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The Role of Antioxidant Supplementation in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review 补充抗氧化剂在造血干细胞移植患者中的作用:一项系统综述
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-14 DOI: 10.1155/ecc/6414419
Shima Heidari, Bita Shahrami, Soroush Rad, Mohammad Biglari, Rayeheh Tavajohi, Mohammad Vaezi

Background

Patients undergoing hematopoietic stem cell transplantation (HSCT) often face complications during the acute posttransplantation period. HSCT complications are linked to oxidative stress (OS) mechanisms due to accumulation of reactive oxygen species. Researchers hypothesize that antioxidant levels may modify OS immediately after HSCT.

Objective

This systematic review aimed to collect evidence on the role of antioxidant supplementation in determining the outcomes and complications of HSCT.

Study Design

A systematic search of two databases was conducted, including studies published until January 2024. Inclusion criteria involved clinical original studies focusing on adults and children undergoing HSCT who received antioxidant supplementation during and/or after HSCT.

Results

The review included 20 eligible studies, featuring antioxidants such as N-acetyl cysteine, vitamin C, zinc, selenium, vitamin E, and melatonin. Outcomes examined included immune system recovery, engraftment, oral mucositis, liver toxicity, nephrotoxicity, and acute graft-versus-host disease. The findings indicate an unclear association between antioxidant use and complications after HSCT. The certainty of evidence for these outcomes was low or very low.

Conclusions

Although the use of antioxidants in HSCT patients has been deemed safe and has even been associated with positive outcomes in some studies, the necessity for antioxidant supplementation during HSCT remains uncertain. Further large randomized controlled trials are necessary to ascertain antioxidant requirements and establish precise supplementation protocols for HSCT patients.

背景:接受造血干细胞移植(HSCT)的患者在急性移植后经常面临并发症。HSCT并发症与活性氧积累引起的氧化应激(OS)机制有关。研究人员假设抗氧化剂水平可能会在HSCT后立即改变OS。目的本系统综述旨在收集抗氧化剂补充在决定造血干细胞移植结果和并发症中的作用的证据。研究设计对两个数据库进行了系统检索,包括截至2024年1月发表的研究。纳入标准涉及临床原始研究,重点是接受HSCT的成人和儿童,在HSCT期间和/或之后接受抗氧化剂补充。结果本综述纳入了20项符合条件的研究,包括抗氧化剂,如n -乙酰半胱氨酸、维生素C、锌、硒、维生素E和褪黑激素。研究结果包括免疫系统恢复、移植、口腔黏膜炎、肝毒性、肾毒性和急性移植物抗宿主病。研究结果表明抗氧化剂的使用与造血干细胞移植后并发症之间的关系尚不清楚。这些结果的证据的确定性很低或非常低。结论:尽管在HSCT患者中使用抗氧化剂被认为是安全的,甚至在一些研究中与积极的结果相关,但在HSCT期间补充抗氧化剂的必要性仍然不确定。需要进一步的大型随机对照试验来确定HSCT患者的抗氧化剂需求并建立精确的补充方案。
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引用次数: 0
Accuracy of the Cancer Functional Assessment Set for Predicting Mortality in Patients With Advanced Cancer Undergoing Chemotherapy and/or Radiotherapy 癌症功能评估集预测晚期癌症化疗和/或放疗患者死亡率的准确性
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-14 DOI: 10.1155/ecc/8862225
Kenta Kawamura, Atsushi Tsukamoto, Kazuhiro Miyata, Kazuhide Tomita, Shinobu Minegishi

Objective

The Cancer Functional Assessment Set (cFAS) is a comprehensive functional tool used to evaluate patients with cancer, and it has the potential to predict mortality with high accuracy. We investigated the accuracy of the cFAS for predicting mortality in hospitalized patients undergoing radiotherapy and/or chemotherapy for advanced cancer, and we calculated a clinically useful cutoff value of the cFAS.

Methods

Patients with advanced cancer undergoing chemotherapy and/or radiotherapy at our hospital were assessed using the cFAS at their admission, and their survival was followed. We plotted receiver operating characteristic (ROC) curves up to 365 days by using mortality data obtained every 30 days after study enrollment.

Results

The areas under the curve (AUCs) were 0.65–0.89 (max. value – min. value within the entire period), and the cutoff value for the cFAS was 66–79 points, calculated using the Youden index. The cutoff value’s sensitivity was 0.44–0.80, and its specificity was 0.76–0.93. The AUC showed a decrease after 150 days of follow-up.

Conclusions

The cFAS was able to predict mortality in patients with cancer undergoing chemotherapy and/or radiotherapy with moderate accuracy within approx. 150 days and with low accuracy thereafter up to 365 days.

