Pub Date : 2017-03-01DOI: 10.1097/ICL.0000000000000229
K. Gumus
Purpose: The management of nonhealing corneal ulcers, particularly in patients with neurotrophic corneas, remains a challenging problem today. Some patients may fail to respond to conventional therapy, making new alternative agents necessary to treat these resistant cases. In this article, we aim to present six challenging cases of refractory corneal ulcers that revealed healing response to the adjuvant treatment with coenzyme Q10 (CoQ10) eye drops and to review the literature examining of new therapeutic agents. Methods: Our study was designed as a descriptive case series demonstrating the use of novel coenzyme Q10 eye drops in refractory corneal ulcers. In our case series, CoQ10 eye drops were added to the existing therapies as an adjuvant agent in six cases: three cases with neurotrophic corneal ulcers, two cases with postinfectious corneal ulcers (one unknown etiology+one Acanthamoeba keratitis), and 1 case with Stevens–Johnson syndrome. All cases were monitored regularly and corneal images were taken at all visits. Results: All nonhealing corneas with conventional therapy revealed recovery after the addition of CoQ10 eye drops. Except for two cases that responded to the CoQ10 eye drops more rapidly (within 1 to 2 weeks), complete corneal healing was observed in four cases between weeks 4 and 8. No adverse events were reported in these cases throughout the follow-up period. Conclusion: Coenzyme Q10 eye drops can be considered as an important adjuvant therapeutic agent promoting corneal epithelial wound healing in challenging cases.
{"title":"Topical Coenzyme Q10 Eye Drops as an Adjuvant Treatment in Challenging Refractory Corneal Ulcers: A Case Series and Literature Review","authors":"K. Gumus","doi":"10.1097/ICL.0000000000000229","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000229","url":null,"abstract":"Purpose: The management of nonhealing corneal ulcers, particularly in patients with neurotrophic corneas, remains a challenging problem today. Some patients may fail to respond to conventional therapy, making new alternative agents necessary to treat these resistant cases. In this article, we aim to present six challenging cases of refractory corneal ulcers that revealed healing response to the adjuvant treatment with coenzyme Q10 (CoQ10) eye drops and to review the literature examining of new therapeutic agents. Methods: Our study was designed as a descriptive case series demonstrating the use of novel coenzyme Q10 eye drops in refractory corneal ulcers. In our case series, CoQ10 eye drops were added to the existing therapies as an adjuvant agent in six cases: three cases with neurotrophic corneal ulcers, two cases with postinfectious corneal ulcers (one unknown etiology+one Acanthamoeba keratitis), and 1 case with Stevens–Johnson syndrome. All cases were monitored regularly and corneal images were taken at all visits. Results: All nonhealing corneas with conventional therapy revealed recovery after the addition of CoQ10 eye drops. Except for two cases that responded to the CoQ10 eye drops more rapidly (within 1 to 2 weeks), complete corneal healing was observed in four cases between weeks 4 and 8. No adverse events were reported in these cases throughout the follow-up period. Conclusion: Coenzyme Q10 eye drops can be considered as an important adjuvant therapeutic agent promoting corneal epithelial wound healing in challenging cases.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"8 1","pages":"73–80"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85450027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-01DOI: 10.1097/ICL.0000000000000243
S. Jain, N. Sharma, P. Maharana, T. Agarwal, R. Sinha, R. Vajpayee
Purpose: To compare the outcomes of 400-&mgr;m microkeratome head with 350-&mgr;m microkeratome head Descemet stripping automated endothelial keratoplasty (DSAEK) in a prospective comparative study. Methods: Twenty cases of pseudophakic bullous keratopathy were randomly allocated into two groups. Group 1 underwent slow, single-pass 400-&mgr;m microkeratome head, whereas group 2 underwent the standard technique of DSAEK using a 350-&mgr;m microkeratome head. The primary outcome measures were best-corrected visual acuity (BCVA) at 6 months. Results: Groups were comparable in baseline characteristics. The mean central graft thickness (GT) at 6 months in group 1 was significantly thinner than group 2 (90.44±28.67 vs. 165.60±62.74 &mgr;m; P=0.003). The BCVA and contrast sensitivity were significantly better in group 1 than in group 2 (BCVA: 0.34±0.15 vs. 0.53±0.19 logMAR units, P=0.02; contrast sensitivity: 1.48±0.13 vs. 1.06±0.22, P=0.001). A significant correlation was found between both postoperative BCVA and contrast sensitivity, with the postoperative GT using Spearman rho correlation analysis (R=0.534, P=0.01 for BCVA and R=−0.522, P=0.02 for contrast sensitivity). The percentage endothelial cell loss was comparable between the 2 groups at the last follow-up (P=0.3). No major complications were observed during the study period. Conclusions: The use of a 400-&mgr;m microkeratome head instead of 350-&mgr;m head can improve the visual outcomes in DSAEK without increasing the risk of complications. The thickness of the DSAEK graft can affect the visual acuity and contrast sensitivity.
