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Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease 气道炎症生物标志物在预测和监测慢性阻塞性肺病患者临床结果中的临床应用
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-18 DOI: 10.1080/14737159.2024.2344777
Dina Yehia, Clarus Leung, Don D. Sin
Chronic obstructive pulmonary disease (COPD) accounts for 545 million people living with chronic respiratory disorders and is the third leading cause of morbidity and mortality around the world. CO...
慢性阻塞性肺病 (COPD) 患者人数高达 5.45 亿,是全球发病率和死亡率的第三大原因。慢性阻塞性肺...
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引用次数: 0
The emerging role of liquid biopsy in oral squamous cell carcinoma detection: advantages and challenges 液体活检在口腔鳞状细胞癌检测中的新兴作用:优势与挑战
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-12 DOI: 10.1080/14737159.2024.2340997
Sudha Gupta, Brijesh Singh, Rajul Abhishek, Sameer Gupta, Manisha Sachan
Oral Squamous Cell Carcinoma (OSCC), the sixth most widespread malignancy in the world, accounts for 90% of all cases of oral cancer. The primary risk factors are tobacco chewing, alcohol consumpti...
口腔鳞状细胞癌(OSCC)是全球第六大最常见的恶性肿瘤,占所有口腔癌病例的 90%。主要的危险因素是咀嚼烟草、饮酒和吸烟。
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引用次数: 0
Tumor-infiltrating lymphocytes as a prognostic and predictive factor for Melanoma. 肿瘤浸润淋巴细胞是黑色素瘤的预后和预测因素。
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2024-02-05 DOI: 10.1080/14737159.2024.2312102
Gracia Maria Vargas, Neha Shafique, Xiaowei Xu, Giorgos Karakousis

Introduction: Tumor-infiltrating lymphocytes (TILs) have been investigated as prognostic factors in melanoma. Recent advancements in assessing the tumor microenvironment in the setting of more widespread use of immune checkpoint blockade have reignited interest in identifying predictive biomarkers. This review examines the function and significance of TILs in cutaneous melanoma, evaluating their potential as prognostic and predictive markers.

Areas covered: A literature search was conducted on papers covering tumor infiltrating lymphocytes in cutaneous melanoma available online in PubMed and Web of Science from inception to 1 December 2023, supplemented by citation searching. This article encompasses the assessment of TILs, the role of TILs in the immune microenvironment, TILs as a prognostic factor, TILs as a predictive factor for immunotherapy response, and clinical applications of TILs in the treatment of cutaneous melanoma.

Expert opinion: Tumor-infiltrating lymphocytes play a heterogeneous role in cutaneous melanoma. While they have historically been associated with improved survival, their status as independent prognostic or predictive factors remains uncertain. Novel methods of TIL assessment, such as determination of TIL subtypes and molecular signaling, demonstrate potential for predicting therapeutic response. Further, while their clinical utility in risk-stratification in melanoma treatment shows promise, a lack of consensus data hinders standardized application.

简介:肿瘤浸润淋巴细胞(TILs肿瘤浸润淋巴细胞(TILs)是黑色素瘤的预后因素之一。最近,随着免疫检查点阻断技术的广泛应用,在评估肿瘤微环境方面取得的进展再次激发了人们对确定预测性生物标志物的兴趣。这篇综述探讨了TILs在皮肤黑色素瘤中的功能和意义,评估了它们作为预后和预测标志物的潜力:本文对PubMed和Web of Science上从开始到2023年12月1日期间有关皮肤黑色素瘤中肿瘤浸润淋巴细胞的在线文献进行了检索,并辅以引文检索。本文包括TILs的评估、TILs在免疫微环境中的作用、TILs作为预后因素、TILs作为免疫疗法反应的预测因素以及TILs在皮肤黑色素瘤治疗中的临床应用:肿瘤浸润淋巴细胞在皮肤黑色素瘤中发挥着不同的作用。虽然肿瘤浸润淋巴细胞历来与生存率的提高有关,但其作为独立预后或预测因素的地位仍不确定。新的 TIL 评估方法(如确定 TIL 亚型和分子信号转导)显示了预测治疗反应的潜力。此外,虽然它们在黑色素瘤治疗风险分级中的临床应用前景看好,但缺乏共识数据阻碍了它们的标准化应用。
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引用次数: 0
PCR diagnostic platforms for non-Aspergillus mold infections: ready for routine implementation in the clinic? 非曲霉菌霉菌感染的 PCR 诊断平台:是否已准备好在临床上常规使用?
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2024-03-19 DOI: 10.1080/14737159.2024.2326474
Frederic Lamoth, Dimitrios P Kontoyiannis