目的癌症功能评估集(Cancer Functional Assessment Set, cFAS)是一种用于评估癌症患者的综合性功能工具,具有较高的预测死亡率的潜力。我们研究了cFAS预测晚期癌症放疗和/或化疗住院患者死亡率的准确性,并计算了cFAS在临床上有用的临界值。方法对我院接受化疗或放疗的晚期肿瘤患者在入院时采用cFAS进行评估,并随访患者的生存情况。我们利用研究入组后每30天获得的死亡率数据绘制了365天的受试者工作特征(ROC)曲线。结果曲线下面积(auc)为0.65 ~ 0.89,最大者为0.89。value(整个期间的最小值),cFAS的临界值为66-79点,使用约登指数计算。敏感性临界值为0.44 ~ 0.80,特异性为0.76 ~ 0.93。随访150天后AUC下降。结论:cFAS能够预测接受化疗和/或放疗的癌症患者的死亡率,准确度在大约。150天,准确度较低,之后可达365天。
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引用次数: 0
Cross-Sectional Study of Factors Associated With Self-Efficacy for Nutritional Planning by Family Caregivers of Patients With Gastrointestinal Cancer 胃肠癌患者家庭照顾者营养计划自我效能感相关因素的横断面研究
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-10 DOI: 10.1155/ecc/6497337
Myung Kyung Lee

Objective

To examine factors associated with the self-efficacy for nutritional planning by family caregivers of patients with gastrointestinal (GI) cancer, with a focus on caregiver burden and decision-making related to the consumption of fruits and vegetables (F&V).

Methods

This cross-sectional study examined 378 family caregivers of patients who had GI cancers, mostly in the stomach, colorectum, or liver. Self-efficacy for nutrition planning, caregiver burden, and decision-making regarding the consumption of F&V were measured using the Nutrition Self-Efficacy Scale, the Brief Assessment Scale for Caregivers, and Henry’s Decisional Balance Scale for F&V consumption, respectively.

Results

Family caregivers who had greater nutritional self-efficacy had higher perceived “pros” regarding the health benefits of F&V, were married, had higher comorbidity scores, and had longer durations of caregiving. Family caregivers who had decreased nutritional self-efficacy had higher perceived “cons” to consuming F&V and increased perceived burden on other family members.

Conclusion

Our results suggest that increased awareness of the benefits and challenges of consuming F&V, along with strong support systems for family caregivers, can improve the diets of patients with GI cancer.

目的探讨影响胃肠道(GI)癌症患者家庭照顾者营养计划自我效能感的因素,重点关注照顾者负担和决策与水果和蔬菜消费(F&;V)的关系。方法本横断面研究调查了378名胃肠道癌症患者的家庭照顾者,这些患者主要发生在胃、结直肠或肝脏。分别采用营养自我效能量表、照护者简易评估量表和亨利食品食品消费决策平衡量表对营养计划、照护者负担和食品食品消费决策效能进行测量。结果具有较高营养自我效能感的家庭照顾者对食品和食品的健康益处有较高的“优点”,已婚,合并症评分较高,照顾时间较长。营养自我效能感降低的家庭照顾者对食品消费的“缺点”感知更高,对其他家庭成员的负担感知增加。结论:我们的研究结果表明,提高对食用食品的益处和挑战的认识,以及对家庭护理人员的强大支持系统,可以改善胃肠道癌患者的饮食。
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引用次数: 0
Validity and Reliability of the Self-Care in MyeloProliferative Neoplasms Inventory (SC-MPNI) 骨髓增殖性肿瘤自我护理量表的效度和信度
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-09 DOI: 10.1155/ecc/8353115
Valentina Biagioli, Alessandro Inzoli, Antonella Barone, Alessandra Iurlo, Paola Guglielmelli, Francesca Palandri, Barbara Mora, Stefana Impera, Silvia Betti, Marco Santoro, Vittorio Rosti, Giovanni Barosi

Objective

This study aimed to develop and psychometrically test a self-report questionnaire for measuring self-care behaviors in patients with myeloproliferative neoplasms (MPNs): the Self-Care in MyeloProliferative Neoplasms Inventory (SC-MPNI).

Methods

A cross-sectional validation study was conducted in 9 Italian hematology centers from November 2021 to January 2024. Adult patients with myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) were asked to complete a paper-and-pencil questionnaire during their outpatient visit or at home. The SC-MPNI was developed according to the Middle-Range Theory of Self-Care of Chronic Illness. This 30-item questionnaire includes three scales: self-care maintenance, self-care monitoring, and self-care management. The construct validity was tested using confirmatory factor analysis (CFA). The reliability of each scale was evaluated using McDonald’s Omega composite reliability.

