European Journal of Pediatrics最新文献

High rates of childhood neurodisability are reported among the Roma, Europe's largest ethnic minority community. Interventions targeting early child development (ECD) during the first 2 years of life can improve neurodevelopmental outcomes in vulnerable children; however, evidence from Roma preschoolers is scarce. In a quasi-experimental observational study, we compared neurodevelopmental outcomes at age 2 years, measured on the INTERGROWTH-21st Project Neurodevelopmental Assessment (INTER-NDA), between Roma children receiving a community-based ECD intervention (RI, n = 98), and age- and sex-matched Roma and non-Roma children (RC, n = 99 and NRC, n = 54, respectively) who did not receive the intervention in Eastern Slovakia. The intervention was delivered between 3 weeks and 20 months in weekly home-based sessions by trained Roma women from matched settlements to RIs. Compared with RC, RI had higher 2-year cognitive (B = 0.15; 95% CI, 0.04, 0.25), language (B = 0.25; 95% CI, 0.11, 0.38) and fine motor (B = 0.08; 95% CI, 0.01, 0.16) scores. After adjustment for covariates, cognitive delay decreased by 88% in RI compared with RC (aOR, 0.12; 95% CI, 0.03, 0.53). Linear growth at 24 months was a key predictor of developmental scores for both groups (range, B = 0.04-0.14; 95% CI, 0.01, 0.07 and 0.09, 0.20).

Conclusions: Our results highlight that, without directly intervening on nutritional and poverty status, a community-based ECD intervention, delivered by trained Roma women to Roma children, can significantly improve neurodevelopmental outcomes at age 2 years.

What is known: • The Roma are Europe's largest ethnic minority. High rates of neurodisability, malnutrition and poverty are reported in Roma preschoolers. • Optimal early child development (ECD) is foundational to lifecourse health and wellbeing. Early interventions improve ECD outcomes in vulnerable children; however, evidence from Roma communities is limited.

What is new: • The Omama project is a community-based ECD intervention, delivered by trained Roma women to Roma children aged 3 weeks to 20 months living in impoverished settlements in Eastern Slovakia. • Roma children receiving the intervention had (i) higher cognitive, language and fine motor scores and (ii) lower rates of cognitive delay compared with controls.

We aimed to determine the prevalence of gastroesophageal reflux disease (GERD) and oropharyngeal dysphagia as explanatory diagnoses, risk factors for acid suppression treatment, and risk factors for repeat hospital visit in infants hospitalized after brief resolved unexplained event (BRUE) using a multicenter pediatric database. We performed a multicenter retrospective database study of infants admitted with BRUE in the Pediatric Health Information System between 2016 and 2021. Data included diagnostic testing, explanatory diagnoses, treatment with acid suppression, and related repeat hospital visits within 6 months. Multivariable logistic regression models were used to determine risk factors for treatment with acid suppression and repeat hospital visit. Of 17,558 subjects admitted to 47 hospitals, 34% were given an explanatory diagnosis of GERD and 1.4% oropharyngeal dysphagia. Twelve percent were treated with acid suppression, with some centers having rates as high as 26%. Multiple factors, including most notably the GERD diagnosis, were associated with increased prescribing risk. Ten percent of subjects had repeat hospital visits. Subjects given an explanatory diagnosis of GERD (OR 1.66, 95% CI 1.48-1.86, p < 0.001) or oropharyngeal dysphagia (OR 2.13, 95% CI 1.55-2.91, p < 0.001) had increased risk for repeat hospital visit as did those treated with acid suppression. CONCLUSION: GERD as an explanatory diagnosis was associated with increased risk of repeat hospital visit, despite its conception as a benign, treatable condition. Treatment with acid suppression was common but did not prevent repeat hospitalization. Oropharyngeal dysphagia as an explanatory diagnosis was also associated with increased risk of repeat hospital visit.

Purpose: The first 1000 days of life are critical for long-term health outcomes, and there is increasing concern about the suitability of commercial food products for infants, toddlers, and children. This study evaluates the compliance of UK commercial baby food products with WHO Nutrient and Promotion Profile Model (NPPM) guidelines.

Methods: Between February and April 2023, data on 469 baby food products marketed for infants and children under 36 months were collected from the online platforms of four major UK supermarkets. Nutritional composition and labelling information were assessed using the NPPM criteria. Quantitative analyses were performed using IBM SPSS, presenting data as means with 95% confidence intervals.

Results: While 75% of products met the minimum energy content criteria, compliance with total sugar content and protein requirements was 59% and 94%, respectively. Overall, only 45% of products adhered to NPPM nutritional standards. Promotional assessments revealed that no products met the requirements for appropriate nutrient, health, or marketing claims. Furthermore, only 5% of products included adequate statements in support of breastfeeding.

