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Ionic release and electrochemical testing of 3-D printed orthodontics metallic bands made of Co-Cr and stainless-steel alloys. 钴铬合金和不锈钢合金制成的3d打印正畸金属带的离子释放和电化学测试。
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf050
Spiros Zinelis, Aikaterini Sakellari, Sotirios Karavoltsos, Georgios Polychronis, Nearchos Panayi, Spyridon N Papageorgiou, Theodore Eliades

Objective: The aim of this study was to investigate the electrochemical characteristics and ionic release of three-dimensional (3D) printed orthodontic metallic bands made of stainless-steel (SS) and Cobalt-Chromium (Co-Cr) alloys.

Materials and methods: Thirty-six orthodontic metallic bands were prepared by 3D printing, employing SS (n = 18) and Co-Cr (n = 18) alloys. The ionic release from each alloy was determined according to ISO 27020:2019 requirements employing flame atomic absorption spectrometry (FAAS). The electrochemical properties were characterized by Open Circuit Potential (OCP), Anodic Scan (AS) and Electrochemical Impedance Spectroscopy (EIS). In all cases a 0.1M NaCl, 0.1 M lactic acid solution was used. The EIS data were fitted to a Randles circuit and the sum of ionic release of probed elements after immersion along with OCP, zero corrosion potential (Ecorr), corrosion current density (Icorr), and pitting corrosion potential (Epit) were compared with t-tests/Mann-Whitney tests (α = 0.05).

Results: SS bands showed an approximately 44-fold higher total ionic release compared to Co-Cr ones. Electrochemical testing revealed no statistically significant differences for Ecorr but Co-Cr illustrated more beneficial OCP, Icorr and Epit values than SS. Both alloys illustrated semicircles in Nyquist plots, implying that the electrochemical process was under charge transfer control, while the equivalent circuit simulation showed a higher charge transfer resistance for Co-Cr alloy (SS:14191.1 vs Co-Cr:33158.7 Ωcm2), implying lower corrosion current and thus decreased corrosion rate.

Conclusion: Immersion and electrochemical testing indicated that Co-Cr alloys showed increased corrosion resistance over SS ones, which might affect efficacy under clinical use.

目的:研究不锈钢(SS)和钴铬合金(Co-Cr)三维打印正畸金属带的电化学特性和离子释放特性。材料与方法:采用SS (n = 18)和Co-Cr (n = 18)合金,采用3D打印技术制备36个正畸金属带。根据ISO 27020:2019要求,采用火焰原子吸收光谱法(FAAS)测定每种合金的离子释放量。采用开路电位(OCP)、阳极扫描(AS)和电化学阻抗谱(EIS)对其电化学性能进行了表征。在所有情况下,使用0.1M NaCl, 0.1M乳酸溶液。将EIS数据拟合到Randles电路中,并用t检验/Mann-Whitney检验比较浸泡后探针元素的离子释放量与OCP、零腐蚀电位(Ecorr)、腐蚀电流密度(Icorr)和点蚀电位(Epit)之和(α = 0.05)。结果:SS谱带的总离子释放量比Co-Cr谱带高约44倍。电化学测试结果显示,Ecorr与SS之间没有统计学差异,但Co-Cr比SS更有利于OCP、Icorr和Epit值。两种合金在Nyquist图中均呈现半圆形,表明电化学过程受电荷转移控制,而等效电路模拟显示Co-Cr合金具有更高的电荷转移电阻(SS:14191.1 vs Co-Cr:33158.7 Ωcm2),表明腐蚀电流更小,从而降低了腐蚀速率。结论:浸渍和电化学试验表明,Co-Cr合金比SS合金具有更强的耐蚀性,可能影响临床使用效果。
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引用次数: 0
Consensus on orthodontic treatment eligibility in Finnish health care system - A comparative analysis of assessment. 芬兰卫生保健系统中正畸治疗资格的共识-评估的比较分析。
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf060
Annika Arpalahti, Anne-Maria Aulu, Elizabete Agafonova, Niina Raij, Heidi Arponen

Background: In many European countries, orthodontic treatment is offered in publicly funded healthcare to those with severe malocclusion. In the Finnish public health care, the modified Grainger's treatment priority index (TPI) is used to determine malocclusion severity and treatment eligibility. The uniform use of occlusal indexes is crucial for equitable treatment allocation.

Objective: This study aimed to investigate equity in access to orthodontic care in one wellbeing services county in Finland.

Materials and methods: We conducted five calibration events, where five orthodontists were calibrated against one gold standard orthodontist with the longest clinical experience. All the orthodontists independently clinically examined random groups of patients using the Finnish modified TPI scoring. The malocclusion severity scores, diagnosis codes, and the determined treatment eligibility were subsequently compared. Agreement between the orthodontists was analyzed with Cohen's Kappa and Bland-Altman statistics.