{"title":"Comparative Evaluation of Use of 400-&mgr;m and 350-&mgr;m Microkeratome Head to Prepare Donor Tissue in Cases of Descemet Stripping Automated Endothelial Keratoplasty","authors":"S. Jain, N. Sharma, P. Maharana, T. Agarwal, R. Sinha, R. Vajpayee","doi":"10.1097/ICL.0000000000000243","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000243","url":null,"abstract":"Purpose: To compare the outcomes of 400-&mgr;m microkeratome head with 350-&mgr;m microkeratome head Descemet stripping automated endothelial keratoplasty (DSAEK) in a prospective comparative study. Methods: Twenty cases of pseudophakic bullous keratopathy were randomly allocated into two groups. Group 1 underwent slow, single-pass 400-&mgr;m microkeratome head, whereas group 2 underwent the standard technique of DSAEK using a 350-&mgr;m microkeratome head. The primary outcome measures were best-corrected visual acuity (BCVA) at 6 months. Results: Groups were comparable in baseline characteristics. The mean central graft thickness (GT) at 6 months in group 1 was significantly thinner than group 2 (90.44±28.67 vs. 165.60±62.74 &mgr;m; P=0.003). The BCVA and contrast sensitivity were significantly better in group 1 than in group 2 (BCVA: 0.34±0.15 vs. 0.53±0.19 logMAR units, P=0.02; contrast sensitivity: 1.48±0.13 vs. 1.06±0.22, P=0.001). A significant correlation was found between both postoperative BCVA and contrast sensitivity, with the postoperative GT using Spearman rho correlation analysis (R=0.534, P=0.01 for BCVA and R=−0.522, P=0.02 for contrast sensitivity). The percentage endothelial cell loss was comparable between the 2 groups at the last follow-up (P=0.3). No major complications were observed during the study period. Conclusions: The use of a 400-&mgr;m microkeratome head instead of 350-&mgr;m head can improve the visual outcomes in DSAEK without increasing the risk of complications. The thickness of the DSAEK graft can affect the visual acuity and contrast sensitivity.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"1040 1","pages":"130–134"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86467886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-01DOI: 10.1097/ICL.0000000000000247
M. Lira, Rita Silva
Purpose: To analyze changes in wettability of hydrogel and silicone hydrogel contact lenses (CLs) when preserved in different lens care systems. Methods: In this research, four silicone hydrogel CLs (senofilcon A, balafilcon A, comfilcon A, and lotrafilcon B) and one conventional CL (etafilcon A) and appropriate lens care solutions (ReNu MultiPlus, Biotrue, OPTI-FREE PureMoist, and AOSept Plus) were used. Lenses were immersed in each lens care system for 12 hr and then CL hydrophobicity was determined through water contact angle (CA) measurements using the OCA 20 instrument (DataPhysics). Results: Mean CA values obtained when CLs were removed from blisters (baseline value) were lower for etafilcon A (49.6°±3.0°) and comfilcon A (48.0°±2.8°) and higher for senofilcon A (78.9°±2.5°), lotrafilcon B (82.6°±1.7°), and balafilcon A (91.5°±0.7°). Depending on CL and lens care combination, it was detected a statistically significant reduction by 70% of the 20 combinations studied and any significant increase in the CA. When compared to baseline values, CA varied between etafilcon A: 2° and 11°, comfilcon A: 1° and 7°, senofilcon A: 2° and 28°, lotrafilcon B: 14° and 31°, and balafilcon A: 18° and 29°. Comfilcon A was the most stable lens material presenting only one significant decrease in CA. Conclusions: This study reveals the existence of interactions between CL material and lens solutions that can play an important role in CL surface wettability. The major changes were obtained in lenses with higher baseline CA, which showed significant changes with each of the solutions. These differences can be positive, because in almost all of the combinations, the lenses became more wettable.
