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Management of Postpartum Hemorrhage 产后出血的处理
Pub Date : 2018-09-11 DOI: 10.2310/OBG.19029
T. Golen, S. Shainker
Postpartum Hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality both in the United States and world-wide.  To ensure prompt treatment, it is crucial to have a clear understanding of the causes of the PPH.  Treatment includes both medical and surgical approaches, with the necessary escalation of care with ongoing hemorrhage. Invasive placentation (placenta accreta, increta, percreta) has become a more common cause of hemorrhage related morbidity and mortality.  Patients with invasive placentation should be managed in a multidisciplinary fashion at a center familiar with this pathology and capable of managing massive hemorrhage.  Obstetrical units should have a PPH protocol as a tool to assist in early recognition and treatment.  Similarly, units should have a massive transfusion protocol at the ready for scenarios of ongoing obstetrical hemorrhage. This review contains 5 figures, 4 tables and 65 referencesKeywords: Postpartum Hemorrhage, Obstetrical Hemorrhage, Uterine Atony, Uterine Inversion, Uterine Tamponade Balloon, Invasive Placentation, Placenta Accreta, Obstetric Hemorrhage Protocol, Massive Transfusion Protocol
产后出血(PPH)是产妇发病率和死亡率的主要原因之一,无论是在美国和世界各地。为了确保及时治疗,对PPH的病因有一个清晰的认识是至关重要的。治疗包括内科和外科两种方法,并对持续出血进行必要的升级护理。侵入性胎盘(胎盘增生、胎盘增量、胎盘percreta)已成为出血相关发病率和死亡率的更常见原因。侵袭性胎盘患者应在熟悉这种病理并有能力处理大出血的中心以多学科方式进行治疗。产科单位应该有PPH协议作为工具,以协助早期识别和治疗。同样,单位应该有一个大规模的输血方案,以应对持续产科出血的情况。关键词:产后出血,产科出血,子宫张力,子宫内翻,子宫填塞球囊,有创胎盘,胎盘增生,产科出血方案,大量输血方案
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引用次数: 0
Infertility Treatment: Ovulation Induction and Insemination 不孕症治疗:促排卵和人工授精
Pub Date : 2018-09-06 DOI: 10.2310/obg.19098
Q. Katler, J. Zolton, A. DeCherney
For the majority of infertility patients, ovulation induction is the initial therapy. Treatment is individualized for a couple based on ovarian reserve testing, semen analysis, and the presence of anatomic pathology. Candidates for ovulation induction include those who are anovulatory and couples with unexplained infertility. The majority of patients diagnosed with anovulation have polycystic ovarian syndrome. Treatment options include clomiphene citrate and letrozole. For patients with hypogonadotropic hypogonadism, treatment involves injections with gonadotropins. Treatment is typically combined with intrauterine insemination to maximize pregnancy rates, especially in patients with male factor infertility or unexplained infertility. A stepwise approach is necessary, as patients who are unsuccessful with less invasive and costly treatments may eventually require in vitro fertilization.This review contains 7 figures, 3 tables and 57 referencesKey Words: clomiphene citrate, gonadotropins, infertility, intrauterine insemination, letrozole, ovulation induction, polycystic ovarian syndrome, unexplained infertility
对于大多数不孕症患者,促排卵是最初的治疗方法。根据卵巢储备测试、精液分析和解剖病理学的存在,对一对夫妇进行个体化治疗。促排卵的候选者包括无排卵者和不明原因不孕的夫妇。大多数诊断为无排卵的患者患有多囊卵巢综合征。治疗方案包括枸橼酸克罗米芬和来曲唑。对于促性腺功能低下的患者,治疗包括注射促性腺激素。治疗通常与宫内人工授精相结合,以最大限度地提高妊娠率,特别是在男性因素不孕或不明原因不孕的患者中。循序渐进的方法是必要的,因为采用侵入性较小且费用昂贵的治疗方法不成功的患者最终可能需要体外受精。关键词:枸橼酸克罗米芬,促性腺激素,不孕症,宫内人工授精,来曲唑,促排卵,多囊卵巢综合征,不明原因不孕
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引用次数: 0
Evaluation of Infertility 不孕症评估
Pub Date : 2018-09-04 DOI: 10.2310/obg.19097
J. Zolton, A. DeCherney
In 2009, the World Health Organization formally recognized infertility as a disease of the reproductive system. This designation serves to ease access to infertility evaluation and treatment. Infertility is a disease of both men and women, and proper evaluation of both partners is necessary. Common causes of infertility are ovulatory dysfunction, tubal and pelvic pathology, unexplained infertility, and male factor. A complete history and physical examination may uncover the underlying etiology, although verification of tubal patency and normal semen analysis is warranted. This period also offers an opportunity to perform preconception testing and optimize women’s health before conception. Treatment for infertility is aimed to restore normal reproductive function and anatomy. In addition, patient education and counseling is indeed a very important aspect of infertility care.This review contains 5 figures, 5 tables and 60 referencesKey Words: anovulation, Antimullerian hormone, antral follicle count, hysterosalpingogram, infertility, infertility evaluation, ovarian reserve testing, polycystic ovarian syndrome, saline infusion sonohysterography