Results: In total, 166 patients, aged 6-63 years, were examined across the calibrations, each representing a comparison between one of the five orthodontists and the gold standard. The agreement between the orthodontists was found to be substantial. The same judgement on treatment eligibility was made in 145 out of 166 cases (87%), whereas a different decision on treatment eligibility was made in 21 cases (13%).

Conclusions: Despite the high level of interobserver agreement, differences in eligibility judgement were observed, which may have important consequences for the patient with respect to treatment provision. Therefore, systematic calibration and regular training in the use of national occlusal indexes should be implemented for all orthodontists.

背景:在许多欧洲国家,正畸治疗是在公共资助的卫生保健提供给那些严重错牙合。在芬兰的公共卫生保健中,改进的Grainger治疗优先指数(TPI)用于确定错颌的严重程度和治疗资格。咬合指标的统一使用对公平分配治疗至关重要。目的:本研究旨在调查芬兰一个福利服务县获得正畸护理的公平性。材料和方法:我们进行了五次校准事件,其中五名正畸医生根据一名具有最长临床经验的金标准正畸医生进行校准。所有的正畸医生都独立地对随机分组的患者进行临床检查,使用芬兰改良的TPI评分。随后比较错颌严重程度评分、诊断代码和确定的治疗资格。采用Cohen's Kappa和Bland-Altman统计分析正畸医师之间的一致性。结果:总共有166名患者,年龄在6-63岁之间,通过校准进行了检查,每个校准代表五名正畸医生中的一名与金标准的比较。正畸医生之间的协议被认为是实质性的。166例中有145例(87%)对治疗资格作出了相同的判断,而21例(13%)对治疗资格作出了不同的决定。结论:尽管观察者之间的一致性很高,但观察到在资格判断上的差异,这可能对患者的治疗提供产生重要影响。因此,应对所有正畸医师进行系统校准和定期使用国家咬合指标的培训。
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引用次数: 0
Changes in clinical crown length and the development of gingival recession associated with orthodontic treatment-induced incisor inclination changes: a retrospective cohort study. 临床冠长变化和牙龈萎缩的发展与正畸治疗引起的切牙倾斜变化相关:一项回顾性队列研究。
IF 2.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf057
Shatha R Alkhalidy, Budoor S K Bin Bahar, Athanasios E Athanasiou, Miltiadis A Makrygiannakis, M Faysal Talass, Eleftherios G Kaklamanos

Background/objectives: Gingival recession results from the displacement of the gingival margin apically to the cementoenamel junction. There is unclear evidence regarding the impact of orthodontic treatment on the development of gingival recessions. The aim of this study was to investigate the changes in clinical crown length and the development of gingival recession on the labial aspect of the maxillary and mandibular incisors associated with orthodontic treatment and relate these changes to the observed variations in their sagittal inclination.

Materials/methods: Eighty-two consecutive subjects treated with fixed orthodontic appliances in both dental arches, possessing high-quality pre- and post-treatment dental casts and lateral cephalometric radiographs, were selected from the archives of a private orthodontic clinic. Incisor clinical crown lengths before and after orthodontic treatment, as well as the presence or absence of recession, were measured using digitized study models. Changes in sagittal inclination were assessed from lateral cephalometric radiographs and categorized as proclination, retroclination, or no change (± 1°). Spearman's correlation coefficient, one-way analysis of variance, and chi-square tests were utilized for analysis.

Results: The mean change in clinical crown lengths for the maxillary incisors ranged from -0.24 to 0.01 mm, while for the mandibular incisors, it varied from 0.06 to 0.10 mm. The inclination changes were -1.78° and 1.03°, respectively, but no correlations were found between these inclination changes and the clinical crown length alterations. Overall, no statistically significant differences were observed in clinical crown length changes concerning the presence of gingival recession among the proclination, retroclination, and no change groups.

Limitations: The sample of this study was retrospective and assessments were carried out immediately post-treatment.

Conclusions/implications: The alteration of incisor inclination during treatment did not appear to impact the changes in labial clinical crown length and the development of gingival recession in this specific sample.