{"title":"Effect of Lens Care Systems on Silicone Hydrogel Contact Lens Hydrophobicity","authors":"M. Lira, Rita Silva","doi":"10.1097/ICL.0000000000000247","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000247","url":null,"abstract":"Purpose: To analyze changes in wettability of hydrogel and silicone hydrogel contact lenses (CLs) when preserved in different lens care systems. Methods: In this research, four silicone hydrogel CLs (senofilcon A, balafilcon A, comfilcon A, and lotrafilcon B) and one conventional CL (etafilcon A) and appropriate lens care solutions (ReNu MultiPlus, Biotrue, OPTI-FREE PureMoist, and AOSept Plus) were used. Lenses were immersed in each lens care system for 12 hr and then CL hydrophobicity was determined through water contact angle (CA) measurements using the OCA 20 instrument (DataPhysics). Results: Mean CA values obtained when CLs were removed from blisters (baseline value) were lower for etafilcon A (49.6°±3.0°) and comfilcon A (48.0°±2.8°) and higher for senofilcon A (78.9°±2.5°), lotrafilcon B (82.6°±1.7°), and balafilcon A (91.5°±0.7°). Depending on CL and lens care combination, it was detected a statistically significant reduction by 70% of the 20 combinations studied and any significant increase in the CA. When compared to baseline values, CA varied between etafilcon A: 2° and 11°, comfilcon A: 1° and 7°, senofilcon A: 2° and 28°, lotrafilcon B: 14° and 31°, and balafilcon A: 18° and 29°. Comfilcon A was the most stable lens material presenting only one significant decrease in CA. Conclusions: This study reveals the existence of interactions between CL material and lens solutions that can play an important role in CL surface wettability. The major changes were obtained in lenses with higher baseline CA, which showed significant changes with each of the solutions. These differences can be positive, because in almost all of the combinations, the lenses became more wettable.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"10 1","pages":"89–94"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82663846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-14DOI: 10.1097/ICL.0000000000000380
Pembe Oltulu, Refik Oltulu, Mehmet Asıl, Gunhal Satirtav, Enver Mirza
Purpose: The aim of this study was to compare signs of dry eye between ulcerative colitis (UC) patients and healthy subjects. Methods: Fifteen patients with UC (group 1) and 15 healthy subjects (group 2) were enrolled in this study. Tear volume measurement, Schirmer-I test with no anesthetic, tear break-up time, and conjunctival impression cytology (CIC) were evaluated in both groups. Results: Patients with UC showed lower tear volumes when compared with healthy subjects (P<0.05). There was a statistically significant difference in distribution of CIC grades between groups 1 and 2 (P<0.05). Tear break-up time and Schirmer-I measurements were significantly lower in group 1 compared with group 2 (P<0.05). Conclusions: The results of this study indicate that UC is associated with demonstrable disturbances in tear function and conjunctival cytology.
{"title":"Conjunctival Impression Cytology and Dry Eye in Patients With Ulcerative Colitis: A Pilot Study","authors":"Pembe Oltulu, Refik Oltulu, Mehmet Asıl, Gunhal Satirtav, Enver Mirza","doi":"10.1097/ICL.0000000000000380","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000380","url":null,"abstract":"Purpose: The aim of this study was to compare signs of dry eye between ulcerative colitis (UC) patients and healthy subjects. Methods: Fifteen patients with UC (group 1) and 15 healthy subjects (group 2) were enrolled in this study. Tear volume measurement, Schirmer-I test with no anesthetic, tear break-up time, and conjunctival impression cytology (CIC) were evaluated in both groups. Results: Patients with UC showed lower tear volumes when compared with healthy subjects (P<0.05). There was a statistically significant difference in distribution of CIC grades between groups 1 and 2 (P<0.05). Tear break-up time and Schirmer-I measurements were significantly lower in group 1 compared with group 2 (P<0.05). Conclusions: The results of this study indicate that UC is associated with demonstrable disturbances in tear function and conjunctival cytology.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"126 1","pages":"S190–S193"},"PeriodicalIF":0.0,"publicationDate":"2017-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87832674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-27DOI: 10.1097/ICL.0000000000000330
Hiroyuki Yazu, M. Doğru, J. Miyauchi, Yoichi Tanaka, Takefumi Yamaguchi, S. Den, Yoshiyuki Satake, K. Tsubota, J. Shimazaki