2009年,世界卫生组织正式承认不孕症是一种生殖系统疾病。这个名称是为了方便获得不孕症的评估和治疗。不孕症是男性和女性共同的疾病,对伴侣双方进行适当的评估是必要的。不孕的常见原因有排卵功能障碍、输卵管和盆腔病变、不明原因不孕和男性因素。完整的病史和体格检查可以发现潜在的病因,但需要确认输卵管通畅和正常精液分析。这一时期还提供了进行孕前检查和优化妇女孕前健康的机会。治疗不孕症的目的是恢复正常的生殖功能和解剖结构。此外,患者教育和咨询确实是不孕症护理的一个非常重要的方面。关键词:无排卵,抗苗勒管激素,卵泡计数,子宫输卵管造影,不孕症,不孕症评估,卵巢储备检测,多囊卵巢综合征,生理盐水输注超声宫腔镜
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引用次数: 0
Infertility 不孕不育
Pub Date : 2018-08-19 DOI: 10.1097/ju.0000000000000968
E. Levens, K. A. Green, A. DeCherney
Infertility affects 12 to 18% of couples in the United States and may be due to female factors, male factors, or both. A systematic evaluation of the common causes of infertility can identify conditions that may be treated by the obstetrician-gynecologist to help the couple achieve their family-building goals or those that require referral to a subspecialist. This review discusses current recommendations regarding the workup and treatment of the common causes of infertility, including tubal and pelvic factors, ovulatory disorders, and male factors. Advances in assisted reproductive technology are also discussed, including the use of genetic screening in in vitro fertilization and fertility preservation options for individuals facing gonadotoxic therapy.This review contains 6 figures, 8 tables, and 53 references.Key words: anovulation, assisted reproductive technology, clomiphene citrate, infertility, letrozole, oocyte cryopreservation, ovulation induction, semen analysis, tubal factor, uterine factor
在美国,12%到18%的夫妇不孕不育,可能是由于女性因素,男性因素,或两者兼而有之。对不孕症的常见原因进行系统的评估,可以确定哪些情况可以由妇产科医生治疗,以帮助夫妇实现家庭建设的目标,哪些情况需要转介给专科医生。这篇综述讨论了目前关于不孕症常见原因的检查和治疗的建议,包括输卵管和盆腔因素、排卵障碍和男性因素。还讨论了辅助生殖技术的进展,包括在体外受精中使用遗传筛选和面对促性腺毒素治疗的个体的生育能力保留选择。本综述包含6个图,8个表,53篇参考文献。关键词:无排卵,辅助生殖技术,枸橼酸克罗米芬,不孕症,来曲唑,卵母细胞冷冻保存,促排卵,精液分析,输卵管因子,子宫因子
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引用次数: 0
Menopause 更年期
Pub Date : 2018-08-19 DOI: 10.2310/obg.1046
S. Reed, E. L. Sutton
The female reproductive system matures in a continuous, natural process from menarche to menopause as the finite numbers of oocytes produced during fetal development are gradually lost to ovulation and senescence. Menopause is defined as the permanent cessation of menses; by convention, the diagnosis of menopause is not made until the individual has had 12 months of amenorrhea. Menopause is thus characterized by the menstrual changes that reflect oocyte depletion and subsequent changes in ovarian hormone production. However, hormonal changes, rather than the cessation of menstruation itself, cause the manifestations that occur around the time of menopause. Therefore, a woman who has undergone a hysterectomy but who retains her ovaries can experience normal menopausal symptoms as oocyte depletion leads to changes in estrogen levels, even though cessation of menstruation occurred with surgery. This review covers definitions, natural menopause, menopausal transition and postmenopausal symptom management, and premature ovarian insufficiency. Figures show stages of reproductive aging, serum concentrations of hormones during menopausal transition and postmenopause, hormonal changes associated with reproductive aging, symptoms of menopausal transition and menopause, treatment algorithm(s), and Women’s Health Initiative findings: risks and benefits of estrogen alone and estrogen plus progestin by age group: 50 to 59, 60 to 69, and 70 to 79 years. Tables list target tissues, physical manifestations, and menopausal symptoms; selective estrogen receptor modulators used in postmenopausal women; differential diagnosis and evaluation of common menopausal symptoms; estrogen doses; progestogen dosing for endometrial protection; nonhormonal pharmaceutical hot flash therapies; and pharmacologic therapy for genitourinary atrophy.This review contains 6 figures, 8 tables, and 122 references.