Introduction: While Aspergillus spp. remain the predominant cause of invasive mold infections, non-Aspergillus molds, such as the Mucorales or Fusarium spp., account for an increasing proportion of cases. The diagnosis of non-Aspergillus invasive mold infections (NAIMI) is challenging because of the low sensitivity and delay of conventional microbiological tests. Therefore, there is a particular interest to develop molecular tools for their early detection in blood or other clinical samples.

Areas covered: This extensive review of the literature discusses the performance of Mucorales-specific PCR and other genus-specific or broad-range fungal PCR that can be used for the diagnosis of NAIMI in diverse clinical samples, with a focus on novel technologies.

Expert opinion: PCR currently represents the most promising approach, combining good sensitivity/specificity and ability to detect NAIMI in clinical samples before diagnosis by conventional cultures and histopathology. Several PCR assays have been designed for the detection of Mucorales in particular, but also Fusarium spp. or Scedosporium/Lomentospora spp. Some commercial Mucorales PCRs are now available. While efforts are still needed for standardized protocols and the development of more rapid and simpler techniques, PCR is on the way to becoming an essential test for the early diagnosis of mucormycosis and possibly other NAIMIs.

导言:虽然曲霉菌属仍然是侵袭性霉菌感染的主要病因,但非曲霉菌霉菌(如粘菌或镰刀菌属)在病例中所占的比例也在不断增加。非曲霉菌侵袭性霉菌感染(NAIMI)的诊断极具挑战性,因为传统微生物检验的灵敏度低且延迟。因此,人们特别关注开发分子工具,以便在血液或其他临床样本中对其进行早期检测:这篇广泛的文献综述讨论了黏菌类特异性 PCR 和其他属特异性或广谱真菌 PCR 的性能,这些 PCR 可用于诊断不同临床样本中的非传染性真菌感染,重点关注新型技术:目前,PCR 是最有前途的方法,它具有良好的灵敏度/特异性,能够在传统培养和组织病理学诊断之前检测临床样本中的 NAIMI。目前已设计出几种 PCR 检测方法,特别是用于检测粘孢子菌,也可用于检测镰刀菌属(Fusarium spp.)或孢子菌属(Scedosporium/Lomentospora spp.)。虽然仍需努力制定标准化方案并开发更快速、更简单的技术,但 PCR 正逐渐成为粘孢子菌病以及其他非传染性疾病早期诊断的一种基本检测方法。
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引用次数: 0
The impact of companion diagnostic testing on medical decision making and IVD regulations. 辅助诊断测试对医疗决策和 IVD 法规的影响。
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI: 10.1080/14737159.2024.2317976
Jan Trøst Jørgensen
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引用次数: 0
Advancements in protein glycosylation biomarkers for ovarian cancer through mass spectrometry-based approaches. 通过质谱方法研究卵巢癌蛋白质糖基化生物标记物的进展。
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2023-12-25 DOI: 10.1080/14737159.2023.2297933
Jua Lee, Ji Eun Park, Daum Lee, Nari Seo, Hyun Joo An

Introduction: Ovarian cancer, characterized by metastasis and reduced 5-year survival rates, stands as a substantial factor in the mortality of gynecological malignancies worldwide. The challenge of delayed diagnosis originates from vague early symptoms and the absence of efficient screening and diagnostic biomarkers for early cancer detection. Recent studies have explored the intricate interplay between ovarian cancer and protein glycosylation, unveiling the potential significance of glycosylation-oriented biomarkers.

Areas covered: This review examines the progress in glycosylation biomarker research, with particular emphasis on advances driven by mass spectrometry-based technologies. We document milestones achieved, discuss encountered limitations, and also highlight potential areas for future research and development of protein glycosylation biomarkers for ovarian cancer.