Purpose: To investigate the association between recurrence of conjunctival papillomas and presence of atypical epithelial changes in patients undergoing surgical excision for conjunctival papilloma. Methods: We retrospectively reviewed 1,195 ophthalmic pathology specimens from 2004 to 2014 at Ichikawa General Hospital. Pathologic specimens of 5 patients with a final diagnosis of “conjunctival papilloma” were stained with hematoxylin–eosin, Ki 67, p53, human papillomavirus (HPV) 16 and 18 antibodies. Results: Of 1,195 patients, 5 patients (4 men, 1 woman; age range: 27∼57 years, mean age: 38.4 years) had a diagnosis of conjunctival papilloma, which constituted to 0.42% of the pathologic diagnosis made for the ophthalmology specimens. All specimens displayed multiple fronds of thickened conjunctival epithelium that enclosed cores of vascularized connective tissues. Three patients with recurrence after surgical excision demonstrated moderate to severe epithelial atypia, who also showed higher staining with Ki67 and p53 compared with patients with no recurrence. HPV16 and 18 antibodies staining did not appear to relate to recurrences. Conclusions: Conjunctival papillomas with higher positive staining for Ki67 and p53 seem to have a higher risk of recurrence even after complete surgical excision and necessitate careful follow-up.
{"title":"Association of Epithelial Atypia With Recurrence After Surgical Excision in Conjunctival Papilloma","authors":"Hiroyuki Yazu, M. Doğru, J. Miyauchi, Yoichi Tanaka, Takefumi Yamaguchi, S. Den, Yoshiyuki Satake, K. Tsubota, J. Shimazaki","doi":"10.1097/ICL.0000000000000330","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000330","url":null,"abstract":"Purpose: To investigate the association between recurrence of conjunctival papillomas and presence of atypical epithelial changes in patients undergoing surgical excision for conjunctival papilloma. Methods: We retrospectively reviewed 1,195 ophthalmic pathology specimens from 2004 to 2014 at Ichikawa General Hospital. Pathologic specimens of 5 patients with a final diagnosis of “conjunctival papilloma” were stained with hematoxylin–eosin, Ki 67, p53, human papillomavirus (HPV) 16 and 18 antibodies. Results: Of 1,195 patients, 5 patients (4 men, 1 woman; age range: 27∼57 years, mean age: 38.4 years) had a diagnosis of conjunctival papilloma, which constituted to 0.42% of the pathologic diagnosis made for the ophthalmology specimens. All specimens displayed multiple fronds of thickened conjunctival epithelium that enclosed cores of vascularized connective tissues. Three patients with recurrence after surgical excision demonstrated moderate to severe epithelial atypia, who also showed higher staining with Ki67 and p53 compared with patients with no recurrence. HPV16 and 18 antibodies staining did not appear to relate to recurrences. Conclusions: Conjunctival papillomas with higher positive staining for Ki67 and p53 seem to have a higher risk of recurrence even after complete surgical excision and necessitate careful follow-up.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"24 1","pages":"S77–S81"},"PeriodicalIF":0.0,"publicationDate":"2017-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74435704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-17DOI: 10.1097/ICL.0000000000000363
Jennie Diec, Daniel Tilia, Varghese Thomas
Objective: To compare subjective, objective and safety performance of silicone hydrogel (SiHy) daily disposable (DD) with hydrogel (Hy) DD contact lenses. Method: Retrospective analysis on approximately 40 participants (Px) each in 5 trials. Lenses grouped into SiHy (delefilcon A, somofilcon A, narafilcon A) and Hy (omafilcon A, nelfilcon A). Participants attended follow-up visits at baseline, 2 weeks, 1 and 3 months. Subjective ratings (1–10 scale), adverse events (percentage of Px), physiological variables (0–4 scale), and wearing time were collected at each visit and compared between groups. Result: Trials enrolled 201 Px totally. No differences in age, sex, and lens wear experience were found between SiHy and Hy groups (P≥0.09). There was greater increase in limbal redness from baseline in Hy group (0.18±0.38 vs. 0.02±0.47, P<0.001), whereas conjunctival staining and indentation were less in Hy group (P<0.001). No differences in comfortable wearing time were found between groups (P=0.41), and comfort at insertion, during day, and end of day was also no different (P≥0.71). Incidence of corneal infiltrative events (SiHy vs. Hy: 6.7% vs. 2.5%; P=0.32) and mechanical adverse events (SiHy vs. Hy: 0.0% vs. 0.0%; P=1.00) were no different. Conclusion: Though some statistical significance was found between the groups, these differences were within measurement error. Neither material types showed superiority in comfort, and adverse event rates were low with both material types. These findings suggest that choice of material is a patient and practitioner preference; however, for patients at risk of hypoxia-related complications, SiHy materials should be considered.
