Purpose: Despite the good results of neoadjuvant chemotherapy used in the treatment of osteosarcoma, post-operative recurrences continue to be a common problem. It is important to seek new approaches to prevent recurrence in post-operative patients and to eliminate the disadvantages of systemic chemotherapy. The study aims to examine the effects of chemotherapeutic (ifosfamide) and immunotherapeutic (mifamurtide) agents, which are adsorbed into cementum in vitro, on the viability of the osteosarcoma cell line K7M2. Methods: After the K7M2 osteosarcoma cell line was cultured, the cells were adhered to and became 70% confluent, and the supernatants were removed, taking care not to lose the cells. Different doses of ifosfamide (10 ug/ml, 20 ug/ml, 40 ug/ml) alone and with cement; Different doses of mifamurtide (0.25 μg/ml, 0.5 μg/ ml, 1 μg/ml) were given by co-culture with mononuclear cells alone and with cement. Cement was used as the control group. Cell viability was determined by WST after the plate was placed in a 37°C 5% CO2 incubator for 24 hours and 48 hours. Results: It was determined that ifosfamide and mifamurtide in cementum were released into the environment compared to the agent alone, causing more cytotoxic effects in osteosarcoma cells at 24 hours. While an increased effect at 48 hours was observed in mifamurtide, it was not detected in the ifosfamide plus cement group compared to the ifosfamide group alone. Conclusion: Our findings support that local application of ifosfamide and mifamurtide in bone cement may be effective in preventing local recurrence of osteosarcoma after surgery; while filling bone defects resulting from excision surgeries. Among post-operative biomaterials, local therapy may be an additive treatment option in preventing recurrence in osteosarcoma by interacting directly and with the microenvironment.
{"title":"The Effect of Ifosfamide and Mifamurtide Loaded Cement on The Viability of Osteosarcoma Cells","authors":"Ömer Bekçioğlu, S. Aktaş, M. Aydın, N. Olgun","doi":"10.5505/tjhs.2021.76486","DOIUrl":"https://doi.org/10.5505/tjhs.2021.76486","url":null,"abstract":"Purpose: Despite the good results of neoadjuvant chemotherapy used in the treatment of osteosarcoma, post-operative recurrences continue to be a common problem. It is important to seek new approaches to prevent recurrence in post-operative patients and to eliminate the disadvantages of systemic chemotherapy. The study aims to examine the effects of chemotherapeutic (ifosfamide) and immunotherapeutic (mifamurtide) agents, which are adsorbed into cementum in vitro, on the viability of the osteosarcoma cell line K7M2. Methods: After the K7M2 osteosarcoma cell line was cultured, the cells were adhered to and became 70% confluent, and the supernatants were removed, taking care not to lose the cells. Different doses of ifosfamide (10 ug/ml, 20 ug/ml, 40 ug/ml) alone and with cement; Different doses of mifamurtide (0.25 μg/ml, 0.5 μg/ ml, 1 μg/ml) were given by co-culture with mononuclear cells alone and with cement. Cement was used as the control group. Cell viability was determined by WST after the plate was placed in a 37°C 5% CO2 incubator for 24 hours and 48 hours. Results: It was determined that ifosfamide and mifamurtide in cementum were released into the environment compared to the agent alone, causing more cytotoxic effects in osteosarcoma cells at 24 hours. While an increased effect at 48 hours was observed in mifamurtide, it was not detected in the ifosfamide plus cement group compared to the ifosfamide group alone. Conclusion: Our findings support that local application of ifosfamide and mifamurtide in bone cement may be effective in preventing local recurrence of osteosarcoma after surgery; while filling bone defects resulting from excision surgeries. Among post-operative biomaterials, local therapy may be an additive treatment option in preventing recurrence in osteosarcoma by interacting directly and with the microenvironment.","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124061078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rehabilitation for Femoro-acetabular Impingement Syndrome","authors":"Kadir Songür, B. Dilek","doi":"10.5505/tjhs.2021.79188","DOIUrl":"https://doi.org/10.5505/tjhs.2021.79188","url":null,"abstract":"","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116259640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yagmur Isin, Erol Kaya, O. Hapa, C. Kızmazoğlu, Onur Gürsan, Berkay Yanik, E. Özer
Objective: Coexistence of lumbar spine disorder with hip diseases is defined as Hip-Spine syndrome, there might be a relation between torsional deformities of the hip and lumbar disc disease. Purpose of the present study was to find whether hip torsional parameters (femur, acetabular anteversion) and clinical findings (hip range of motion, hip score) differ in patients with lumbar disc disease. Method: Patients with lomber disc herniation (n: 20) and control subjects (n: 20) without any lumbar spine or hip disease were enrolled in the study. Femoral anteversion (FeAv), acetabular anteversion (AA), center of edge angle (CE), degree of hip flexion, extension, Harris Hip scores (HHS) were evaluated bilaterally. Results: HHS score, degree of extension plus flexion was lower at diseased side when it is compared to the control subjects (p < 0.001). Unilaterally affected patients had lower AA than control subjects (AA: 13 ± 40 vs16 ± 20 p: 0.01). Conclusion: As there is a link between hip and spine disorders, present study aims to find whether there is a causal relation between hip torsional deviations and lumbar disc disease. Partially supporting the hypothesis, diseased side had lower degrees of acetabular anteversion compared to control subjects at unilaterally affected patients. Mechanical and /or hip torsional parameters especially the acetabular retroversion may have an etiopathogenetic role in unilateral lumbar disc disease.