女性生殖系统从初潮到更年期是一个连续的自然过程,胎儿发育过程中产生的有限数量的卵母细胞逐渐失去排卵和衰老。更年期被定义为永久停止月经;按照惯例,绝经的诊断是不作出,直到个人已经有12个月的闭经。因此,更年期的特点是月经变化,反映了卵母细胞的减少和随后卵巢激素产生的变化。然而,荷尔蒙的变化,而不是月经停止本身,导致更年期前后出现的表现。因此,接受子宫切除术但保留卵巢的妇女可以经历正常的更年期症状,因为卵母细胞减少导致雌激素水平的变化,即使手术后月经停止。这篇综述涵盖了定义,自然绝经,绝经过渡和绝经后症状管理,和卵巢早衰。图表显示了生殖衰老的阶段、绝经过渡期和绝经后的血清激素浓度、与生殖衰老相关的激素变化、绝经过渡期和绝经的症状、治疗方法以及妇女健康倡议的发现:按年龄组分别使用雌激素和雌激素加黄体酮的风险和益处:50至59岁、60至69岁和70至79岁。表列出了靶组织、生理表现和更年期症状;选择性雌激素受体调节剂在绝经后妇女中的应用常见更年期症状的鉴别诊断与评价雌激素剂量;孕激素剂量对子宫内膜的保护作用非激素药物治疗潮热;以及泌尿生殖系统萎缩的药物治疗。本综述包含6个图,8个表,122篇参考文献。
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引用次数: 0
Nonsurgical Management of Overactive Bladder 膀胱过动症的非手术治疗
Pub Date : 2018-08-13 DOI: 10.2310/obg.19151
S. Jakus-Waldman
Overactive bladder affects up to one-third of elderly adults and 17% of adult women in the United States. The diagnosis is based on patient-reported symptoms of urinary urgency and frequency, with or without urinary incontinence after exclusion of any other possible pathology. Treatment options are based on a staged approach beginning with lifestyle and behavioral modifications. Bladder training and pelvic floor muscle training have been shown to be as effective as antimuscarinic medication and possibly most useful when these therapies are combined with medication. A newer class of OAB medication, β3-adrenergic agonists, has fewer side effects compared to antimuscarinics and is an important alternative for elderly patients at a risk of dementia.This review contains 5 figures and 63 referencesKey Words: anticholinergic medication, antimuscarinics, β-adrenergic agonists, nocturia, overactive bladder, urge incontinence, urinary frequency, urinary urgency
在美国,多达三分之一的老年人和17%的成年女性患有膀胱过度活动。诊断是基于患者报告的尿急和尿频症状,排除任何其他可能的病理后伴有或不伴有尿失禁。治疗方案基于分阶段的方法,从生活方式和行为改变开始。膀胱训练和盆底肌肉训练已被证明与抗毒蕈碱药物一样有效,当这些疗法与药物联合使用时可能最有效。一种新的OAB药物,β3-肾上腺素激动剂,与抗uscarinics相比,副作用更小,是有痴呆风险的老年患者的重要选择。关键词:抗胆碱能药物,抗毒蕈素,β-肾上腺素能激动剂,夜尿症,膀胱过动症,急迫性尿失禁,尿频,尿急
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引用次数: 0
Gestational Trophoblastic Disease 妊娠滋养细胞疾病
Pub Date : 2018-08-13 DOI: 10.2310/obg.19167
D. Roque, A. Urh, E. Kalife
Gestational trophoblastic disease (GTD) represents a group of disorders that derive from placental trophoblastic tissue, including hydatidiform moles, postmolar gestational trophoblastic neoplasia (GTN), and gestational choriocarcinoma. GTN is the most curable gynecologic malignancy and tends to be more common after a complete molar pregnancy than a partial mole. Human chorionic gonadotropin (β-hCG) represents a marker for GTD and should be followed for 6 months after molar pregnancy evacuation to rule out the development of postmolar GTN. GTN is defined by a plateaued, rising, or prolonged elevated β-hCG value after molar evacuation; histologic diagnosis of choriocarcinoma, invasive mole, placental site trophoblastic tumor, or epithelioid trophoblastic