目的:比较硅胶水凝胶(SiHy)日用一次性(DD)隐形眼镜与水凝胶(Hy) DD隐形眼镜的主客观及安全性能。方法:回顾性分析5项试验，每组约40例(Px)。镜片分为SiHy (delefilcon A, somfilcon A, narafilcon A)和Hy (omafilcon A, nelfilcon A)。参与者在基线、2周、1和3个月进行随访。每次就诊时收集主观评分(1-10分)、不良事件(Px百分比)、生理变量(0-4分)和佩戴时间，并进行组间比较。结果:试验共入组201 Px。SiHy组与Hy组在年龄、性别、配戴经验等方面均无差异(P≥0.09)。Hy组角膜缘发红较基线增加较多(0.18±0.38 vs. 0.02±0.47,P<0.001)，而Hy组结膜染色和压痕较少(P<0.001)。两组间舒适穿着时间无差异(P=0.41)，插入时、白天和结束时的舒适度也无差异(P≥0.71)。角膜浸润事件发生率(SiHy vs. Hy: 6.7% vs. 2.5%;P=0.32)和机械不良事件(SiHy vs. Hy: 0.0% vs. 0.0%;P=1.00)无差异。结论:组间差异虽有统计学意义，但均在测量误差范围内。两种材料在舒适度上都没有优势，而且不良事件发生率都很低。这些发现表明，材料的选择是患者和医生的偏好;然而，对于有缺氧相关并发症风险的患者，应考虑使用SiHy材料。
{"title":"Comparison of Silicone Hydrogel and Hydrogel Daily Disposable Contact Lenses","authors":"Jennie Diec, Daniel Tilia, Varghese Thomas","doi":"10.1097/ICL.0000000000000363","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000363","url":null,"abstract":"Objective: To compare subjective, objective and safety performance of silicone hydrogel (SiHy) daily disposable (DD) with hydrogel (Hy) DD contact lenses. Method: Retrospective analysis on approximately 40 participants (Px) each in 5 trials. Lenses grouped into SiHy (delefilcon A, somofilcon A, narafilcon A) and Hy (omafilcon A, nelfilcon A). Participants attended follow-up visits at baseline, 2 weeks, 1 and 3 months. Subjective ratings (1–10 scale), adverse events (percentage of Px), physiological variables (0–4 scale), and wearing time were collected at each visit and compared between groups. Result: Trials enrolled 201 Px totally. No differences in age, sex, and lens wear experience were found between SiHy and Hy groups (P≥0.09). There was greater increase in limbal redness from baseline in Hy group (0.18±0.38 vs. 0.02±0.47, P<0.001), whereas conjunctival staining and indentation were less in Hy group (P<0.001). No differences in comfortable wearing time were found between groups (P=0.41), and comfort at insertion, during day, and end of day was also no different (P≥0.71). Incidence of corneal infiltrative events (SiHy vs. Hy: 6.7% vs. 2.5%; P=0.32) and mechanical adverse events (SiHy vs. Hy: 0.0% vs. 0.0%; P=1.00) were no different. Conclusion: Though some statistical significance was found between the groups, these differences were within measurement error. Neither material types showed superiority in comfort, and adverse event rates were low with both material types. These findings suggest that choice of material is a patient and practitioner preference; however, for patients at risk of hypoxia-related complications, SiHy materials should be considered.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"82 1","pages":"S167–S172"},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75014630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-17DOI: 10.1097/ICL.0000000000000359
E. Yildiz, Meltem Toklu, Ece Turan Vural
Objectives: To determine changes in the vision-related quality of life in patients undergoing deep anterior lamellar keratoplasty (DALK) by using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). Methods: Thirty-five patients who were scheduled for DALK between March 1, 2013, and March 1, 2014 were asked to complete the NEI VFQ-25. NEI VFQ-25 was administered again at 6 months and at 1 year postoperatively. Data on patients' age, sex, preoperative diagnosis, preoperative and postoperative best-corrected visual acuity, and postoperative astigmatism were recorded. Results: Successful DALK with the Anwar big bubble technique was achieved in 23 of 35 (65.7%) patients. The indications for surgery were keratoconus in 15 patients (62.2%), stromal corneal dystrophies in 4 (17%), and corneal scar in 4 (17%). The mean preoperative NEI VFQ-25 composite score (55.2±19.7) improved significantly (76.9±11.6) at 6 months after DALK and continued to improve (84.3±6.6) at 1 year postoperatively (Friedman test, P=0.001). All NEI VFQ-25 subscale item scores increased significantly after surgery. The patients' age was significantly correlated with the NEI VFQ-25 subscale score of mental health at 6 month and at 1 year postoperatively (r=0.92, P=0.008 and r=0.94, P=0.005, respectively). There was a negative relationship between postoperative astigmatism at 1 year and NEI VFQ-25 ocular pain, social functioning, peripheral vision, and mental health subscale scores (r=−0.76, P=−0.07; r=−0.53, P=0.2; r=−0.53, P=0.27; r=−0.80, P=0.05). Conclusion: Vision-related quality of life improved significantly after DALK and continued to improve after suture removal.