Expert opinion: The association of glycosylation in ovarian cancer is well known, but current research lacks desired sensitivity and specificity for early detection. Notably, investigations into protein-specific and site-specific glycoproteomics have the potential to significantly enhance our understanding of ovarian cancer and facilitate the identification of glycosylation-based biomarkers. Furthermore, the integration of advanced mass spectrometry techniques with AI-driven analysis and glycome databases holds the promise for revolutionizing biomarker discovery for ovarian cancer, ultimately transforming diagnosis and improving patient outcomes.

导言:卵巢癌以转移和降低 5 年生存率为特征,是全球妇科恶性肿瘤死亡率的一个重要因素。由于早期症状模糊,且缺乏有效的筛查和诊断生物标志物来进行早期癌症检测,这就给延迟诊断带来了挑战。最近的研究探索了卵巢癌与蛋白质糖基化之间错综复杂的相互作用,揭示了以糖基化为导向的生物标志物的潜在意义:这篇综述探讨了糖基化生物标记物研究的进展,特别强调了基于质谱技术的研究进展。我们记录了取得的阶段性成果,讨论了遇到的局限性,还强调了卵巢癌蛋白质糖基化生物标记物未来研究和开发的潜在领域:糖基化与卵巢癌的关系众所周知,但目前的研究缺乏早期检测所需的灵敏度和特异性。值得注意的是,对蛋白质特异性和位点特异性糖蛋白组学的研究有可能大大提高我们对卵巢癌的认识,促进糖基化生物标志物的鉴定。此外,先进的质谱技术与人工智能驱动的分析和糖蛋白数据库的整合有望彻底改变卵巢癌生物标志物的发现,最终改变诊断方法并改善患者预后。
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引用次数: 0
SOWAHB polymorphisms affect thyroid cancer risk in the Chinese Han population. SOWAHB多态性影响中国汉族人群患甲状腺癌的风险。
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2024-01-23 DOI: 10.1080/14737159.2024.2305183
Man Zhang, Jing Liang, Junhui Han, Wenjing Zhang, Panpan Wan, Leteng Yang, Xufeng Zang, Wanli Ren, Ling Zhang, Hao Dai, Yue Wu, Tianbo Jin

Objectives: This study aimed to detect the correlation between SOWAHB polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.

Methods: We genotyped SOWAHB variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between SOWAHB polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.

Results: Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: p = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: p = 0.000, log-additive: p = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: p = 0.011, recessive: p = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: p = 0.030, dominant: p = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: p = 0.018, recessive: p = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: p = 0.001, dominant: p = 0.003).

Conclusion: SOWAHB SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.