Conclusion: This study highlights the need for stricter nutritional and promotional standards in the UK baby food industry to foster healthier early dietary habits. Regulatory measures are essential to align commercial baby food products with WHO recommendations, reducing inappropriate claims and improving nutritional quality.

Effective leadership is essential in neonatal intensive care units (NICUs), where complex, high-stakes environments require coordinated multidisciplinary teamwork. Strong leadership improves clinical outcomes, team performance, and staff well-being. This systematic review assesses various leadership models and interventions in NICUs to identify best practices and areas for future research. A systematic search was conducted on PubMed, Web of Science, and Scopus, covering studies published from 2010 to October 2024. Articles were screened using the PRISMA guidelines, and inclusion criteria focused on primary studies in NICU settings evaluating leadership interventions. Data extraction and quality assessment were performed using the Newcastle-Ottawa Scale. Nine studies from diverse countries and research designs were included. Leadership interventions varied from simulation-based training programs to co-leadership models. High-fidelity simulation boot camps significantly improved self-perceived skills, teamwork, and leadership confidence among trainees. While most studies reported positive impacts on team performance and patient safety, one large-scale quality improvement program showed no significant improvement in clinical outcomes for very-low-birth-weight infants.

Conclusion: The findings emphasize that leadership interventions, including structured training and co-leadership, enhance team dynamics and clinical outcomes in NICUs. However, variability in study designs and reliance on self-reported data highlight the need for standardized evaluation methods. Future research should focus on long-term impacts, cross-context comparisons, and refining leadership frameworks to address the unique challenges of NICU settings. Promoting effective leadership not only improves patient care but also fosters a resilient and collaborative work environment.

What is known: • Leadership is crucial in NICUs, where complex, high-stakes environments demand coordinated, multidisciplinary teamwork. Strong leadership enhances clinical outcomes, team performance, and staff well-being. • No systematic review of leadership interventions in neonatal care has been conducted to date.

What is new: • Recent studies highlight a range of tools, including simulation-based training programs and co-leadership models. • High-fidelity simulations have been shown to significantly improve participants' self-perceived skills, teamwork, and leadership confidence.

Most of the available tools to assess adherence to Mediterranean diet (MedDiet) were constructed for adults, having limited applicability to children and adolescents. The aim of this study is to validate a specific questionnaire to assess adherence to MedDiet in children aged 3 to 6 years (MED4CHILD questionnaire). The validation was performed in a baseline examination of a cohort of children who were recruited in schools in seven cities. Of the total sample of 1509 children, we included 858 children aged 3 to 6 years with complete information on adherence to the MedDiet, food consumption, anthropometry and cardiometabolic characteristics. Adherence to the MedDiet was assessed using an 18-item questionnaire, adapted from validated questionnaire for adults using the Delphi method. Food and beverage consumption was assessed using a validated COME-Kids Food and Beverage Frequency Questionnaire. Anthropometric measurements and cardiometabolic risk factors were assessed using standard methods. Statistical analyses included kappa agreement, ANOVA and linear regression models. Higher MED4CHILD scores were associated with higher intakes of food characteristic of the MedDiet. The MED4CHILD questionnaire showed moderate validity, especially for key items of the Mediterranean diet (kappa ranging from 0.333 to 0.665). Direct significant associations were found between MED4CHILD scores and cardiometabolic profile, including waist circumference (p), triglycerides and HOMA-IR (p < 0.05).

Conclusion: The 18-item MED4CHILD questionnaire showed moderate validity for assessing adherence to the MedDiet in children aged 3 to 6 years, in terms of agreement with food and beverage consumption and favourable cardiometabolic profile.

What is known: • The Mediterranean diet has been linked to a number of health benefits and the assessment of children's adherence to this diet is important for public health and research. • The tools available to assess MedDiet compliance are mainly for adults.

What is new: • The MED4CHILD questionnaire is a simple, inexpensive and rapid tool for assessing MedDiet compliance in children. • This tool showed moderate relative validity and a high score was associated with a favourable cardiometabolic profile.