{"title":"Vision-Related Quality of Life Before and After Deep Anterior Lamellar Keratoplasty","authors":"E. Yildiz, Meltem Toklu, Ece Turan Vural","doi":"10.1097/ICL.0000000000000359","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000359","url":null,"abstract":"Objectives: To determine changes in the vision-related quality of life in patients undergoing deep anterior lamellar keratoplasty (DALK) by using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). Methods: Thirty-five patients who were scheduled for DALK between March 1, 2013, and March 1, 2014 were asked to complete the NEI VFQ-25. NEI VFQ-25 was administered again at 6 months and at 1 year postoperatively. Data on patients' age, sex, preoperative diagnosis, preoperative and postoperative best-corrected visual acuity, and postoperative astigmatism were recorded. Results: Successful DALK with the Anwar big bubble technique was achieved in 23 of 35 (65.7%) patients. The indications for surgery were keratoconus in 15 patients (62.2%), stromal corneal dystrophies in 4 (17%), and corneal scar in 4 (17%). The mean preoperative NEI VFQ-25 composite score (55.2±19.7) improved significantly (76.9±11.6) at 6 months after DALK and continued to improve (84.3±6.6) at 1 year postoperatively (Friedman test, P=0.001). All NEI VFQ-25 subscale item scores increased significantly after surgery. The patients' age was significantly correlated with the NEI VFQ-25 subscale score of mental health at 6 month and at 1 year postoperatively (r=0.92, P=0.008 and r=0.94, P=0.005, respectively). There was a negative relationship between postoperative astigmatism at 1 year and NEI VFQ-25 ocular pain, social functioning, peripheral vision, and mental health subscale scores (r=−0.76, P=−0.07; r=−0.53, P=0.2; r=−0.53, P=0.27; r=−0.80, P=0.05). Conclusion: Vision-related quality of life improved significantly after DALK and continued to improve after suture removal.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"11 1","pages":"144–148"},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82887648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-17DOI: 10.1097/ICL.0000000000000365
Allison C. Brown, J. Ross, Danielle Jones, S. Collier, T. Ayers, R. M. Hoekstra, Bryon Backensen, S. Roy, M. Beach, J. Yoder
Objective: To identify modifiable risk factors contributing to Acanthamoeba keratitis (AK) infection. Methods: A case–control investigation was conducted. Case patients were soft contact lens wearers with laboratory-confirmed AK. Control were soft contact lens wearers ≥12 years of age, with no history of AK. Case patients were recruited from 14 ophthalmology referral centers and a clinical laboratory. Control were matched on state of residence and type of primary eye care provider (ophthalmologist or optometrist). Participants were interviewed using a standardized questionnaire. Univariable and multivariable conditional logistic regression analyses were conducted. Matched odds ratios (mORs) were calculated. Results: Participants included 88 case patients and 151 matched control. Case patients were more likely to be aged <25 years (unadjusted mOR 2.7, 95% confidence interval 1.3–5.5) or aged >53 years (mOR 2.5, 1.1–5.7), and more likely to be men (mOR 2.6, 1.4–4.8). Unadjusted analyses identified multiple risk factors: rinsing (mOR 6.3, 1.3–29.9) and storing lenses in tap water (mOR 3.9, 1.2–12.3), topping off solution in the lens case (mOR 4.0, 2.0–8.0), having worn lenses ⩽5 years (mOR 2.4, 1.3–4.4), rinsing the case with tap water before storing lenses (mOR 2.1, 1.1–4.1), and using hydrogen peroxide (mOR 3.6, 1.1–11.7) versus multipurpose solution. Significant risk factors in multivariable modeling included age >53 years, male sex, topping off, and using saline solution. Conclusions: Numerous modifiable risk factors for AK were identified, mostly involving hygiene practices. To reduce the risk of AK, lens wearers should observe recommended lens care practices.