tumor; or identification of metastasis after molar pregnancy evacuation. Classification for GTN as low (score ≤ 6) or high risk (score > 7) is based on the World Health Organization prognostic score. This scoring system helps select treatment, which usually entails actinomycin D or methotrexate for low-risk disease and EMA/CO (etoposide, methotrexate, actinomycin D/cyclophosphamide, vincristine) for high-risk disease. These regimens can achieve cure rates approaching 100% and over 90% for low- and high-risk disease, respectively. This review contains 5 figures, 8 tables and 49 referencesKey words: choriocarcinoma, gestational trophoblastic disease, gestational trophoblastic neoplasia, human chorionic gonadotropin, hydatidiform mole, invasive mole
妊娠滋养层疾病(GTD)是一组源于胎盘滋养层组织的疾病,包括葡萄胎样痣、磨牙后妊娠滋养层瘤变(GTN)和妊娠绒毛膜癌。GTN是最可治愈的妇科恶性肿瘤,在完全的臼齿妊娠后比部分的臼齿妊娠后更常见。人绒毛膜促性腺激素(β-hCG)是GTD的一个标志,在磨牙妊娠排出后应随访6个月,以排除磨牙后GTN的发生。GTN定义为摩尔抽液后β-hCG值稳定、上升或延长升高;绒毛膜癌、侵袭性痣、胎盘部位滋养细胞瘤或上皮样滋养细胞瘤的组织学诊断;或确认磨牙妊娠排出后的转移。根据世界卫生组织的预后评分,将GTN分为低危(评分≤6分)或高危(评分> 7分)。该评分系统有助于选择治疗方法,对于低风险疾病通常需要放线菌素D或甲氨蝶呤,对于高风险疾病通常需要EMA/CO(依托泊苷、甲氨蝶呤、放线菌素D/环磷酰胺、长春新碱)。对于低危和高危疾病,这些方案的治愈率分别接近100%和90%以上。关键词:绒毛膜癌,妊娠滋养细胞疾病,妊娠滋养细胞瘤,人绒毛膜促性腺激素,葡萄胎,侵袭性葡萄胎
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引用次数: 0
The Menopause Transition: Physiology, Definition, Symptoms, Diagnosis, and Evaluation 更年期过渡:生理学,定义,症状,诊断和评估
Pub Date : 2018-08-10 DOI: 10.2310/obg.19103
Jessica L. Bauer, N. Santoro
The menopause transition is a gradual physiologic process characterized by an intricate interplay between hypothalamic-pituitary axis dysfunction and ovarian follicle failure. Clinically, symptoms are variable and can range from minimal to severe. The hallmark symptom of the perimenopause and postmenopause is the hot flash; however, systemically low estrogen has widespread effects in the aging woman, including important changes in the cardiovascular, musculoskeletal, genitourinary, and central nervous systems. The diagnosis of menopause is a clinical one. Although there is no single laboratory marker that can predict the final menstrual period, an elevated follicle stimulating hormone is the classic marker of a menopausal state. Newer evidence suggests that antimullerian hormone may be more predictive of the final menstrual period; however, more studies are needed. An understanding of the physiology and symptomatology of the menopausal transition is crucial for educating women about their health risks later in life.This review contains 2 figures and 30 referencesKey Words: hot flashes, menopause, perimenopause, postmenopause, race/ethnicity in menopause, stages of transition in menopause, stress/psychological complications, women’s health
绝经过渡是一个渐进的生理过程,其特点是下丘脑-垂体轴功能障碍和卵巢卵泡衰竭之间复杂的相互作用。在临床上,症状是可变的,可以从轻微到严重。更年期前后的标志性症状是潮热;然而,全身性低雌激素对老年妇女有广泛的影响,包括心血管、肌肉骨骼、泌尿生殖系统和中枢神经系统的重要变化。更年期的诊断是临床诊断。虽然没有单一的实验室标记可以预测最后的月经期,但促卵泡激素升高是绝经状态的典型标志。新的证据表明,抗苗勒管激素可能更能预测最后的月经期;然而,还需要更多的研究。了解更年期的生理和症状对于教育妇女了解她们以后生活中的健康风险至关重要。关键词:潮热,更年期,围绝经期,绝经后,更年期的种族/民族,更年期的过渡阶段,压力/心理并发症,妇女健康