This study aimed to estimate the effects of an intensive school-based physical education intervention on the risk of developing overweight or obesity in primary school students when accounting for the moderating role of socioeconomic status. This quasi-experimental trial included data from primary school students participating in an intensive physical education program comprising 4.5 h of weekly physical activity compared to 1.5 h per week in the control group. Socioeconomic status was estimated by maternal education. The study outcome was overweight or obesity status determined by longitudinal measures of body mass index over 4.5 years. Intervention effects and the moderating role of socioeconomic status were estimated using multilevel mixed-effects logistic models. We included data from 588 children in the intensive physical education group and 415 children in the control group (52.9% female; mean [SD] age = 8.5 [1.4] years). There was a significant 3-way interaction between intervention group, socioeconomic status, and time (p = 0.018). Within the control group, children from the low socioeconomic strata had a greater probability of being overweight or obese from 36 months onward compared to children from the high socioeconomic strata. The physical activity intervention reduced the risk of overweight or obesity among children from the low socioeconomic strata; after 4.5 years, the risk reduction (95% CI) was 11.4 (2.4 to 20.4)%.

Conclusion: A school-based physical activity intervention, delivered through a physical education program, effectively reduces overweight and obesity risk in disadvantaged primary school students and may address some of the adverse health-related impacts of living with low socioeconomic status.

What is known: • School-based physical activity programs offer promising solutions for improving health-related physical activity in children. However, the impact of socioeconomic context on the effectiveness of these programs is unclear.

What is new: • An intensive school-based physical activity intervention effectively reduces overweight and obesity risk in disadvantaged primary school students and may address some of the adverse health-related impacts of living with low socioeconomic status.

Delayed cord clamping (DCC) has been widely adopted in both term and preterm infants to improve neonatal outcomes by increasing blood volume and supporting oxygenation. However, the optimal cord management for intrauterine growth-restricted (IUGR) infants is unclear. To systematically review and meta-analyze the effects of DCC compared to early cord clamping (ECC) in IUGR infants. We followed the PRISMA guidelines for meta-analysis. Six databases were searched for randomized controlled trials (RCTs) and observational studies comparing DCC and ECC in IUGR infants, focusing on neonatal resuscitation measures, hematological parameters, morbidities, and mortality. The Cochrane Collaboration tool and Newcastle-Ottawa scale were used for RCTs and observational studies, respectively. Eight studies with 1531 participants were included, comprising six RCTs and two observational studies. Serum ferritin at 3 months and initial Hb were significantly higher in the DCC group (MD: 36.16 ng/ml [95% CI: 34.09, 38.24]), (MD: 1.64 gm/dl [95%CI: 0.88, 2.4]) respectively. The risk of polycythemia was higher in the DCC group (RR 1.88, 95% CI [1.27, 2.8]), without an increase in the peak total serum bilirubin or the need for exchange transfusion. Conclusion: DCC may be beneficial and safe in IUGR infants, improving hematological parameters without affecting neonatal morbidity and mortality. Further high-quality, large trials are needed to confirm these findings and assess neurodevelopmental impact.

Purpose: This systematic review analyzes economic evaluations of newborn screening for congenital cytomegalovirus (cCMV) infection to identify key factors influencing cost-effectiveness and differences in methodological approaches.

Methods: Following a pre-registered PROSPERO protocol (CRD42023441587), we conducted a comprehensive literature search across multiple databases on July 4, 2024. The review included both full economic evaluations (cost and outcomes) and partial economic evaluations (cost only). Two reviewers independently performed data extraction and synthesis. Quality assessment used the Consensus Health Economic Criteria extended checklist and the Consolidated Health Economic Evaluation Reporting Standards 2022 Statement.

Results: From 543 records, nine studies met inclusion criteria: four full and five partial economic evaluations. Two full economic evaluations provided the incremental cost-effectiveness ratio per quality-adjusted life year. Full economic evaluations using decision trees and Markov models generally found universal screening more cost-effective than targeted screening, despite higher incremental costs. Partial evaluations focused on direct costs, with varying inclusion of long-term care costs. Most studies adopted a healthcare system perspective, excluding indirect costs. Quality assessment of full economic evaluations revealed high methodological standards but identified common limitations in outcome measurement and reporting.

Conclusions: Available evidence suggests potential cost-effectiveness of newborn cCMV screening, particularly with early intervention strategies. However, limited full economic evaluations and heterogeneous methodological approaches preclude definitive conclusions, highlighting the need for additional research across diverse healthcare contexts.

What is known: • Congenital cytomegalovirus (cCMV) infection is a condition that can be detected through newborn screening, and understanding its economic implications is important for healthcare systems. • Economic evaluations can be categorized into full evaluations (analyzing both costs and outcomes) and partial evaluations (focusing only on costs).

What is new: • Based on a systematic review of 543 records, universal screening appears more cost-effective than targeted screening for cCMV, implementation challenges and healthcare system variations significantly impact its practical adoption. • The review identified significant methodological limitations in existing studies, particularly in outcome measurement and reporting, highlighting the need for more comprehensive research across different healthcare contexts.