背景/目的:牙龈退缩是由于牙龈边缘根部向牙髓-牙釉质交界处移位引起的。关于正畸治疗对牙龈衰退发展的影响尚无明确证据。本研究的目的是研究临床冠长度的变化和上颌和下颌切牙唇侧牙龈退缩的发展与正畸治疗的关系,并将这些变化与观察到的矢状倾斜的变化联系起来。材料/方法:从某私立正畸诊所档案中选择82例连续使用固定正畸器治疗的患者,这些患者均拥有高质量的治疗前和治疗后牙模和侧位头颅x线片。使用数字化研究模型测量正畸治疗前后门牙临床牙冠长度,以及是否存在退缩。通过侧位头颅x线片评估矢状面倾斜度的变化,并将其分为前倾、后倾或无变化(±1°)。采用Spearman相关系数、单因素方差分析和卡方检验进行分析。结果:上颌切牙牙冠长度的平均变化范围为-0.24 ~ 0.01 mm,下颌骨切牙牙冠长度的平均变化范围为0.06 ~ 0.10 mm。倾斜度变化分别为-1.78°和1.03°,但与临床冠长变化无相关性。总的来说,在前倾组、后倾组和未改变组中,与牙龈退缩相关的临床冠长变化没有统计学上的显著差异。局限性:本研究的样本是回顾性的,并在治疗后立即进行评估。结论/意义:在治疗过程中,切牙倾斜度的改变似乎没有影响临床唇冠长度的变化和牙龈退缩的发展。
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引用次数: 0
Optimizing orthodontic treatment protocol for patients with periodontitis or reduced periodontium: a systematic review and meta-analysis. 优化牙周炎或牙周炎减少患者的正畸治疗方案:一项系统回顾和荟萃分析。
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf045
Sally Abd El-Meniem El-Haddad, Ferdous Bukhary, Renad Yousef Alrahaimi, Albaraa Rashed Alkhaldi, Almaha AlDhelaan

Background: An increasing number of adults with periodontitis are pursuing orthodontic treatment to enhance their occlusion and aesthetics. To manage these patients effectively, it is essential to develop a tailored orthodontic treatment plan that addresses key factors such as anchorage, biomechanics, and interdisciplinary collaboration between orthodontists and periodontists. This comprehensive approach can significantly improve treatment outcomes.

Objectives: This study aims to identify the most effective orthodontic protocols for treating patients with periodontitis or a reduced periodontium, paving a foundation for better clinical practices and improved patient satisfaction.

Search methods: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. Selection Criteria: It focused on patients aged 20-50 years, with no systemic disorders, and studies published since 2000.

Data collection and analysis: Data was collected and the quality was assessed using the Critical Appraisal Skills Program (CASP) checklist. A meta-analysis was performed using the R program, with I2 used to quantify heterogeneity. Sensitivity analysis was performed on each subset of studies.

Results: The sensitivity analysis reveals that orthodontic therapy significantly resulted in improved clinical attachment level (CAL), with a pooled mean gain of 3.84-4.34 mm. Also, a significant reduction in probing depth (PD) with a pooled mean reduction of 4.32 mm was revealed after orthodontic treatment for periodontitis patients .

Conclusion: This study suggested that individualized, interdisciplinary orthodontic and periodontic protocols are crucial for managing patients with periodontitis or reduced periodontium. Tailored approaches using conservative forces and regenerative strategies significantly improve clinical outcomes, making one-size-fits-all methods inadequate.

Registration: PROSPERO: ID: CRD42024573973.

背景:越来越多的成人牙周炎患者正在寻求正畸治疗,以提高他们的咬合和美观。为了有效地管理这些患者,制定量身定制的正畸治疗计划至关重要,该计划应解决诸如锚固,生物力学以及正畸医生和牙周病医生之间的跨学科合作等关键因素。这种综合方法可以显著改善治疗效果。目的:本研究旨在确定治疗牙周炎或牙周组织减少患者最有效的正畸治疗方案,为更好的临床实践和提高患者满意度奠定基础。检索方法:本综述遵循系统评价和荟萃分析首选报告项目(PRISMA)指南。入选标准:年龄20-50岁,无全身性疾病,2000年以来发表的研究。数据收集和分析:使用关键评估技能计划(CASP)检查表收集数据并评估质量。采用R程序进行meta分析,I2用于量化异质性。对每个研究子集进行敏感性分析。结果:敏感性分析显示,正畸治疗显著提高了临床附着水平(CAL),合并平均增加3.84 ~ 4.34 mm。此外,牙周炎患者在正畸治疗后,探诊深度(PD)显著减少,平均减少4.32 mm。结论:本研究表明,个性化,跨学科的正畸和牙周治疗方案对于治疗牙周炎或牙周减少患者至关重要。使用保守力量和再生策略的量身定制的方法显着提高了临床结果,使得一刀切的方法是不够的。注册:PROSPERO: ID: CRD42024573973。
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引用次数: 0
Smartphones or digital SLRs for clinical dental photography: is there a difference? 智能手机和数码单反用于临床牙科摄影:有区别吗?
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf033
Kirandeep Nandhra, Julian Woolley, Dirk Bister, Martyn Sherriff, Huw Jeremiah

Background: Clinical photography is a fundamental aspect of orthodontic treatment and has become critical to patient care, communication and documentation. Digital Single Lens Reflex (DSLR) cameras with a ring flash have been established as a gold standard for clinical photography for many years, however smartphones are increasingly being utilized by both patients and clinicians due to their convenience, cost effectiveness and good accessibility.

Aims/ objectives: This study compared the image quality, dimensional accuracy, ease of use and accuracy of shade representation of images produced by recent flagship smartphones versus DSLR cameras with a ring flash.

