Samuel Ansong, Desmond Nkrumah, Reinhard Isaac Nketia, Samuel Oppong Bekoe, Abena Amponsaa Brobbey, Evelyn Asante-Kwatia, Gustav Komlaga
Sida cordifolia has been used to treat malaria in Ghana albeit without scientific evidence of antimalarial activity and safety. This work aimed to assess the antimalarial properties and acute toxicity of the aqueous leaf extract of S. cordifolia in murine models. Aqueous extract of the plant was analysed for both suppressive and curative antimalarial properties in chloroquine-sensitive ANKA strains of rodent Plasmodium berghei-infected mice. Acute toxicity evaluation was performed in rats according to the OECD 425 guidelines. The extract displayed antiplasmodial activity in vivo with ED50 of 117.49 ± 15.22 mg/kg and 144.84 ± 18.17 mg/kg in suppressive and curative studies, respectively. The highest % parasitaemia suppression exerted was 76.90 ± 0.64% and 61.50 ± 0.97%, respectively, in the suppressive and curative studies. Survival of infected mice treated with the extract was significantly prolonged. This was dependent on the dose of the extract but imperfectly related to the % parasitaemia suppression. Related antimalarial parameters including percentage hematocrit, changes in body weight, and temperature of experimental mice indicated alleviation of malarial symptoms of treated animals. The extract did not show toxicity in rats. Sida cordifolia L. has antimalarial properties, and was safe. It suppressed parasitaemia in both suppressive and curative studies, was not toxic to animals and prolonged the life of infected animals under treatment. This, therefore, justifies the traditional use of S. cordifolia for the treatment of malaria in Ghana.
{"title":"Antimalarial Properties of Sida cordifolia L. Leaf Extract in Mice: Survivability Depends Less on Parasitaemia Suppression","authors":"Samuel Ansong, Desmond Nkrumah, Reinhard Isaac Nketia, Samuel Oppong Bekoe, Abena Amponsaa Brobbey, Evelyn Asante-Kwatia, Gustav Komlaga","doi":"10.1155/2023/5560711","DOIUrl":"https://doi.org/10.1155/2023/5560711","url":null,"abstract":"<i>Sida cordifolia</i> has been used to treat malaria in Ghana albeit without scientific evidence of antimalarial activity and safety. This work aimed to assess the antimalarial properties and acute toxicity of the aqueous leaf extract of <i>S. cordifolia</i> in murine models. Aqueous extract of the plant was analysed for both suppressive and curative antimalarial properties in chloroquine-sensitive ANKA strains of rodent <i>Plasmodium berghei</i>-infected mice. Acute toxicity evaluation was performed in rats according to the OECD 425 guidelines. The extract displayed antiplasmodial activity <i>in vivo</i> with ED<sub>50</sub> of 117.49 ± 15.22 mg/kg and 144.84 ± 18.17 mg/kg in suppressive and curative studies, respectively. The highest % parasitaemia suppression exerted was 76.90 ± 0.64% and 61.50 ± 0.97%, respectively, in the suppressive and curative studies. Survival of infected mice treated with the extract was significantly prolonged. This was dependent on the dose of the extract but imperfectly related to the % parasitaemia suppression. Related antimalarial parameters including percentage hematocrit, changes in body weight, and temperature of experimental mice indicated alleviation of malarial symptoms of treated animals. The extract did not show toxicity in rats. <i>Sida cordifolia</i> L. has antimalarial properties, and was safe. It suppressed parasitaemia in both suppressive and curative studies, was not toxic to animals and prolonged the life of infected animals under treatment. This, therefore, justifies the traditional use of <i>S. cordifolia</i> for the treatment of malaria in Ghana.","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katiana Simões Lopes, A. A. M. Marques, Karyne Garcia Tafarelo Moreno, A. C. dos Santos, R. I. Souza, E. Lourenço, Rodrigo Juliano Oliveira, R. Gomes, F. Lívero, A. Gasparotto Júnior
Solidago microglossa DC. (Asteraceae), “arnica brasileira,” is a Brazilian species popularly used to treat hypertension or renal ailments. This study investigated the cardioprotective effects of standardized S. microglossa extract (EESM) in nicotine-treated spontaneously hypertensive rats (SHRs). Moreover, the molecular mechanisms involved in the cardiovascular effects were also investigated. The acute toxicity was evaluated in female Wistar rats. Afterwards, six-month-old male spontaneously hypertensive rats received the EESM (14, 28, and 56 mg/kg), hydrochlorothiazide (25 mg/kg), and vehicle (filtered water; 0.1 mL/100 g) once daily for 28 days. All treatments were associated with 1.8 mg/kg of nicotine. At the end of the experimental period, the renal function, electrocardiographic profile, blood pressure, ventricular function, biochemical parameter, and mesenteric vascular bed reactivity were evaluated. Relative organ weights and cardiac morphometry were also investigated. Nicotine treatment in 6-month-old SHRs induced a significant reduction in renal function, with reduced urinary volume and lower renal elimination of sodium and creatinine. In addition, serum markers of the redox state and blood pressure levels remained significantly elevated, contributing to changes in vascular reactivity and left ventricular hypertrophy associated with reduced ventricular function. After 28 days of treatment, we found that the highest dose of EESM could mitigate all renal and cardiovascular changes developed by the nicotine-treated hypertensive rats. This study presented EESM as a possible cardioprotective drug that prevents cardiovascular dysfunctions in nicotine-treated hypertensive rats. Our data suggest EESM as a potential adjuvant therapy when cardioprotective effects are required.