Results

Overall, 285 patients with MPNs (53% male; mean age = 60 years ± 13) were included. They were diagnosed with MF (43%), PV (29%), or ET (28%). The self-care maintenance scale (13 items and 3 factors: adherence, healthy lifestyle, and prevention) fit well when tested with a three-factor model, and its reliability was 0.87. The self-care monitoring scale (9 items and 2 factors: symptom monitoring and parameter and test monitoring) fit well when tested with a two-factor model, and its reliability was 0.85. The self-care management scale (8 items and 2 factors: provider-directed behaviors and spontaneous behaviors) fit well when tested with a two-factor model, and its reliability was 0.79.

Conclusion

The SC-MPNI is a valid and reliable self-report instrument to measure self-care behaviors in people living with MPNs.

目的编制一份用于测量骨髓增生性肿瘤患者自我护理行为的自我报告问卷:骨髓增生性肿瘤自我护理量表(SC-MPNI),并对其进行心理计量学检验。方法于2021年11月至2024年1月在意大利9个血液学中心进行横断面验证研究。患有骨髓纤维化(MF)、真性红细胞增多症(PV)和原发性血小板增多症(ET)的成年患者被要求在门诊或在家完成一份纸笔调查问卷。SC-MPNI是根据慢性疾病自我照顾中程理论开发的。问卷共30个项目,包括三个量表:自我护理维持、自我护理监测和自我护理管理。采用验证性因子分析(CFA)检验结构效度。采用McDonald 's Omega复合信度评估各量表的信度。结果共纳入285例MPNs患者(53%为男性,平均年龄60岁±13岁)。他们被诊断为MF(43%)、PV(29%)或ET(28%)。自我护理维持量表(13项,依从性、健康生活方式、预防3个因子)经三因素模型检验拟合良好,信度为0.87。自我保健监测量表(9项2因子:症状监测和参数及测试监测)经双因素模型检验拟合良好,信度为0.85。自我护理管理量表(8项2因子:提供者导向行为和自发行为)经双因子模型检验拟合良好,信度为0.79。结论SC-MPNI是一种有效、可靠的自我报告工具,可用于测量mpn患者的自我保健行为。
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引用次数: 0
Exploring Chemotherapy-Induced Peripheral Neuropathy Severity Patterns in Young Adult Women With Breast Cancer Receiving Weekly or Dose Dense Paclitaxel 探索化疗诱导的周围神经病变严重程度模式的年轻成年女性乳腺癌患者接受每周或剂量密集紫杉醇
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-07 DOI: 10.1155/ecc/4229814
Robert Knoerl, Emanuele Mazzola, Lindsay Frazier, Roy L. Freeman, Marilyn Hammer, Fangxin Hong, Ann LaCasce, Jennifer Ligibel, Marlise R. Luskin, Donna Berry

Purpose

The purpose of this secondary analysis was to explore paclitaxel-induced peripheral neuropathy severity patterns among women with breast cancer receiving weekly or dose dense paclitaxel regimens.

Methods

Young adult women with breast cancer (18–39 years) beginning cancer treatment with dose dense (175 mg/m2 every 14 days) or weekly (80 mg/m2) paclitaxel completed the QLQ-CIPN20 before the first paclitaxel infusion (T1) and then at two time points during paclitaxel chemotherapy (T2: 350 mg/m2 and T3: 700 mg/m2). QLQ-CIPN20 scores were compared between women receiving dose dense or weekly paclitaxel across the three time points using mixed-effect linear regression models.

Results

Among women receiving dose dense paclitaxel (n = 27), mean QLQ-CIPN4 scores increased from 4.63 at T1 to 15.43 at T3, while among women receiving weekly paclitaxel (n = 12), mean QLQ-CIPN4 scores increased from 2.08 at T1 to 5.56 at T3. Similar trends were observed for changes in QLQ-CIPN20 sensory and motor subscale scores among both groups. Overall, while CIPN severity was worse at each time point among women receiving dose dense paclitaxel relative to women receiving weekly paclitaxel, there were no statistically significant differences between groups for changes in QLQ-CIPN4 (p = 0.24), QLQ-CIPN20 sensory (p = 0.41), or QLQ-CIPN20 motor score (p = 0.68) over time.

Conclusions

The results may be used to promote awareness among patients and clinicians regarding potential trajectories of paclitaxel-induced peripheral neuropathy for women with breast cancer.

