Adults of all ages are worse at recognizing pairs of items that were previously seen together relative to the individual items, and this paired-associative memory deficit is exacerbated in aging. Less is known about memory for higher associative loads, which place greater demands on binding processes that link items into a cohesive memory trace, among other processes (e.g., working memory, recollection). In this study, adults across the lifespan (n = 250, 18-78 years) completed a novel recognition task in which they studied word pairs, triplets, and quadruplets and were tested on their memory for repeated, recombined, and novel word sets. Associative memory deficits were seen in adults of all ages as fewer correct responses to repeated sets (hits), more incorrect responses to recombined sets (recombined false alarm, FA), and larger differences between these measures (associative memory) at higher set sizes. In addition, older adults had worse associative memory performance (higher recombined FA, lower associative memory) that increased at higher set sizes. These findings indicate that associative memory deficits increase with demands on binding or other processes at higher associative loads and with aging. They further demonstrate the feasibility of manipulating and assessing associative memory load using our novel QuadMax task.
Introduction: Previous research has identified an association between olfactory impairment (reduced odor sensitivity/ identification/ discrimination) and cognitive impairment in older adults. The present study focused on the relationship between olfactory memory performance and cognitive/affective functioning.
Method: Recognition performance for olfactory and visual stimuli (control condition) was tested through a matching task in older adults (n = 44; Mage = 76 years) and younger adults (n = 56; Mage = 24 years). Additionally, negative affect (anxiety, depression) and cognitive functioning were assessed via validated questionnaires and a neuropsychological test battery.
Results: The older participants performed worse than the younger adults in the olfactory memory task. In older adults, difficulties in remembering odors were associated with reduced odor identification and executive functioning (reduced cognitive flexibility). Affective well-being was not related to olfactory memory performance.
Implication: Olfactory memory impairment in older adulthood might be a marker for cognitive decline in areas related to executive functions.
Background: The aim of the study was to investigate the validity and reliability of the Turkish version of the Fear of Falling Questionnaire-Revised (FFQ-R) in older adults with mild cognitive impairment (MCI) living in a nursing home.
Methods: The study was conducted with 107 (69 women) older adults. The participants were evaluated with the FFQ-R, the Falls Efficacy Scale (FES), the Mini-Mental State Examination (MMSE), the Barthel Index and Montgomery-Åsberg Depression Rating Scale (MADRS)". FFQ-R was refilled one month later for retesting.
Results: Cronbach's alpha value of the FFQ-R was 0.971. The global internal consistency was excellent (>0.80). Intraclass correlation coefficient of the FFQ-R was 0.962 (95% CI: 0.92-0.98), indicating excellent test-retest reliability. The Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC) values of the FFQ-R was 0.80 and 2.21, respectively. The correlation between the total score of FFQ-R and the FES was excellent (r = 0.963, p < .001). The relationship between FFQ-R and MMSE was excellent (r = -0.821, p < .001). Besides, there was a moderate correlation between the FFQ-R with Barthel Index (r = -0.648, p < .001) and FFR-Q with MADRS (r = 0.568, p < .001).
Conclusion: Turkish version of the FFQ-R is a valid and reliable tool to assess the fear of falling in nursing home residents.
Objective: To overcome memory decrements in healthy aging, compensation strategies and mnemonics have been found to be promising. The effects of musical mnemonics in aging have been scarcely studied.
Methods: The present study examined the effects of musical presentation of digits (pitch sequences, rhythms, and their combinations) on working memory performance in young and older adults, as compared to spoken presentation.
Results: A facilitating effect of rhythm was found in both groups, whereas pitch and melodic cues affected performance negatively in older adults only. Musical training did not moderate the effect of musical mnemonics.
Discussion: To investigate whether persons with working memory impairment also benefit from musical mnemonics, follow-up research in older persons with, for instance, mild cognitive impairment or Alzheimer's dementia is recommended.
Objectives: Living a long life does not guarantee the maintenance of optimal cognitive functioning; however, similar to older adults in general, cognitive reserve may also protect oldest-old adults from cognitive decline. The purpose of this study was to assess cognitive reserve among centenarians and octogenarians and to evaluate a process model of cognitive reserve.