研究目的本研究旨在检测中国汉族人群中SOWAHB多态性与甲状腺癌(TC)风险之间的相关性:方法:我们使用Agena MassARRAY对510名TC患者和509名对照者的SOWAHB变异进行了基因分型。我们评估了 SOWAHB 多态性与 TC 易感性之间的关联,并通过 FPRP 分析评估了显著结果。我们通过MDR分析SNP-SNP相互作用来预测TC风险:结果:rs2703129 CC携带者患TC的概率较低(显性、隐性:p = 0.002),而rs1874564 AG携带者患TC的风险较高(显性、隐性:p = 0.000,对数加成:p = 0.028)。在年龄大于 45 岁的受试者中,rs2703129 可降低 TC 易感性(显性:p = 0.011,隐性:p = 0.007),但 rs1874564 与 TC 风险之间的关联性增加(显性:p = 0.030,显性:p = 0.047)。此外,rs2703129 与男性 TC 风险较低有关(显性:p = 0.018,隐性:p = 0.013)。相反,rs1874564 与女性 TC 风险增加有关(共显性:p = 0.001,显性:p = 0.003):结论:SOWAHB SNPs与TC的发生有关,rs2703129可能是TC的保护位点。
{"title":"<i>SOWAHB</i> polymorphisms affect thyroid cancer risk in the Chinese Han population.","authors":"Man Zhang, Jing Liang, Junhui Han, Wenjing Zhang, Panpan Wan, Leteng Yang, Xufeng Zang, Wanli Ren, Ling Zhang, Hao Dai, Yue Wu, Tianbo Jin","doi":"10.1080/14737159.2024.2305183","DOIUrl":"10.1080/14737159.2024.2305183","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to detect the correlation between <i>SOWAHB</i> polymorphisms and Thyroid cancer (TC) risk in the Chinese Han population.</p><p><strong>Methods: </strong>We genotyped <i>SOWAHB</i> variants in 510 TC patients and 509 controls using Agena MassARRAY. We assessed the association between <i>SOWAHB</i> polymorphisms and TC susceptibility, with the significant results evaluated through FPRP analysis. We predicted TC risk by the SNP-SNP interaction, analyzed by MDR.</p><p><strong>Results: </strong>Carriers with rs2703129 CC had a lower probability of TC (codominant, recessive: <i>p</i> = 0.002), while subjects with rs1874564 AG had an increased risk of developing TC (codominant, recessive: <i>p</i> = 0.000, log-additive: <i>p</i> = 0.028). In subjects aged > 45 years, rs2703129 may reduce TC predisposition (codominant: <i>p</i> = 0.011, recessive: <i>p</i> = 0.007), but there was an increased association between rs1874564 and TC risk (codominant: <i>p</i> = 0.030, dominant: <i>p</i> = 0.047). Also, rs2703129 was associated with a lower risk of TC among males (codominant: <i>p</i> = 0.018, recessive: <i>p</i> = 0.013). Conversely, rs1874564 was associated with an increased risk of TC in females (codominant: <i>p</i> = 0.001, dominant: <i>p</i> = 0.003).</p><p><strong>Conclusion: </strong><i>SOWAHB</i> SNPs were related to the occurrence of TC, and rs2703129 may be a protective site for TC.</p>","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"333-339"},"PeriodicalIF":5.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of lung cancer and stages via breath analysis using a self-made electronic nose device. 使用自制的电子鼻装置,通过呼气分析检测肺癌及其分期。
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2024-02-19 DOI: 10.1080/14737159.2024.2316755
Binson V A, Philip Mathew, Sania Thomas, Luke Mathew

Background: Breathomics is an emerging area focusing on monitoring and diagnosing pulmonary diseases, especially lung cancer. This research aims to employ metabolomic methods to create a breathprint in human-expelled air to rapidly identify lung cancer and its stages.

Research design and methods: An electronic nose (e-nose) system with five metal oxide semiconductor (MOS) gas sensors, a microcontroller, and machine learning algorithms was designed and developed for this application. The volunteers in this study include 114 patients with lung cancer and 147 healthy controls to understand the clinical potential of the e-nose system to detect lung cancer and its stages.

Results: In the training phase, in discriminating lung cancer from controls, the XGBoost classifier model with 10-fold cross-validation gave an accuracy of 91.67%. In the validation phase, the XGBoost classifier model correctly identified 35 out of 42 patients with lung cancer samples and 44 out of 51 healthy control samples providing an overall sensitivity of 83.33% and specificity of 86.27%.

Conclusions: These results indicate that the exhaled breath VOC analysis method may be developed as a new diagnostic tool for lung cancer detection. The advantages of e-nose based diagnostics, such as an easy and painless method of sampling, and low-cost procedures, will make it an excellent diagnostic method in the future.

背景:呼吸组学是一个新兴领域,主要用于监测和诊断肺部疾病,尤其是肺癌。本研究旨在利用代谢组学方法在人体排出的空气中建立呼吸指纹,以快速识别肺癌及其分期:研究设计和开发了一个电子鼻(e-nose)系统,其中包含五个金属氧化物半导体(MOS)气体传感器、一个微控制器和机器学习算法。这项研究的志愿者包括 114 名肺癌患者和 147 名健康对照者,目的是了解电子鼻系统检测肺癌及其分期的临床潜力:在训练阶段,XGBoost 分类器模型在区分肺癌和对照组时的准确率为 91.67%。在验证阶段,XGBoost 分类器模型正确识别了 42 个肺癌患者样本中的 35 个样本和 51 个健康对照样本中的 44 个样本,总体灵敏度为 83.33%,特异度为 86.27%:这些结果表明,呼出气体挥发性有机化合物分析方法可作为一种新的肺癌检测诊断工具。基于电子鼻的诊断方法具有取样简便、无痛苦、成本低廉等优点,未来将成为一种很好的诊断方法。
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引用次数: 0
Body fluid markers for multiple sclerosis and differential diagnosis from atypical demyelinating disorders. 多发性硬化症的体液标志物以及与非典型脱髓鞘疾病的鉴别诊断。
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-04-01 Epub Date: 2024-03-27 DOI: 10.1080/14737159.2024.2334849
Angelika Bauer, Harald Hegen, Markus Reindl