{"title":"Coexistence of Hip Torsional Deformities in Patients With Lumbar Disc Herniation; A Case-Control Study","authors":"Yagmur Isin, Erol Kaya, O. Hapa, C. Kızmazoğlu, Onur Gürsan, Berkay Yanik, E. Özer","doi":"10.5222/tjhs.2021.36855","DOIUrl":"https://doi.org/10.5222/tjhs.2021.36855","url":null,"abstract":"Objective: Coexistence of lumbar spine disorder with hip diseases is defined as Hip-Spine syndrome, there might be a relation between torsional deformities of the hip and lumbar disc disease. Purpose of the present study was to find whether hip torsional parameters (femur, acetabular anteversion) and clinical findings (hip range of motion, hip score) differ in patients with lumbar disc disease. Method: Patients with lomber disc herniation (n: 20) and control subjects (n: 20) without any lumbar spine or hip disease were enrolled in the study. Femoral anteversion (FeAv), acetabular anteversion (AA), center of edge angle (CE), degree of hip flexion, extension, Harris Hip scores (HHS) were evaluated bilaterally. Results: HHS score, degree of extension plus flexion was lower at diseased side when it is compared to the control subjects (p < 0.001). Unilaterally affected patients had lower AA than control subjects (AA: 13 ± 40 vs16 ± 20 p: 0.01). Conclusion: As there is a link between hip and spine disorders, present study aims to find whether there is a causal relation between hip torsional deviations and lumbar disc disease. Partially supporting the hypothesis, diseased side had lower degrees of acetabular anteversion compared to control subjects at unilaterally affected patients. Mechanical and /or hip torsional parameters especially the acetabular retroversion may have an etiopathogenetic role in unilateral lumbar disc disease.","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127173923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selahaddin Aydemir, Cihangir Türemiş, H. Havitcioglu, O. Hapa
Objective: This study aims to report the results of 16 patients having proximal femur osteoid osteoma who were treated with CT guided mini-open excision, drilling, or x-ray guided excision Method: 16 patients receiving surgical treatment (7 CT guided mini-open excision, 6 CT guided percutaneous drilling, 3 Scopy guided mini-open excision) who were followed for at least one year were evaluated. Preoperative and latest follow-up VAS pain scoring and degree (0-10 point) or level (1 ‘high to 4 ‘worse’) of patient satisfaction were analyzed. Results: Mean postoperative VAS pain score (0.7±1.1) was lower compared to pre-operative values (8±1) (p: 0.0004). The mean level and point of satisfaction were 1.3±0.6 and 8±2 points. There was no difference between CT-guided mini-open excision or Ct-guided percutaneous drilling for any parameter. There was not any recurrence or major complication during follow-up. Conclusion: Although histological verification of the lesion was more obvious in the CT-guided excision group, both groups resulted in similar relief of pain and high satisfaction at all patients with no recurrence of symptoms or major complications.