Methods: A total of 321 centenarians and octogenarians from the Georgia Centenarian Study were included in this study. Cognitive reserve components included level of education, occupational responsibility, current social engagement, past engaged lifestyle, and activity. Cognitive functioning was measured with the Mini-Mental Status Examination.
Results: Structural equation modeling was computed, and the overall model fit well, χ2 (df = 3) = 5.02, p = .17; CFI = .99, RMSEA = .05. Education is directly and indirectly related to cognitive functioning through occupational responsibility and past engaged lifestyle. Current social engagement is related to cognitive functioning directly and indirectly through current activities. The four direct predictors (i.e., education, current social engagement, current activity, and past engaged lifestyle) explained 35% of the variance in cognitive functioning.
Conclusion: The results provide important information for cognitive reserve theories with implications for interventions that build cognitive reserve.
Objectives: This study examined the effects of one-month naringin administration and exercise training on cognitive impairment and H2S signaling pathway in an Amyloid β (Aβ)-injected rat.
Methods: Rats were divided into four groups: control group; rats underwent Aβ microinjection surgery, exercise group; rats underwent Aβ microinjection surgery and trained by treadmill for four weeks, naringin group; rats underwent Aβ microinjection surgery, and rats orally administrated 80 mg.kg-1 naringin for four weeks, naringin+exercise group; rats underwent Aβ microinjection surgery and were trained by treadmill for four weeks, and also, rats orally administrated 80 mg.kg-1 naringin for four weeks. After one month of treatment, spatial learning and memory were measured, and then hippocampi were sampled. S-adenosylmethionine (SAM), cystathionine-β-synthase (CBS), hydrogen sulfide (H2S) levels, and neuronal death were detected in the hippocampi of rats.
Results: Naringin and exercise improved spatial learning (latency time, P < .001) and memory (P < .001) in the Morris Water Maze test in Aβ-injected rats compared with the control group. SAM (P < .01), CBS (P < .001), and H2S (P < .01) levels are increased in the naringin+exercise group compared with the control group.
Conclusion: The result of this study supports the effect of exercise and/or naringin to improve cognitive dysfunction and cell death through the production of H2S.
Background: Physical inactivity significantly increases risk of cardiovascular diseases, which are highly prevalent in aging. Conversely, higher levels of physical activity in aging have been associated with benefits for physical and cognitive health and is hypothesized to prevent and reduce development of cardiovascular risk factors. However, those older adults with the highest activity levels (i.e., Master Athletes [MA]) are relatively understudied, and even fewer studies involve female MA.
Objective: The aim of this study was to compare the physiological, physical, and cognitive profiles of an 83-year-old track-and-field MA runner to a sample of inactive age-matched females.
Results: Results revealed the MA had a high peak oxygen uptake and had superior performance on visuospatial memory tasks compared to her inactive counterparts. Cerebral blood flow was slightly elevated in the MA, but lower cerebrovascular reactivity was revealed compared to the other female included in the magnetic resonance imaging portion.
Conclusion: Our results suggest that high levels of physical activity have benefits on multiple aspects of an aging female's life and that more studies should include MA, as well as a spectrum of cardiorespiratory fitness to further understand the role of physical activity in female aging.
Introduction: Carers of Alzheimer's suffer from caregiver overload, anxiety and depression. Changes in caregiving brought about by pandemic restrictions (COVID-19) may play a role. The aim was to explore the caregiver profile and assess the influence of the pandemic on informal and formal caregivers in a Spanish sample.
Method: Sixty caregivers participated. An ad hoc questionnaire, ZBI, STAI and BDI were administered.
Results: Informal caregivers were more overloaded, anxious and depressed than professional caregivers. Both groups perceived themselves to be more sad, worried and stressed than in the pre-pandemic situation. The pandemic-generated variables associated with caregiving did not influence caregiver overload in both groups. In informal caregivers, worsening of the patient with stress and changes in perceived social support with anxiety and depression. In professional caregivers, changes in routine were associated with stress and lower depression and changes in perceived social support with higher caregiver strain. Changes in caregiving routine and changes in perceived social support were predictors of overload and emotional distress in both caregivers.
Conclusions: Overload was not influenced by the pandemic situation. Changes in caregiving routine and lack of social support were found to be predictors of overload and emotional distress in both types of caregivers.
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