Material and methods: A sample of four recent smartphones and three semi-professional DSLR cameras were compared taking a comprehensive set of orthodontic intra and extra oral clinical photographs. The following outcome measures were assessed for each device: Camera sensor size, image quality, ease of use, dimensional accuracy and colour shade representation.

Results: DSLR cameras with a ring flash were statistically significantly superior to smartphones for camera sensor size, image quality rating and dimensional accuracy. There was no significant difference between all devices for their ease-of-use rating or accuracy of colour shade representation.

Conclusion: Based on the results of this study, the authors recommend the use of DSLR cameras with a ring flash as a gold standard for clinical photography due to reduced quality rating and image distortion produced by many smartphone cameras.

背景:临床摄影是正畸治疗的一个基本方面,已经成为病人护理,沟通和记录的关键。带环形闪光灯的数码单反相机(DSLR)多年来一直是临床摄影的黄金标准,然而智能手机由于其便利性、成本效益和良好的可及性而越来越多地被患者和临床医生使用。目的/目的:本研究比较了最近的旗舰智能手机与带环形闪光灯的数码单反相机所产生的图像质量、尺寸精度、易用性和阴影表示的准确性。材料与方法:以4台近期智能手机和3台半专业数码单反相机为样本,进行综合口腔内、口腔外临床照片的比较。评估了每个设备的以下结果指标:相机传感器尺寸、图像质量、易用性、尺寸精度和颜色阴影表示。结果:带环形闪光灯的数码单反相机在相机传感器尺寸、图像质量评级和尺寸精度方面明显优于智能手机。所有设备在易用性评分或色度表征的准确性方面没有显着差异。结论:基于本研究的结果,作者建议使用带环形闪光灯的单反相机作为临床摄影的黄金标准,因为许多智能手机相机会降低质量评级和图像失真。
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引用次数: 0
The impact of orthodontic-surgical treatment on female patients' temporomandibular symptoms, psychological distress, and quality of life. 正畸手术治疗对女性患者颞下颌关节症状、心理困扰及生活质量的影响。
IF 2.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf062
Elli Suomela, Outi Alanko, Martti T Tuomisto, Erkki Svedström, Timo Peltomäki, Auli Suominen, Tero Soukka, Anna-Liisa Svedström-Oristo

Objective: To analyze changes in patients' temporomandibular dysfunction (TMD) symptoms during orthodontic-surgical treatment and to investigate associations between symptoms, findings in temporomandibular joints (TMJs), satisfaction with occlusal function, psychological distress, and orthognathic quality of life (OQoL).

Subjects and methods: Thirty-six consecutive female patients started orthodontic-surgical treatment, and 28 voluntary controls participated. Patients and controls filled in a semi-structured diary (regarding satisfaction and TMD symptoms) and the Orthognathic Quality of Life Questionnaire (OQLQ); patients also filled in the Symptom Checklist-90 (SCL-90). Patients' data were analyzed before treatment (T1), after preoperative orthodontics (T3), and one year after jaw surgery (T5). Controls' data were collected at respective time points (CT1, CT2, CT3). Magnetic Resonance Imaging (MRI) studies were performed on patients' and controls' TMJs at T1/CT1.

Results: Before surgery, patients reported more TMD symptoms than controls. The most frequent symptoms were head/neck pain, stiffness/fatigue of the jaws, and pain in jaw joints. The most common finding in TMJ-MRI was anterior disc displacement with or without reduction. One year after surgery, improvement was seen in patients' satisfaction and OQLQ scores. Patients' number of symptoms correlated negatively with satisfaction and positively with OQLQ scores. No significant correlations were found between the severity of TMJ-MRI findings and satisfaction, number of symptoms, OQLQ function, or sum score.

Conclusions: Although TMJ-MRI findings are common among orthodontic-surgical patients, they are not always reflected in subjective symptoms, nor in self-perceived treatment outcome. Individual characteristics, not detectable using objective measures, constitute an important aspect and should therefore reserve more emphasis.