该次要分析的目的是探讨接受每周或剂量密集紫杉醇治疗的乳腺癌妇女紫杉醇诱导的周围神经病变的严重程度模式。方法年轻成年乳腺癌女性(18-39岁),开始剂量密集(175 mg/m2 / 14天)或每周(80 mg/m2)紫杉醇治疗,在第一次紫杉醇输注(T1)前完成QLQ-CIPN20,然后在紫杉醇化疗(T2: 350 mg/m2和T3: 700 mg/m2)的两个时间点完成QLQ-CIPN20。使用混合效应线性回归模型比较三个时间点接受剂量密集或每周紫杉醇治疗的妇女的QLQ-CIPN20评分。结果在接受剂量密集紫杉醇治疗的女性(n = 27)中,QLQ-CIPN4平均评分从T1时的4.63上升到T3时的15.43,而在每周接受紫杉醇治疗的女性(n = 12)中,QLQ-CIPN4平均评分从T1时的2.08上升到T3时的5.56。在两组中,QLQ-CIPN20感觉和运动亚量表得分的变化趋势相似。总体而言,虽然接受剂量强化紫杉醇治疗的女性在每个时间点的CIPN严重程度比每周接受紫杉醇治疗的女性更差,但两组间QLQ-CIPN4 (p = 0.24)、QLQ-CIPN20感觉评分(p = 0.41)或QLQ-CIPN20运动评分(p = 0.68)随时间的变化无统计学差异。结论该结果可用于提高患者和临床医生对乳腺癌女性紫杉醇诱导的周围神经病变潜在轨迹的认识。
{"title":"Exploring Chemotherapy-Induced Peripheral Neuropathy Severity Patterns in Young Adult Women With Breast Cancer Receiving Weekly or Dose Dense Paclitaxel","authors":"Robert Knoerl,&nbsp;Emanuele Mazzola,&nbsp;Lindsay Frazier,&nbsp;Roy L. Freeman,&nbsp;Marilyn Hammer,&nbsp;Fangxin Hong,&nbsp;Ann LaCasce,&nbsp;Jennifer Ligibel,&nbsp;Marlise R. Luskin,&nbsp;Donna Berry","doi":"10.1155/ecc/4229814","DOIUrl":"https://doi.org/10.1155/ecc/4229814","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of this secondary analysis was to explore paclitaxel-induced peripheral neuropathy severity patterns among women with breast cancer receiving weekly or dose dense paclitaxel regimens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Young adult women with breast cancer (18–39 years) beginning cancer treatment with dose dense (175 mg/m<sup>2</sup> every 14 days) or weekly (80 mg/m<sup>2</sup>) paclitaxel completed the QLQ-CIPN20 before the first paclitaxel infusion (T1) and then at two time points during paclitaxel chemotherapy (T2: 350 mg/m<sup>2</sup> and T3: 700 mg/m<sup>2</sup>). QLQ-CIPN20 scores were compared between women receiving dose dense or weekly paclitaxel across the three time points using mixed-effect linear regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among women receiving dose dense paclitaxel (<i>n</i> = 27), mean QLQ-CIPN4 scores increased from 4.63 at T1 to 15.43 at T3, while among women receiving weekly paclitaxel (<i>n</i> = 12), mean QLQ-CIPN4 scores increased from 2.08 at T1 to 5.56 at T3. Similar trends were observed for changes in QLQ-CIPN20 sensory and motor subscale scores among both groups. Overall, while CIPN severity was worse at each time point among women receiving dose dense paclitaxel relative to women receiving weekly paclitaxel, there were no statistically significant differences between groups for changes in QLQ-CIPN4 (<i>p</i> = 0.24), QLQ-CIPN20 sensory (<i>p</i> = 0.41), or QLQ-CIPN20 motor score (<i>p</i> = 0.68) over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results may be used to promote awareness among patients and clinicians regarding potential trajectories of paclitaxel-induced peripheral neuropathy for women with breast cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/4229814","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical and Psychological Burdens Among Breast Cancer Survivors: Evaluating Post-Treatment Gait Impairment, Falls, and Depression Using Real-World Data 乳腺癌幸存者的生理和心理负担:使用真实世界数据评估治疗后的步态障碍、跌倒和抑郁
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-06 DOI: 10.1155/ecc/5558563
Asmaa Namoos, Nicholas Thomson, Carol Olson, Vanessa Sheppard, Michel Aboutanos

Background

Breast cancer survivors face a dual burden of physical and psychological challenges, which may persist long after treatment. This study aims to evaluate the physical impairments and psychological outcomes among breast cancer survivors compared to individuals without breast cancer.

Methods

We conducted a retrospective cohort study using data from 3650 breast cancer survivors and 145,280 individuals without breast cancer from the Virginia Commonwealth University Health System (VCUHS) between January 2024 and 2025. Data were extracted through the TriNetX platform using ICD-10 codes to identify relevant diagnoses and outcomes. Physical outcomes included abnormalities of gait and mobility, unsteadiness on feet, and falls. Psychological outcomes assessed were depression, stress-related disorders, and anxiety following falls. Risk differences, risk ratios (RR), and odds ratios with 95% confidence intervals (CIs) were calculated to compare outcomes between groups.