{"title":"Risk Factors for Acanthamoeba Keratitis—A Multistate Case–Control Study, 2008–2011","authors":"Allison C. Brown, J. Ross, Danielle Jones, S. Collier, T. Ayers, R. M. Hoekstra, Bryon Backensen, S. Roy, M. Beach, J. Yoder","doi":"10.1097/ICL.0000000000000365","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000365","url":null,"abstract":"Objective: To identify modifiable risk factors contributing to Acanthamoeba keratitis (AK) infection. Methods: A case–control investigation was conducted. Case patients were soft contact lens wearers with laboratory-confirmed AK. Control were soft contact lens wearers ≥12 years of age, with no history of AK. Case patients were recruited from 14 ophthalmology referral centers and a clinical laboratory. Control were matched on state of residence and type of primary eye care provider (ophthalmologist or optometrist). Participants were interviewed using a standardized questionnaire. Univariable and multivariable conditional logistic regression analyses were conducted. Matched odds ratios (mORs) were calculated. Results: Participants included 88 case patients and 151 matched control. Case patients were more likely to be aged <25 years (unadjusted mOR 2.7, 95% confidence interval 1.3–5.5) or aged >53 years (mOR 2.5, 1.1–5.7), and more likely to be men (mOR 2.6, 1.4–4.8). Unadjusted analyses identified multiple risk factors: rinsing (mOR 6.3, 1.3–29.9) and storing lenses in tap water (mOR 3.9, 1.2–12.3), topping off solution in the lens case (mOR 4.0, 2.0–8.0), having worn lenses ⩽5 years (mOR 2.4, 1.3–4.4), rinsing the case with tap water before storing lenses (mOR 2.1, 1.1–4.1), and using hydrogen peroxide (mOR 3.6, 1.1–11.7) versus multipurpose solution. Significant risk factors in multivariable modeling included age >53 years, male sex, topping off, and using saline solution. Conclusions: Numerous modifiable risk factors for AK were identified, mostly involving hygiene practices. To reduce the risk of AK, lens wearers should observe recommended lens care practices.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"25 1","pages":"S173–S178"},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85411904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-13DOI: 10.1097/ICL.0000000000000345
Alberto Domínguez-Vicent, J. Esteve-Taboada, A. Recchioni, R. Brautaset
Objective: To assess the power profile and in vitro optical quality of scleral contact lenses with different powers as a function of the optical aperture. Methods: The mini and semiscleral contact lenses (Procornea) were measured for five powers per design. The NIMO TR-1504 (Lambda-X) was used to assess the power profile and Zernike coefficients of each contact lens. Ten measurements per lens were taken at 3- and 6-mm apertures. Furthermore, the optical quality of each lens was described in Zernike coefficients, modulation transfer function, and point spread function (PSF). A convolution of each lens PSF with an eye-chart image was also computed. Results: The optical power fluctuated less than 0.5 diopters (D) along the optical zone of each lens. However, the optical power obtained for some lenses did not match with its corresponding nominal one, the maximum difference being 0.5 D. In optical quality, small differences were obtained among all lenses within the same design. Although significant differences were obtained among lenses (P<0.05), these showed small impact in the image quality of each convolution. Conclusions: Insignificant power fluctuations were obtained along the optical zone measured for each scleral lens. Additionally, the optical quality of both lenses has showed to be independent of the lens power within the same aperture.