目的:分析正畸手术治疗中患者颞下颌功能障碍(TMD)症状的变化,探讨症状、颞下颌关节(TMJs)表现、咬合功能满意度、心理困扰和正颌生活质量(OQoL)之间的关系。对象和方法:连续36例女性患者开始正畸手术治疗,28例自愿参加。患者和对照组填写半结构化日记(关于满意度和TMD症状)和正颌生活质量问卷(OQLQ);同时填写症状表-90 (SCL-90)。分析患者治疗前(T1)、术前正畸治疗后(T3)和颌骨手术后1年(T5)的数据。在各自的时间点(CT1、CT2、CT3)收集对照组数据。在T1/CT1时对患者和对照组的TMJs进行磁共振成像(MRI)研究。结果:手术前,患者报告的TMD症状多于对照组。最常见的症状是头/颈部疼痛,下颌僵硬/疲劳,以及下颌关节疼痛。TMJ-MRI最常见的发现是前盘移位伴或不伴复位。术后一年,患者满意度和oqq评分均有改善。患者症状数量与满意度呈负相关,与OQLQ评分呈正相关。TMJ-MRI结果的严重程度与满意度、症状数量、OQLQ功能或总评分之间没有显著相关性。结论:虽然TMJ-MRI结果在正畸手术患者中很常见,但它们并不总是反映在主观症状中,也不反映在自我感知的治疗结果中。无法用客观措施检测到的个人特征是一个重要方面,因此应给予更多的重视。
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引用次数: 0
Age-dependent impact of Zoledronic acid on periodontal structures under orthodontic loading. 正畸负荷下唑来膦酸对牙周结构的年龄依赖性影响。
IF 2.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf032
Ana Zilda Nazar Bergamo, Francisco José Albuquerque de Paula, Renato Corrêa Viana Casarin, Letícia Fernanda Duffles, Ariane Zamarioli, Alberto Consolaro, Marília P Lucisano, Murilo Fernando Neuppmann Feres, Léa Assed Bezerra da Silva, Paulo Nelson-Filho

Objectives: This study aimed to evaluate zoledronic acid (ZOL) induced alterations in the alveolar bone, periodontal ligament, and cementum under orthodontic forces in mice of different ages, focusing on the early and late half-life of ZOL administration.

Methods: Juvenile (6-week; n = 30) and adult (12-week; n = 20) mice (C57BL/6J) were divided into five groups, with three groups receiving a single ZOL dose. A 0.35 N orthodontic force was applied 1 and 12 weeks after ZOL administration. Alveolar bone, cementum, periodontal ligament response, osteoclast activity, calcium and 1,25(OH)2D3 levels were assessed at 12 h and 12 weeks after force application.

Results: ZOL reduced tooth displacement and osteoclast counts in the adult and juvenile (latency phase of medication) groups compared to the juvenile control group (P < .05). The thickness of the periodontal ligament and number of blood vessels decreased moderately in adult mice and slightly in juveniles (P < .05), particularly in the ZOL-treated groups. Cementum resorption and alveolar crest irregularities were observed in all the ZOL-treated groups. Juvenile mice that underwent force application 12 weeks after ZOL administration exhibited responses similar to those observed in adult mice.

Limitations: This study demonstrated that the periodontal ligament and alveolar bone of juvenile and adult mice respond differently to ZOL treatment. However, the mechanisms underlying these differential effects remain unclear, highlighting the need for further investigation of bone remodeling markers to better understand the impact of ZOL during both the active and latency phases in young and adult subjects.

Conclusions: ZOL intake influenced the alveolar bone, periodontal ligament, cementum, blood vessel count, and tooth displacement under orthodontic force. The extent of these changes was age dependent, with distinct effects observed in juvenile and adult mice. Juvenile mice analyzed in the latency phase of medication exhibited behaviors resembling those of adult mice.

目的:本研究旨在评价唑来膦酸(ZOL)在不同年龄小鼠正畸力作用下对牙槽骨、牙周韧带和牙骨质的影响,重点研究ZOL给药的早期半衰期和晚期半衰期。方法:幼鼠(6周;N = 30)和成人(12周;n = 20)只小鼠(C57BL/6J)分为5组,其中3组给予单剂量ZOL。ZOL给药后1周和12周分别施加0.35 N正畸力。在施加力后12小时和12周评估牙槽骨、牙骨质、牙周韧带反应、破骨细胞活性、钙和125 (OH)2D3水平。结果:与幼年对照组相比,ZOL在成年和幼年(给药潜伏期)组减少了牙齿位移和破骨细胞计数(P)。局限性:本研究表明,幼鼠和成年小鼠对ZOL治疗的牙周韧带和牙槽骨的反应不同。然而,这些差异效应的机制尚不清楚,因此需要进一步研究骨重塑标志物,以更好地了解ZOL在年轻和成年受试者的活跃期和潜伏期的影响。结论:ZOL的摄入对正畸力作用下牙槽骨、牙周韧带、牙骨质、血管计数及牙位移有影响。这些变化的程度与年龄有关,在幼年和成年小鼠中观察到不同的影响。在药物潜伏期分析的幼年小鼠表现出与成年小鼠相似的行为。
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引用次数: 0
Objective adherence to oral appliance therapy in patients with obstructive sleep apnea: a one-year longitudinal analysis. 目的:阻塞性睡眠呼吸暂停患者口腔器械治疗依从性:一项为期一年的纵向分析。
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf037
Yanlong Chen, Benjamin T Pliska, Bingshuang Zou, Fernanda R Almeida

Introduction: Oral appliance (OA) therapy is widely used as an alternative to continuous positive airway pressure (CPAP) therapy for treating obstructive sleep apnea (OSA). Traditionally, OA adherence has been assessed through subjective self-reports before, but the availability of objective adherence sensors now allows for more accurate monitoring. This study aimed to analyze one-year objective adherence data to identify adherence patterns over time and factors influencing adherence to OA therapy.