Results

Breast cancer survivors exhibited a higher risk of physical impairments compared to nonbreast cancer individuals. The risk of gait and mobility abnormalities was 2.725% in breast cancer survivors versus 1.741% in the comparison group (RR: 1.565; 95% CI: 1.285–1.906; p < 0.0001). Unsteadiness on feet was more prevalent among breast cancer survivors (0.817%) compared to 0.296% in non-cancer individuals (RR: 2.762; 95% CI: 1.91–3.993; p < 0.0001). Additionally, breast cancer survivors had a higher risk of falls (1.644%) compared to nonbreast cancer patients (1.081%) (RR: 1.521; 95% CI: 1.178–1.964; p = 0.0012). Psychologically, breast cancer survivors who experienced falls were more likely to suffer from depression (28.57% vs. 13.1%, p = 0.0002), stress-related disorders (14.29% vs. 3.49%, p < 0.0001), and anxiety (28.57% vs. 15.72%, p = 0.0040) compared to fallers without breast cancer.

Conclusion

Functional limitations such as unsteadiness and falls are significantly more common among breast cancer survivors and are strongly associated with psychological distress. These findings support mobility impairments as a potential pathway linking cancer treatment to adverse mental health outcomes. Future research should integrate structured ICD-10 data with unstructured oncology notes to enhance fall prediction models and guide personalized survivorship care.

乳腺癌幸存者面临着身体和心理的双重负担,这可能在治疗后很长一段时间内持续存在。本研究旨在评估乳腺癌幸存者与非乳腺癌个体相比的身体损伤和心理结果。方法:我们进行了一项回顾性队列研究,使用了2024年1月至2025年1月期间来自弗吉尼亚联邦大学卫生系统(VCUHS)的3650名乳腺癌幸存者和145280名非乳腺癌患者的数据。使用ICD-10代码通过TriNetX平台提取数据,以确定相关诊断和结果。身体结果包括步态和活动异常、脚不稳和跌倒。评估的心理结果包括抑郁、压力相关障碍和跌倒后的焦虑。计算风险差异、风险比(RR)和95%置信区间(ci)的优势比,比较两组间的结果。结果:与非乳腺癌个体相比,乳腺癌幸存者表现出更高的身体损伤风险。乳腺癌幸存者步态和活动异常的风险为2.725%,对照组为1.741% (RR: 1.565; 95% CI: 1.285-1.906; p < 0.0001)。脚不稳在乳腺癌幸存者中更为普遍(0.817%),而在非癌症个体中为0.296% (RR: 2.762; 95% CI: 1.91-3.993; p < 0.0001)。此外,乳腺癌幸存者摔倒的风险(1.644%)高于非乳腺癌患者(1.081%)(RR: 1.521; 95% CI: 1.178-1.964; p = 0.0012)。在心理上,与没有患乳腺癌的跌倒者相比,经历过跌倒的乳腺癌幸存者更容易患抑郁症(28.57%对13.1%,p = 0.0002)、压力相关疾病(14.29%对3.49%,p < 0.0001)和焦虑(28.57%对15.72%,p = 0.0040)。结论不稳、跌倒等功能障碍在乳腺癌幸存者中更为常见,并与心理困扰密切相关。这些发现支持活动障碍是将癌症治疗与不良心理健康结果联系起来的潜在途径。未来的研究应将结构化的ICD-10数据与非结构化的肿瘤学记录结合起来,以增强跌倒预测模型并指导个性化的生存护理。
{"title":"Physical and Psychological Burdens Among Breast Cancer Survivors: Evaluating Post-Treatment Gait Impairment, Falls, and Depression Using Real-World Data","authors":"Asmaa Namoos,&nbsp;Nicholas Thomson,&nbsp;Carol Olson,&nbsp;Vanessa Sheppard,&nbsp;Michel Aboutanos","doi":"10.1155/ecc/5558563","DOIUrl":"https://doi.org/10.1155/ecc/5558563","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast cancer survivors face a dual burden of physical and psychological challenges, which may persist long after treatment. This study aims to evaluate the physical impairments and psychological outcomes among breast cancer survivors compared to individuals without breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study using data from 3650 breast cancer survivors and 145,280 individuals without breast cancer from the Virginia Commonwealth University Health System (VCUHS) between January 2024 and 2025. Data were extracted through the TriNetX platform using ICD-10 codes to identify relevant diagnoses and outcomes. Physical outcomes included abnormalities of gait and mobility, unsteadiness on feet, and falls. Psychological outcomes assessed were depression, stress-related disorders, and anxiety following falls. Risk differences, risk ratios (RR), and odds ratios with 95% confidence intervals (CIs) were calculated to compare outcomes between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Breast cancer survivors exhibited a higher risk of physical impairments compared to nonbreast cancer individuals. The risk of gait and mobility abnormalities was 2.725% in breast cancer survivors versus 1.741% in the comparison group (RR: 1.565; 95% CI: 1.285–1.906; <i>p</i> &lt; 0.0001). Unsteadiness on feet was more prevalent among breast cancer survivors (0.817%) compared to 0.296% in non-cancer individuals (RR: 2.762; 95% CI: 1.91–3.993; <i>p</i> &lt; 0.0001). Additionally, breast cancer survivors had a higher risk of falls (1.644%) compared to nonbreast cancer patients (1.081%) (RR: 1.521; 95% CI: 1.178–1.964; <i>p</i> = 0.0012). Psychologically, breast cancer survivors who experienced falls were more likely to suffer from depression (28.57% vs. 13.1%, <i>p</i> = 0.0002), stress-related disorders (14.29% vs. 3.49%, <i>p</i> &lt; 0.0001), and anxiety (28.57% vs. 15.72%, <i>p</i> = 0.0040) compared to fallers without breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Functional limitations such as unsteadiness and falls are significantly more common among breast cancer survivors and are strongly associated with psychological distress. These findings support mobility impairments as a potential pathway linking cancer treatment to adverse mental health outcomes. Future research should integrate structured ICD-10 data with unstructured oncology notes to enhance fall prediction models and guide personalized survivorship care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/5558563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability Test of the Oral Nutritional Supplement Adherence Assessment Scale for Colorectal Cancer Patients 结直肠癌患者口服营养补充剂依从性评估量表的信度检验
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-03 DOI: 10.1155/ecc/8572726
Manli Liu, Qingran Lin, Shuxian Zhang, Mei Feng, Guihong Wu