{"title":"Power Profiles and In Vitro Optical Quality of Scleral Contact Lenses: Effect of the Aperture and Power","authors":"Alberto Domínguez-Vicent, J. Esteve-Taboada, A. Recchioni, R. Brautaset","doi":"10.1097/ICL.0000000000000345","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000345","url":null,"abstract":"Objective: To assess the power profile and in vitro optical quality of scleral contact lenses with different powers as a function of the optical aperture. Methods: The mini and semiscleral contact lenses (Procornea) were measured for five powers per design. The NIMO TR-1504 (Lambda-X) was used to assess the power profile and Zernike coefficients of each contact lens. Ten measurements per lens were taken at 3- and 6-mm apertures. Furthermore, the optical quality of each lens was described in Zernike coefficients, modulation transfer function, and point spread function (PSF). A convolution of each lens PSF with an eye-chart image was also computed. Results: The optical power fluctuated less than 0.5 diopters (D) along the optical zone of each lens. However, the optical power obtained for some lenses did not match with its corresponding nominal one, the maximum difference being 0.5 D. In optical quality, small differences were obtained among all lenses within the same design. Although significant differences were obtained among lenses (P<0.05), these showed small impact in the image quality of each convolution. Conclusions: Insignificant power fluctuations were obtained along the optical zone measured for each scleral lens. Additionally, the optical quality of both lenses has showed to be independent of the lens power within the same aperture.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"8 1","pages":"149–158"},"PeriodicalIF":0.0,"publicationDate":"2017-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88100135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-04DOI: 10.1097/ICL.0000000000000357
Jian Li, P. Dong, Hu Liu
Objective: The aim of this study was to explore the effects of the overnight wear orthokeratology (OK) lenses on corneal shape and tear film stability. Methods: Forty patients with myopia aged between 11 and 18 years who wore OK lens continuously for more than 1 year were selected. Refractive error (D), corneal curvature, corneal surface regularity index (SRI), tear breakup time (TBUT), Schirmer I test score, and corneal staining were measured at the following time points: 1 week before wearing the OK lens (T0) and 1 week (T1), 1 month (T2), 3 months (T3), 6 months (T4), and 12 months (T5) after wear. Results: Compared with T0, the average spherical refractions at other time points had become less myopic, flattens the central cornea, the SRI increased, and the TBUT decreased (P<0.01). All the aforementioned variables became stable at T1. Conversely, results of the Schirmer I test showed no significant changes. The number of patients with a corneal epithelium stained with fluorescein increased; staining was mainly of the grade I type. At each time point, the TBUT in patients with grade I corneal fluorescein staining was significantly lower than in patients with grade 0 staining (P<0.05). Conclusions: The overnight wear OK lenses may have decreased the degree of myopia and flattened the cornea while leaving basal tear secretion unaffected; however, the stability of tears decreased, therefore regular follow-ups are recommended.
{"title":"Effect of Overnight Wear Orthokeratology Lenses on Corneal Shape and Tears","authors":"Jian Li, P. Dong, Hu Liu","doi":"10.1097/ICL.0000000000000357","DOIUrl":"https://doi.org/10.1097/ICL.0000000000000357","url":null,"abstract":"Objective: The aim of this study was to explore the effects of the overnight wear orthokeratology (OK) lenses on corneal shape and tear film stability. Methods: Forty patients with myopia aged between 11 and 18 years who wore OK lens continuously for more than 1 year were selected. Refractive error (D), corneal curvature, corneal surface regularity index (SRI), tear breakup time (TBUT), Schirmer I test score, and corneal staining were measured at the following time points: 1 week before wearing the OK lens (T0) and 1 week (T1), 1 month (T2), 3 months (T3), 6 months (T4), and 12 months (T5) after wear. Results: Compared with T0, the average spherical refractions at other time points had become less myopic, flattens the central cornea, the SRI increased, and the TBUT decreased (P<0.01). All the aforementioned variables became stable at T1. Conversely, results of the Schirmer I test showed no significant changes. The number of patients with a corneal epithelium stained with fluorescein increased; staining was mainly of the grade I type. At each time point, the TBUT in patients with grade I corneal fluorescein staining was significantly lower than in patients with grade 0 staining (P<0.05). Conclusions: The overnight wear OK lenses may have decreased the degree of myopia and flattened the cornea while leaving basal tear secretion unaffected; however, the stability of tears decreased, therefore regular follow-ups are recommended.","PeriodicalId":12216,"journal":{"name":"Eye & Contact Lens: Science & Clinical Practice","volume":"32 1","pages":"304–307"},"PeriodicalIF":0.0,"publicationDate":"2017-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80990438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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