{"title":"Proximal Femur Osteoid Osteoma Treatment: CT Guided Drilling or Excision?","authors":"Selahaddin Aydemir, Cihangir Türemiş, H. Havitcioglu, O. Hapa","doi":"10.5505/tjhs.2021.57966","DOIUrl":"https://doi.org/10.5505/tjhs.2021.57966","url":null,"abstract":"Objective: This study aims to report the results of 16 patients having proximal femur osteoid osteoma who were treated with CT guided mini-open excision, drilling, or x-ray guided excision Method: 16 patients receiving surgical treatment (7 CT guided mini-open excision, 6 CT guided percutaneous drilling, 3 Scopy guided mini-open excision) who were followed for at least one year were evaluated. Preoperative and latest follow-up VAS pain scoring and degree (0-10 point) or level (1 ‘high to 4 ‘worse’) of patient satisfaction were analyzed. Results: Mean postoperative VAS pain score (0.7±1.1) was lower compared to pre-operative values (8±1) (p: 0.0004). The mean level and point of satisfaction were 1.3±0.6 and 8±2 points. There was no difference between CT-guided mini-open excision or Ct-guided percutaneous drilling for any parameter. There was not any recurrence or major complication during follow-up. Conclusion: Although histological verification of the lesion was more obvious in the CT-guided excision group, both groups resulted in similar relief of pain and high satisfaction at all patients with no recurrence of symptoms or major complications.","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133086498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Zhamilov, Can Doruk Basa, Ismail Eralp Kacmaz, Ali Reisoglu, H. Ağuş
Objectives: This study aimed to investigate the functional and radiological outcomes in Legg–Calvé–Perthes Disease (LCPD) patients undergoing soft tissue release surgery. Materials and methods: Ten children (11 hips) diagnosed with LCPD who had previously been conservatively treated with movement limitation were included in the study. Patients in the late fragmentation period of the disease were evaluated with arthrography in hip-neutral, abduction, abduction/internal rotation, and adduction positions using radioscopy. Dynamic examination using arthrography was performed to determine whether the patient had any bone pathologies (hinging). For patients with no bone pathology, adductor longus and iliopsoas tenotomy and inferior capsulotomy were performed. Sitting was allowed immediately following surgery, and mobilization with support was allowed after the wound had healed. Patients were followed up at regular intervals. Functional assessments of patients were made using the Harris hip scoring system. Evaluation of radiological imaging was carried out according to the Stulberg classification. Results: The mean age of patients was 10.9 (6–15) years. According to the Herring lateral pillar classification, one patient was type B, three were type B/C, and seven were Type C. At the 12-month follow-up, the active range of motion was increased, and hip pain decreased. At the final follow-up (patients followed for 1–5 years; mean: 3 years), one patient was evaluated as type II, seven as type IV, and three as type V according to the Stulberg classification. The mean Harris hip score was 92.3. Conclusion: Soft tissue release surgery performed as tenotomy in LCPD patients had no effect in terms of radiological characterization, but had positive functional impacts.
{"title":"Functional Outcomes of Soft Tissue Release Surgery in Advanced Legg-Calve-Perthes Disease","authors":"V. Zhamilov, Can Doruk Basa, Ismail Eralp Kacmaz, Ali Reisoglu, H. Ağuş","doi":"10.5505/tjhs.2021.66375","DOIUrl":"https://doi.org/10.5505/tjhs.2021.66375","url":null,"abstract":"Objectives: This study aimed to investigate the functional and radiological outcomes in Legg–Calvé–Perthes Disease (LCPD) patients undergoing soft tissue release surgery. Materials and methods: Ten children (11 hips) diagnosed with LCPD who had previously been conservatively treated with movement limitation were included in the study. Patients in the late fragmentation period of the disease were evaluated with arthrography in hip-neutral, abduction, abduction/internal rotation, and adduction positions using radioscopy. Dynamic examination using arthrography was performed to determine whether the patient had any bone pathologies (hinging). For patients with no bone pathology, adductor longus and iliopsoas tenotomy and inferior capsulotomy were performed. Sitting was allowed immediately following surgery, and mobilization with support was allowed after the wound had healed. Patients were followed up at regular intervals. Functional assessments of patients were made using the Harris hip scoring system. Evaluation of radiological imaging was carried out according to the Stulberg classification. Results: The mean age of patients was 10.9 (6–15) years. According to the Herring lateral pillar classification, one patient was type B, three were type B/C, and seven were Type C. At the 12-month follow-up, the active range of motion was increased, and hip pain decreased. At the final follow-up (patients followed for 1–5 years; mean: 3 years), one patient was evaluated as type II, seven as type IV, and three as type V according to the Stulberg classification. The mean Harris hip score was 92.3. Conclusion: Soft tissue release surgery performed as tenotomy in LCPD patients had no effect in terms of radiological characterization, but had positive functional impacts.","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126078252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The purpose of the present study was to evaluate the expectation and satisfaction of patients treated with hip arthroscopy for moderate to advanced hip osteoarthritis. Method: Eighteen patients with Tönnis grade 2 or 3 hip osteoarthritis who were treated with hip arthroscopy and followed up for at least one year, were included in the study. All patients received partial labrum debridement with limited rim excision (3-5mm), chondroplasty and excision of osteophytes/cam lesion. Demographic data, education level, VAS scores, time to the last follow-up, expectation and satisfaction levels were evaluated. Results: There was not any correlation between any parameters tested except a negative correlation between time to follow up and satisfaction level, time to follow-up and satisfaction point. When short-term follow-up patients were compared with longer term follow-up groups, patient satisfaction levels, and scores were higher. Conclusion: Satisfaction levels of patients, treated with arthroscopic debridement for advanced hip osteoarthritis, is dependent on the follow-up time. Patients are satisfied up to 2 years postoperatively.