Materials and methods: Fifty-five OSA patients were recruited from a cohort study and underwent clinical follow-ups at baseline, 1, 6 and 12 months. Patients were treated with custom-made, titratable OAs, and adherence was objectively collected using embedded sensors. Adherence data were analyzed using both intention-to-treat (ITT) and per-protocol (PP) approaches. Statistical methods, including comparative analyses, logistic regression models, and multivariate linear regression were performed to identify predictors of adherence.

Results: Twenty-one patients dropped out before the 12-month follow-up, leaving 34 completed the entire study. At the 1-month follow-up, 80.0% of patients were classified as adherent, with a mean wearing time of 5.98 ± 2.38 hours per night. By 6 months, adherence decreased to 67.3%, with a mean wearing time of 5.69 ± 2.08 hours per night. Several significant predictors of adherence were identified, including larger baseline overjet, younger age, and marital status.

Conclusions: OA adherence declined significantly within the first 6 months but stabilized between 6 and 12 months. Key baseline factors, such as larger overjet, younger age, and being married or partnered are predictors of better adherence, while psychological Comorbidities are associated with lower adherence.

口腔器械(OA)治疗被广泛用于替代持续气道正压(CPAP)治疗阻塞性睡眠呼吸暂停(OSA)。传统上,OA依从性是通过主观自我报告来评估的,但现在有了客观依从性传感器,可以进行更准确的监测。本研究旨在分析一年的客观依从性数据,以确定随时间的依从性模式和影响OA治疗依从性的因素。材料和方法:从队列研究中招募55名OSA患者,分别在基线、1个月、6个月和12个月进行临床随访。患者接受定制的、可滴定的oa治疗,并使用嵌入式传感器客观地收集依从性。依从性数据采用意向治疗(ITT)和每个方案(PP)方法进行分析。统计方法包括比较分析、逻辑回归模型和多元线性回归来确定依从性的预测因素。结果:21例患者在12个月的随访前退出,34例患者完成了整个研究。随访1个月时,80.0%的患者被分类为黏贴,平均每晚佩戴时间为5.98±2.38小时。6个月后,依从性下降到67.3%,平均每晚佩戴时间为5.69±2.08小时。确定了几个重要的依从性预测因素,包括较大的基线覆盖、年龄较小和婚姻状况。结论:OA依从性在前6个月内显著下降,但在6至12个月内稳定。关键的基线因素,如更大的覆盖、更年轻、已婚或有伴侣是更好的依从性的预测因素,而心理合并症与较低的依从性有关。
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引用次数: 0
Reporting and interpretation of subgroup analyses in orthodontic meta-analysis; a meta-epidemiological study. 正畸meta分析中亚组分析的报告与解释一项元流行病学研究。
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1093/ejo/cjaf053
Lorna Hirst, Iro Ntaga, Jadbinder Seehra, Dimitrios Mavridis, Nikolaos Pandis

Background/objectives: In systematic reviews (SRs) with a meta-analysis, a subgroup analysis can be utilised to explore heterogeneity of treatment effects across patient characteristics and assess how patient characteristics, types of intervention, or trial characteristics modify the treatment effect. The aim of this meta-epidemiological study was to investigate the reporting and interpretation of subgroup analyses in the orthodontic literature.

Methodology: SRs published between 1st January 2017 - 30th June 2024 in five orthodontic journals and the Cochrane Database of Systematic Reviews (CDSR) were hand searched from journal websites. We assessed the presence of testing for subgroup differences (interaction test) and the interpretation and reporting of subgroup analysis limitations were also reviewed. Descriptive statistics of the SR characteristics and univariable cross-tabulation to detect associations between journal type and variables affecting interpretation of subgroup analyses were undertaken. On an exploratory basis, exact logistic regression was used to examine the effect of publication year on the correct interpretation of subgroup results.

Results: Five thousand one-hundred and one (5101) articles were screened, 298 SRs were identified of which 70 met the inclusion criteria. In the subgroup analysis, interpretation of the p-value was undertaken in just over half of cases (n = 40, 57.1%). Only 32.9% (n = 23) of subgroup analyses were deemed correctly interpretated. Most commonly, no subgroup limitations were reported by the authors (n = 48, 68.6%) even when such limitations existed. There was no association between year of publication and correct interpretation of subgroup analyses (OR:0.93, 95% CI: 0.70, 1.22, p = 0.62).

Conclusion: There appears to be a lack of awareness of how to correctly interpret subgroup analyses from forest plots. Only a third of orthodontic subgroup analyses assessed in this study were correctly interpreted. Misinterpretation of the effect of covariates (e.g. patient characteristics) on the effect of a treatment intervention could potentially have a negative impact on patient healthcare decisions. Recommendations to improve the interpretation of subgroup analyses are proposed.

