colorectal Cancer in China: Mediation Model Analysis","authors":"Qun-Hong Liu, Li-Fang Yuan, Li-Ling Zhou, Li-Hao Ye, Xia Yang","doi":"10.1155/ecc/1832643","DOIUrl":"https://doi.org/10.1155/ecc/1832643","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>It has been shown that physical activity (PA) improves health outcomes in patients with colorectal cancer. Some studies have explored a few correlates of PA separately. However, the specific factors underlying cognitive appraisals and their pathways remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the relationship between benefit finding and PA among patients with colorectal cancer and examine the mediating role of cancer-related fatigue in this relationship.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was performed at the colorectal departments of a hospital in Guangzhou, China between November 2023 and May 2024. A total of 355 patients with colorectal cancer were included in the analysis. Data were collected using the International Physical Activity Questionnaire-Long Form, Benefit Finding Scale, and Cancer Fatigue Scale. Spearman’s correlation and a structural equation model were used to analyze the data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Benefit finding directly (<i>β</i> = 0.20, <i>p</i> < 0.001, 95% confidence interval = 0.09–0.31) and indirectly (<i>β</i> = 0.04, <i>p</i> = 0.030, 95% confidence interval = 0.01–0.09) influenced PA through cancer-related fatigue. Moreover, cancer-related fatigue partially mediated the effect of benefit finding on PA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Benefit finding and cancer-related fatigue directly and indirectly influenced PA among patients with colorectal cancer. Future health education and effective interventions should focus on helping patients actively cope with disease to concurrently increase benefit finding and reduce cancer-related fatigue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Implications for Nursing</h3>\u0000 \u0000 <p>The findings provide new insights into PA in patients with colorectal cancer and suggest that developing positive strategies to increase benefit finding and reduce cancer-related fatigue can thereby improve PA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/1832643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145366955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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