{"title":"Kalça Osteoartritinde Artroskopik Debridman Sonrası Hasta Memnuniyeti ve Hastanın Beklentisi","authors":"Berkay Yanık, Ali Asma, Onur Hapa","doi":"10.5222/tjhs.2021.40085","DOIUrl":"https://doi.org/10.5222/tjhs.2021.40085","url":null,"abstract":"Objective: The purpose of the present study was to evaluate the expectation and satisfaction of patients treated with hip arthroscopy for moderate to advanced hip osteoarthritis. Method: Eighteen patients with Tönnis grade 2 or 3 hip osteoarthritis who were treated with hip arthroscopy and followed up for at least one year, were included in the study. All patients received partial labrum debridement with limited rim excision (3-5mm), chondroplasty and excision of osteophytes/cam lesion. Demographic data, education level, VAS scores, time to the last follow-up, expectation and satisfaction levels were evaluated. Results: There was not any correlation between any parameters tested except a negative correlation between time to follow up and satisfaction level, time to follow-up and satisfaction point. When short-term follow-up patients were compared with longer term follow-up groups, patient satisfaction levels, and scores were higher. Conclusion: Satisfaction levels of patients, treated with arthroscopic debridement for advanced hip osteoarthritis, is dependent on the follow-up time. Patients are satisfied up to 2 years postoperatively.","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134090889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"After an invaluable good friend: Prof. Dr. Freddie H. FU (Dec 11, 1950 – Sept 24, 2021)","authors":"V. Lök","doi":"10.5505/tjhs.2022.85047","DOIUrl":"https://doi.org/10.5505/tjhs.2022.85047","url":null,"abstract":"","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122105160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yaradılmış, A. Kılıç, A. Evren, M. Tokgöz, Hakan Şeşen, M. Altay
{"title":"Effect of Lumbar Variables on Acetabular Version: Analysis with Pelvic-CT Scan","authors":"Y. Yaradılmış, A. Kılıç, A. Evren, M. Tokgöz, Hakan Şeşen, M. Altay","doi":"10.5505/tjhs.2022.03522","DOIUrl":"https://doi.org/10.5505/tjhs.2022.03522","url":null,"abstract":"","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"197 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115654575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atraumatic Fracture in Hip Modular Tumor Resection Prosthesis: A Case Report","authors":"M. Gunay, Mustafa Kavak","doi":"10.5505/tjhs.2022.21931","DOIUrl":"https://doi.org/10.5505/tjhs.2022.21931","url":null,"abstract":"","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129541407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. N. Kuyubaşı, N. D. Demirkıran, Suleyman Kozlu, S. Öner
{"title":"Retrospective Comparison of Surgical Techniques for Hip Fractures","authors":"S. N. Kuyubaşı, N. D. Demirkıran, Suleyman Kozlu, S. Öner","doi":"10.5505/tjhs.2023.70299","DOIUrl":"https://doi.org/10.5505/tjhs.2023.70299","url":null,"abstract":"","PeriodicalId":120558,"journal":{"name":"Turkish Journal of Hip Surgery","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130777802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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