背景/目的:在采用荟萃分析的系统评价(SRs)中,亚组分析可用于探索不同患者特征的治疗效果的异质性,并评估患者特征、干预类型或试验特征如何改变治疗效果。这项荟萃流行病学研究的目的是调查正畸文献中亚组分析的报告和解释。方法:从期刊网站手工检索2017年1月1日至2024年6月30日在五种正畸期刊和Cochrane系统评价数据库(CDSR)上发表的sr。我们评估了亚组差异测试的存在(相互作用测试),并对亚组分析局限性的解释和报告进行了回顾。进行了SR特征的描述性统计和单变量交叉表,以检测影响亚组分析解释的期刊类型和变量之间的关联。在探索性的基础上,采用精确逻辑回归来检验出版年份对亚组结果正确解释的影响。结果:共筛选5101篇文献,共鉴定出srr 298篇,其中符合纳入标准的文献70篇。在亚组分析中,超过一半的病例(n = 40, 57.1%)对p值进行了解释。只有32.9% (n = 23)的亚组分析被认为正确解释。最常见的是,即使存在亚组限制,作者也没有报告亚组限制(n = 48, 68.6%)。发表年份与亚组分析的正确解释之间没有关联(OR:0.93, 95% CI: 0.70, 1.22, p = 0.62)。结论:对如何正确解释森林样地的亚群分析似乎缺乏认识。在本研究中,只有三分之一的正畸亚组分析被正确解释。误读协变量(如患者特征)对治疗干预效果的影响可能对患者的医疗保健决策产生潜在的负面影响。提出了改进亚群分析解释的建议。
{"title":"Reporting and interpretation of subgroup analyses in orthodontic meta-analysis; a meta-epidemiological study.","authors":"Lorna Hirst, Iro Ntaga, Jadbinder Seehra, Dimitrios Mavridis, Nikolaos Pandis","doi":"10.1093/ejo/cjaf053","DOIUrl":"10.1093/ejo/cjaf053","url":null,"abstract":"<p><strong>Background/objectives: </strong>In systematic reviews (SRs) with a meta-analysis, a subgroup analysis can be utilised to explore heterogeneity of treatment effects across patient characteristics and assess how patient characteristics, types of intervention, or trial characteristics modify the treatment effect. The aim of this meta-epidemiological study was to investigate the reporting and interpretation of subgroup analyses in the orthodontic literature.</p><p><strong>Methodology: </strong>SRs published between 1st January 2017 - 30th June 2024 in five orthodontic journals and the Cochrane Database of Systematic Reviews (CDSR) were hand searched from journal websites. We assessed the presence of testing for subgroup differences (interaction test) and the interpretation and reporting of subgroup analysis limitations were also reviewed. Descriptive statistics of the SR characteristics and univariable cross-tabulation to detect associations between journal type and variables affecting interpretation of subgroup analyses were undertaken. On an exploratory basis, exact logistic regression was used to examine the effect of publication year on the correct interpretation of subgroup results.</p><p><strong>Results: </strong>Five thousand one-hundred and one (5101) articles were screened, 298 SRs were identified of which 70 met the inclusion criteria. In the subgroup analysis, interpretation of the p-value was undertaken in just over half of cases (n = 40, 57.1%). Only 32.9% (n = 23) of subgroup analyses were deemed correctly interpretated. Most commonly, no subgroup limitations were reported by the authors (n = 48, 68.6%) even when such limitations existed. There was no association between year of publication and correct interpretation of subgroup analyses (OR:0.93, 95% CI: 0.70, 1.22, p = 0.62).</p><p><strong>Conclusion: </strong>There appears to be a lack of awareness of how to correctly interpret subgroup analyses from forest plots. Only a third of orthodontic subgroup analyses assessed in this study were correctly interpreted. Misinterpretation of the effect of covariates (e.g. patient characteristics) on the effect of a treatment intervention could potentially have a negative impact on patient healthcare decisions. Recommendations to improve the interpretation of subgroup analyses are proposed.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative microscopic analysis of plastic dispersion from 3D-printed and thermoformed orthodontic aligners. 3d打印和热成型正畸矫正器塑料分散的比较显微分析。
IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-04-08 DOI: 10.1093/ejo/cjaf014
Piero Antonio Zecca, Marina Borgese, Mario Raspanti, Francesca Zara, Rosamaria Fastuca, Marco Serafin, Alberto Caprioglio

Aim: To compare directly printed aligners (DPA) and thermoformed aligners (TFA), evaluating the potential release and dispersion of microplastic (MP) and nanoplastic (NP) particles under simulated oral conditions.