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引用次数: 0
Musculoskeletal Problems In The Female Athlete 女性运动员的肌肉骨骼问题
Pub Date : 2018-08-09 DOI: 10.2310/obg.1512
I. Asif, K. Harmon, Mallory Shasteen
Musculoskeletal injuries in the female athlete are, for the most part, similar to those in the male athlete. However, there are differences in the incidence of these injuries and in the sports in which they tend to occur. Female athletes have a higher rate of noncontact anterior cruciate ligament injuries than male athletes. Other musculoskeletal problems are also more common in females, such as multidirectional instability of the shoulder, adhesive capsulitis, and patellofemoral pain. This review addresses injuries that are seen commonly in female athletes and outlines current diagnosis and treatment options.This review contains 3 figures and 32 referencesKey words: ACL tear, adhesive capsulitis, atraumatic, female athlete, injection, knee, patellofemoral pain, shoulder
在大多数情况下,女运动员的肌肉骨骼损伤与男运动员相似。然而,这些损伤的发生率和容易发生的运动是不同的。女运动员非接触性前交叉韧带损伤的发生率高于男运动员。其他肌肉骨骼问题在女性中也更为常见,如肩部多向不稳定、粘连性囊炎和髌骨痛。本文综述了在女运动员中常见的损伤,并概述了目前的诊断和治疗方案。关键词:前交叉韧带撕裂,粘连性囊炎,非外伤性,女运动员,注射,膝关节,髌股疼痛,肩部
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引用次数: 0
Stress Fractures And The Reproductive System In The Female Athlete 应力性骨折和女性运动员的生殖系统
Pub Date : 2018-08-09 DOI: 10.2310/obg.1513
I. Asif, K. Harmon, Mallory Shasteen
Stress fractures are more common in the female athlete. Stress fractures of the pubic ramus and femoral neck are particularly more common in females than in males. Rib stress fractures are an important injury to consider in the female rower, whereas spondylolysis is a common cause of low back pain in female athletes who hyperextend their spines. The higher incidence of stress fractures in females is mainly due to the higher prevalence of disordered eating and subsequent energy imbalance, which leads to detrimental effects on bone. This review discusses stress fractures and unique issues related to exercise and the female reproductive system.This review contains 6 figures, 5 tables and 49 referencesKey words: amenorrhea, bone mineral density, disordered eating, female athlete triad, femoral neck, pregnancy, pubic ramus, rib, spondylolysis, stress fracture
应力性骨折在女运动员中更为常见。耻骨支和股骨颈应力性骨折在女性中比男性更常见。在女性赛艇运动员中,肋骨应力性骨折是一种重要的损伤,而峡部裂是导致脊柱过度伸展的女性运动员腰痛的常见原因。女性应力性骨折的发生率较高,主要是由于饮食失调和随之而来的能量失衡的患病率较高,从而对骨骼产生不利影响。这篇综述讨论了应力性骨折和与运动和女性生殖系统有关的独特问题。关键词:闭经,骨密度,饮食失调,女运动员三联症,股骨颈,妊娠,耻骨支,肋骨,峡部裂,应力性骨折
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引用次数: 0
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DeckerMed Obstetrics and Gynecology
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