{"title":"Cardioprotective Effects of Solidago microglossa DC. in Nicotine-Treated Hypertensive Rats","authors":"Katiana Simões Lopes, A. A. M. Marques, Karyne Garcia Tafarelo Moreno, A. C. dos Santos, R. I. Souza, E. Lourenço, Rodrigo Juliano Oliveira, R. Gomes, F. Lívero, A. Gasparotto Júnior","doi":"10.1155/2023/6611569","DOIUrl":"https://doi.org/10.1155/2023/6611569","url":null,"abstract":"Solidago microglossa DC. (Asteraceae), “arnica brasileira,” is a Brazilian species popularly used to treat hypertension or renal ailments. This study investigated the cardioprotective effects of standardized S. microglossa extract (EESM) in nicotine-treated spontaneously hypertensive rats (SHRs). Moreover, the molecular mechanisms involved in the cardiovascular effects were also investigated. The acute toxicity was evaluated in female Wistar rats. Afterwards, six-month-old male spontaneously hypertensive rats received the EESM (14, 28, and 56 mg/kg), hydrochlorothiazide (25 mg/kg), and vehicle (filtered water; 0.1 mL/100 g) once daily for 28 days. All treatments were associated with 1.8 mg/kg of nicotine. At the end of the experimental period, the renal function, electrocardiographic profile, blood pressure, ventricular function, biochemical parameter, and mesenteric vascular bed reactivity were evaluated. Relative organ weights and cardiac morphometry were also investigated. Nicotine treatment in 6-month-old SHRs induced a significant reduction in renal function, with reduced urinary volume and lower renal elimination of sodium and creatinine. In addition, serum markers of the redox state and blood pressure levels remained significantly elevated, contributing to changes in vascular reactivity and left ventricular hypertrophy associated with reduced ventricular function. After 28 days of treatment, we found that the highest dose of EESM could mitigate all renal and cardiovascular changes developed by the nicotine-treated hypertensive rats. This study presented EESM as a possible cardioprotective drug that prevents cardiovascular dysfunctions in nicotine-treated hypertensive rats. Our data suggest EESM as a potential adjuvant therapy when cardioprotective effects are required.","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9826513
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2021/1426753.].
[本文撤回文章 DOI：10.1155/2021/1426753]。
{"title":"Retracted: Clinical Study of Stellate Ganglion Block Combined with General Anesthesia on Hemodynamics, Cognitive Function, and Gastrointestinal Function in Elderly Patients Undergoing Partial Hepatectomy.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9826513","DOIUrl":"https://doi.org/10.1155/2023/9826513","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/1426753.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9826513"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138836034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9848149
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2023/1744625.].
[此文撤稿，DOI: 10.1155/2023/1744625.]。
{"title":"Retracted: Clinical Value of Serum SIRT1 Combined with Uterine Hemodynamics in Predicting Disease Severity and Fetal Growth Restriction in Preeclampsia.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9848149","DOIUrl":"https://doi.org/10.1155/2023/9848149","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2023/1744625.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9848149"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138836035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9804916
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/6507865.].
[本文撤消了文章 DOI：10.1155/2022/6507865]。
{"title":"Retracted: Value of MSCT plus MRI in the Detection of Colon Cancer.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9804916","DOIUrl":"https://doi.org/10.1155/2023/9804916","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/6507865.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9804916"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138836144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9898674
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2021/4288739.].
[本文撤回了文章 DOI：10.1155/2021/4288739]。
{"title":"Retracted: Changes of Intestinal Flora and Lymphocyte Subsets in Patients with Chronic Renal Failure.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9898674","DOIUrl":"https://doi.org/10.1155/2023/9898674","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/4288739.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9898674"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9848914
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/6370766.].
[本文撤回了文章 DOI：10.1155/2022/6370766.]。
{"title":"Retracted: CircAGFG1 Promotes Osteosarcoma Progression and Stemness by Competing with miR-302a-3p to Upregulate the Expression of LATS2.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9848914","DOIUrl":"https://doi.org/10.1155/2023/9848914","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/6370766.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9848914"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9761613
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/2327669.].
[本文撤回了文章 DOI：10.1155/2022/2327669.]。
{"title":"Retracted: Circ-GTF2I/miR-590-5p Axis Aggravates Myocardial Ischemia-Reperfusion Injury by Regulating Kelch Repeat and BTB Domain-Containing Protein 7.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9761613","DOIUrl":"https://doi.org/10.1155/2023/9761613","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/2327669.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9761613"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9839030
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/8150444.].
[本文撤回了文章 DOI：10.1155/2022/8150444.]。
{"title":"Retracted: Clinical Efficacy of Budesonide/Glycopyrronium Bromide/Formoterol in the Treatment of Patients with Acute Respiratory Distress Syndrome and Its Effect on Inflammatory Factors.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9839030","DOIUrl":"https://doi.org/10.1155/2023/9839030","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/8150444.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9839030"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13eCollection Date: 2023-01-01DOI: 10.1155/2023/9831716
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2022/1739561.].
[此文撤稿，DOI: 10.1155/2022/1739561.]。
{"title":"Retracted: Clinical Observation of Reduning Combined with Recombinant Human Interferon <i>α</i>-2b in the Treatment of Children with Viral Pneumonia.","authors":"Evidence-Based Complementary And Alternative Medicine","doi":"10.1155/2023/9831716","DOIUrl":"https://doi.org/10.1155/2023/9831716","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2022/1739561.].</p>","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":"2023 ","pages":"9831716"},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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