Introduction: Body fluid markers could be helpful to predict the conversion into clinically definite multiple sclerosis (MS) in people with a first demyelinating event of the central nervous system (CNS). Consequently, biomarkers such as oligoclonal bands, which are integrated in the current MS diagnostic criteria, could assist early MS diagnosis.

Areas covered: This review examines existing knowledge on a broad spectrum of body fluid markers in people with a first CNS demyelinating event, explores their potential to predict conversion to MS, to assess MS disease activity, as well as their utility to differentiate MS from atypical demyelinating disorders such as neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disease.

Expert opinion: This field of research has shown a dramatic increase of evidence, especially in the last decade. Some biomarkers are already established in clinical routine (e.g. oligoclonal bands) while others are currently implemented (e.g. kappa free light chains) or considered as breakthroughs (e.g. neurofilament light). Determination of biomarkers poses challenges for continuous monitoring, especially if exclusively detectable in cerebrospinal fluid. A handful of biomarkers are measurable in blood which holds a significant potential.

导言体液标志物有助于预测中枢神经系统(CNS)首次出现脱髓鞘症状的患者是否会转变为临床明确的多发性硬化症(MS)。因此,已纳入现行多发性硬化症诊断标准的寡克隆带等生物标志物有助于早期诊断多发性硬化症:本综述研究了首次中枢神经系统脱髓鞘事件患者体液标志物的现有知识,探讨了这些标志物在预测多发性硬化症转归、评估多发性硬化症疾病活动性方面的潜力,以及它们在区分多发性硬化症与非典型脱髓鞘疾病(如神经性脊髓炎视网膜谱系障碍和髓鞘少突胶质细胞糖蛋白相关疾病)方面的效用:这一研究领域的证据急剧增加,尤其是在过去十年中。一些生物标志物已在临床常规中确立(如少克隆带),而另一些生物标志物目前正在实施(如 kappa 游离轻链)或被视为突破性成果(如神经丝光)。生物标记物的确定给持续监测带来了挑战,特别是如果只能在脑脊液中检测到生物标记物。少数几种生物标志物可在血液中测量,具有很大的潜力。
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引用次数: 0
A state-of-the-art overview of candidate diagnostic biomarkers for attention-Deficit/Hyperactivity disorder (ADHD) 注意力缺陷/多动障碍(ADHD)候选诊断生物标志物的最新概况
IF 5.1 3区 医学 Q1 PATHOLOGY Pub Date : 2024-03-20 DOI: 10.1080/14737159.2024.2333277
Valeria Parlatini, Alessio Bellato, Alessandra Gabellone, Lucia Margari, Lucia Marzulli, Emilia Matera, Maria Giuseppina Petruzzelli, Marco Solmi, Christoph U. Correll, Samuele Cortese
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental conditions and is highly heterogeneous in terms of symptom profile, associated cognitive deficits, comor...
注意力缺陷/多动障碍(ADHD)是最常见的神经发育疾病之一,在症状特征、相关认知缺陷、共性和个体差异等方面存在很大差异。
{"title":"A state-of-the-art overview of candidate diagnostic biomarkers for attention-Deficit/Hyperactivity disorder (ADHD)","authors":"Valeria Parlatini, Alessio Bellato, Alessandra Gabellone, Lucia Margari, Lucia Marzulli, Emilia Matera, Maria Giuseppina Petruzzelli, Marco Solmi, Christoph U. Correll, Samuele Cortese","doi":"10.1080/14737159.2024.2333277","DOIUrl":"https://doi.org/10.1080/14737159.2024.2333277","url":null,"abstract":"Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental conditions and is highly heterogeneous in terms of symptom profile, associated cognitive deficits, comor...","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":"52 1","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Expert Review of Molecular Diagnostics
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