Pub Date : 2022-01-01DOI: 10.1158/2326-6074.tumimm21-p074
M. Robinson, K. Vervier, Simon Harris, A. Popple, D. Klisko, Robyn Hudson, G. Bakdash, Laure Castan, C. Villemin, David John Adams, Doreen Milne, C. Booth, C. Parkinson, R. Rabbie, S. Welsh, E. Barker, K. Dalchau, P. Corrie, T. Lawley
{"title":"Abstract P074: MB097: A therapeutic consortium of bacteria clinically-defined by precision microbiome profiling of immune checkpoint inhibitor patients with potent anti-tumor efficacy in vitro and in vivo","authors":"M. Robinson, K. Vervier, Simon Harris, A. Popple, D. Klisko, Robyn Hudson, G. Bakdash, Laure Castan, C. Villemin, David John Adams, Doreen Milne, C. Booth, C. Parkinson, R. Rabbie, S. Welsh, E. Barker, K. Dalchau, P. Corrie, T. Lawley","doi":"10.1158/2326-6074.tumimm21-p074","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p074","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117185902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1158/2326-6074.tumimm21-p068
N. Blessin, E. Bady, T. Mandelkow, Cheng Yang, J. Raedler, R. Simon, C. Fraune, M. Lennartz, S. Minner, E. Burandt, D. Höflmayer, G. Sauter, K. Möller, S. Weidemann
{"title":"Abstract P068: Automated cell type specific PD-L1 quantification by artificial intelligence using high throughput bleach & stain 15-marker multiplex fluorescence immunohistochemistry in human cancers","authors":"N. Blessin, E. Bady, T. Mandelkow, Cheng Yang, J. Raedler, R. Simon, C. Fraune, M. Lennartz, S. Minner, E. Burandt, D. Höflmayer, G. Sauter, K. Möller, S. Weidemann","doi":"10.1158/2326-6074.tumimm21-p068","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p068","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125595079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-045
Bharani Muppavarapu, Ethan V. Abel, Melanie M. Mayberry
{"title":"Abstract PO-045: Targeting HNF1A-dependent cell proliferation and stemness in PDAC using BET inhibitors","authors":"Bharani Muppavarapu, Ethan V. Abel, Melanie M. Mayberry","doi":"10.1158/1538-7445.panca21-po-045","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-045","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127232265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-054
Nebojsa Skorupan, M. Ahmad, S. Steinberg, J. Trepel, D. Cridebring, Haiyong Han, D. V. Von Hoff, C. Alewine
{"title":"Abstract PO-054: A phase II trial of the super-enhancer inhibitor Minnelide in advanced refractory adenosquamous carcinoma of the pancreas (ASCP)","authors":"Nebojsa Skorupan, M. Ahmad, S. Steinberg, J. Trepel, D. Cridebring, Haiyong Han, D. V. Von Hoff, C. Alewine","doi":"10.1158/1538-7445.panca21-po-054","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-054","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126170198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-049
Thao N. D. Pham, Christina Spaulding, M. Shields, Mahmoud G. Khalafalla, D. Principe, D. Bentrem, H. Munshi
{"title":"Abstract PO-049: Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit anti-tumor immunity","authors":"Thao N. D. Pham, Christina Spaulding, M. Shields, Mahmoud G. Khalafalla, D. Principe, D. Bentrem, H. Munshi","doi":"10.1158/1538-7445.panca21-po-049","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-049","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131815064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-ia-007
K. Olive
{"title":"Abstract IA-007: The KPC model has helped advance pancreatic cancer therapy: Agree","authors":"K. Olive","doi":"10.1158/1538-7445.panca21-ia-007","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-ia-007","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132905166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-043
A. Lumeau, N. Bery, C. Ribeyre, S. Elkaoutari, G. Labrousse, M. Madrid-Mencía, V. Pancaldi, M. Pillaire, V. Bergoglio, Nelson Dusseti, J. Hoffmann, L. Buscail, M. Lutzmann, P. Cordelier
{"title":"Abstract PO-043: Cytidine deaminase protects pancreatic cancer cells from replicative stress and drive response to DNA-targeting drugs","authors":"A. Lumeau, N. Bery, C. Ribeyre, S. Elkaoutari, G. Labrousse, M. Madrid-Mencía, V. Pancaldi, M. Pillaire, V. Bergoglio, Nelson Dusseti, J. Hoffmann, L. Buscail, M. Lutzmann, P. Cordelier","doi":"10.1158/1538-7445.panca21-po-043","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-043","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117329620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-052
L. Pompella, Michela Falco, Carlo Caputo, A. Grimaldi, G. Tirino, S. Campione, F. Sparano, M. Iacovino, Chiara Carmen Miceli, C. Molino, M. Montella, R. Franco, G. Galizia, G. Conzo, V. Napolitano, Annamaria Auricchio, F. Cardella, F. Ciardiello, M. Caraglia, A. Lombardi, G. Misso, F. De Vita
{"title":"Abstract PO-052: A pilot study of miRNA expression profile in surgically resected pancreatic ductal adenocarcinoma: Initial report from a bi-institutional cohort","authors":"L. Pompella, Michela Falco, Carlo Caputo, A. Grimaldi, G. Tirino, S. Campione, F. Sparano, M. Iacovino, Chiara Carmen Miceli, C. Molino, M. Montella, R. Franco, G. Galizia, G. Conzo, V. Napolitano, Annamaria Auricchio, F. Cardella, F. Ciardiello, M. Caraglia, A. Lombardi, G. Misso, F. De Vita","doi":"10.1158/1538-7445.panca21-po-052","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-052","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124723120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-039
P. Ferguson, M. Vincent, Y. Najajreh, B. Shilton, Stephen Ritter, R. Al-Awar, R. Marcellus, M. Mohammed, M. Isaac, James Koropatnnick
{"title":"Abstract PO-039: Antiproliferative activity of inhibitors of RAD51, singly and in combination with chemotherapy drugs, against pancreatic cancer cell lines","authors":"P. Ferguson, M. Vincent, Y. Najajreh, B. Shilton, Stephen Ritter, R. Al-Awar, R. Marcellus, M. Mohammed, M. Isaac, James Koropatnnick","doi":"10.1158/1538-7445.panca21-po-039","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-039","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129992735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.1158/1538-7445.panca21-po-046
D. Latifi, W. de Koning, S. P. Lau, F. Grevers, C. van Dam, C. V. van Eijck, D. Mustafa
{"title":"Abstract PO-046: The effect of neoadjuvant therapy on immune profiling of pancreatic ductal adenocarcinoma: A prospective study of the PREOPANC-1 randomized controlled trial","authors":"D. Latifi, W. de Koning, S. P. Lau, F. Grevers, C. van Dam, C. V. van Eijck, D. Mustafa","doi":"10.1158/1538-7445.panca21-po-046","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-046","url":null,"abstract":"","PeriodicalId":120683,"journal":{"name":"Other Topics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132280335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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