Background

This study aimed to evaluate the reliability of a self-administered oral nutritional supplement adherence assessment scale for patients with colorectal cancer.

Methods

A presurvey was conducted with 25 colorectal cancer patients already taking nutritional supplements, obtained using purposive sampling to assess the comprehensibility and linguistic expression of the scale items. Following this, 310 questionnaires were distributed during the main survey, with 303 validly returned, yielding a validity rate of 97.74%.

Results

The scale underwent linguistic debugging, resulting in a final version comprising 3 dimensions and 28 items. Exploratory factor analysis (EFA) demonstrated statistically significant KMO values ranging from 0.864 to 0.902 for the three dimensions (p < 0.001). Two common factors were extracted from the knowledge dimension, contributing to a cumulative variance of 66.22%. One common factor was extracted from the belief dimension, with a cumulative variance contribution of 66.29%. The behavior dimension also demonstrated a cumulative variance contribution of 61.78%. The scale exhibited a Cronbach’s α coefficient of 0.904, split-half reliability of 0.857, a retest reliability coefficient of 0.859, and a content validity index (S-CVI) of 0.903.

Conclusion

The developed oral nutritional supplement adherence assessment scale for colorectal cancer patients demonstrated strong reliability and validity, making it an effective tool for evaluating adherence to oral nutritional supplementation. This scale can serve as a reference for the future development of related assessment tools and may contribute to improving nutritional management and clinical outcomes for patients with colorectal cancer.

本研究旨在评估结直肠癌患者自我给药口服营养补充剂依从性评估量表的可靠性。方法对25例已服用营养补充剂的结直肠癌患者进行问卷调查,采用目的抽样法对量表项目的可理解性和语言表达性进行评价。主调查共发放问卷310份,回收有效问卷303份,有效度为97.74%。结果量表经过语言调试,最终形成了包含3个维度、28个项目的最终版本。探索性因子分析(EFA)显示,三个维度的KMO值在0.864至0.902之间具有统计学意义(p < 0.001)。从知识维度提取两个共同因素,累积方差为66.22%。从信念维度中提取了一个共同因子,累积方差贡献率为66.29%。行为维度的累积方差贡献为61.78%。量表的Cronbach’s α系数为0.904,分半信度为0.857,重测信度系数为0.859,内容效度指数(S-CVI)为0.903。结论所编制的结直肠癌患者口服营养补充剂依从性评价量表具有较强的信度和效度,是评价结直肠癌患者口服营养补充剂依从性的有效工具。该量表可为未来相关评估工具的开发提供参考,并有助于改善结直肠癌患者的营养管理和临床结果。
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引用次数: 0
Assessment of Symptoms Prevalence and Quality of Life Among Cancer Survivors in Oman 阿曼癌症幸存者的症状、患病率和生活质量评估
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-09-26 DOI: 10.1155/ecc/2551044
Mohammad Al Qadire, Hanan Abdelrahman, Mohammed Al-Azri, Sulaiman Al Sabei, Omar Al Omari, Huda Al Awaisi, Rama Al Qadire

Purpose: To assess the prevalence and characteristics of symptoms and quality of life (QoL) among cancer survivors in Oman.

Methods: A cross-sectional correlational descriptive design was employed in three major healthcare settings in Muscat, Oman.