Materials and methods: DPA samples (Graphy Tera Harz TC-85-DAC resin) and TFA samples (Invisalign® SmartTrack) were subjected to rubs in an ultrapure water bath. The liquid was collected post-friction and analyzed for MPs and NPs using various techniques: optical microscopy (OM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Also, plastic residues were quantified by weighing after drying within a laminar flow hood. Microscopic image analyses comprised the quantification of the average size of MPs and NPs, their concentration by TEM, and the roughness analysis by AFM.

Results: The masses of MPs and NPs separated after rubbing were 0.001 g/200 µl and 0.004 g/200 µl for TFA and DPA samples, respectively. TEM analysis confirmed that DPA samples had larger (203.08 ± 2651.65 μm²) and more numerous particles compared to TFA (0.23 ± 27.53 μm²), even though it was not possible to distinguish the MPs and NPs due to clustering of the plastic residuals. AFM analysis indicated a bigger root mean square grain size for TFA than DPA; similarly, the mean roughness was lesser in the DPA sample than TFA one.

Conclusions: DPA generated larger and more numerous plastic particles compared to TFA, though grain-size characterization was challenging due to particle aggregation. This suggests that the manufacturing process and materials used in DPA could impact the creation of MPs and NPs during simulated mastication, highlighting a potential area for process optimization.

目的:比较直接打印对准剂(DPA)和热成型对准剂(TFA),评估微塑料(MP)和纳米塑料(NP)颗粒在模拟口腔条件下的潜在释放和分散。材料和方法:DPA样品(Graphy Tera Harz TC-85-DAC树脂)和TFA样品(Invisalign®SmartTrack)在超纯水浴中摩擦。摩擦后收集液体,并使用各种技术:光学显微镜(OM)、透射电子显微镜(TEM)和原子力显微镜(AFM)分析MPs和NPs。此外,塑料残留物被定量称重后,在层流罩内干燥。显微图像分析包括定量MPs和NPs的平均尺寸,TEM测定其浓度,AFM测定其粗糙度。结果:TFA和DPA样品摩擦后分离的MPs和NPs质量分别为0.001 g/200µl和0.004 g/200µl。TEM分析证实,DPA样品比TFA样品(0.23±27.53 μ²)具有更大(203.08±2651.65 μ²)和更多的颗粒,尽管由于塑料残留的聚类而无法区分MPs和NPs。AFM分析表明,TFA的均方根晶粒尺寸大于DPA;同样,DPA样品的平均粗糙度小于TFA样品。结论:与TFA相比,DPA产生的塑料颗粒更大,数量更多,尽管由于颗粒聚集,粒度表征具有挑战性。这表明DPA中使用的制造工艺和材料可能会影响模拟咀嚼过程中MPs和NPs的产生,突出了工艺优化的潜在领域。
{"title":"Comparative microscopic analysis of plastic dispersion from 3D-printed and thermoformed orthodontic aligners.","authors":"Piero Antonio Zecca, Marina Borgese, Mario Raspanti, Francesca Zara, Rosamaria Fastuca, Marco Serafin, Alberto Caprioglio","doi":"10.1093/ejo/cjaf014","DOIUrl":"10.1093/ejo/cjaf014","url":null,"abstract":"<p><strong>Aim: </strong>To compare directly printed aligners (DPA) and thermoformed aligners (TFA), evaluating the potential release and dispersion of microplastic (MP) and nanoplastic (NP) particles under simulated oral conditions.</p><p><strong>Materials and methods: </strong>DPA samples (Graphy Tera Harz TC-85-DAC resin) and TFA samples (Invisalign® SmartTrack) were subjected to rubs in an ultrapure water bath. The liquid was collected post-friction and analyzed for MPs and NPs using various techniques: optical microscopy (OM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Also, plastic residues were quantified by weighing after drying within a laminar flow hood. Microscopic image analyses comprised the quantification of the average size of MPs and NPs, their concentration by TEM, and the roughness analysis by AFM.</p><p><strong>Results: </strong>The masses of MPs and NPs separated after rubbing were 0.001 g/200 µl and 0.004 g/200 µl for TFA and DPA samples, respectively. TEM analysis confirmed that DPA samples had larger (203.08 ± 2651.65 μm²) and more numerous particles compared to TFA (0.23 ± 27.53 μm²), even though it was not possible to distinguish the MPs and NPs due to clustering of the plastic residuals. AFM analysis indicated a bigger root mean square grain size for TFA than DPA; similarly, the mean roughness was lesser in the DPA sample than TFA one.</p><p><strong>Conclusions: </strong>DPA generated larger and more numerous plastic particles compared to TFA, though grain-size characterization was challenging due to particle aggregation. This suggests that the manufacturing process and materials used in DPA could impact the creation of MPs and NPs during simulated mastication, highlighting a potential area for process optimization.</p>","PeriodicalId":11989,"journal":{"name":"European journal of orthodontics","volume":"47 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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European journal of orthodontics
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