Results: The sample comprise 292 cancer survivors with an average age of 47.9 years (SD = 13.0) and a mean survival period of 2.5 years (SD = 3.3). The most reported symptoms were lack of energy (55.1%), numbness or tingling (53.8%), pain (53.1%), and worrying (51.7%), with an average of 10.9 symptoms per survivor. The overall QoL score was 23.9 (SD = 5.0), with the highest scores in the family (25.5, SD = 5.8) and psychological/spiritual (25.1, SD = 5.8) domains. Employment, marital status, and higher income were significant predictors of better QoL, while multiple treatments and high psychological symptoms were linked to poorer QoL.

Conclusion: This study highlights the significant symptom burden and its impact on QoL among cancer survivors in Oman. Tailored interventions addressing both physical and psychological needs are essential to enhance survivors’ QoL.

目的:评估阿曼癌症幸存者的患病率、症状特征和生活质量(QoL)。方法:在阿曼马斯喀特的三个主要卫生保健机构采用横断面相关描述性设计。结果:样本包括292例癌症幸存者,平均年龄为47.9岁(SD = 13.0),平均生存期为2.5年(SD = 3.3)。报告最多的症状是缺乏能量(55.1%),麻木或刺痛(53.8%),疼痛(53.1%)和担忧(51.7%),平均每个幸存者有10.9个症状。总体生活质量得分为23.9 (SD = 5.0),其中家庭得分最高(25.5,SD = 5.8),心理/精神得分最高(25.1,SD = 5.8)。就业、婚姻状况和高收入是较好的生活质量的显著预测因素,而多种治疗和高心理症状与较差的生活质量有关。结论:本研究突出了阿曼癌症幸存者显著的症状负担及其对生活质量的影响。针对生理和心理需求的量身定制的干预措施对于提高幸存者的生活质量至关重要。
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引用次数: 0
The Psychological Impacts and Coping Strategies of People Under 60 Living With Mesothelioma Cancer: A Qualitative Study 60岁以下间皮瘤患者的心理影响及应对策略:一项定性研究
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-09-24 DOI: 10.1155/ecc/6743766
Benjamin Lond, Iain Williamson, Lindsay Apps, Liz Darlison, Kerry Quincey

Introduction: Mesothelioma is a life-limiting cancer that results in an array of psychological difficulties. While this cancer is associated with older men exposed to asbestos, it can develop in people under 60, though little research has considered the challenges and ways of supporting this younger demographic.

Methods: Online semistructured interviews were carried out one-to-one with a total of 18 individuals; 6 men and 12 women, aged 26–59 (mean age 45), diagnosed with pleural or peritoneal mesothelioma. Participants could also share and discuss photographs to help further convey their cancer experiences. An interpretative phenomenological approach guided the analysis of transcript and photographic data.

Results: Two themes with discrete subthemes are presented: “dying young of an older person’s disease,” which explores individuals’ experiences of shock at diagnosis and widespread sense of disrupted living, concern for family members, and lack of peer support, and “living young with an older person’s disease,” which explores psychobehavioral coping via focus on the atypicality of mesothelioma in young groups, return to everyday living, and via activities and exercise to manage anxiety and foster a sense of agency.

Conclusion: Findings demonstrate the need to develop tailored clinical and psychotherapeutic support to address the practical and psychological difficulties younger people encounter.

间皮瘤是一种限制生命的癌症,导致一系列的心理困难。虽然这种癌症与接触石棉的老年男性有关,但它也可能发生在60岁以下的人群中,尽管很少有研究考虑到支持年轻人群的挑战和方法。方法:采用一对一在线半结构化访谈,共18人;6男12女,年龄26-59岁(平均45岁),诊断为胸膜间皮瘤或腹膜间皮瘤。参加者亦可分享及讨论照片,以进一步传达他们的癌症经历。解释性现象学方法指导了对笔录和摄影数据的分析。结果:提出了两个具有离散子主题的主题:“死于老年人疾病的年轻”,探讨了个人在诊断时的震惊经历和普遍的生活中断感,对家庭成员的关注,以及缺乏同伴支持;“活在老年人疾病的年轻时代”,探讨了心理行为应对,通过关注年轻群体中间皮瘤的非典型性,回归日常生活,通过活动和锻炼来管理焦虑和培养代理感。结论:研究结果表明,需要开发量身定制的临床和心理治疗支持,以解决年轻人遇到的实际和心理困难。
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引用次数: 0
Maternal Quality of Life During Pregnancy and Early Childhood Cancer: A Mixed-Methods Case-Control Study 孕期产妇生活质量与儿童早期癌症:一项混合方法病例对照研究
IF 1.9 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-09-24 DOI: 10.1155/ecc/3235446
Behnaz Aflatoonian, Hossein Mirzaei, Morteza Hashemian, Mohammad Reza Aflatoonian

Introduction: This study investigates the relationship between maternal quality of life during pregnancy and childhood cancer risk, hypothesizing that lower maternal well-being increases the likelihood of cancer development in children.

Methods: This embedded explanatory sequential mixed-methods case-control study was conducted in Kerman, Iran, including 191 children under six, with 136 diagnosed with cancer in 2023. From these, 73 mothers of affected children were purposefully selected and compared to 118 mothers of healthy children, matched by age and socioeconomic status. Maternal factors (e.g., age, education, employment, medical history, and lifestyle) were assessed using validated questionnaires (GHQ-28, SES), administered through structured interviews. Logistic regression (SPSS 28) and Python-based heatmap visualization were used for analysis. Qualitative data were extracted from interview narratives and analyzed thematically.

Results: Between 2014 and 2023, pediatric cancer diagnoses increased, especially malignant types. Significant maternal factors included older age, unemployment, lower education, medical history, and smoking. Paternal education, occupational exposure, and smoking also contributed. Qualitative themes—persistent anxiety, depressive thoughts, and perceived lack of purpose—offered contextual depth to the statistical findings.

Conclusions: Maternal quality of life during pregnancy significantly influences childhood cancer risk. Integrated interventions addressing maternal mental health, socioeconomic disparities, and occupational exposures are essential. Public health policies should prioritize maternal well-being to create protective environments for children.

本研究调查了怀孕期间母亲生活质量与儿童癌症风险之间的关系,并假设较低的母亲幸福感会增加儿童癌症发展的可能性。方法:这项嵌入式解释性序列混合方法病例对照研究在伊朗Kerman进行,包括191名6岁以下儿童,其中136名在2023年被诊断为癌症。有目的地从中选择73名受影响儿童的母亲,并与118名健康儿童的母亲进行比较,按年龄和社会经济地位进行匹配。使用有效问卷(GHQ-28, SES)通过结构化访谈对产妇因素(如年龄、教育、就业、病史和生活方式)进行评估。采用Logistic回归(SPSS 28)和基于python的热图可视化进行分析。从访谈叙述中提取定性数据并进行主题分析。结果:2014 - 2023年,儿童癌症诊断率上升,尤其是恶性类型。显著的母亲因素包括年龄较大、失业、教育程度较低、病史和吸烟。父亲的教育、职业暴露和吸烟也有影响。定性主题——持续的焦虑、抑郁的想法和感知到的缺乏目标——为统计结果提供了上下文深度。结论:孕期孕产妇生活质量显著影响儿童癌症风险。针对孕产妇心理健康、社会经济差异和职业暴露的综合干预措施至关重要。公共卫生政策应优先考虑产妇福祉,为儿童创造保护性环境。
{"title":"Maternal Quality of Life During Pregnancy and Early Childhood Cancer: A Mixed-Methods Case-Control Study","authors":"Behnaz Aflatoonian,&nbsp;Hossein Mirzaei,&nbsp;Morteza Hashemian,&nbsp;Mohammad Reza Aflatoonian","doi":"10.1155/ecc/3235446","DOIUrl":"https://doi.org/10.1155/ecc/3235446","url":null,"abstract":"<p><b>Introduction:</b> This study investigates the relationship between maternal quality of life during pregnancy and childhood cancer risk, hypothesizing that lower maternal well-being increases the likelihood of cancer development in children.</p><p><b>Methods:</b> This embedded explanatory sequential mixed-methods case-control study was conducted in Kerman, Iran, including 191 children under six, with 136 diagnosed with cancer in 2023. From these, 73 mothers of affected children were purposefully selected and compared to 118 mothers of healthy children, matched by age and socioeconomic status. Maternal factors (e.g., age, education, employment, medical history, and lifestyle) were assessed using validated questionnaires (GHQ-28, SES), administered through structured interviews. Logistic regression (SPSS 28) and Python-based heatmap visualization were used for analysis. Qualitative data were extracted from interview narratives and analyzed thematically.</p><p><b>Results:</b> Between 2014 and 2023, pediatric cancer diagnoses increased, especially malignant types. Significant maternal factors included older age, unemployment, lower education, medical history, and smoking. Paternal education, occupational exposure, and smoking also contributed. Qualitative themes—persistent anxiety, depressive thoughts, and perceived lack of purpose—offered contextual depth to the statistical findings.</p><p><b>Conclusions:</b> Maternal quality of life during pregnancy significantly influences childhood cancer risk. Integrated interventions addressing maternal mental health, socioeconomic disparities, and occupational exposures are essential. Public health policies should prioritize maternal well-being to create protective environments for children.</p>","PeriodicalId":11953,"journal":{"name":"European Journal of Cancer Care","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ecc/3235446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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European Journal of Cancer Care
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